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1,283 results on '"Liu, Guang-Hui"'

8. CHIT1-positive microglia drive motor neuron ageing in the primate spinal cord

Author

Sun, Shuhui, Li, Jiaming, Wang, Si, Li, Jingyi, Ren, Jie, Bao, Zhaoshi, Sun, Le, Ma, Xibo, Zheng, Fangshuo, Ma, Shuai, Sun, Liang, Wang, Min, Yu, Yan, Ma, Miyang, Wang, Qiaoran, Chen, Zhiyuan, Ma, He, Wang, Xuebao, Wu, Zeming, Zhang, Hui, Yan, Kaowen, Yang, Yuanhan, Zhang, Yixin, Zhang, Sheng, Lei, Jinghui, Teng, Zhao-Qian, Liu, Chang-Mei, Bai, Ge, Wang, Yan-Jiang, Li, Jian, Wang, Xiaoqun, Zhao, Guoguang, Jiang, Tao, Belmonte, Juan Carlos Izpisua, Qu, Jing, Zhang, Weiqi, and Liu, Guang-Hui

Published
2023
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12. The Aging Biomarker Consortium represents a new era for aging research in China

Author

Ren, Jie, Song, Moshi, Zhang, Weiqi, Cai, Jian-Ping, Cao, Feng, Cao, Zhongwei, Chan, Piu, Chen, Chang, Chen, Guobing, Chen, Hou-Zao, Chen, Jun, Chen, Xiao-Chun, Ci, Weimin, Ding, Bi-Sen, Ding, Qiurong, Gao, Feng, Gao, Shaorong, Han, Jing-Dong J., He, Qi-Yang, Huang, Kai, Ju, Zhenyu, Kong, Qing-Peng, Li, Ji, Li, Jian, Li, Jingyi, Li, Xin, Liu, Baohua, Liu, Feng, Liu, Jun-Ping, Liu, Lin, Liu, Qiang, Liu, Qiang, Liu, Xingguo, Liu, Yong, Luo, Xianghang, Ma, Shuai, Ma, Xinran, Mao, Zhiyong, Nie, Jing, Peng, Yaojin, Qu, Jing, Ren, Ruibao, Song, Weihong, Songyang, Zhou, Sun, Liang, Sun, Yi Eve, Sun, Yu, Tian, Mei, Tian, Xiao-Li, Tian, Ye, Wang, Jianwei, Wang, Shusen, Wang, Si, Wang, Wengong, Wang, Xia, Wang, Xiaoning, Wang, Yan-Jiang, Wang, Yunfang, Wong, Catherine C. L., Xiang, Andy Peng, Xiao, Yichuan, Xiao, Zhi-Xiong, Xie, Zhengwei, Xiong, Wei, Xu, Daichao, Yang, Ze, Ye, Jing, Yu, Wei, Yue, Rui, Zhang, Cuntai, Zhang, Hongbo, Zhang, Liang, Zhang, Xinchao, Zhang, Yong, Zhang, Yun-Wu, Zhang, Zhuohua, Zhao, Tongbiao, Zhao, Yuzheng, Zhou, Zhongjun, Zhu, Dahai, Zou, Weiguo, Pei, Gang, and Liu, Guang-Hui

Published
2023
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13. In vivo partial cellular reprogramming enhances liver plasticity and regeneration

Author

Hishida, Tomoaki, Yamamoto, Mako, Hishida-Nozaki, Yuriko, Shao, Changwei, Huang, Ling, Wang, Chao, Shojima, Kensaku, Xue, Yuan, Hang, Yuqing, Shokhirev, Maxim, Memczak, Sebastian, Sahu, Sanjeeb Kumar, Hatanaka, Fumiyuki, Ros, Ruben Rabadan, Maxwell, Matthew B, Chavez, Jasmine, Shao, Yanjiao, Liao, Hsin-Kai, Martinez-Redondo, Paloma, Guillen-Guillen, Isabel, Hernandez-Benitez, Reyna, Esteban, Concepcion Rodriguez, Qu, Jing, Holmes, Michael C, Yi, Fei, Hickey, Raymond D, Garcia, Pedro Guillen, Delicado, Estrella Nuñez, Castells, Antoni, Campistol, Josep M, Yu, Yang, Hargreaves, Diana C, Asai, Akihiro, Reddy, Pradeep, Liu, Guang-Hui, and Belmonte, Juan Carlos Izpisua

Subjects
Chronic Liver Disease and Cirrhosis, Stem Cell Research - Nonembryonic - Non-Human, Digestive Diseases, Liver Disease, Stem Cell Research, Regenerative Medicine, Development of treatments and therapeutic interventions, 5.2 Cellular and gene therapies, Oral and gastrointestinal, Animals, Cell Dedifferentiation, Cellular Reprogramming, Hepatocytes, Liver, Liver Regeneration, Mammals, Mice, CP: Stem cell research, dedifferentiation, liver, regeneration, reprogramming, Biochemistry and Cell Biology, Medical Physiology
Abstract

Mammals have limited regenerative capacity, whereas some vertebrates, like fish and salamanders, are able to regenerate their organs efficiently. The regeneration in these species depends on cell dedifferentiation followed by proliferation. We generate a mouse model that enables the inducible expression of the four Yamanaka factors (Oct-3/4, Sox2, Klf4, and c-Myc, or 4F) specifically in hepatocytes. Transient in vivo 4F expression induces partial reprogramming of adult hepatocytes to a progenitor state and concomitantly increases cell proliferation. This is indicated by reduced expression of differentiated hepatic-lineage markers, an increase in markers of proliferation and chromatin modifiers, global changes in DNA accessibility, and an acquisition of liver stem and progenitor cell markers. Functionally, short-term expression of 4F enhances liver regenerative capacity through topoisomerase2-mediated partial reprogramming. Our results reveal that liver-specific 4F expression in vivo induces cellular plasticity and counteracts liver failure, suggesting that partial reprogramming may represent an avenue for enhancing tissue regeneration.

Published
2022

19. Wiskott-Aldrich syndrome protein forms nuclear condensates and regulates alternative splicing

Author

Yuan, Baolei, Zhou, Xuan, Suzuki, Keiichiro, Ramos-Mandujano, Gerardo, Wang, Mengge, Tehseen, Muhammad, Cortés-Medina, Lorena V, Moresco, James J, Dunn, Sarah, Hernandez-Benitez, Reyna, Hishida, Tomoaki, Kim, Na Young, Andijani, Manal M, Bi, Chongwei, Ku, Manching, Takahashi, Yuta, Xu, Jinna, Qiu, Jinsong, Huang, Ling, Benner, Christopher, Aizawa, Emi, Qu, Jing, Liu, Guang-Hui, Li, Zhongwei, Yi, Fei, Ghosheh, Yanal, Shao, Changwei, Shokhirev, Maxim, Comoli, Patrizia, Frassoni, Francesco, Yates, John R, Fu, Xiang-Dong, Esteban, Concepcion Rodriguez, Hamdan, Samir, Izpisua Belmonte, Juan Carlos, and Li, Mo

Subjects
Rare Diseases, Human Genome, Genetics, Generic health relevance, Alternative Splicing, Cell Nucleus, Humans, RNA Polymerase II, RNA Splicing Factors, RNA-Binding Proteins, Wiskott-Aldrich Syndrome, Wiskott-Aldrich Syndrome Protein
Abstract

The diverse functions of WASP, the deficiency of which causes Wiskott-Aldrich syndrome (WAS), remain poorly defined. We generated three isogenic WAS models using patient induced pluripotent stem cells and genome editing. These models recapitulated WAS phenotypes and revealed that WASP deficiency causes an upregulation of numerous RNA splicing factors and widespread altered splicing. Loss of WASP binding to splicing factor gene promoters frequently leads to aberrant epigenetic activation. WASP interacts with dozens of nuclear speckle constituents and constrains SRSF2 mobility. Using an optogenetic system, we showed that WASP forms phase-separated condensates that encompasses SRSF2, nascent RNA and active Pol II. The role of WASP in gene body condensates is corroborated by ChIPseq and RIPseq. Together our data reveal that WASP is a nexus regulator of RNA splicing that controls the transcription of splicing factors epigenetically and the dynamics of the splicing machinery through liquid-liquid phase separation.

Published
2022

20. Biomarkers of aging

Author

Bao, Hainan, Cao, Jiani, Chen, Mengting, Chen, Min, Chen, Wei, Chen, Xiao, Chen, Yanhao, Chen, Yu, Chen, Yutian, Chen, Zhiyang, Chhetri, Jagadish K., Ding, Yingjie, Feng, Junlin, Guo, Jun, Guo, Mengmeng, He, Chuting, Jia, Yujuan, Jiang, Haiping, Jing, Ying, Li, Dingfeng, Li, Jiaming, Li, Jingyi, Liang, Qinhao, Liang, Rui, Liu, Feng, Liu, Xiaoqian, Liu, Zuojun, Luo, Oscar Junhong, Lv, Jianwei, Ma, Jingyi, Mao, Kehang, Nie, Jiawei, Qiao, Xinhua, Sun, Xinpei, Tang, Xiaoqiang, Wang, Jianfang, Wang, Qiaoran, Wang, Siyuan, Wang, Xuan, Wang, Yaning, Wang, Yuhan, Wu, Rimo, Xia, Kai, Xiao, Fu-Hui, Xu, Lingyan, Xu, Yingying, Yan, Haoteng, Yang, Liang, Yang, Ruici, Yang, Yuanxin, Ying, Yilin, Zhang, Le, Zhang, Weiwei, Zhang, Wenwan, Zhang, Xing, Zhang, Zhuo, Zhou, Min, Zhou, Rui, Zhu, Qingchen, Zhu, Zhengmao, Cao, Feng, Cao, Zhongwei, Chan, Piu, Chen, Chang, Chen, Guobing, Chen, Hou-Zao, Chen, Jun, Ci, Weimin, Ding, Bi-Sen, Ding, Qiurong, Gao, Feng, Han, Jing-Dong J., Huang, Kai, Ju, Zhenyu, Kong, Qing-Peng, Li, Ji, Li, Jian, Li, Xin, Liu, Baohua, Liu, Feng, Liu, Lin, Liu, Qiang, Liu, Qiang, Liu, Xingguo, Liu, Yong, Luo, Xianghang, Ma, Shuai, Ma, Xinran, Mao, Zhiyong, Nie, Jing, Peng, Yaojin, Qu, Jing, Ren, Jie, Ren, Ruibao, Song, Moshi, Songyang, Zhou, Sun, Yi Eve, Sun, Yu, Tian, Mei, Wang, Shusen, Wang, Si, Wang, Xia, Wang, Xiaoning, Wang, Yan-Jiang, Wang, Yunfang, Wong, Catherine C. L., Xiang, Andy Peng, Xiao, Yichuan, Xie, Zhengwei, Xu, Daichao, Ye, Jing, Yue, Rui, Zhang, Cuntai, Zhang, Hongbo, Zhang, Liang, Zhang, Weiqi, Zhang, Yong, Zhang, Yun-Wu, Zhang, Zhuohua, Zhao, Tongbiao, Zhao, Yuzheng, Zhu, Dahai, Zou, Weiguo, Pei, Gang, and Liu, Guang-Hui

Published
2023
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21. Intervention with metabolites emulating endogenous cell transitions accelerates muscle regeneration in young and aged mice

Author

Hernandez-Benitez, Reyna, Wang, Chao, Shi, Lei, Ouchi, Yasuo, Zhong, Cuiqing, Hishida, Tomoaki, Liao, Hsin-Kai, Magill, Eric A., Memczak, Sebastian, Soligalla, Rupa D., Fresia, Chiara, Hatanaka, Fumiyuki, Lamas, Veronica, Guillen, Isabel, Sahu, Sanjeeb, Yamamoto, Mako, Shao, Yanjiao, Aguirre-Vazquez, Alain, Nuñez Delicado, Estrella, Guillen, Pedro, Rodriguez Esteban, Concepcion, Qu, Jing, Reddy, Pradeep, Horvath, Steve, Liu, Guang-Hui, Magistretti, Pierre, and Izpisua Belmonte, Juan Carlos

Published
2024
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26. Decoding aging-dependent regenerative decline across tissues at single-cell resolution

Author

Cai, Yusheng, Xiong, Muzhao, Xin, Zijuan, Liu, Chengyu, Ren, Jie, Yang, Xiying, Lei, Jinghui, Li, Wei, Liu, Feifei, Chu, Qun, Zhang, Yiyuan, Yin, Jian, Ye, Yanxia, Liu, Dingyi, Fan, Yanling, Sun, Shuhui, Jing, Yaobin, Zhao, Qian, Zhao, Liyun, Che, Shanshan, Zheng, Yandong, Yan, Haoteng, Ma, Shuai, Wang, Si, Izpisua Belmonte, Juan Carlos, Qu, Jing, Zhang, Weiqi, and Liu, Guang-Hui

Published
2023
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30. Determining a multimodal aging clock in a cohort of Chinese women

Author

Li, Jiaming, Xiong, Muzhao, Fu, Xiang-Hong, Fan, Yanling, Dong, Chen, Sun, Xiaoyan, Zheng, Fang, Wang, Si-Wei, Liu, Lixiao, Xu, Ming, Wang, Cui, Ping, Jiale, Che, Shanshan, Wang, Qiaoran, Yang, Kuan, Zuo, Yuesheng, Lu, Xiaoyong, Zheng, Zikai, Lan, Tian, Wang, Si, Ma, Shuai, Sun, Shuhui, Zhang, Bin, Chen, Chen-Shui, Cheng, Ke-Yun, Ye, Jinlin, Qu, Jing, Xue, Yongbiao, Yang, Yun-Gui, Zhang, Feng, Zhang, Weiqi, and Liu, Guang-Hui

Published
2023
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39. The landscape of aging

Author

Cai, Yusheng, Song, Wei, Li, Jiaming, Jing, Ying, Liang, Chuqian, Zhang, Liyuan, Zhang, Xia, Zhang, Wenhui, Liu, Beibei, An, Yongpan, Li, Jingyi, Tang, Baixue, Pei, Siyu, Wu, Xueying, Liu, Yuxuan, Zhuang, Cheng-Le, Ying, Yilin, Dou, Xuefeng, Chen, Yu, Xiao, Fu-Hui, Li, Dingfeng, Yang, Ruici, Zhao, Ya, Wang, Yang, Wang, Lihui, Li, Yujing, Ma, Shuai, Wang, Si, Song, Xiaoyuan, Ren, Jie, Zhang, Liang, Wang, Jun, Zhang, Weiqi, Xie, Zhengwei, Qu, Jing, Wang, Jianwei, Xiao, Yichuan, Tian, Ye, Wang, Gelin, Hu, Ping, Ye, Jing, Sun, Yu, Mao, Zhiyong, Kong, Qing-Peng, Liu, Qiang, Zou, Weiguo, Tian, Xiao-Li, Xiao, Zhi-Xiong, Liu, Yong, Liu, Jun-Ping, Song, Moshi, Han, Jing-Dong J., and Liu, Guang-Hui

Published
2022
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40. FTO stabilizes MIS12 and counteracts senescence

Author

Zhang, Sheng, Wu, Zeming, Shi, Yue, Wang, Si, Ren, Jie, Yu, Zihui, Huang, Daoyuan, Yan, Kaowen, He, Yifang, Liu, Xiaoqian, Ji, Qianzhao, Liu, Beibei, Liu, Zunpeng, Qu, Jing, Liu, Guang-Hui, Ci, Weimin, Wang, Xiaoqun, and Zhang, Weiqi

Published
2022
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41. Nuclear lamina erosion-induced resurrection of endogenous retroviruses underlies neuronal aging

Author

Zhang, Hui, Li, Jiaming, Yu, Yang, Ren, Jie, Liu, Qiang, Bao, Zhaoshi, Sun, Shuhui, Liu, Xiaoqian, Ma, Shuai, Liu, Zunpeng, Yan, Kaowen, Wu, Zeming, Fan, Yanling, Sun, Xiaoyan, Zhang, Yixin, Ji, Qianzhao, Cheng, Fang, Wei, Peng-Hu, Ma, Xibo, Zhang, Shiqiang, Xie, Zhengwei, Niu, Yuyu, Wang, Yan-Jiang, Han, Jing-Dong J., Jiang, Tao, Zhao, Guoguang, Ji, Weizhi, Izpisua Belmonte, Juan Carlos, Wang, Si, Qu, Jing, Zhang, Weiqi, and Liu, Guang-Hui

Published
2023
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44. Precise in vivo genome editing via single homology arm donor mediated intron-targeting gene integration for genetic disease correction

Author

Suzuki, Keiichiro, Yamamoto, Mako, Hernandez-Benitez, Reyna, Li, Zhe, Wei, Christopher, Soligalla, Rupa Devi, Aizawa, Emi, Hatanaka, Fumiyuki, Kurita, Masakazu, Reddy, Pradeep, Ocampo, Alejandro, Hishida, Tomoaki, Sakurai, Masahiro, Nemeth, Amy N, Nuñez Delicado, Estrella, Campistol, Josep M, Magistretti, Pierre, Guillen, Pedro, Rodriguez Esteban, Concepcion, Gong, Jianhui, Yuan, Yilin, Gu, Ying, Liu, Guang-Hui, López-Otín, Carlos, Wu, Jun, Zhang, Kun, and Izpisua Belmonte, Juan Carlos

Subjects
Genetics, Regenerative Medicine, Aging, Human Genome, Biotechnology, Generic health relevance, Good Health and Well Being, Animals, CRISPR-Cas Systems, DNA Repair, Dependovirus, GATA3 Transcription Factor, Gene Editing, Gene Knock-In Techniques, Genetic Therapy, Genetic Vectors, Human Embryonic Stem Cells, Humans, Introns, Mice, Mice, Inbred C57BL, Mice, Inbred ICR, Neurons, RNA, Guide, Kinetoplastida, Rats, Tubulin, Biochemistry and Cell Biology, Clinical Sciences, Developmental Biology
Abstract

In vivo genome editing represents a powerful strategy for both understanding basic biology and treating inherited diseases. However, it remains a challenge to develop universal and efficient in vivo genome-editing tools for tissues that comprise diverse cell types in either a dividing or non-dividing state. Here, we describe a versatile in vivo gene knock-in methodology that enables the targeting of a broad range of mutations and cell types through the insertion of a minigene at an intron of the target gene locus using an intracellularly linearized single homology arm donor. As a proof-of-concept, we focused on a mouse model of premature-aging caused by a dominant point mutation, which is difficult to repair using existing in vivo genome-editing tools. Systemic treatment using our new method ameliorated aging-associated phenotypes and extended animal lifespan, thus highlighting the potential of this methodology for a broad range of in vivo genome-editing applications.

Published
2019

48. Resurrection of endogenous retroviruses during aging reinforces senescence

Author

Liu, Xiaoqian, Liu, Zunpeng, Wu, Zeming, Ren, Jie, Fan, Yanling, Sun, Liang, Cao, Gang, Niu, Yuyu, Zhang, Baohu, Ji, Qianzhao, Jiang, Xiaoyu, Wang, Cui, Wang, Qiaoran, Ji, Zhejun, Li, Lanzhu, Esteban, Concepcion Rodriguez, Yan, Kaowen, Li, Wei, Cai, Yusheng, Wang, Si, Zheng, Aihua, Zhang, Yong E., Tan, Shengjun, Cai, Yingao, Song, Moshi, Lu, Falong, Tang, Fuchou, Ji, Weizhi, Zhou, Qi, Belmonte, Juan Carlos Izpisua, Zhang, Weiqi, Qu, Jing, and Liu, Guang-Hui

Published
2023
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