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This study describes the hemoglobin concentration ([Hb]) and hematocrit (HCT) of over 1,000 Tibetan and Han children, adolescents, and young adults who were born and raised at 3,200 m, 3,800 m, or 4,300 m in Qinghai Province, western China. At 3,200 m, no altitude effect is evident in the hematological characteristics of either group. At 3,800 m and 4,300 m, both groups show [Hb] and HCT values that are above low-altitude norms. At both altitudes, Tibetan and Han children show no differences in the pattern of hematological response up to age 13. Among adolescents and young adults, however, the [Hb] and HCT of Han males and females are elevated compared to Tibetans. This indicates that the adolescent period may involve a divergence in the responses to hypoxia made by some individuals in these two groups. Also, many other adolescents and young adults in both groups show similar hematological characteristics, indicating that many Tibetans and Han share similar hematological responses to hypoxia. KEY WORDS hemoglobin; hematocrit; altitude hypoxia; children; adolescents

In this paper, we consider an inverse conductive scattering problem for the Helmholtz equation from measurements on the outer boundary. We want to seek reconstruction algorithms to detect the number, location, size and shape of inhomogeneities within a body. This problem is nonlinear and ill-posed, thus we should consider regularization techniques in order to improve the corresponding approximation. We examine the viability of our proposed reconstruction algorithms through the use of numerical experiments. [ABSTRACT FROM AUTHOR]

This study compares the stature, weight, skinfolds, upper arm muscle area, and chest dimensions of Tibetan children, adolescents, and young adults who were born and raised, or who had lived from infancy, at 3,200 m, 3,800 m, and 4,300 m in Qinghai Province, People's Republic of China. While the individuals measured in Qinghai are among the tallest and heaviest Tibetans reported in the literature, they are nevertheless smaller and lighter than well-off children living at low altitude. The pattern of size variation among Tibetan males and females measured at the three high altitudes, along with evidence of a secular trend at 4,300 m, suggests that nutrition may significantly effect growth at high altitude. Only minor differences in thorax dimensions exist between Tibetan males and females measured at 3,200 m and 3,800 m. However, Tibetan males at 4,300 m possess slightly narrower and deeper chests (during and after adolescence) than males at 3,200 m and 3,800 m. Since individuals from 3,800 m and 4,300 m belong to the same local populations, this characteristic is unlikely to be genetically determined. However, it may be related to differences in the degree of hypoxia or to the influences of other environmental conditions. KEY WORDS: high-altitude hypoxia; children; adolescents; thorax growth; Qinghai-Tibetan Plateau

In this paper, we consider an inverse scattering problem of reconstructing the shape and impedance for a cavity from one point source and several measurements placed on a curve inside the cavity. This inverse problem is nonlinear and ill-posed. To overcome such difficulties, we apply an iterative regularized approach to reconstruct both the boundary and the surface impedance, and prove injectivity for the linearized system at the exact solution. Finally, some numerical experiments are presented to demonstrate the feasibility and effectiveness of the proposed regularization method. [ABSTRACT FROM AUTHOR]

In this paper, we study an inverse source problem for the Helmholtz equation from measurements. The purpose of this paper is to reconstruct the salient features of the hidden sources within a body. We propose three stable reconstruction algorithms to detect the number, the location, the size, and the shape of the hidden sources along with compact support from a single measurement of near-field Cauchy data on the external boundary. This problem is nonlinear and ill-posed; thus, we should consider regularization techniques in reconstruction algorithms. We give several numerical experiments to demonstrate the viability of our proposed reconstruction algorithms. [ABSTRACT FROM AUTHOR]

In this paper, we consider a conductivity interface problem to recover the salient features of the inclusion within a body from noisy observation data on the boundary. Based on integral equations, we propose iterative algorithms to detect the location, the size and the shape of the conductivity inclusion. This problem is severely ill-posed and nonlinear, thus we should consider regularization techniques in order to improve the corresponding approximation. We give several examples to show the viability of our proposed reconstruction algorithms. [ABSTRACT FROM AUTHOR]

The endoplasmic reticulum, a key cellular organelle, regulates a wide variety of cellular activities. Endoplasmic reticulum autophagy, one of the quality control systems of the endoplasmic reticulum, plays a pivotal role in maintaining endoplasmic reticulum homeostasis by controlling endoplasmic reticulum turnover, remodeling, and proteostasis. In this review, we briefly describe the endoplasmic reticulum quality control system, and subsequently focus on the role of endoplasmic reticulum autophagy, emphasizing the spatial and temporal mechanisms underlying the regulation of endoplasmic reticulum autophagy according to cellular requirements. We also summarize the evidence relating to how defective or abnormal endoplasmic reticulum autophagy contributes to the pathogenesis of neurodegenerative diseases. In summary, this review highlights the mechanisms associated with the regulation of endoplasmic reticulum autophagy and how they influence the pathophysiology of degenerative nerve disorders. This review would help researchers to understand the roles and regulatory mechanisms of endoplasmic reticulum-phagy in neurodegenerative disorders., (Copyright © 2025 Copyright: © 2025 Neural Regeneration Research.)