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154 results on '"Liu, Hai-Ning"'

14. microRNA-106b-5p Promotes Cell Growth and Sensitizes Chemosensitivity to Sorafenib by Targeting the BTG3/Bcl-xL/p27 Signaling Pathway in Hepatocellular Carcinoma

Author

Enkhnaran, Bilegsaikhan, primary, Zhang, Guang-Cong, additional, Zhang, Ning-Ping, additional, Liu, Hai-Ning, additional, Wu, Hao, additional, Xuan, Shi, additional, Yu, Xiang-Nan, additional, Song, Guang-Qi, additional, Shen, Xi-Zhong, additional, Zhu, Ji-Min, additional, Liu, Xiu-Ping, additional, and Liu, Tao-Tao, additional

Published
2022
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17. microRNA-106b-5p Promotes Cell Growth and Sensitizes Chemosensitivity to Sorafenib by Targeting the BTG3/Bcl-xL/p27 Signaling Pathway in Hepatocellular Carcinoma

Author

Bilegsaikhan, Enkhnaran, primary, Zhang, Ning-Ping, additional, Zhang, Guang-Cong, additional, Liu, Hai-Ning, additional, Wu, Hao, additional, Shi, Xuan, additional, Yu, Xiang-Nan, additional, Song, Guang-Qi, additional, Shen, Xi-Zhong, additional, Liu, Xiu-Ping, additional, Zhu, Ji-Min, additional, and Liu, Tao-Tao, additional

Published
2020
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19. The protective effect and mechanism of the FXR agonist obeticholic acid via targeting gut microbiota in non-alcoholic fatty liver disease

Author

Zhang, Dan-Ying, Zhu, Lin, Liu, Hai-Ning, Tseng, Yu-Jen, Weng, Shu-Qiang, Liu, Tao-Tao, Dong, Ling, and Shen, Xi-Zhong

Subjects
Male, Drug Design, Development and Therapy, non-alcoholic fatty liver disease, Receptors, Cytoplasmic and Nuclear, Chenodeoxycholic Acid, Protective Agents, digestive system, metabolic diseases, Gastrointestinal Microbiome, Bile Acids and Salts, Mice, Inbred C57BL, Mice, bile acid, Animals, farnesoid X receptor, Original Research
Abstract

Dan-Ying Zhang,1,* Lin Zhu,2,* Hai-Ning Liu,1,* Yu-Jen Tseng,3 Shu-Qiang Weng,1 Tao-Tao Liu,1 Ling Dong,1 Xi-Zhong Shen1,41Department of Gastroenterology, Zhongshan Hospital of Fudan University, Shanghai 200032, People’s Republic of China; 2Department of Geriatrics, Zhongshan Hospital of Fudan University, Shanghai 200032, People’s Republic of China; 3Department of Gastroenterology, Huashan Hospital of Fudan University, Shanghai 200040, People’s Republic of China; 4Shanghai Institute of Liver Diseases, Zhongshan Hospital of Fudan University, Shanghai 200032, People’s Republic of China*These authors contributed equally to this workBackground: It is reported that various diseases such as non-alcoholic fatty liver disease (NAFLD) are associated with imbalance of microbiome. And FXR has been well investigated in liver diseases.Purpose: The objective of this study was to identify the role of farnesoid X receptor agonist obeticholic acid via targeting gut microbiota in NAFLD.Patients and methods: Male C57BL/6 mice were fed either a normal-chow diet or a high-fat diet (HFD). Obeticholic acid(30mg/(kg·d)) and/or a combination of antibiotics were administered orally by gavage to mice for 12 weeks. Gut microbiota profiles were established through 16S rRNA amplicon sequencing. The effects of obeticholic acid on liver inflammation, the gut barrier, endotoxemia, gut microbiome and composition of the bile acid were also investigated.Results: Obeticholic acid treatment can significantly improve obesity, circulation metabolism disorders, liver inflammation and fibrosis, and intestinal barrier damage caused by HFD. Removal of normal commensal bacteria can weaken the effect of obeticholic acid. The gut microbial structure was changed, and abundance of Blautia was increased significantly after treated with obeticholic acid. After obeticholic acid treatment, the concentration of taurine-bound bile acid caused by HFD was reduced in the liver.Conclusion: Taken together, these data suggest that obeticholic acid has aprotective effect on NAFLD via changing the components of gut microbiota, specifically increasing the abundance of Blautia.Keywords: non-alcoholic fatty liver disease, farnesoid X receptor, gastrointestinal microbiome, bile acid, metabolic diseases

Published
2019

20. Additional file 5: of Serum microRNA signatures and metabolomics have high diagnostic value in gastric cancer

Author

Liu, Hai-Ning, Wu, Hao, Yu-Jen Tseng, Chen, Yan-Jie, Dan-Ying Zhang, Zhu, Lin, Dong, Ling, Xi-Zhong Shen, and Liu, Tao-Tao

Abstract

Table S4. Significantly different metabolites between the gastric cancer patients and the healthy controls. Abbreviations: VIP, variable importance in the projection; MZ, mass-to-charge ratio; RT, retention time. (DOCX 15Â kb)

Published
2018
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24. Additional file 4: of Serum microRNA signatures and metabolomics have high diagnostic value in gastric cancer

Author

Liu, Hai-Ning, Wu, Hao, Yu-Jen Tseng, Chen, Yan-Jie, Dan-Ying Zhang, Zhu, Lin, Dong, Ling, Xi-Zhong Shen, and Liu, Tao-Tao

Abstract

Table S3. MicroRNA expressions and the results of the statistical test. Z value was performed when Wilcoxon-Mann-Whitney test was used in the GC patients versus the control group, and t value was performed when Studentâ s t-test was used. Abbreviations: GC, gastric cancer. (DOCX 14Â kb)

Published
2018
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35. Dieldrin and endrin removal from water by triolein-embedded adsorbent

Author

Qu Jiuhui, Huo Jinxian, Ru Jia, LI Guoting, Liu Huijuan, and Liu Hai-ning

Subjects
chemistry.chemical_classification, Pollutant, Dieldrin, chemistry.chemical_compound, Multidisciplinary, Adsorption, chemistry, Ion strength, Environmental chemistry, Humic acid, Endrin, Triolein, Equilibrium constant
Abstract

A novel triolein-embedded adsorbent for removal of persistent organic pollutants (POPs) from water was developed. In this paper, taking dieldrin and endrin as the target pollutants, different factors (temperature, ion strength, pH, and concentration of humic acid) that affect the adsorption rate were investigated. Adsorption isotherms of these two pollutants fitted to Freundlich model well identified the partition mechanism between the adsorbent and water. However, the equilibrium constant of dieldrin was larger than that of endrin due to larger octanol-water coefficient of dieldrin. Adsorption rate of dieldrin increased with the increase of temperature, the decrease of ion strength, pH and concentration of humic acid, whereas adsorption rate of endrin decreased with the increase of temperature and pH. Humic acid firstly increased, and then decreased the adsorption rate of endrin. Ion strength hardly affected the adsorption rate of endrin.

Published
2005

38. Serum microRNA signatures and metabolomics have high diagnostic value in colorectal cancer using two novel methods.

Author

Liu, Hai‐Ning, Liu, Tao‐Tao, Wu, Hao, Chen, Yan‐Jie, Tseng, Yu‐Jen, Yao, Can, Weng, Shu‐Qiang, Dong, Ling, and Shen, Xi‐Zhong

Abstract

Recently, many new diagnostic biomarkers have been developed for colorectal cancer. We chose 2 methods with high diagnostic efficiency, the detection of serum microRNA and metabolomics based on gas chromatography/mass spectrometry (GC/MS), and aimed to establish appropriate models. We reviewed the diagnostic value of all microRNA identified by previous diagnostic tests. We selected appropriate microRNA to validate their diagnostic efficiency, and determined the optimal combination. We included 85 patients with colorectal cancer (CRC) and 78 healthy controls (HC) and detected the expression of the microRNA. GC/MS analysis was conducted, and we used 3 multivariate statistical methods to establish diagnostic models. The concentrations of carcinoembryonic antigen (CEA) and carbohydrate antigen 19‐9 (CA19‐9) were detected for comparison with the novel models. Ultimately, 62 published studies and 63 microRNA were included in this review. MiR‐21, miR‐29a, miR‐92a, miR‐125b and miR‐223 were selected to further validate their diagnostic value. The serum levels of the 5 microRNA in CRC patients were significantly higher than those in the HC. The combination of miR‐21, miR‐29a, miR‐92a and miR‐125b had the highest area under the curve (AUC) at 0.952, with a sensitivity of 84.7% and a specificity of 98.7%. The GC/MS analysis exhibited an excellent diagnostic value and the AUC reached 1.0. With regard to traditional biomarkers, the AUC of CEA and CA19‐9 were 0.808 and 0.705, respectively. The application prospects are good for microRNA and metabolomics as new diagnostic methods because of their high diagnostic value compared with traditional biomarkers. [ABSTRACT FROM AUTHOR]

Published
2018
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43. Animal Reservoir, Natural and Socioeconomic Variations and the Transmission of Hemorrhagic Fever with Renal Syndrome in Chenzhou, China, 2006–2010

Author

Xiao, Hong, primary, Tian, Huai-Yu, additional, Gao, Li-Dong, additional, Liu, Hai-Ning, additional, Duan, Liang-Song, additional, Basta, Nicole, additional, Cazelles, Bernard, additional, Li, Xiu-Jun, additional, Lin, Xiao-Ling, additional, Wu, Hong-Wei, additional, Chen, Bi-Yun, additional, Yang, Hui-Suo, additional, Xu, Bing, additional, and Grenfell, Bryan, additional

Published
2014
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