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Background: This study aimed to better characterize the clinicopathologic characteristics, outcomes, and prognostic factors of AITL in China. Methods: We retrospectively analyzed 312 patients with AITL enrolled between January 2011 and December 2020 from five institutions in China. Results: The median age was 65 years, with 92.6% advanced stage, 59.7% elevated LDH, 46.1% anemia, and 44.0% hypergammaglobulinemia. The majority of patients (84.9%) received anthracycline‐based regimens with or without etoposide, and only 6.1% underwent autologous stem cell transplantation following first remission. The 5‐year OS and PFS estimates were 43.4% and 25.0% with no significant improvement of survival between patients treated during 2011–2015 and 2016–2020, respectively. Both the International Prognostic Index (IPI) and the prognostic index for PTCL, not otherwise specified (PIT), were predictive for OS. In multivariate analysis, age >70 years, elevated LDH, and albumin level <35 g/L were independent prognostic factors for OS. Combining these three factors, a novel prognostic model (the Chinese AITL score) was constructed, which stratified patients into low‐, intermediate‐, and high‐risk groups, with 5‐year OS rates of 69.0%, 41.5%, and 23.7%, respectively. This new model was successfully validated in an independent cohort. Conclusions: Patients with AITL were mainly treated with anthracycline‐based regimens, and the outcomes were still unsatisfactory in China. Our novel prognostic model may improve our ability to identify patients at different risks for alternative therapies. [ABSTRACT FROM AUTHOR]

The article titled "Retraction Note: Curcumin amends Ca2+ dysregulation in microglia by suppressing the activation of P2×7 receptor" has been retracted by the Editors-in-Chief of Molecular & Cellular Biochemistry due to concerns regarding a figure presented in the work. An investigation found similarities between two panels in different figures, raising doubts about the overall scientific validity of the article. The authors have not responded to the Publisher's correspondence. Springer Nature, the publisher, remains neutral in terms of jurisdictional claims and institutional affiliations. [Extracted from the article]

Although extensive literature has addressed depression among adolescents, few studies have emphasized the classification features of depressive symptoms in adolescents. To gain insight into the hierarchy and heterogeneity of depression in adolescents based on symptoms, 5086 adolescents completed the Chinese version of the Center for Epidemiological Studies Depression Scale (CES-D). Using Latent Class Analysis (LCA), we identified different subgroups of adolescents based on depressive symptoms. Multivariate logistic regression analysis was implemented to examine the relations between latent classes and demographic covariates. Four latent classes of individuals with depressive symptoms displaying a pattern of hierarchical organization were identified. The four classes were ordered by the degree of severity, ranging from the students reporting the highest number of depressive symptoms to the lowest number: "probable clinical depression", "subthreshold depression", "mild depression" and "low depression", accounting for 8.2%, 19.2%, 41.8% and 30.8% of total sample respectively. Further analyses revealed that compared to the "mild depression" class, the rest of three classes differed significantly across age groups and only child (vs. sibling) status. In conclusion, classifying the groups of adolescents based on features of depressive symptoms is potentially useful for understanding risk factors and developing tailored prevention and intervention programs for this age group. [ABSTRACT FROM AUTHOR]

Previous studies of the Children's Hope Scale (CHS) have not compared its factor structure using samples of Chinese early adolescents and American early adolescents. Contrary to expectations, the one-factor model revealed a better fit for the Chinese sample (N = 1184) whereas the two-factor model revealed a better fit for the American sample (N = 1049). Full measurement invariance was not demonstrated for the two-factor model of the CHS with the Chinese adolescents. This finding indicated that researchers should not make mean level comparisons between the two factors of agency and pathways across early adolescents from these two nations. Partial scalar invariance was achieved for the one-factor model, which suggested that researchers may tentatively make comparisons between Chinese and American early adolescents using CHS total scores. Although caution should be exercised in interpreting the mean differences, Chinese adolescents reported a lower total mean level of hope than American adolescents. Differences in the findings are discussed within the collectivism-individualism framework. [ABSTRACT FROM AUTHOR]

Curcumin (Cur) is widely used as an anti-inflammation agent and has anti-depression potential. Neuroinflammation mediated by Ca2+ channel activation is closely associated with the progression of post-stroke depression (PSD). In the current study, the role of P2X7 receptor (P2X7R) in the anti-PSD function of Cur was explored. Rats were subjected to middle cerebral artery occlusion (MCAO) surgery and chronic mild stress administration to induce PSD symptoms and then treated with Cur. The behaviors of rats were assessed with sucrose preference and forced swim tests. The accumulation of Ca2+ and the systemic inflammatory response in rats were detected. To determine the role of P2X7R in the anti-PSD function of curcumin, the PSD mice were further administrated with P2X7R agonist and antagonist. The administration of Cur attenuated behavior disorders associated with PSD. Moreover, the Ca2+ accumulation and the inflammatory response associated with PSD were also blocked by Cur. Cur also inhibited the activation of Ca2+ channel. The induced activity of P2X7R blocked the function of Cur by maintaining the symptoms of PSD in Cur-treated rats. Collectively, the anti-PSD function of Cur was dependent on the inhibition of P2X7R, which then deactivated Ca2+ channel-mediated inflammatory response associated with PSD progression. [ABSTRACT FROM AUTHOR]

Curcumin (Cur) is widely used as an anti-inflammation agent and has anti-depression potential. Neuroinflammation mediated by Ca 2+ channel activation is closely associated with the progression of post-stroke depression (PSD). In the current study, the role of P2X7 receptor (P2X7R) in the anti-PSD function of Cur was explored. Rats were subjected to middle cerebral artery occlusion (MCAO) surgery and chronic mild stress administration to induce PSD symptoms and then treated with Cur. The behaviors of rats were assessed with sucrose preference and forced swim tests. The accumulation of Ca 2+ and the systemic inflammatory response in rats were detected. To determine the role of P2X7R in the anti-PSD function of curcumin, the PSD mice were further administrated with P2X7R agonist and antagonist. The administration of Cur attenuated behavior disorders associated with PSD. Moreover, the Ca 2+ accumulation and the inflammatory response associated with PSD were also blocked by Cur. Cur also inhibited the activation of Ca 2+ channel. The induced activity of P2X7R blocked the function of Cur by maintaining the symptoms of PSD in Cur-treated rats. Collectively, the anti-PSD function of Cur was dependent on the inhibition of P2X7R, which then deactivated Ca 2+ channel-mediated inflammatory response associated with PSD progression.