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In this work, fabrication of Cu2O@Cu1.75S core‐shell octahedrons was achieved through a facile water bath stirring process. Compared with pure Cu2O, the composite showed enhanced sensing performance for NO2. The response value of Cu2O@Cu1.75S to 5 ppm NO2 at 40 °C is seven times that of Cu2O to 5 ppm NO2 at 75 °C. Moreover, Cu2O@Cu1.75S has the ability to detect 100 ppb NO2 and has good NO2 sensing selectivity and long‐term stability. This study shows that Cu2O@Cu1.75S hybrid is a type of outstanding NO2 gas sensing material on account of its low working temperature and high sensing sensitivity. [ABSTRACT FROM AUTHOR]

Introduction: Identifying patients with high-risk T-cell acute lymphoblastic leukemia (T-ALL) is crucial for personalized therapy; however, the lack of robust biomarkers hinders prognosis assessment. To address this issue, our study aimed to screen and validate genes whose expression may serve as predictive indicators of outcomes in T-ALL patients while also investigating the underlying molecular mechanisms., Methods: Differentially expressed genes (DEGs) between T-ALL patients and healthy controls were identified by integrating data from three independent public datasets. Functional annotation of these DEGs and protein-protein interactions were also conducted. Further, we enrolled a prospective cohort of T-ALL patients (n = 20) at our center, conducting RNA-seq analysis on their bone marrow samples. Survival-based univariate Cox analysis was employed to identify gene expressions related to survival, and an intersection algorithm was sequentially applied. Furthermore, we validated the identified genes using cases from the Therapeutically Applicable Research to Generate Effective Treatments database, plotting Kaplan-Meier curves for secondary validation., Results: Through the integration of survival-related genes with DEGs identified in T-ALL, our analysis revealed six T-ALL-specific genes, the expression levels of which were linked to prognostic value. Notably, the independent prognostic value of SLC40A1 and TES expression levels was confirmed in both an external cohort and a prospective cohort at our center., Conclusion: In summary, our preliminary study indicates that the expression levels of TES and SLC40A1 genes show promise as potential indicators for predicting survival outcomes in T-ALL patients., (© 2024 S. Karger AG, Basel.)