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2,132 results on '"Liu, DongSheng"'

4. Exploring distinct modes of inter-spike cross-linking for enhanced neutralization by SARS-CoV-2 antibodies

Author

Nan, Xuanyu, Li, Yujie, Zhang, Rui, Wang, Ruoke, Lv, Niannian, Li, Jiayi, Chen, Yuanfang, Zhou, Bini, Wang, Yangjunqi, Wang, Ziyi, Zhu, Jiayi, Chen, Jing, Li, Jinqian, Chen, Wenlong, Zhang, Qi, Shi, Xuanling, Zhao, Changwen, Chen, Chunying, Liu, Zhihua, Zhao, Yuliang, Liu, Dongsheng, Wang, Xinquan, Yan, Li-Tang, Li, Taisheng, Zhang, Linqi, and Yang, Yuhe R.

Published
2024
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15. DNA-based nanostructures for RNA delivery

Author

Wu Yuanyuan, Luo Liangzhi, Hao Ziyang, and Liu Dongsheng

Subjects
dna origami, frame guided assembly (fga), dna hydrogel, rna delivery, gene therapy, dna-based nanostructures, Medicine
Abstract

RNA-based therapeutics have emerged as a promising approach for the treatment of various diseases, including cancer, genetic disorders, and infectious diseases. However, the delivery of RNA molecules into target cells has been a major challenge due to their susceptibility to degradation and inefficient cellular uptake. To overcome these hurdles, DNA-based nano technology offers an unprecedented opportunity as a potential delivery platform for RNA therapeutics. Due to its excellent characteristics such as programmability and biocompatibility, these DNA-based nanostructures, composed of DNA molecules assembled into precise and programmable structures, have garnered significant attention as ideal building materials for protecting and delivering RNA payloads to the desired cellular destinations. In this review, we highlight the current progress in the design and application of three DNA-based nanostructures: DNA origami, lipid-nanoparticle (LNP) technology related to frame guided assembly (FGA), and DNA hydrogel for the delivery of RNA molecules. Their biomedical applications are briefly discussed and the challenges and future perspectives in this field are also highlighted.

Published
2024
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44. Autonomous Navigation of an Ultrasound Probe Towards Standard Scan Planes with Deep Reinforcement Learning

Author

Li, Keyu, Wang, Jian, Xu, Yangxin, Qin, Hao, Liu, Dongsheng, Liu, Li, and Meng, Max Q. -H.

Subjects
Computer Science - Robotics, Computer Science - Artificial Intelligence, Computer Science - Machine Learning
Abstract

Autonomous ultrasound (US) acquisition is an important yet challenging task, as it involves interpretation of the highly complex and variable images and their spatial relationships. In this work, we propose a deep reinforcement learning framework to autonomously control the 6-D pose of a virtual US probe based on real-time image feedback to navigate towards the standard scan planes under the restrictions in real-world US scans. Furthermore, we propose a confidence-based approach to encode the optimization of image quality in the learning process. We validate our method in a simulation environment built with real-world data collected in the US imaging of the spine. Experimental results demonstrate that our method can perform reproducible US probe navigation towards the standard scan plane with an accuracy of $4.91mm/4.65^\circ$ in the intra-patient setting, and accomplish the task in the intra- and inter-patient settings with a success rate of $92\%$ and $46\%$, respectively. The results also show that the introduction of image quality optimization in our method can effectively improve the navigation performance., Comment: Accepted at ICRA 2021

Published
2021
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47. High Resolution Imagery-Based Statistical Analysis for Urban Rivers Extraction and Quality Classification—Case Study in Beijing District of China

Author

Liu, Dongsheng, Han, Ling, Angrisani, Leopoldo, Series Editor, Arteaga, Marco, Series Editor, Panigrahi, Bijaya Ketan, Series Editor, Chakraborty, Samarjit, Series Editor, Chen, Jiming, Series Editor, Chen, Shanben, Series Editor, Chen, Tan Kay, Series Editor, Dillmann, Rüdiger, Series Editor, Duan, Haibin, Series Editor, Ferrari, Gianluigi, Series Editor, Ferre, Manuel, Series Editor, Hirche, Sandra, Series Editor, Jabbari, Faryar, Series Editor, Jia, Limin, Series Editor, Kacprzyk, Janusz, Series Editor, Khamis, Alaa, Series Editor, Kroeger, Torsten, Series Editor, Li, Yong, Series Editor, Liang, Qilian, Series Editor, Martín, Ferran, Series Editor, Ming, Tan Cher, Series Editor, Minker, Wolfgang, Series Editor, Misra, Pradeep, Series Editor, Möller, Sebastian, Series Editor, Mukhopadhyay, Subhas, Series Editor, Ning, Cun-Zheng, Series Editor, Nishida, Toyoaki, Series Editor, Oneto, Luca, Series Editor, Pascucci, Federica, Series Editor, Qin, Yong, Series Editor, Seng, Gan Woon, Series Editor, Speidel, Joachim, Series Editor, Veiga, Germano, Series Editor, Wu, Haitao, Series Editor, Zamboni, Walter, Series Editor, Zhang, Junjie James, Series Editor, Wang, Liheng, editor, Wu, Yirong, editor, and Gong, Jianya, editor

Published
2023
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