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Your search keyword '"Liu, Guo-Chen"' showing total 16 results
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16 results on '"Liu, Guo-Chen"'

2. Electrically driven single-photon emission from an isolated single molecule

Author

Li Zhang, Yun-Jie Yu, Liu-Guo Chen, Yang Luo, Ben Yang, Fan-Fang Kong, Gong Chen, Yang Zhang, Qiang Zhang, Yi Luo, Jin-Long Yang, Zhen-Chao Dong, and J. G. Hou

Subjects
Science
Abstract

Molecular emitters offer a promising solution for single-photon generation. Here, by exploiting electronic decoupling by an ultrathin dielectric spacer and emission enhancement by a resonant plasmonic nanocavity, the authors demonstrate electrically driven single-photon emission from a single molecule.

Published
2017
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8. Porous Organic Polymer-Derived Nanopalladium Catalysts for Chemoselective Synthesis of Antitumor Benzofuro[2,3- b]pyrazine from 2-Bromophenol and Isonitriles

Author

Wang, Mao-Rui, Deng, Li, Liu, Guo-Chen, Wen, Ling, Wang, Jin-Ge, Huang, Ke-Bin, Tang, Hai-Tao, and Pan, Ying-Ming

Subjects
Organic polymer, Pyrazine, 010405 organic chemistry, Chemistry, Organic Chemistry, Sequence (biology), Antineoplastic Agents, Chemistry Techniques, Synthetic, 010402 general chemistry, 01 natural sciences, Biochemistry, Combinatorial chemistry, Catalysis, 0104 chemical sciences, chemistry.chemical_compound, Phenols, Pyrazines, Nitriles, Physical and Theoretical Chemistry, Porosity
Abstract

An efficient strategy for the synthesis of benzofuro[2,3- b]pyrazines was developed. These tricyclic scaffolds were formed through a multistep cascade sequence, which includes double insertion of isonitriles and chemoselective bicyclization. In this reaction, a nanopalladium was used as a recyclable catalyst. Product 3w exhibited excellent anticancer activity toward T-24 (IC

Published
2019

10. The Heterogeneity Between Lynch-Associated and Sporadic MMR Deficiency in Colorectal Cancers

Author

Liu, Guo-Chen, primary, Liu, Ran-Yi, additional, Yan, Jun-Ping, additional, An, Xin, additional, Jiang, Wu, additional, Ling, Yi-Hong, additional, Chen, Jie-Wei, additional, Bei, Jin-Xin, additional, Zuo, Xiao-Yu, additional, Cai, Mu-Yan, additional, Liu, Ze-Xian, additional, Zuo, Zhi-Xiang, additional, Liu, Ji-Hong, additional, Pan, Zhi-Zhong, additional, and Ding, Pei-Rong, additional

Published
2018
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11. Effect of Neoadjuvant Chemoradiotherapy with Capecitabine versus Fluorouracil for Locally Advanced Rectal Cancer: A Meta-Analysis

Author

Liu, Guo-Chen, Yan, Jun-Ping, He, Qing, An, Xin, Pan, Zhi-Zhong, and Ding, Pei-Rong

Subjects
Article Subject
Abstract

A meta-analysis was carried out to compare the efficacy and safety of capecitabine plus radiation with 5-fluorouracil (5-FU) plus radiotherapy (RT) as neoadjuvant treatment in locally advanced rectal cancer (LARC). We searched the Cochrane database, Ovid, Medline, Embase, ISI databases, and Chinese Biomedical Literature Database between January 1998 and October 2014. Trials of capecitabine compared with 5-FU plus RT as neoadjuvant treatment for LARC were considered for inclusion. RevMan software was used to analyze these data. Nine trials were included in this meta-analysis, which covered a total of 3141 patients. The meta-analysis showed that capecitabine group had statistically significant better pCR rates (OR, 1.34; 95% CI, 1.10–1.64; P=0.003), T downstaging rates (OR, 1.58; 95% CI, 1.22–2.06; P=0.0007), N downstaging rates (OR, 2.06; 95% CI, 1.34–3.16; P=0.001), less distant metastasis (OR, 0.63; 95% CI, 0.44–0.88; P=0.007), and lowered leucocytes (OR, 0.25; 95% CI, 0.11–0.54; P=0.0005), but with higher incidence of hand-foot syndrome (HFS) (OR, 4.43; 95% CI, 1.59–12.33; P=0.004). Capecitabine was more efficient than 5-FU in terms of tumor response in neoadjuvant treatment for patients with LARC and favourably low toxicity with the exception of HFS.

Published
2016
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14. Evaluation of capecitabine and oxaliplatin administered prior to and then concomitant to radiotherapy in high risk locally advanced rectal cancer

Author

Gao, Yuan-Hong, primary, An, Xin, additional, Sun, Wei-Jiang, additional, Cai, Juan, additional, Cai, Mu-Yan, additional, Kong, Ling-Heng, additional, Lin, Jun-Zhong, additional, Liu, Guo-Chen, additional, Tang, Jing-Hua, additional, Wu, Xiao-Jun, additional, Chen, Gong, additional, Pan, Zhi-Zhong, additional, and Ding, Pei-Rong, additional

Published
2013
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16. The Heterogeneity Between Lynch-Associated and Sporadic MMR Deficiency in Colorectal Cancers.

Author

Liu GC, Liu RY, Yan JP, An X, Jiang W, Ling YH, Chen JW, Bei JX, Zuo XY, Cai MY, Liu ZX, Zuo ZX, Liu JH, Pan ZZ, and Ding PR

Subjects
Adult, Aged, Aged, 80 and over, Biomarkers, Tumor, Colorectal Neoplasms complications, Colorectal Neoplasms diagnosis, Colorectal Neoplasms mortality, Female, Genetic Heterogeneity, Humans, Immunohistochemistry, Kaplan-Meier Estimate, Lymphocyte Count, Male, Microsatellite Instability, Middle Aged, Mutation, Neoplasm Staging, Proportional Hazards Models, Prospective Studies, Exome Sequencing, Young Adult, Brain Neoplasms complications, Colorectal Neoplasms etiology, Colorectal Neoplasms, Hereditary Nonpolyposis complications, Neoplastic Syndromes, Hereditary complications
Abstract

Background: Previous studies demonstrated that prognosis of germline deficiency in mismatch repair protein (dMMR) was different from that of sporadic dMMR. The underlying mechanism has not been studied., Methods: From a prospectively maintained database, we collected dMMR colorectal cancer (CRC) patients identified by postoperative immunohistochemistry screening. According to genetic test, patients were grouped as Lynch-associated or sporadic dMMR. We compared the clinical-pathological features, prognosis, and immunoreactive differences between the two groups. By whole-exome sequencing and neoantigen detection pipeline, mutational frequencies and neoantigen burdens were also compared. All statistical tests were two-sided., Results: Sixty-seven sporadic dMMR and 85 Lynch-associated CRC patients were included in the study. Sporadic dMMR patients were older (P < .001) and their tumors were poorly differentiated (P = .03). The survival was better in the Lynch-associated group (P = .001). After adjustment, the difference still remained statistically significant (hazard ratio = 0.29, 95% confidence interval = 0.09 to 0.95, P = .04). The scores of Crohn's-like reaction (CRO; P < .001), immunoreactions in the invasive margin (IM; P = .01), tumor stroma (TS; P = .009), and cancer nest (CN; P = .02) of the Lynch-associated group were statistically significantly higher. The numbers of CD3+, CD8+, Foxp3+ tumor-infiltrating lymphocytes (TILs) in IM; CD3+, CD4+ TILs in TS; and CD3+, CD4+, CD8+ TILs in CN were statistically significantly higher in Lynch-associated dMMR patients. Based on the 16 patients who under went whole-exome sequencing, there were also more somatic mutations and neoantigen burdens in the Lynch-associated group compared with the sporadic dMMR group (439/pt vs 68/pt, P = .006; 628/pt vs 97/pt, P = .009)., Conclusions: There are heterogeneities in dMMR CRCs. Lynch-associated dMMR patients present with more somatic mutations and neoantigens compared with sporadic dMMR, which probably results in stronger immunoreactions and survival improvement.

Published
2018
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