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18 results on '"Liu, Moyi"'

4. List of contributors

Author

Alam, Mohammad Abrar, primary, Cao, Jin-Xu, additional, Cao, Peng, additional, Chang, Yingjie, additional, Chang, Junbiao, additional, Chen, Cheng, additional, Chen, Xin, additional, Chen, Xingyu, additional, Chen, Yu-Ting, additional, Chen, Jianjun, additional, Chen, Jiong, additional, Chen, Lianru, additional, Chen, Qiushi, additional, Chen, Baobao, additional, Chen, Fangyuan, additional, Chen, Lixia, additional, Cui, Sunliang, additional, Dang, Wen, additional, Ding, Li, additional, Duan, Zhi-Kang, additional, Fang, Hao, additional, Fu, Caiyun, additional, Gao, Yue, additional, Gao, Shenghua, additional, Gu, Shuang-Xi, additional, Gu, Jing, additional, Han, Bo, additional, He, Shanmei, additional, Hou, Wei, additional, Hou, Xuben, additional, Hu, Wenhao, additional, Hu, Honggang, additional, Huang, Junli, additional, Huang, Xiao-Xiao, additional, Huang, Ling, additional, Huang, Zhifeng, additional, Jia, Ruifang, additional, Jiang, Jia, additional, Ju, Han, additional, Li, Zheng, additional, Li, Hua, additional, Li, Tengfei, additional, Li, Guo-Bo, additional, Li, Ning, additional, Li, Honglin, additional, Li, Jianqi, additional, Li, Zhuoqiao, additional, Li, Shiliang, additional, Liang, Chengyuan, additional, Liao, Chenzhong, additional, Liu, Chao, additional, Liu, Feng, additional, Liu, Jinping, additional, Liu, Moyi, additional, Liu, Ruiqi, additional, Liu, Tao, additional, Liu, Chuanfeng, additional, Liu, Xiao, additional, Liu, Huanhai, additional, Liu, Wukun, additional, Liu, Xinyong, additional, Lou, Jianfeng, additional, Lu, Xiaoyun, additional, Lu, Yunlong, additional, Lu, Ying-Yuan, additional, Lu, Yuhang, additional, Menéndez-Arias, Luis, additional, Miao, Runyu, additional, Miao, Zhenyuan, additional, Ming, Wei, additional, Ou, Tian-Miao, additional, Ouyang, Qin, additional, Pang, Xiaojing, additional, Peng, Xinyan, additional, Peng, Si-Yu, additional, Qi, Jiaxin, additional, Qian, Hai, additional, Sang, Zhipei, additional, Shi, Jing, additional, Song, Yihui, additional, Su, Ma, additional, Sun, Jia-Wei, additional, Tian, Lei, additional, Wang, Lei, additional, Wang, Cuizhu, additional, Wang, Dongmei, additional, Wang, Nan, additional, Wang, Nanxi, additional, Wang, Qin, additional, Wang, Lu-Lu, additional, Wang, Qianyun, additional, Wang, Xiao-Na, additional, Wang, Yawen, additional, Wang, Mei-Man, additional, Wu, Min, additional, Wu, Junzhe, additional, Xian, Min, additional, Xie, Zhiying, additional, Xin, Liang, additional, Xiong, Weichen, additional, Xu, Hongtao, additional, Xu, Xinfang, additional, Yan, Jianyu, additional, Yan, Zhibin, additional, Yan, Ziqin, additional, Yang, Ke-Wu, additional, Yang, Zeng-Bao, additional, Yang, Yan, additional, Yi, Wei, additional, Yu, Bin, additional, Yuan, Zhen, additional, Zeng, Ke-Wu, additional, Zeng, Rong, additional, Zha, Wenlong, additional, Zhai, Xiaopei, additional, Zhan, Peng, additional, Zhang, Ying, additional, Zhang, Wan, additional, Zhang, Leihao, additional, Zhang, Luyong, additional, Zhang, Chen, additional, Zhang, Hao, additional, Zhang, Wannan, additional, Zhang, Jie, additional, Zhang, Shuang-Shuang, additional, Zhang, Qingwei, additional, Zhao, Yujun, additional, Zhao, Lin, additional, Zhao, Yuqing, additional, Zhou, Di, additional, Zhou, Cong, additional, Zhou, Feilong, additional, Zhou, Zhi, additional, Zhu, Qiang, additional, Zhu, Yuan-Yuan, additional, Zhu, Jianxun, additional, Zhuang, Chunlin, additional, Zi, Jiachen, additional, Zou, Jing, additional, and Zou, Taotao, additional

Published
2023
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5. Recent Advances in the Development of Targeted Activation Strategies for Organoboron Prodrugs.

Author

Liu, Moyi and Zou, Taotao

Subjects
*ORGANOBORON compounds, *REACTIVE oxygen species, *NEURODEGENERATION, *RADICALS (Chemistry), *PRODRUGS
Abstract

Elevated levels of reactive oxygen species (ROS) are a hallmark of varieties of diseases such as cancer, inflammation, and neurodegenerative disorders. Inspired by the discrepancy of ROS concentrations between pathological tissues and the normal counterparts, an increasing number of ROS‐responsive theragnostic prodrugs are developed in past years, with particularly high proportions of organoboron‐based prodrugs that can respond to H2O2. Unfortunately, increasing studies have demonstrated that the intrinsic ROS (H2O2) levels in most pathological tissue are only slightly higher than normal tissues and are not adequate to activate organoboron prodrugs; in contrast, several organoboron compounds have been clinically approved in which boronic acid acts as electrophilic warhead. To this end, developing more robust and universal approaches for boronic acid‐prodrug activation becomes highly attractive. In this context, we discuss the recently reported activation strategies for boron‐caged prodrugs with a particular focus on their design principles and activation mechanisms. The perspectives on the future directions for this important research area are discussed as well. [ABSTRACT FROM AUTHOR]

Published
2024
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6. Ion Pairing Enables Targeted Prodrug Activation via Red Light Photocatalysis: A Proof-of-Concept Study with Anticancer Gold Complexes

Author

Xie, Zhiying, Cao, Bei, Zhao, Jing, Liu, Moyi, Lao, Yuhan, Luo, Hejiang, Zhong, Zhi, Xiong, Xiaolin, Wei, Wei, Zou, Taotao, Xie, Zhiying, Cao, Bei, Zhao, Jing, Liu, Moyi, Lao, Yuhan, Luo, Hejiang, Zhong, Zhi, Xiong, Xiaolin, Wei, Wei, and Zou, Taotao

Abstract

Photocatalysis has found increasing applications in biological systems, for example, in localized prodrug activation; however, high-energy light is usually required without giving sufficient efficiency and target selectivity. In this work, we report that ion pairing between photocatalysts and prodrugs can significantly improve the photoactivation efficiency and enable tumor-targeted activation by red light. This is exemplified by a gold-based prodrug (1d) functionalized with a morpholine moiety. Such a modification causes 1d to hydrolyze in aqueous solution, forming a cationic species that tightly interacts with anionic photosensitizers including Eosin Y (EY) and Rose Bengal (RB), along with a significant bathochromic shift of absorption tailing to the far-red region. As a result, a high photoactivation efficiency of 1d by EY or RB under low-energy light was found, leading to an effective release of active gold species in living cells, as monitored by a gold-specific biosensor (GolS-mCherry). Importantly, the morpholine moiety, with pK a similar to 6.9, in 1d brings in a highly pH-sensitive and preferential ionic interaction under a slightly acidic condition over the normal physiological pH, enabling tumor-targeted prodrug activation by red light irradiation in vitro and in vivo. Since a similar absorption change was found in other morpholine/amine-containing clinic drugs, photocages, and precursors of reactive labeling intermediates, it is believed that the ion-pairing strategy could be extended for targeted activation of different prodrugs and for mapping of an acidic microenvironment by low-energy light.

Published
2024

16. Organogold(III) Complexes Display Conditional Photoactivities: Evolving From Photodynamic into Photoactivated Chemotherapy in Response to O2 Consumption for Robust Cancer Therapy.

Author

Luo, Yunli, Cao, Bei, Zhong, Mingjie, Liu, Moyi, Xiong, Xiaolin, and Zou, Taotao

Subjects
CANCER treatment, PHOTODYNAMIC therapy, CANCER chemotherapy, ANTINEOPLASTIC agents, PHOTOSENSITIZATION
Abstract

Photodynamic therapy (PDT) is a spatiotemporally controllable, powerful approach in combating cancers but suffers from low activity under hypoxia, whereas photoactivated chemotherapy (PACT) operates in an O2‐independent manner but compromises the ability to harness O2 for potent photosensitization. Herein we report that cyclometalated gold(III)‐alkyne complexes display a PDT‐to‐PACT evolving photoactivity for efficient cancer treatment. On the one hand, the gold(III) complexes can act as dual photosensitizers and substrates, leading to conditional PDT activity in oxygenated condition that progresses to highly efficient PACT (ϕ up to 0.63) when O2 is depleted in solution and under cellular environment. On the other hand, the conditional PDT‐to‐PACT reactivity can be triggered by external photosensitizers in a similar manner in vitro and in vivo, giving additional tumor‐selectivity and/or deep tissue penetration by red‐light irradiation that leads to robust anticancer efficacy. [ABSTRACT FROM AUTHOR]

Published
2022
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18. Inversion of Riesz Potentials for Dunkl Transform.

Author

Liu, Moyi, Song, Futao, and Wang, Rongxin

Subjects
*RIESZ spaces, *WAVELET transforms, *AUTOMORPHISMS, *FOURIER transforms, *INVARIANT measures
Abstract

The inversion of Riesz potentials for Dunkl transform when G=Z2d is given by using the generalized wavelet transforms. It is also proved that the Riesz potentials Iακ are automorphisms on the Semyanistyi-Lizorkin spaces. [ABSTRACT FROM AUTHOR]

Published
2018
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