Search

Your search keyword '"Liu, Minna"' showing total 102 results
Start Over Author "Liu, Minna"
102 results on '"Liu, Minna"'

1. BLOOM: A 176B-Parameter Open-Access Multilingual Language Model

Author

Workshop, BigScience, Scao, Teven Le, Fan, Angela, Akiki, Christopher, Pavlick, Ellie, Ilić, Suzana, Hesslow, Daniel, Castagné, Roman, Luccioni, Alexandra Sasha, Yvon, François, Gallé, Matthias, Tow, Jonathan, Rush, Alexander M., Biderman, Stella, Webson, Albert, Ammanamanchi, Pawan Sasanka, Wang, Thomas, Sagot, Benoît, Muennighoff, Niklas, del Moral, Albert Villanova, Ruwase, Olatunji, Bawden, Rachel, Bekman, Stas, McMillan-Major, Angelina, Beltagy, Iz, Nguyen, Huu, Saulnier, Lucile, Tan, Samson, Suarez, Pedro Ortiz, Sanh, Victor, Laurençon, Hugo, Jernite, Yacine, Launay, Julien, Mitchell, Margaret, Raffel, Colin, Gokaslan, Aaron, Simhi, Adi, Soroa, Aitor, Aji, Alham Fikri, Alfassy, Amit, Rogers, Anna, Nitzav, Ariel Kreisberg, Xu, Canwen, Mou, Chenghao, Emezue, Chris, Klamm, Christopher, Leong, Colin, van Strien, Daniel, Adelani, David Ifeoluwa, Radev, Dragomir, Ponferrada, Eduardo González, Levkovizh, Efrat, Kim, Ethan, Natan, Eyal Bar, De Toni, Francesco, Dupont, Gérard, Kruszewski, Germán, Pistilli, Giada, Elsahar, Hady, Benyamina, Hamza, Tran, Hieu, Yu, Ian, Abdulmumin, Idris, Johnson, Isaac, Gonzalez-Dios, Itziar, de la Rosa, Javier, Chim, Jenny, Dodge, Jesse, Zhu, Jian, Chang, Jonathan, Frohberg, Jörg, Tobing, Joseph, Bhattacharjee, Joydeep, Almubarak, Khalid, Chen, Kimbo, Lo, Kyle, Von Werra, Leandro, Weber, Leon, Phan, Long, allal, Loubna Ben, Tanguy, Ludovic, Dey, Manan, Muñoz, Manuel Romero, Masoud, Maraim, Grandury, María, Šaško, Mario, Huang, Max, Coavoux, Maximin, Singh, Mayank, Jiang, Mike Tian-Jian, Vu, Minh Chien, Jauhar, Mohammad A., Ghaleb, Mustafa, Subramani, Nishant, Kassner, Nora, Khamis, Nurulaqilla, Nguyen, Olivier, Espejel, Omar, de Gibert, Ona, Villegas, Paulo, Henderson, Peter, Colombo, Pierre, Amuok, Priscilla, Lhoest, Quentin, Harliman, Rheza, Bommasani, Rishi, López, Roberto Luis, Ribeiro, Rui, Osei, Salomey, Pyysalo, Sampo, Nagel, Sebastian, Bose, Shamik, Muhammad, Shamsuddeen Hassan, Sharma, Shanya, Longpre, Shayne, Nikpoor, Somaieh, Silberberg, Stanislav, Pai, Suhas, Zink, Sydney, Torrent, Tiago Timponi, Schick, Timo, Thrush, Tristan, Danchev, Valentin, Nikoulina, Vassilina, Laippala, Veronika, Lepercq, Violette, Prabhu, Vrinda, Alyafeai, Zaid, Talat, Zeerak, Raja, Arun, Heinzerling, Benjamin, Si, Chenglei, Taşar, Davut Emre, Salesky, Elizabeth, Mielke, Sabrina J., Lee, Wilson Y., Sharma, Abheesht, Santilli, Andrea, Chaffin, Antoine, Stiegler, Arnaud, Datta, Debajyoti, Szczechla, Eliza, Chhablani, Gunjan, Wang, Han, Pandey, Harshit, Strobelt, Hendrik, Fries, Jason Alan, Rozen, Jos, Gao, Leo, Sutawika, Lintang, Bari, M Saiful, Al-shaibani, Maged S., Manica, Matteo, Nayak, Nihal, Teehan, Ryan, Albanie, Samuel, Shen, Sheng, Ben-David, Srulik, Bach, Stephen H., Kim, Taewoon, Bers, Tali, Fevry, Thibault, Neeraj, Trishala, Thakker, Urmish, Raunak, Vikas, Tang, Xiangru, Yong, Zheng-Xin, Sun, Zhiqing, Brody, Shaked, Uri, Yallow, Tojarieh, Hadar, Roberts, Adam, Chung, Hyung Won, Tae, Jaesung, Phang, Jason, Press, Ofir, Li, Conglong, Narayanan, Deepak, Bourfoune, Hatim, Casper, Jared, Rasley, Jeff, Ryabinin, Max, Mishra, Mayank, Zhang, Minjia, Shoeybi, Mohammad, Peyrounette, Myriam, Patry, Nicolas, Tazi, Nouamane, Sanseviero, Omar, von Platen, Patrick, Cornette, Pierre, Lavallée, Pierre François, Lacroix, Rémi, Rajbhandari, Samyam, Gandhi, Sanchit, Smith, Shaden, Requena, Stéphane, Patil, Suraj, Dettmers, Tim, Baruwa, Ahmed, Singh, Amanpreet, Cheveleva, Anastasia, Ligozat, Anne-Laure, Subramonian, Arjun, Névéol, Aurélie, Lovering, Charles, Garrette, Dan, Tunuguntla, Deepak, Reiter, Ehud, Taktasheva, Ekaterina, Voloshina, Ekaterina, Bogdanov, Eli, Winata, Genta Indra, Schoelkopf, Hailey, Kalo, Jan-Christoph, Novikova, Jekaterina, Forde, Jessica Zosa, Clive, Jordan, Kasai, Jungo, Kawamura, Ken, Hazan, Liam, Carpuat, Marine, Clinciu, Miruna, Kim, Najoung, Cheng, Newton, Serikov, Oleg, Antverg, Omer, van der Wal, Oskar, Zhang, Rui, Zhang, Ruochen, Gehrmann, Sebastian, Mirkin, Shachar, Pais, Shani, Shavrina, Tatiana, Scialom, Thomas, Yun, Tian, Limisiewicz, Tomasz, Rieser, Verena, Protasov, Vitaly, Mikhailov, Vladislav, Pruksachatkun, Yada, Belinkov, Yonatan, Bamberger, Zachary, Kasner, Zdeněk, Rueda, Alice, Pestana, Amanda, Feizpour, Amir, Khan, Ammar, Faranak, Amy, Santos, Ana, Hevia, Anthony, Unldreaj, Antigona, Aghagol, Arash, Abdollahi, Arezoo, Tammour, Aycha, HajiHosseini, Azadeh, Behroozi, Bahareh, Ajibade, Benjamin, Saxena, Bharat, Ferrandis, Carlos Muñoz, McDuff, Daniel, Contractor, Danish, Lansky, David, David, Davis, Kiela, Douwe, Nguyen, Duong A., Tan, Edward, Baylor, Emi, Ozoani, Ezinwanne, Mirza, Fatima, Ononiwu, Frankline, Rezanejad, Habib, Jones, Hessie, Bhattacharya, Indrani, Solaiman, Irene, Sedenko, Irina, Nejadgholi, Isar, Passmore, Jesse, Seltzer, Josh, Sanz, Julio Bonis, Dutra, Livia, Samagaio, Mairon, Elbadri, Maraim, Mieskes, Margot, Gerchick, Marissa, Akinlolu, Martha, McKenna, Michael, Qiu, Mike, Ghauri, Muhammed, Burynok, Mykola, Abrar, Nafis, Rajani, Nazneen, Elkott, Nour, Fahmy, Nour, Samuel, Olanrewaju, An, Ran, Kromann, Rasmus, Hao, Ryan, Alizadeh, Samira, Shubber, Sarmad, Wang, Silas, Roy, Sourav, Viguier, Sylvain, Le, Thanh, Oyebade, Tobi, Le, Trieu, Yang, Yoyo, Nguyen, Zach, Kashyap, Abhinav Ramesh, Palasciano, Alfredo, Callahan, Alison, Shukla, Anima, Miranda-Escalada, Antonio, Singh, Ayush, Beilharz, Benjamin, Wang, Bo, Brito, Caio, Zhou, Chenxi, Jain, Chirag, Xu, Chuxin, Fourrier, Clémentine, Periñán, Daniel León, Molano, Daniel, Yu, Dian, Manjavacas, Enrique, Barth, Fabio, Fuhrimann, Florian, Altay, Gabriel, Bayrak, Giyaseddin, Burns, Gully, Vrabec, Helena U., Bello, Imane, Dash, Ishani, Kang, Jihyun, Giorgi, John, Golde, Jonas, Posada, Jose David, Sivaraman, Karthik Rangasai, Bulchandani, Lokesh, Liu, Lu, Shinzato, Luisa, de Bykhovetz, Madeleine Hahn, Takeuchi, Maiko, Pàmies, Marc, Castillo, Maria A, Nezhurina, Marianna, Sänger, Mario, Samwald, Matthias, Cullan, Michael, Weinberg, Michael, De Wolf, Michiel, Mihaljcic, Mina, Liu, Minna, Freidank, Moritz, Kang, Myungsun, Seelam, Natasha, Dahlberg, Nathan, Broad, Nicholas Michio, Muellner, Nikolaus, Fung, Pascale, Haller, Patrick, Chandrasekhar, Ramya, Eisenberg, Renata, Martin, Robert, Canalli, Rodrigo, Su, Rosaline, Su, Ruisi, Cahyawijaya, Samuel, Garda, Samuele, Deshmukh, Shlok S, Mishra, Shubhanshu, Kiblawi, Sid, Ott, Simon, Sang-aroonsiri, Sinee, Kumar, Srishti, Schweter, Stefan, Bharati, Sushil, Laud, Tanmay, Gigant, Théo, Kainuma, Tomoya, Kusa, Wojciech, Labrak, Yanis, Bajaj, Yash Shailesh, Venkatraman, Yash, Xu, Yifan, Xu, Yingxin, Xu, Yu, Tan, Zhe, Xie, Zhongli, Ye, Zifan, Bras, Mathilde, Belkada, Younes, and Wolf, Thomas

Subjects
Computer Science - Computation and Language
Abstract

Large language models (LLMs) have been shown to be able to perform new tasks based on a few demonstrations or natural language instructions. While these capabilities have led to widespread adoption, most LLMs are developed by resource-rich organizations and are frequently kept from the public. As a step towards democratizing this powerful technology, we present BLOOM, a 176B-parameter open-access language model designed and built thanks to a collaboration of hundreds of researchers. BLOOM is a decoder-only Transformer language model that was trained on the ROOTS corpus, a dataset comprising hundreds of sources in 46 natural and 13 programming languages (59 in total). We find that BLOOM achieves competitive performance on a wide variety of benchmarks, with stronger results after undergoing multitask prompted finetuning. To facilitate future research and applications using LLMs, we publicly release our models and code under the Responsible AI License.

Published
2022

9. Research Progress on Ferroptosis as a Therapeutic Strategy in Renal Cell Carcinoma

Author

Liu Minna, Min Bai, Na Cui, Yi Ding, and Peng Zhang

Subjects
Community and Home Care
Abstract

Renal cell carcinoma (RCC) is a common type of kidney cancer in adults and constitutes approximately 90% of all renal malignancies. Although advancements have been made in the treatment of RCC, the 5 -year survival rate is still low, and new treatment modalities are still required. Ferroptosis is an iron-dependent programmed cell death caused by the accumulation of lipid peroxide products. Recent studies revealed the involvement of ferroptosis metabolism, lipid peroxidation, and System XC-GSH-GPX4 shafts as major mechanisms closely related to RCC progression. Nanoparticles in combination with small molecular ferroptosis induction agents have the advantages of solubility, targeted enhancement, low systemic toxicity, controllable drug control, and synergy advantage in emerging combination therapies. In the future, it is possible to be used in nano treatment. The relationship between ferroptosis-related mechanisms and RCC progression and its role in the treatment could provide novel treatment strategies for patients with advance-stage RCC.

Published
2022

11. A Controlled Scheduling Algorithm Decreasing the Incidence of Starvation in Grid Environments

Author

Liu, Minna, Ou, Kairi, Zhao, Yuelong, Sun, Tian, Hutchison, David, editor, Kanade, Takeo, editor, Kittler, Josef, editor, Kleinberg, Jon M., editor, Mattern, Friedemann, editor, Mitchell, John C., editor, Naor, Moni, editor, Nierstrasz, Oscar, editor, Pandu Rangan, C., editor, Steffen, Bernhard, editor, Sudan, Madhu, editor, Terzopoulos, Demetri, editor, Tygar, Doug, editor, Vardi, Moshe Y., editor, Weikum, Gerhard, editor, Goebel, Randy, editor, Siekmann, Jörg, editor, Wahlster, Wolfgang, editor, Deng, Hepu, editor, Wang, Lanzhou, editor, Wang, Fu Lee, editor, and Lei, Jingsheng, editor

Published
2009
Full Text
View/download PDF

19. English: Garden as a microcosm of city

Author

Liu, Minna (author) and Liu, Minna (author)

Abstract

Mostar, a city famous for its world-known Old Bridge built in the Ottoman period, has experienced the violent atrocities during the Bosnian conflict from 1992 to 1995. After the war, despite its very mixed population, the city’s urban space now is not shared by the different communities. Instead, It is fragmented and polarised by the two biggest national groups, leading to a Croat west bank and a Bosniac east bank. Whether physically or psychologically, the city Mostar is considered a divided city. Under this extremely difficult and complex context in the post-war situation, any proposal is facing tough pressure to coordinate and implement. That’s why transforming a place full of potential to a garden as a microcosm could be a good choice to first light the current situation. In order to address the problems, a garden as a microcosm of the city Mostar is supposed to help to inspire how to re-introduce the river to the city again, improve the living quality of inhabitants and empower visitors to develop different perspectives related to the research objective. By gathering and expressing the features which reflect the history of the city’s development and culture into one coherent, memorable and recognizable place. It also expresses the desire to re-create or to redefine what has been lost during the development of the city. Visitors of this garden could experience directly the beauty of Mostar spatially but are also encouraged to empower different perspectives towards to city Mostar itself, to develop another version of what is possible in Mostar in future linking what happened before., Architecture, Urbanism and Building Sciences

Published
2019

20. Dynamic mechanical relaxation in LaCe-based metallic glasses: influence of the chemical composition

Author

Universitat Politècnica de Catalunya. Departament de Física, Universitat Politècnica de Catalunya. GCM - Grup de Caracterització de Materials, Liu, Minna, Qiao, Jichao, Hao, Qi, Chen, Yinghong, Yao, Yao, Crespo Artiaga, Daniel, Pelletier, J. M., Universitat Politècnica de Catalunya. Departament de Física, Universitat Politècnica de Catalunya. GCM - Grup de Caracterització de Materials, Liu, Minna, Qiao, Jichao, Hao, Qi, Chen, Yinghong, Yao, Yao, Crespo Artiaga, Daniel, and Pelletier, J. M.

Abstract

The mechanical relaxation behavior of the (La0.5Ce0.5)65Al10(CoxCu1-x)25 at% (x = 0, 0.2, 0.4, 0.6, and 0.8) metallic glasses was probed by dynamic mechanical analysis. The intensity of the secondary ß relaxation increases along with the Co/Cu ratio, as has been reported in metallic glasses where the enthalpy of mixing for all pairs of atoms is negative. Furthermore, the intensity of the secondary ß relaxation decreases after physical aging below the glass transition temperature, which is probably due to the reduction of the atomic mobility induced by physical aging., Peer Reviewed, Postprint (published version)

Published
2019

35. Identification of genes and pathways potentially related to PHF20 by gene expression profile analysis of glioblastoma U87 cell line

Author

Liu, Tianlong, primary, Zhang, Tiejun, additional, Zhou, Feng, additional, Wang, Jitao, additional, Zhai, Xiaohu, additional, Mu, Nan, additional, Park, Jongsun, additional, Liu, Minna, additional, Liu, Wenxing, additional, Shang, Peijin, additional, Ding, Yi, additional, Wen, Aidong, additional, and Li, Yuwen, additional

Published
2017
Full Text
View/download PDF

37. p53 upregulated by HIF-1 α promotes hypoxia-induced G2/M arrest and renal fibrosis in vitro and in vivo.

Author

Liu, Limin, Zhang, Peng, Bai, Ming, He, Lijie, Zhang, Lei, Liu, Ting, Yang, Zhen, Duan, Menglu, Liu, Minna, Liu, Baojian, Du, Rui, Qian, Qi, and Sun, Shiren

Abstract

Hypoxia plays an important role in the genesis and progression of renal fibrosis. The underlying mechanisms, however, have not been sufficiently elucidated. We examined the role of p53 in hypoxia-induced renal fibrosis in cell culture (human and rat renal tubular epithelial cells) and a mouse unilateral ureteral obstruction (UUO) model. Cell cycle of tubular cells was determined by flow cytometry, and the expression of profibrogenic factors was determined by RT-PCR, immunohistochemistry, and western blotting. Chromatin immunoprecipitation and luciferase reporter experiments were performed to explore the effect of HIF-1α on p53 expression. We showed that, in hypoxic tubular cells, p53 upregulation suppressed the expression of CDK1 and cyclins B1 and D1, leading to cell cycle (G2/M) arrest (or delay) and higher expression of TGF-β, CTGF, collagens, and fibronectin. p53 suppression by siRNA or by a specific p53 inhibitor (PIF-α) triggered opposite effects preventing the G2/M arrest and profibrotic changes. In vivo experiments in the UUO model revealed similar antifibrotic results following intraperitoneal administration of PIF-α (2.2 mg/kg). Using gain-of-function, loss-of-function, and luciferase assays, we further identified an HRE3 region on the p53 promoter as the HIF-1α-binding site. The HIF-1α–HRE3 binding resulted in a sharp transcriptional activation of p53. Collectively, we show the presence of a hypoxia-activated, p53-responsive profibrogenic pathway in the kidney. During hypoxia, p53 upregulation induced by HIF-1α suppresses cell cycle progression, leading to the accumulation of G2/M cells, and activates profibrotic TGF-β and CTGF-mediated signaling pathways, causing extracellular matrix production and renal fibrosis. [ABSTRACT FROM AUTHOR]

Published
2019
Full Text
View/download PDF

38. Distributed cognitive theory: Learning concept of network era

Author

Liu Minna

Subjects
Cognitive science, Entertainment, Process (engineering), Constructivism (philosophy of education), Motor cognition, Behaviorism, Education theory, Cognition, Sociology, Socially distributed cognition
Abstract

The arrival of network era changed the way of people's life, production and entertainment, and with them comes the birth of new forms of network education. The change of education environment calls for new theory as the support, thus the era of network experiences behaviorism, constructivism and the distributed cognition of the development process. Distributed cognition theory advocated cognition is distributed in intra-individual, between individuals, media, environment, culture, society. Distributed cognition theory is highly in accordance with the era of network learning concept; therefore it becomes the basis of the education theory of the network era.

Published
2012

39. Network Teaching Model Based on the Concept of Eco-psychology

Author

Liu Minna

Subjects
Mode (computer interface), Knowledge management, Computer science, Ecopsychology, Network teaching, business.industry, Teaching method, Ecological psychology, Distance education, ComputingMilieux_COMPUTERSANDEDUCATION, Context (language use), Situational ethics, business
Abstract

Change in the form of teaching needs the new teaching mode support, especially for network teaching. Each model is based on the theory of teaching and learning, effective theory leads to effective teaching model. Eco-psychology advocates study of human psychology and behavior in a real environment, and the major view is that learning occurs in the interaction between the learner and the environment. This article thus concludes that the building of a eco-psychology network teaching model is based on the three requirements: interaction principle, the situational principle and dynamic principle, and the practical application is constructed based on the concept of eco-psychology online teaching modes: an interactive online teaching mode, which consists of four main components; situation creation, learners interaction with the environment, learner intentions guidance and correction, transfer.

Published
2010

40. Notice of Retraction: On the Educational Equity under the Educational Informatization

Author

Liu Minna

Subjects
Educational equity, Equity (economics), ComputingMilieux_THECOMPUTINGPROFESSION, Notice, business.industry, Constitution, media_common.quotation_subject, Information technology, Public relations, GeneralLiterature_MISCELLANEOUS, Cultural diversity, Political science, ComputingMilieux_COMPUTERSANDEDUCATION, Harmonious Society, ComputingMilieux_COMPUTERSANDSOCIETY, Informatization, business, media_common
Abstract

The idea of educational equity has a long history. With the society developing many problems about educational equity has come out. But whenever it is people need educational equity especially for the harmonious society. About the concept of educational equity, different scholar has different idea. Taking one with another educational equity includes three parts: equality of educational opportunity, equality of educational process, and equity of educational results. Nowadays, educational informatization has brought education into a new development. It impact on the educational equity, not only promote the realization of the educational equity, but also brought new problems to it. It leads the education into the new unfair. This paper mostly analyzes the impact of educational equity under the educational informatization and puts forward many ideas to achieve a better educational equity.

Published
2009

43. Single-crystalline MoO3 nanoplates: topochemical synthesis and enhanced ethanol-sensing performance

Author

Chen, Deliang, primary, Liu, Minna, additional, Yin, Li, additional, Li, Tao, additional, Yang, Zhen, additional, Li, Xinjian, additional, Fan, Bingbing, additional, Wang, Hailong, additional, Zhang, Rui, additional, Li, Zhengxin, additional, Xu, Hongliang, additional, Lu, Hongxia, additional, Yang, Daoyuan, additional, Sun, Jing, additional, and Gao, Lian, additional

Published
2011
Full Text
View/download PDF

46. Phenylboronate-diol crosslinked polymer/SWCNT hybrid gels with reversible sol-gel transition.

Author

Li, Wenjun, Liu, Minna, Chen, Hongbiao, Xu, Jiao, Gao, Yong, and Li, Huaming

Subjects
CARBON nanotubes, POLYMER colloids, CROSSLINKED polymers, SOL-gel processes, POLYMERS
Abstract

This work demonstrates the successful incorporation of functionalized single-walled carbon nanotubes (f-SWCNTs) into the phenylboronate-diol crosslinked polymer gel to create a hybrid system with reversible sol-gel transition. The phenylboronic acid-containing and diol-containing polymers were first separately prepared by the reversible addition-fragmentation chain transfer polymerization. Covalent functionalization of single-walled carbon nanotubes (SWCNTs) with an azide-derivatized, diol-containing polymer was then accomplished by a nitrene addition reaction. Subsequently, the hybrid gels were prepared by crosslinking the mixture of f-SWCNTs and diol-containing polymer with the phenylboronic acid-containing polymer. The hybrid gel has been characterized by scanning electron microscopy (SEM) and rheological analysis. The SEM measurement demonstrated a homogeneous dispersion of f-SWCNTs within the gel matrices. Rheological experiments also demonstrated that the hybrid gel exhibited storage moduli significantly higher than those of the native gel obtained from the phenylboronic acid-containing and diol-containing polymers. The hybrid gel can be switched into their starting polymer (f-SWCNTs) solutions by adjusting the pH of the system. Moreover, the hybrid gel revealed a self-healing property that occurred autonomously without any outside intervention. By employing this dynamic character, it is possible to regenerate the used gel, and thus, it has the potential to perform in a range of dynamic or bioresponsive applications Copyright © 2013 John Wiley & Sons, Ltd. [ABSTRACT FROM AUTHOR]

Published
2014
Full Text
View/download PDF

47. Large-scale synthesis and enhanced visible-light-driven photocatalytic performance of hierarchical Ag/AgCl nanocrystals derived from freeze-dried PVP–Ag+ hybrid precursors with porosity.

Author

Chen, Deliang, Liu, Minna, Chen, Qianqian, Ge, Lianfang, Fan, Bingbing, Wang, Hailong, Lu, Hongxia, Yang, Daoyuan, Zhang, Rui, Yan, Qishe, Shao, Guosheng, Sun, Jing, and Gao, Lian

Subjects
*VISIBLE spectra, *PHOTOCATALYSIS, *SILVER compounds, *POVIDONE, *FREEZE-drying, *NANOCRYSTAL synthesis
Abstract

Highlights: [•] Hierarchical Ag/AgCl nanocrystals were synthesized via a freeze-drying route. [•] The Ag/AgCl nanocrystals strongly absorb visible light in 400–800nm. [•] The enhancement in photocatalysis results from the high visible-light absorbance. [•] The freeze-dried PVP–Ag+ hybrid plays a key role in forming hierarchical Ag/AgCl. [•] The hierarchical structure is helpful to improve photocatalytic performance. [ABSTRACT FROM AUTHOR]

Published
2014
Full Text
View/download PDF

49. Creative Construction of Resources under Constraints in the Case of Cirque du Soleil.

Author

Hsiao, Ruey-Lin, Ou, Su Hua, and Liu, Minna

Abstract

This article considers entrepreneurs as strategists, and examines their practices in leveraging limited resources within disadvantaged situations. A case study of art curators' improvising behaviors illustrates novel solutions may be devised by deploying a range of available resources at hand. Taking a constructivist standpoint, our research elaborates the micro-process of resource construction and identifies two modes of imbuing values into previous redundant resources: multiplying values and diversifying values. Theoretically, this study speaks to entrepreneurship literature and offers insights into the theory of bricolage. Practically, this paper examines how constraints could be overcome by means of creative re-construction of seemingly worthless resources. [ABSTRACT FROM AUTHOR]

Published
2013
Full Text
View/download PDF

50. PI3K/AKT signaling and neuroprotection in ischemic stroke: molecular mechanisms and therapeutic perspectives.

Author

Liu T, Li X, Zhou X, Chen W, Wen A, Liu M, and Ding Y

Abstract

Abstract: It has been reported that the PI3K/AKT signaling pathway plays a key role In the pathogenesis of ischemic stroke. As a result, the development of drugs targeting the PI3K/AKT signaling pathway has attracted increasing attention from researchers. This article reviews the pathological mechanisms and advancements in research related to the signaling pathways in ischemic stroke, with a focus on the PI3K/AKT signaling pathway.The key findings include the following: (1) The complex pathological mechanisms of ischemic stroke can be categorized into five major types: excitatory amino acid toxicity, Ca2+ overload, inflammatory response, oxidative stress, and apoptosis. (2) The PI3K/AKT-mediated signaling pathway is closely associated with the occurrence and progression of ischemic stroke, which primarily involves the NF-kB, NRF2, BCL-2, mTOR, and endothelial NOS signaling pathways. (3) Natural products, including flavonoids, quinones, alkaloids, phenylpropanoids, phenols, terpenoids, and iridoids, show great potential as candidate substances for the development of innovative anti-stroke medications. (4) Recently, novel therapeutic techniques, such as electroacupuncture and mesenchymal stem cell therapy, have demonstrated the potential to improve stroke outcomes by activating the PI3K/AKT signaling pathway, providing new possibilities for the treatment and rehabilitation of patients with ischemic stroke. Future investigations should focus on the direct regulatory mechanisms of drugs targeting the PI3K/AKT signaling pathway and their clinical translation to develop innovative treatment strategies for ischemic stroke., (Copyright © 2025 Copyright: © 2025 Neural Regeneration Research.)

Published
2024
Full Text
View/download PDF

Catalog

Books, media, physical & digital resources
See catalog results