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2. Juvenile dermatomyositis complications: navigating gastrointestinal perforations and treatment challenges, a case report

Author

Chen Xiangyuan, Zeng Xiaoling, Sun Guangchao, Zeng Huasong, and Liu Dexin

Subjects
Juvenile dermatomyositis, anti-nuclear matrix protein 2, gastrointestinal perforation, Janus kinase inhibitors, case report, Pediatrics, RJ1-570
Abstract

Juvenile dermatomyositis (JDM) is a rare autoimmune disorder with multi-system involvement, often presenting with a heliotrope rash, Gottron's papules, and proximal muscle weakness. JDM patients with anti-nuclear matrix protein 2 (anti-NXP2) positivity tend to have more severe manifestations, including a higher risk of gastrointestinal (GI) complications such as dysphagia, intestinal motility changes, edema, malabsorption, ulcers, and perforations. These complications are associated with poor outcomes and high mortality rates, particularly in patients with anti-NXP2 positivity. A case is presented of a 12-year-old girl with JDM who developed multiple GI perforations after being treated with high-dose methylprednisolone. Despite multiple surgical attempts, the patient experienced continued leakage and new perforations. The treatment approach was shifted to include jejunostomy, plasma exchanges, fresh frozen plasma support, and tofacitinib, leading to gradual improvement in muscle strength and reduction in inflammation. GI involvement in JDM is a significant concern due to its association with poor prognosis and high mortality. The use of high-dose glucocorticoids must be carefully considered in JDM patients with GI involvement, as they may contribute to the development of perforations and complicate treatment. A combination of plasma exchange, fresh frozen plasma support, low-dose glucocorticoids, and Janus kinase inhibitors may offer a safer treatment strategy for managing refractory JDM with GI complications. The case highlights the importance of a multidisciplinary approach to treatment and the need for further research to determine the necessity of high-dose glucocorticoid therapy following GI involvement in JDM.

Published
2024
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9. Research on Master-Slave Coordinated Control Method of Dual-Arm Robot

Author

Liu, Dexin, Zhang, Jiancheng, Li, Yuan, Angrisani, Leopoldo, Series Editor, Arteaga, Marco, Series Editor, Chakraborty, Samarjit, Series Editor, Chen, Jiming, Series Editor, Chen, Shanben, Series Editor, Chen, Tan Kay, Series Editor, Dillmann, Rüdiger, Series Editor, Duan, Haibin, Series Editor, Ferrari, Gianluigi, Series Editor, Ferre, Manuel, Series Editor, Hirche, Sandra, Series Editor, Jabbari, Faryar, Series Editor, Jia, Limin, Series Editor, Kacprzyk, Janusz, Series Editor, Khamis, Alaa, Series Editor, Kroeger, Torsten, Series Editor, Li, Yong, Series Editor, Liang, Qilian, Series Editor, Martín, Ferran, Series Editor, Ming, Tan Cher, Series Editor, Minker, Wolfgang, Series Editor, Misra, Pradeep, Series Editor, Möller, Sebastian, Series Editor, Mukhopadhyay, Subhas, Series Editor, Ning, Cun-Zheng, Series Editor, Nishida, Toyoaki, Series Editor, Oneto, Luca, Series Editor, Panigrahi, Bijaya Ketan, Series Editor, Pascucci, Federica, Series Editor, Qin, Yong, Series Editor, Seng, Gan Woon, Series Editor, Speidel, Joachim, Series Editor, Veiga, Germano, Series Editor, Wu, Haitao, Series Editor, Zamboni, Walter, Series Editor, Zhang, Junjie James, Series Editor, You, Peng, editor, Li, Heng, editor, and Chen, Zhenxiang, editor

Published
2023
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39. Mapping QTL for fiber- and seed-related traits in Gossypium tomentosum CSSLs with G. hirsutum background

Author

Hao, Yongshui, primary, Liu, Xueying, additional, Wang, Qianqian, additional, Wang, Shuxin, additional, Li, Qingqing, additional, Wang, Yaqing, additional, Guo, Zhongni, additional, Wu, Tiantian, additional, Yang, Qing, additional, Bai, Yuting, additional, Cui, Yuru, additional, Yang, Peng, additional, Wang, Wenwen, additional, Teng, Zhonghua, additional, Liu, Dexin, additional, Guo, Kai, additional, Liu, Dajun, additional, Zhang, Jian, additional, and Zhang, Zhengsheng, additional

Published
2024
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47. Transcriptomic Analysis of Alternative Splicing Events during Different Fruit Ripening Stages of Coffea arabica L.

Author

Yu, Haohao, Bi, Xiaofei, Li, Zhongxian, Fu, Xingfei, Li, Yanan, Li, Yaqi, Yang, Yang, Liu, Dexin, Li, Guiping, Dong, Wenjiang, and Hu, Faguang

Subjects
ALTERNATIVE RNA splicing, FRUIT ripening, METHIONINE metabolism, TRANSCRIPTOMES, ATP-binding cassette transporters, COFFEE beans, COFFEE
Abstract

To date, genomic and transcriptomic data on Coffea arabica L. in public databases are very limited, and there has been no comprehensive integrated investigation conducted on alternative splicing (AS). Previously, we have constructed and sequenced eighteen RNA-seq libraries of C. arabica at different ripening stages of fruit development. From this dataset, a total of 3824, 2445, 2564, 2990, and 3162 DSGs were identified in a comparison of different fruit ripening stages. The largest proportion of DSGs, approximately 65%, were of the skipped exon (SE) type. Biologically, 9 and 29 differentially expressed DSGs in the spliceosome pathway and carbon metabolism pathway, respectively, were identified. These DSGs exhibited significant variations, primarily in S1 vs. S2 and S5 vs. S6, and they involve many aspects of organ development, hormone transduction, and the synthesis of flavor components. Through the examination of research findings regarding the biological functions and biochemical pathways associated with DSGs and DEGs, it was observed that six DSGs significantly enriched in ABC transporters, namely, LOC113712394, LOC113726618, LOC113739972, LOC113725240, LOC113730214, and LOC113707447, were continually down-regulated at the fruit ripening stage. In contrast, a total of four genes, which were LOC113732777, LOC113727880, LOC113690566, and LOC113711936, including those enriched in the cysteine and methionine metabolism, were continually up-regulated. Collectively, our findings may contribute to the exploration of alternative splicing mechanisms for focused investigations of potential genes associated with the ripening of fruits in C. arabica. [ABSTRACT FROM AUTHOR]

Published
2024
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