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5. Identification of positively selected genes in Mycobacterium tuberculosis from southern Xinjiang Uygur autonomous region of China

Author

Deng, Lele, primary, Wang, Quan, additional, Liu, Haican, additional, Jiang, Yi, additional, Xu, Miao, additional, Xiang, Yu, additional, Yang, Ting, additional, Yang, Shuliu, additional, Yan, Di, additional, Li, Machao, additional, Zhao, Lili, additional, Zhao, Xiuqin, additional, Wan, Kanglin, additional, He, Guangxue, additional, Mijiti, Xiaokaiti, additional, and Li, Guilian, additional

Published
2024
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7. Prevalence, Transmission and Genetic Diversity of Pyrazinamide Resistance Among Multidrug-Resistant Mycobacterium tuberculosis Isolates in Hunan, China

Author

Liu, Binbin, primary, Su, Pan, additional, Hu, Peilei, additional, Yan, Mi, additional, Li, Wenbin, additional, Yi, Songlin, additional, Chen, Zhenhua, additional, Zhang, Xiaoping, additional, Guo, Jingwei, additional, Wan, Xiaojie, additional, Wang, Jue, additional, Gong, Daofang, additional, Bai, Hua, additional, Wan, Kanglin, additional, Liu, Haican, additional, Li, Guilian, additional, and Tan, Yunhong, additional

Published
2024
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10. Comparison of the Immunogenicity and Efficacy of rBCG-EPCP009, BCG Prime-EPCP009 Booster, and EPCP009 Protein Regimens as Tuberculosis Vaccine Candidates

Author

Wang, Ruihuan, primary, Fan, Xueting, additional, Xu, Da, additional, Li, Machao, additional, Zhao, Xiuqin, additional, Cao, Bin, additional, Qian, Chengyu, additional, Yu, Jinjie, additional, Fang, Dan’ang, additional, Gu, Yujie, additional, Wan, Kanglin, additional, and Liu, Haican, additional

Published
2023
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15. Association of Single-Nucleotide Polymorphisms in the VDR Gene with Tuberculosis and Infection of Beijing Genotype Mycobacterium tuberculosis

Author

Yu, Jinjie, primary, Liu, Mengwen, additional, Mijiti, Xiaokaiti, additional, Liu, Haican, additional, Wang, Quan, additional, Yin, Chunjie, additional, Anwaierjiang, Aiketaguli, additional, Xu, Miao, additional, Li, Machao, additional, Deng, Lele, additional, Xiao, Hui, additional, Zhao, Xiuqin, additional, Wan, Kanglin, additional, Li, Guilian, additional, and Yuan, Xiuqin, additional

Published
2023
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16. Genetic Characterization Conferred Co-Resistance to Isoniazid and Ethionamide in Mycobacterium tuberculosis Isolates from Southern Xinjiang, China

Author

Cao, Bin, primary, Mijiti, Xiaokaiti, additional, Deng, Le-Le, additional, Wang, Quan, additional, Yu, Jin-Jie, additional, Anwaierjiang, Aiketaguli, additional, Qian, Chengyu, additional, Li, Machao, additional, Fang, Dan-Ang, additional, Jiang, Yi, additional, Zhao, Li-Li, additional, Zhao, Xiuqin, additional, Wan, Kanglin, additional, Liu, Haican, additional, Li, Guilian, additional, and Yuan, Xiuqin, additional

Published
2023
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17. A novel multi-component protein vaccine ECP001 containing a protein polypeptide antigen nPstS1 riching in T-cell epitopes showed good immunogenicity and protection in mice

Author

Yu, Jinjie, primary, Fan, Xueting, additional, Luan, Xiuli, additional, Wang, Ruihuan, additional, Cao, Bin, additional, Qian, Chengyu, additional, Li, Guilian, additional, Li, Machao, additional, Zhao, Xiuqin, additional, Liu, Haican, additional, Wan, Kanglin, additional, and Yuan, Xiuqin, additional

Published
2023
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20. A Multistage Antigen Complex Epera013 Promotes Efficient and Comprehensive Immune Responses in BALB/c Mice

Author

Qian, Chengyu, primary, Fan, Xueting, additional, Wang, Ruihuan, additional, Cao, Bin, additional, Yu, Jinjie, additional, Luan, Xiuli, additional, Li, Guilian, additional, Jiang, Yi, additional, Li, Machao, additional, Zhao, Xiuqin, additional, Fang, Danang, additional, Wan, Kanglin, additional, Liu, Haican, additional, and Lou, Yongliang, additional

Published
2023
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21. Molecular Epidemiology of Clinical Mycobacterium tuberculosis Isolates from Southern Xinjiang, China Using Spoligotyping and 15-Locus MIRU-VNTR Typing

Author

Yin, Chunjie, primary, Mijiti, Xiaokaiti, additional, Liu, Haican, additional, Wang, Quan, additional, Cao, Bin, additional, Anwaierjiang, Aiketaguli, additional, Li, Machao, additional, Liu, Mengwen, additional, Jiang, Yi, additional, Xu, Miao, additional, Wan, Kanglin, additional, Zhao, Xiuqin, additional, Li, Guilian, additional, and Xiao, Hui, additional

Published
2023
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30. High Immunogenicity of a T-Cell Epitope-Rich Recombinant Protein Rv1566c-444 From Mycobacterium tuberculosis in Immunized BALB/c Mice, Despite Its Low Diagnostic Sensitivity

Author

Luan, Xiuli, primary, Fan, Xueting, additional, Wang, Ruihuan, additional, Deng, Yunli, additional, Chen, Zixin, additional, Li, Na, additional, Yan, Yuhan, additional, Li, Xiaoyan, additional, Liu, Haican, additional, Li, Guilian, additional, and Wan, Kanglin, additional

Published
2022
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31. Deep N-terminomics of Mycobacterium tuberculosis H37Rv extensively correct annotated encoding genes

Author

Shi, Jiahui, primary, Meng, Shuhong, additional, Wan, Li, additional, Zhang, Zhenpeng, additional, Jiang, Songhao, additional, Zhu, Huiming, additional, Dai, Erhei, additional, Chang, Lei, additional, Gao, Huiying, additional, Wan, Kanglin, additional, Zhang, Liqun, additional, Zhao, Xiuqin, additional, Liu, Haican, additional, Lyu, Zhitang, additional, Zhang, Yao, additional, and Xu, Ping, additional

Published
2022
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32. Mycolicibacterium baixiangningiae sp. nov. and Mycolicibacterium mengxianglii sp. nov., two new rapidly growing mycobacterial species

Author

Cheng, Yanpeng, primary, Lei, Wenjing, additional, Wang, Xiaoxia, additional, Tian, Zhi, additional, Liu, Haican, additional, Yang, Jing, additional, Lu, Shan, additional, Lai, Xin-He, additional, Pu, Ji, additional, Huang, Ying, additional, Zhang, Sihui, additional, Yang, Caixin, additional, Lian, Xingxing, additional, Bai, Yibo, additional, Wan, Kanglin, additional, Wang, Suping, additional, and Xu, Jianguo, additional

Published
2021
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34. Quantitative proteomics reveals that dormancy-related proteins mediate the attenuation in mycobacterium strains

Author

Wang, Hong, primary, Wan, Li, additional, Shi, Jiahui, additional, Zhang, Tao, additional, Zhu, Huiming, additional, Jiang, Songhao, additional, Meng, Shuhong, additional, Wu, Shujia, additional, Sun, Jinshuai, additional, Chang, Lei, additional, Zhang, Liqun, additional, Wan, Kanglin, additional, Yang, Jiaqi, additional, Zhao, Xiuqin, additional, Liu, Haican, additional, Zhang, Yao, additional, Dai, Erhei, additional, and Xu, Ping, additional

Published
2021
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35. Prevalence and Molecular Characteristics Based on Whole Genome Sequencing of Mycobacterium tuberculosis Resistant to Four Anti-Tuberculosis Drugs from Southern Xinjiang, China

Author

Anwaierjiang, Aiketaguli, primary, Wang, Quan, additional, Liu, Haican, additional, Yin, Chunjie, additional, Xu, Miao, additional, Li, Machao, additional, Liu, Mengwen, additional, Liu, Yan, additional, Zhao, Xiuqin, additional, Liu, Jinbao, additional, Li, Guilian, additional, Mijiti, Xiaokaiti, additional, and Wan, Kanglin, additional

Published
2021
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36. Detection of Resistance to Fluoroquinolones and Second-Line Injectable Drugs Among Mycobacterium tuberculosis by a Reverse Dot Blot Hybridization Assay

Author

Li,Guilian, Guo,Qian, Liu,Haican, Wan,Li, Jiang,Yi, Li,Machao, Zhao,Li-li, Zhao,Xiuqin, Liu,Zhiguang, and Wan,Kanglin

Subjects
Infection and Drug Resistance
Abstract

Guilian Li,1,* Qian Guo,1,2,* Haican Liu,1 Li Wan,1 Yi Jiang,1 Machao Li,1 Li-li Zhao,1 Xiuqin Zhao,1 Zhiguang Liu,1 Kanglin Wan1 1State Key Laboratory for Infectious Disease Prevention and Control, Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, National Institute for Communicable Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Beijing 102206, People’s Republic of China; 2Department of Molecular Biology, Shanghai Jiao Tong University Affiliated Sixth People’s Hospital, Shanghai 200233, People’s Republic of China*These authors contributed equally to this workCorrespondence: Kanglin Wan Email wankanglin@icdc.cnBackground: Reliable and timely determination of second-line drug resistance is essential for early initiation effective anti-tubercular treatment among multi-drug resistant (MDR) patients and blocking the spread of MDR and extensively drug-resistant tuberculosis. Molecular methods have the potency to provide accurate and rapid drug susceptibility results. We aimed to establish and evaluate the accuracy of a reverse dot blot hybridization (RDBH) assay to simultaneously detect the resistance of fluoroquinolones (FQs), kanamycin (KN), amikacin (AMK), capreomycin (CPM) and second-line injectable drugs (SLIDs) in Mycobacterium tuberculosis.Methods: We established and evaluated the accuracy of the RDBH assay by comparing to the phenotypic drug susceptibility testing (DST) and sequencing in 170 M. tuberculosis, of which 94 and 27 were respectively resistant to ofloxacin (OFX) and SLIDs.Results: The results show that, compared to phenotypic DST, the sensitivity and specificity of the RDBH assay for resistance detection were 63.8% and 100.0% for OFX, 60.0% and 100.0% for KN, 61.5% and 98.1% for AMK, 50.0% and 99.3% for CPM, and 55.6% and 100% for SLIDs, respectively; compared to sequencing, the sensitivity and specificity of the RDBH assay were 95.2% and 100.0% for OFX, 93.8% and 100.0% for SLIDs or KN (both based on mutations in rrs 1400 region and eis promoter), and 91.6% and 100.0% for AMK or CPM (both based on mutations in rrs 1400 region), respectively. The turnaround time of the RDBH assay was 7 h for testing 42 samples.Conclusion: Our data suggested that compared to sequencing, the RDBH assay could serve as a rapid and reliable method for testing the resistance of M. tuberculosis against OFX and SLIDs, enabling early administration of appropriate treatment regimens among MDR tuberculosis patients.Keywords: Mycobacterium tuberculosis, drug resistance, reverse dot blot hybridization, fluoroquinolones, second-line injectable drugs, ofloxacin, kanamycin, amikacin, capreomycin

Published
2020

45. Epidemiological characteristics and trends of notifiable infectious diseases in China from 1986 to 2016.

Author

Yi Jiang, Xiangfeng Dou, Chenqi Yan, Li Wan, Haican Liu, Machao Li, Ruibai Wang, Guilian Li, Lili Zhao, Zhiguang Liu, Xiuqin Zhao, Kanglin Wan, Jiang, Yi, Dou, Xiangfeng, Yan, Chenqi, Wan, Li, Liu, Haican, Li, Machao, Wang, Ruibai, and Li, Guilian

Abstract

Background: Since the 1980s, China has undergone significant social change and the incidence of infectious diseases has also changed considerably. Here, we report the epidemiological features and changes in notifiable infectious diseases in China from 1986 to 2016 to explore the factors contributing to the successful control of infectious diseases and the challenges faced in the prevention and control of infectious diseases.Methods: The data of notifiable infectious diseases in China from 1986 to 2016 were collected from the monthly analysis report of the National Infectious Disease Surveillance System. Joinpoint regression models were used to examine incidence and mortality trends from 1986 to 2016. IBM SPSS Statistics version 22.0, Excel 2010 and R x64 3.5.2 were used for data analysis.Results: A total of 132 858 005 cases of notifiable infectious diseases were reported over these 31 years, with an average yearly incidence of 342.14/100 000. There were 284 694 deaths with an average yearly mortality rate of 0.73/100 000. The overall incidence and overall mortality of notifiable infectious diseases both showed a "U" distribution (ie, a decrease, stable, an increase, stable again). The top five diseases in terms of incidence were hand, foot and mouth disease, viral hepatitis, tuberculosis, other infectious causes of diarrhea and dysentery, accounting for 78.0% of all reported cases. The top five causes of death were HIV/AIDS, rabies, tuberculosis, viral hepatitis and epidemic encephalitis B, which accounted for 76.07% of all mortalities. The diseases with the top five fatality rates were rabies, H5N1, H7N9, HIV/AIDS and plague, with rates of 91.06%, 66.07%, 38.51%, 25.19% and 10.31%, respectively.Conclusions: This analysis will benefit the future monitoring of infectious diseases and public health measures in China. [ABSTRACT FROM AUTHOR]

Published
2020
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47. Identification and evaluation of the novel immunodominant antigen Rv2351c from Mycobacterium tuberculosis

Author

Wang, Xuezhi, primary, Chen, Shuangshuang, additional, Xu, Yongjuan, additional, Zheng, Huajun, additional, Xiao, Tongyang, additional, Li, Yuqing, additional, Chen, Xing, additional, Huang, Mingxiang, additional, Zhang, Haifeng, additional, Fang, Xijing, additional, Jiang, Yi, additional, Li, Machao, additional, Liu, Haican, additional, and Wan, Kanglin, additional

Published
2017
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49. Cross-resistance of isoniazid, para-aminosalicylic acid and pasiniazid against isoniazid-resistant Mycobacterium tuberculosisisolates in China

Author

Li, Guilian, Zhang, Jingrui, Jiang, Yi, Zhao, Li-li, Liu, Haican, Li, Machao, Zhao, Xiuqin, and Wan, Kanglin

Abstract

•84.6% (11/13) of p-aminosalicylic acid-resistant Mycobacterium tuberculosisisolates were susceptible to pasiniazid.•63 isoniazid (INH)-resistant isolates harboured mutations in the katGgene, inhApromoter or oxyR–ahpCintergenic region.•82.5% (52/63) of INH-resistant isolates with these mutations were susceptible to pasiniazid.•11 of 13 pasiniazid-resistant isolates carried mutations in katG, the inhApromoter or the oxyR–ahpCintergenic region.

Published
2020
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50. Polymorphisms of FtsK/SpoIIIE protein in Mycobacterium tuberculosis complex strains may affect both protein function and host immune reaction

Author

Jiang, Yi, Liu, Haican, Qiu, Yan, Li, Guilian, Dou, Xiangfeng, and Wan, Kanglin

Subjects
fungi, Original Article
Abstract

FtsK/SpoIIIE family ATPases are conserved throughout bacteria and are involved in the translocation of DNA and proteins through membrane-spanning pores. Through comparison of 26 whole-genome-sequenced M. tuberculosis complex (MTBC) strains downloaded from NCBI website, we found that FtsK/SpoIIIE protein presented polymorphisms. One M. bovis strain and three BCG strains even showed the two T cell epitopes missing. Then we chose 159 clinical M. tuberculosis isolates from China, amplified gene encoding FtsK/SpoIIIE protein (Rv3871) and compared the sequences. The results showed that there are polymorphisms existed in FtsK/SpoIIIE protein among MTBC, which may affect both protein function and host immune reaction. In addition, position 1497 could be used as a good phylogenetic marker for Beijing strains.

Published
2014

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