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ABSTRACT Aim Design Methods Results Conclusion Implication Patient or Public Contribution To identify distinct profiles of fear of cancer recurrence (FCR) among breast cancer patients of reproductive age, investigate the relationship between these profiles and reproductive concerns and explore potential risk factors encompassing sociodemographic, clinical and reproductive characteristics.A cross‐sectional study was conducted from January 2022 to September 2022.A convenience sample of 210 reproductive‐aged breast cancer patients completed a questionnaire that included a general information section, the Fear of Progression Questionnaire‐Short Form (FoP‐Q‐SF) and the Reproductive Concerns After Cancer Scale (RCAC). Latent profile analysis was conducted using the scores of the 12 items from the FoP‐Q‐SF as explicit variables, while univariate and multiple logistic regression analyses were employed for statistical analysis.Three latent variables were identified: low FCR‐stable group (27.6%), moderate FCR‐uneasy group (17.2%) and high FCR‐intense group (55.2%). This study found that FCR was predicted by age, education level, cancer stage, chemotherapy and fertility intention. Furthermore, patients with heightened reproductive concerns exhibited a higher likelihood of belonging to the high FCR‐intense group.These findings indicate that FCR varies among breast cancer patients of reproductive age and demonstrates individual differences.Early identification of FCR patterns in patients is crucial for medical professionals, with particular attention given to those in the high‐intensity FCR group. Tailored prevention and care strategies should be implemented based on the unique characteristics and influencing factors associated with different potential categories of FCR among patients of childbearing age with breast cancer.No patient or public contribution. [ABSTRACT FROM AUTHOR]

This paper intends to develop an interactive, comprehensive information visualization platform of Instagram hashtag analysis. Instagram hashtags has developed themselves into all different kinds of group or communities for users to share hobbies and find similar friends. In order to analyze topic influence and user interest trend from Instagram, which contains billions of end-users and has worldwide influence, hashtag analysis is necessary to gather such information and compare the proportion of people involving in each tags and rank them to visualize. The visualization is developed in 3D space and consists of time-varying data flow of tags, together with tag comparison analysis, as well as event researches. In the rest of the paper, we mainly discuss the design idea and the development process of the system. An example of the system design work will be shown in the discussion, which involves 4 popular hashtags discussed on Instagram and are shown on the system, displayed as an 3D histogram, together with another comparison histogram to compare different tags, as well as an event view in the back.

During diabetic kidney disease (DKD), ectopic ceramide (CER) accumulation in renal tubular epithelial cells (RTECs) is associated with interstitial fibrosis and albuminuria. As RTECs are primarily responsible for renal energy metabolism, their function is intimately linked to mitochondrial quality control. The role of CER synthesis in the progression of diabetic renal fibrosis has not been thoroughly investigated. In this study, we observed a significant upregulation of ceramide synthase 6 ( Cers6 ) expression in the renal cortex of db/db mice, coinciding with increased production of CER (d18:1/14:0) and CER (d18:1/16:0) by Cer6. Concurrently, the number of damaged mitochondria in RTECs rose. Cers6 deficiency reduced the abnormal accumulation of CER (d18:1/14:0) and CER (d18:1/16:0) in the kidney cortex, restoring the PTEN-induced kinase 1 (PINK1)-mediated mitophagy in RTECs, and resulting in a decrease in damaged mitochondria and attenuation of interstitial fibrosis in DKD. Automated docking analysis suggested that both CER (d18:1/14:0) and CER (d18:1/16:0) could bind to the PINK1 protein. Furthermore, inhibiting PINK1 expression in CERS6 knockdown HK-2 cells diminished the therapeutic effect of CERS6 deficiency on DKD. In summary, CERS6-derived CER (d18:1/14:0) and CER (d18:1/16:0) inhibit PINK1-regulated mitophagy by possibly binding to the PINK1 protein, thereby exacerbating the progression of renal interstitial fibrosis in DKD. NEW & NOTEWORTHY This article addresses the roles of ceramide synthase 6 ( CERS6 ) and CERS6-derived ceramides in renal tubular epithelial cells of diabetic kidney disease (DKD) associated interstitial fibrosis. Results from knockdown of CERS6 adjusted the ceramide pool in kidney cortex and markedly protected from diabetic-induced kidney fibrosis in vivo and in vitro. Mechanically, CERS6-derived ceramides might interact with PINK1 to inhibit PINK1/Parkin-mediated mitophagy and aggravate renal interstitial fibrosis in DKD.