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1. Diagnostic Value of Aortic Valve Calcification Levels in the Assessment of Low-Gradient Aortic Stenosis

Author

Adrichem, Rik, Hokken, Thijmen W., Bouwmeester, Sjoerd, Abdelkarim, Ola, Vogel, Birgit, Blusztein, David I., Veulemans, Verena, Kuneman, Jurrien H., Geleijnse, Marcel L., Verhemel, Sarah, Van den Dorpel, Mark M.P., Kardys, Isabella, Tonino, Pim A.L., Chang, Su Min, Faza, Nadeen N., Jou, Stephanie, Ueyama, Hiroki A., Bartkowiak, Joanna, Zeus, Tobias, Bax, Jeroen J., Bertrand, Philippe B., Hahn, Rebecca T., Kodali, Susheel K., Lerakis, Stamatios, Mehran, Roxana, Little, Stephen H., Houthuizen, Patrick, and Van Mieghem, Nicolas M.

Published
2024
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3. 3D Printing, Computational Modeling, and Artificial Intelligence for Structural Heart Disease

Author

Wang, Dee Dee, Qian, Zhen, Vukicevic, Marija, Engelhardt, Sandy, Kheradvar, Arash, Zhang, Chuck, Little, Stephen H, Verjans, Johan, Comaniciu, Dorin, O'Neill, William W, and Vannan, Mani A

Subjects
Biomedical and Clinical Sciences, Cardiovascular Medicine and Haematology, Clinical Research, Bioengineering, Heart Disease, Cardiovascular, Good Health and Well Being, Artificial Intelligence, Cardiac Catheterization, Cardiac Surgical Procedures, Heart Diseases, Humans, Predictive Value of Tests, Printing, Three-Dimensional, 3D printing, artificial intelligence, computational modeling, computed tomography, left atrial appendage, structural heart disease, transcatheter aortic valve replacement, transcatheter mitral valve replacement, transesophageal echocardiogram, Cardiorespiratory Medicine and Haematology, Clinical Sciences, Cardiovascular System & Hematology, Cardiovascular medicine and haematology, Clinical sciences
Abstract

Structural heart disease (SHD) is a new field within cardiovascular medicine. Traditional imaging modalities fall short in supporting the needs of SHD interventions, as they have been constructed around the concept of disease diagnosis. SHD interventions disrupt traditional concepts of imaging in requiring imaging to plan, simulate, and predict intraprocedural outcomes. In transcatheter SHD interventions, the absence of a gold-standard open cavity surgical field deprives physicians of the opportunity for tactile feedback and visual confirmation of cardiac anatomy. Hence, dependency on imaging in periprocedural guidance has led to evolution of a new generation of procedural skillsets, concept of a visual field, and technologies in the periprocedural planning period to accelerate preclinical device development, physician, and patient education. Adaptation of 3-dimensional (3D) printing in clinical care and procedural planning has demonstrated a reduction in early-operator learning curve for transcatheter interventions. Integration of computation modeling to 3D printing has accelerated research and development understanding of fluid mechanics within device testing. Application of 3D printing, computational modeling, and ultimately incorporation of artificial intelligence is changing the landscape of physician training and delivery of patient-centric care. Transcatheter structural heart interventions are requiring in-depth periprocedural understanding of cardiac pathophysiology and device interactions not afforded by traditional imaging metrics.

Published
2021

7. Impact of Left Atrial Pressure on Outcomes After Mitral Transcatheter Edge-to-Edge Repair

Author

Sammour, Yasser M, primary, Bou Chaaya, Rody Georges, additional, Hatab, Taha, additional, Zaid, Syed, additional, Aoun, Joe, additional, Makram, Omar M, additional, Wessly, Priscilla, additional, Samimi, Sahar, additional, Nagueh, Sherif F, additional, Zoghbi, William A, additional, Atkins, Marvin D, additional, Reardon, Michael J, additional, Faza, Nadeen, additional, Little, Stephen H., additional, Kleiman, Neal S, additional, and Goel, Sachin S, additional

Published
2024
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8. Myocardial Blood Flow Reserve, Microvascular Coronary Health, and Myocardial Remodeling in Patients With Aortic Stenosis

Author

Alahdab, Fares, primary, Ahmed, Ahmed I., additional, Nayfeh, Malek, additional, Han, Yushui, additional, Abdelkarim, Ola, additional, Alfawara, Moath S., additional, Little, Stephen H., additional, Reardon, Michael J., additional, Faza, Nadeen N., additional, Goel, Sachin S., additional, Alkhouli, Mohamad, additional, Zoghbi, William, additional, and Al‐Mallah, Mouaz H., additional

Published
2024
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9. Examining the typical hemodynamic performance of nearly 3000 modern surgical aortic bioprostheses

Author

Klautz, Robert J M, primary, Rao, Vivek, additional, Reardon, Michael J, additional, Deeb, G Michael, additional, Dagenais, Francois, additional, Moront, Michael G, additional, Little, Stephen H, additional, Labrousse, Louis, additional, Patel, Himanshu J, additional, Ito, Saki, additional, Li, Shuzhen, additional, Sabik, Joseph F, additional, and Oh, Jae K, additional

Published
2024
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10. Prognostic Value of Right Ventricular Afterload in Patients Undergoing Mitral Transcatheter Edge‐to‐Edge Repair

Author

Bou Chaaya, Rody G., primary, Hatab, Taha, additional, Samimi, Sahar, additional, Qamar, Fatima, additional, Kharsa, Chloe, additional, Aoun, Joe, additional, Faza, Nadeen, additional, Little, Stephen H., additional, Atkins, Marvin D., additional, Reardon, Michael J., additional, Kleiman, Neal S., additional, Nagueh, Sherif F., additional, Zoghbi, William A., additional, Guha, Ashrith, additional, Zaid, Syed, additional, and Goel, Sachin S., additional

Published
2024
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14. Intraventricular Vortex Interaction between Transmitral Flow and Paravalvular Leak.

Author

Morisawa, Daisuke, Falahatpisheh, Ahmad, Avenatti, Eleonora, Little, Stephen H, and Kheradvar, Arash

Subjects
Aortic Valve, Mitral Valve, Heart Ventricles, Humans, Echocardiography, Doppler, Color, Coronary Circulation, Kinetics, Hydrodynamics, Transcatheter Aortic Valve Replacement, TAVI, Diastolic function, Heart valves
Abstract

Paravalvular leak (PVL) is a complication of transcatheter aortic valve replacement. Despite its marked clinical impact, no previous study has reported how PVL affects the intraventricular fluid dynamics. This study aims to delineate vortex interaction between PVL and transmitral flow and the influence of PVL orifice location on intraventricular fluid dynamics using Echocardiographic Particle Image Velocimetry. Three different conditions of no PVL, anterior PVL and posterior PVL were experimentally studied and clinically compared. Circulation, impulse, kinetic energy (KE) and change in KE (ΔKE) were calculated. As well, vortex formation analyses and streamline description were performed to study vortex interactions. The anterior PVL jet streamed into the LV and interfered with the transmitral flow. Posterior PVL jet formed a large clockwise vortex and collided with transmitral flow, which resulted in flow disturbance. Compared to no PVL condition, average circulation, impulse, KE and ΔKE increased in presence of PVL. In conclusion, we found that PVL jets lead to abnormal vortex formation that interfere with natural advancement of transmitral flow, and negatively affect the LV fluid dynamics parameters. PVL orifice location strongly affects the intraventricular vortex formation, and posterior PVL may have more negative effects compared to anterior PVL.

Published
2018

15. Echocardiographic Profiling Predicts Clinical Outcomes After Mitral Transcatheter Edge‐to‐Edge Repair

Author

Hatab, Taha, primary, Samimi, Sahar, additional, Bou Chaaya, Rody G., additional, Qamar, Fatima, additional, Kharsa, Chloe, additional, Wessly, Priscilla, additional, Faza, Nadeen, additional, Little, Stephen H., additional, Atkins, Marvin D., additional, Reardon, Michael J., additional, Kleiman, Neal S., additional, Zoghbi, William A., additional, Nagueh, Sherif F., additional, Zaid, Syed, additional, and Goel, Sachin S., additional

Published
2024
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17. Guidelines for the Evaluation of Prosthetic Valve Function With Cardiovascular Imaging: A Report From the American Society of Echocardiography Developed in Collaboration With the Society for Cardiovascular Magnetic Resonance and the Society of Cardiovascular Computed Tomography

Author

Zoghbi, William A., primary, Jone, Pei-Ni, additional, Chamsi-Pasha, Mohammed A., additional, Chen, Tiffany, additional, Collins, Keith A., additional, Desai, Milind Y., additional, Grayburn, Paul, additional, Groves, Daniel W., additional, Hahn, Rebecca T., additional, Little, Stephen H., additional, Kruse, Eric, additional, Sanborn, Danita, additional, Shah, Sangeeta B., additional, Sugeng, Lissa, additional, Swaminathan, Madhav, additional, Thaden, Jeremy, additional, Thavendiranathan, Paaladinesh, additional, Tsang, Wendy, additional, Weir-McCall, Jonathan R., additional, and Gill, Edward, additional

Published
2024
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18. Abstract 11868: Design and Development of Automatic Extraction Transformation and Load (ETL) Process and Machine Learning for Echocardiography Data Extraction and Validation: Houston Methodist CVD Learning Health System Registry

Author

BOSE, BUDHADITYA, Butt, Sara A, POURNAZARI, PAYAM, Arshad, Hassaan B, Nicolas, Charlie C, Gullapelli, Rakesh, Nwana, Nwabunie, Javed, Zulqarnain, Patel, Kershaw, PASHA, MOHAMMED A. C, Little, Stephen H, FAZA, NADEEN N, Jones, Stephen L, CAINZOS, MIGUEL A, SOSTMAN, DIRK H, Zoghbi, William A, Nagueh, Sherif, and KHURRAM, NASIR

Published
2022
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23. Emerging Trends in Heart Valve Engineering: Part IV. Computational Modeling and Experimental Studies.

Author

Kheradvar, Arash, Groves, Elliott M, Falahatpisheh, Ahmad, Mofrad, Mohammad K, Hamed Alavi, S, Tranquillo, Robert, Dasi, Lakshmi P, Simmons, Craig A, Jane Grande-Allen, K, Goergen, Craig J, Baaijens, Frank, Little, Stephen H, Canic, Suncica, and Griffith, Boyce

Subjects
Humans, Heart Valve Diseases, Heart Valve Prosthesis, Models, Cardiovascular, Computer Simulation, Female, Male, Biaxial testing, Computational modeling, Heart valves, Multiscale modeling, Numerical simulation, Particle image velocimetry, Biomedical Engineering, Medical and Health Sciences, Engineering
Abstract

In this final portion of an extensive review of heart valve engineering, we focus on the computational methods and experimental studies related to heart valves. The discussion begins with a thorough review of computational modeling and the governing equations of fluid and structural interaction. We then move onto multiscale and disease specific modeling. Finally, advanced methods related to in vitro testing of the heart valves are reviewed. This section of the review series is intended to illustrate application of computational methods and experimental studies and their interrelation for studying heart valves.

Published
2015

24. Emerging trends in heart valve engineering: Part III. Novel technologies for mitral valve repair and replacement.

Author

Kheradvar, Arash, Groves, Elliott M, Simmons, Craig A, Griffith, Boyce, Alavi, S Hamed, Tranquillo, Robert, Dasi, Lakshmi P, Falahatpisheh, Ahmad, Grande-Allen, K Jane, Goergen, Craig J, Mofrad, Mohammad RK, Baaijens, Frank, Canic, Suncica, and Little, Stephen H

Subjects
Mitral Valve, Animals, Humans, Heart Valve Prosthesis Implantation, Tissue Engineering, Bioprosthesis, Heart Valve Prosthesis, Heart valve engineering, Mitral valve repair, Mitral valve replacement, Transcatheter mitral valve, Assistive Technology, Heart Disease, Bioengineering, Cardiovascular, Biomedical Engineering, Engineering, Medical and Health Sciences
Abstract

In this portion of an extensive review of heart valve engineering, we focus on the current and emerging technologies and techniques to repair or replace the mitral valve. We begin with a discussion of the currently available mechanical and bioprosthetic mitral valves followed by the rationale and limitations of current surgical mitral annuloplasty methods; a discussion of the technique of neo-chordae fabrication and implantation; a review the procedures and clinical results for catheter-based mitral leaflet repair; a highlight of the motivation for and limitations of catheter-based annular reduction therapies; and introduce the early generation devices for catheter-based mitral valve replacement.

Published
2015

25. Emerging trends in heart valve engineering: Part II. Novel and standard technologies for aortic valve replacement.

Author

Kheradvar, Arash, Groves, Elliott M, Goergen, Craig J, Alavi, S Hamed, Tranquillo, Robert, Simmons, Craig A, Dasi, Lakshmi P, Grande-Allen, K Jane, Mofrad, Mohammad RK, Falahatpisheh, Ahmad, Griffith, Boyce, Baaijens, Frank, Little, Stephen H, and Canic, Suncica

Subjects
Aortic Valve, Animals, Humans, Tissue Engineering, Bioprosthesis, Heart Valve Prosthesis, Heart valve engineering, Mechanical heart valve, Transcatheter aortic valves, Bioprosthetic heart valves, Biomedical Engineering, Medical and Health Sciences, Engineering
Abstract

The engineering of technologies for heart valve replacement (i.e., heart valve engineering) is an exciting and evolving field. Since the first valve replacement, technology has progressed by leaps and bounds. Innovations emerge frequently and supply patients and physicians with new, increasingly efficacious and less invasive treatment options. As much as any other field in medicine the treatment of heart valve disease has experienced a renaissance in the last 10 years. Here we review the currently available technologies and future options in the surgical and transcatheter treatment of aortic valve disease. Different valves from major manufacturers are described in details with their applications.

Published
2015

26. Emerging trends in heart valve engineering: Part I. Solutions for future.

Author

Kheradvar, Arash, Groves, Elliott M, Dasi, Lakshmi P, Alavi, S Hamed, Tranquillo, Robert, Grande-Allen, K Jane, Simmons, Craig A, Griffith, Boyce, Falahatpisheh, Ahmad, Goergen, Craig J, Mofrad, Mohammad RK, Baaijens, Frank, Little, Stephen H, and Canic, Suncica

Subjects
Animals, Humans, Tissue Engineering, Bioprosthesis, Heart, Artificial, Heart Valve Prosthesis, Cellular Microenvironment, Heart valve engineering, Tissue engineered heart valves, Polymeric heart valves, Engineering, Medical and Health Sciences, Biomedical Engineering
Abstract

As the first section of a multi-part review series, this section provides an overview of the ongoing research and development aimed at fabricating novel heart valve replacements beyond what is currently available for patients. Here we discuss heart valve replacement options that involve a biological component or process for creation, either in vitro or in vivo (tissue-engineered heart valves), and heart valves that are fabricated from polymeric material that are considered permanent inert materials that may suffice for adults where growth is not required. Polymeric materials provide opportunities for cost-effective heart valves that can be more easily manufactured and can be easily integrated with artificial heart and ventricular assist device technologies. Tissue engineered heart valves show promise as a regenerative patient specific model that could be the future of all valve replacement. Because tissue-engineered heart valves depend on cells for their creation, understanding how cells sense and respond to chemical and physical stimuli in their microenvironment is critical and therefore, is also reviewed.

Published
2015

27. Building a Novel Artificial Intelligence–Driven Echocardiographic Data Pipeline: Findings From a Large Learning Health System

Author

Bose, Budhaditya, Butt, Sara A., Arshad, Hassan B., Nicolas, Charlie C., Gullapelli, Rakesh, Nwana, Nwabunie, Javed, Zulqarnain, Shahid, Izza, Pournazari, Payam, Patel, Kershaw, Chamsi Pasha, M.A., Little, Stephen H., Faza, Nadeen S., Jones, Stephen, Cainzos, M.A., Al-Kindi, Sadeer, Saad, Jean Michel, Zoghbi, William, Nagueh, Sherif F., and Nasir, Khurram

Published
2024
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28. 2019 AATS/ACC/ASE/SCAI/STS expert consensus systems of care document: A proposal to optimize care for patients with valvular heart disease: A joint report of the American Association for Thoracic Surgery, American College of Cardiology, American Society of Echocardiography, Society for Cardiovascular Angiography and Interventions, and Society of Thoracic Surgeons

Author

Nishimura, Rick A., O’Gara, Patrick T., Bavaria, Joseph E., Brindis, Ralph G., Carroll, John D., Kavinsky, Clifford J., Lindman, Brian R., Linderbaum, Jane A., Little, Stephen H., Mack, Michael J., Mauri, Laura, Miranda, William R., Shahian, David M., and Sundt, Thoralf M., III

Published
2019
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32. Feasibility and Outcomes of Mitral Transcatheter Edge‐To‐Edge Repair in Patients With Variable Degrees of Mitral Annular Calcification

Author

Hatab, Taha, primary, Bou Chaaya, Rody G., additional, Zaid, Syed, additional, Wessly, Priscilla, additional, Satish, Priyanka, additional, Villanueva, Victoria, additional, Faza, Nadeen, additional, Little, Stephen H., additional, Atkins, Marvin D., additional, Reardon, Michael J., additional, Kleiman, Neal S., additional, Zoghbi, William A., additional, and Goel, Sachin S., additional

Published
2023
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33. TAV-in-TAV in Failed Homograft

Author

Hatab, Taha, primary, Zaid, Syed, additional, Wessly, Priscilla, additional, Reardon, Michael J., additional, Atkins, Marvin D., additional, Faza, Nadeen, additional, Little, Stephen H., additional, Kleiman, Neal S., additional, and Goel, Sachin S., additional

Published
2023
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34. Meta-analysis of Transcatheter Edge-to-Edge Repair for Atrial Functional Mitral Regurgitation

Author

Hatab, Taha, primary, Khan, Safi U., additional, Arshad, Hassaan B., additional, Zaid, Syed, additional, Wessly, Priscilla, additional, Faza, Nadeen, additional, Little, Stephen H., additional, Reardon, Michael J., additional, Atkins, Marvin D., additional, Kleiman, Neal S., additional, Zoghbi, William A., additional, and Goel, Sachin S., additional

Published
2023
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35. Feasibility and Safety of Intracardiac Echocardiography Guidance in Mitral Transcatheter Edge-to-Edge Repair: Analysis of the National Inpatient Sample Data from 2015 to 2020

Author

Hashem, Anas, primary, Khalouf, Amani, additional, Agrawal, Ankit, additional, Mohamad, Mohamad Salah, additional, Nayfeh, Tarek, additional, Kashou, Anthony, additional, Chaaya, Rody G Bou, additional, Rai, Devesh, additional, Verghese, Basil, additional, Little, Stephen H., additional, Goldsweig, Andrew, additional, Naidu, Srihari, additional, and Goel, Sachin S., additional

Published
2023
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36. Impact of Mitral Annular Calcification on Outcomes After Mitral Transcatheter Edge-to-Edge Repair

Author

Hatab, Taha, primary, Wessly, Priscilla, additional, Syed, Zaid, additional, Telmesani, Amr, additional, Villanueva, Victoria, additional, Faza, Nadeen, additional, Atkins, Marvin D., additional, Reardon, Michael J., additional, Kleiman, Neal S., additional, Little, Stephen H., additional, Zoghbi, William A., additional, and Goel, Sachin S., additional

Published
2023
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37. Now You See Me Now You Don’t

Author

Hatab, Taha, primary, Zaid, Syed, additional, Toro, Saleem, additional, Wessly, Priscilla, additional, Malahfji, Maan, additional, Faza, Nadeen, additional, Little, Stephen H., additional, Kleiman, Neal S., additional, Reardon, Michael J., additional, and Goel, Sachin S., additional

Published
2023
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38. The (Heart and) Soul of a Human Creation: Designing Echocardiography for the Big Data Age

Author

Arnaout, Rima, primary, Hahn, Rebecca T., additional, Hung, Judy W., additional, Jone, Pei-Ni, additional, Lester, Steven J., additional, Little, Stephen H., additional, Mackensen, G. Burkhard, additional, Rigolin, Vera, additional, Sachdev, Vandana, additional, Saric, Muhamed, additional, Sengupta, Partho P., additional, Strom, Jordan B., additional, Taub, Cynthia C., additional, Thamman, Ritu, additional, and Abraham, Theodore, additional

Published
2023
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39. List of Contributors

Author

Berman, Darren, primary, Buechel, Ronny R., additional, Feinstein, Jeffrey A., additional, Filippini, Stefano, additional, Ghosh, Reena Maria, additional, Giannopoulos, Andreas A., additional, Hibino, Narutoshi, additional, Hussein, Nabil, additional, Jonathan, Plasencia, additional, Justin, Ryan, additional, Kenny, Damien, additional, Lam, Christopher Z., additional, Little, Stephen H., additional, Marsden, Alison L., additional, Mc Mahon, Colin J., additional, Mitsouras, Dimitris, additional, Nam, Lucy L., additional, Olivieri, Laura, additional, Ouda, Ahmed, additional, Plucinotta, Francesca, additional, Pophal, Stephen, additional, Schievano, Silvia, additional, Silvestro, Elizabeth, additional, Sinha, Sanjay, additional, Taylor, Andrew M., additional, Valverde, Israel, additional, van Arsdell, Glen, additional, Vukicevic, Marija, additional, Whitehead, Kevin K., additional, Yoo, Shi-Joon, additional, and Yang, Weiguang, additional

Published
2020
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50. Impact of aortic valve replacement in symptomatic low-risk patients with less than severe aortic stenosis

Author

Ito, Saki, primary, Laham, Roger, additional, Nkomo, Vuyisile T, additional, Forrest, John K, additional, Reardon, Michael J, additional, Little, Stephen H, additional, Mumtaz, Mubashir, additional, Gada, Hemal, additional, Bajwa, Tanvir, additional, Langholz, David, additional, Heiser, John, additional, Chawla, Atul, additional, Jenson, Bart, additional, Attizanni, Guilherme, additional, Markowitz, Alan H, additional, Huang, Jian, additional, and Oh, Jae K, additional

Published
2023
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