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Airfoil printed circuit heat exchangers (PCHEs) possess exceptional comprehensive performance. In recent years, extensive research has been conducted on the layout and structure optimization of airfoil fins. As biomimetic technologies gradually mature, bionics has achieved numerous outcomes in optimizing airfoil aerodynamic characteristic. Inspired by the sailfish geometry, four types of bionic airfoils are proposed based on the NACA 0015 airfoil, to enhance the thermal-hydraulic performance of the airfoil PCHEs. The results show that while the four types of sailfish airfoils are effective in terms of drag reduction, their overall performance at the same pumping power is suboptimal, with only one type providing an advantage at the low Re region. Moreover, airfoils with concave head curves further increase the weakening of heat transfer by the velocity boundary layer.

Secreted phosphoprotein 1 (SPP1), also known as osteopontin, is a phosphorylated protein. High SPP1 expression levels have been detected in multiple cancers and are associated with poor prognosis and reduced survival rates. However, only a few pan‐cancer analyses have targeted SPP1. We conducted a comprehensive analysis using multiple public databases, including TIMER and TCGA, to investigate the expression levels of SPP1 in 33 different tumor types. In addition, we verified the effect of SPP1 on osteosarcoma. To assess the impact of SPP1 on patient outcomes, we employed univariate Cox regression and Kaplan–Meier survival analyses to analyze overall survival (OS), disease‐specific survival (DSS), and progression‐free interval (PFI) in these tumor patients. We also explored SPP1 gene alterations in various tumor tissues using cBioPortal. We then examined the relationship between SPP1 and clinical characteristics, TME, immune regulatory genes, immune checkpoints, TMB, and MSI using R language. In addition, we used GSEA to investigate the molecular mechanisms underlying the role of SPP1. Bioinformatics analysis indicated that SPP1 was upregulated in 17 tumors. Overexpression of SPP1 results in poor OS, DSS, and PFI in CESC, ESCA, GBM, LGG, LIHC, PAAD, PRAD, and skin cutaneous melanoma. SPP1 expression was positively associated with immunocyte infiltration, immune regulatory genes, immune checkpoints, TMB, MSI, and drug sensitivity in certain cancers. We found that high expression of SPP1 in osteosarcoma was related to drug resistance and metastasis and further demonstrated that SPP1 can stimulate osteosarcoma cell proliferation via CCND1 by activating the PI3K/Akt pathway. These findings strongly suggest that SPP1 is a potential prognostic marker and novel target for cancer immunotherapy. [ABSTRACT FROM AUTHOR]

Cancer is a major cause of death globally, and traditional treatments often have limited efficacy and adverse effects. Immunotherapy has shown promise in various malignancies but is less effective in tumors with low immunogenicity or immunosuppressive microenvironment, especially sarcomas. Tertiary lymphoid structures (TLSs) have been associated with a favorable response to immunotherapy and improved survival in cancer patients. However, the immunological mechanisms and clinical significance of TLS in malignant tumors are not fully understood. In this review, we elucidate the composition, neogenesis, and immune characteristics of TLS in tumors, as well as the inflammatory response in cancer development. An in‐depth discussion of the unique immune characteristics of TLSs in lung cancer, breast cancer, melanoma, and soft tissue sarcomas will be presented. Additionally, the therapeutic implications of TLS, including its role as a marker of therapeutic response and prognosis, and strategies to promote TLS formation and maturation will be explored. Overall, we aim to provide a comprehensive understanding of the role of TLS in the tumor immune microenvironment and suggest potential interventions for cancer treatment. [ABSTRACT FROM AUTHOR]

The atomization of sewage sludge is a key step in its drying process. This study conducts an industrial-scale experimental study to investigate the performance of a self-developed internal-mixing air-blast nozzle for atomizing sewage sludge. The size of atomized droplets is calculated using image processing technology. Using the specific size and characteristic size of the droplets, the droplet distribution and the droplet motion behavior in spray field are investigated at various air-to-liquid mass flow rate ratio (ALR). The larger the ALR, the smaller the atomization droplets. By installing outlet diffusers and impaction pins, the atomization angle can be increased and the distribution of droplets in the spray field can be improved. The outlet diffuser with an outlet angle of 90° and the square impaction pin exhibit optimal effect. Experiments with real scale and industrial grade have a significant reference value for industrial applications of sludge atomization. [ABSTRACT FROM AUTHOR]