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216 results on '"Liu, Ruozhuo"'

6. AMPK activation attenuates central sensitization in a recurrent nitroglycerin-induced chronic migraine mouse model by promoting microglial M2-type polarization

Author

Lu, Guangshuang, primary, Xiao, Shaobo, additional, Meng, Fanchao, additional, Zhang, Leyi, additional, Chang, Yan, additional, Zhao, Jinjing, additional, Gao, Nan, additional, Su, Wenjie, additional, Guo, Xinghao, additional, Liu, Yingyuan, additional, Li, Chenhao, additional, Tang, Wenjing, additional, Zou, Liping, additional, Yu, Shengyuan, additional, and Liu, Ruozhuo, additional

Published
2024
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25. The applicability research of the diagnostic criteria for 10.2 Heamodialysis-related headache in the international classification of headache disorders-3rd edition.

Author

Yang, Ying, Meng, Fanchao, Zhu, Hanyu, Zhang, Lei, Lu, Guangshuang, Xiao, Shaobo, He, Jiaji, Yu, Shengyuan, and Liu, Ruozhuo

Subjects
HEADACHE risk factors, HEADACHE diagnosis, MIGRAINE, CROSS-sectional method, RISK assessment, DISEASE prevalence, QUESTIONNAIRES, TENSION headache, HEADACHE, HEMODIALYSIS
Abstract

Background: Headache during hemodialysis (HDH) is prevalent but not negligible. Despite the high prevalence of dialysis headaches, they have rarely been studied. Therefore, this study aimed to evaluate the prevalence, risk factors, and clinical characteristics of HDH and reappraise the HDH diagnostic criteria in the International Classification of Headache Disorders 3 (ICHD-3). Methods: One hundred and fifty-four patients completed this randomized cross-sectional study. Consecutive patients who underwent haemodialysis were assessed using a semi-structured questionnaire. The patients were administered face-to-face questionnaires while undergoing dialysis. Results: This study included 154 patients. Before commencing dialysis, 3.24% (5/154) of the patients had migraine without aura, 1.29% (2/154) had menstrual-related migraine, 0.6% (1/154) had tension-type headaches, and 0.6% (1/154) had an unclassifiable headache. One case (0.6%) of headache resolved after dialysis treatment. HDH was diagnosed in 9.09% (14/154) of the patients. Headache after haemodialysis (HAH) was reported in 6.49% (10/154) of patients. The most prevalent features of HDH were frontal or temporal location, bilateral headaches, dull and throbbing nature, and moderate severity. HDH started at a mean of 2.33 ± 0.79 h after dialysis commenced. The average headache duration was 6.56 ± 1.57 h (median = 3.0 h), with 66.67% of the patients reporting a duration of ≤4 h. HDH was more prevalent in females than males (P = 0.01, P < 0.05). Female sex was a risk factor for HDH (P = 0.01，P < 0.05). Conclusions: The diagnostic criteria for 10.2 HDH in ICHD-3 may miss several HAH. Therefore, ICHD-3 should be revised according to the literature and further studies. [ABSTRACT FROM AUTHOR]

Published
2023
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31. Additional file 1 of Functional correlation of ATP1A2 mutations with phenotypic spectrum: from pure hemiplegic migraine to its variant forms

Author

Li, Yingji, Tang, Wenjing, Kang, Li, Kong, Shanshan, Dong, Zhao, Zhao, Dengfa, Liu, Ruozhuo, and Yu, Shengyuan

Abstract

Additional file 1: Supplementary Figure 1. Representative images of transfection efficiency of wild-type and mutant constructs with 100μm scales. Supplementary Figure 2. Survival assays in HeLa cells. The survival rate of each mutant was significantly reduced compared to the wild-type (R65W: P = 0.032, other mutants: P < 0.0001, two-way ANOVA). Supplementary Figure 3. Survival assays in HEK293T cells. The survival rate of each mutant was significantly reduced compared to the wild-type (R65W: P = 0.016, other mutants: P < 0.0001, two-way ANOVA). Supplementary Figure 4. Survival assays in HeLa cells in the absence of ouabain. The survival rates of cells in each mutant group were similar to those in the WT group (P > 0.05, two-way ANOVA). Supplementary Table 1. Clinical characteristics of previously published patients with studied ATP1A2 mutations.

Published
2021
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45. Impact of ESR1 Gene Polymorphisms on Migraine Susceptibility

Author

Li, Li, Liu, Ruozhuo, Dong, Zhao, Wang, Xiaolin, and Yu, Shengyuan

Subjects
Male, Polymorphism, Genetic, Genotype, Risk Factors, Migraine Disorders, Estrogen Receptor alpha, Humans, Female, Genetic Predisposition to Disease, Systematic Reviewand Meta-Analysis, White People, Research Article
Abstract

An increasing number of studies have explored genetic associations between the functionally important polymorphisms in estrogen receptor 1 (ESR1) gene and migraine susceptibility. The previously reported associations have nevertheless been inconsistent. The present work incorporating the published data derived from 8 publications was performed to assess the impact of these polymorphisms on incident migraine. Strength of the genetic risk was estimated by means of an odds ratio along with the 95% confidence interval (OR and 95% CI). From the results, we found individuals who harbored the 325-GG genotype, compared with those harboring the CC genotype or CG and CC combined genotypes, had almost 50% greater risk of migraine. The same genetic models showed notable associations in subgroups of Caucasians and migraine with aura (MA). For 594G>A, a moderately increased risk of migraine was seen under AG versus GG. The AA + AG versus GG model, however, showed a borderline association with migraine. Subgroup analyses according to ethnicity and subtype of migraine provided statistical evidence of significantly increased risk of migraine in Caucasians and of a marginal association with MA, respectively. Both 325C>G and 594G>A polymorphisms showed no major effects either in males or in females. Based on the statistical data, we conclude some of the ESR1 gene polymorphisms may have major contributions to the pathogenesis of migraine in Caucasian populations.

Published
2015

47. Unnecessary Neuroimaging for Patients With Primary Headaches.

Author

Wang, Rongfei, Liu, Ruozhuo, Dong, Zhao, Su, Hui, Ao, Ran, Liu, Yinglu, Wang, Yan, Ma, Lin, and Yu, Shengyuan

Subjects
*PRIMARY headache disorders, *COMPUTED tomography, *DECISION support systems, *INFORMATION storage & retrieval systems, *MEDICAL databases, *MAGNETIC resonance imaging, *NEURORADIOLOGY, *UNNECESSARY surgery, *DIAGNOSIS
Abstract

Background – Headache may be due to either a primary or secondary disorder, and neuroimaging assessments can play an important role when differentiating between these types of headache. Although many studies have reported no significant differences between primary headache patients and the general population in terms of abnormal neuroimaging findings, others have shown that neuroimaging may be employed to rule out secondary causes of headache that could impact morbidity and mortality. This issue remains under debate. Thus, the present study compared the neuroimaging findings of headache patients and healthy controls. Methods – This study recruited 1070 healthy controls and 1070 primary headache patients from the Chinese People's Liberation Army General Hospital. The primary headache patients were diagnosed by computerized clinical decision support systems, and re‐diagnosed by a specialist. All participants were assessed with either computed tomography or magnetic resonance imaging (MRI) scans. The neuroimaging findings were classified as significant abnormalities, non‐significant abnormalities, or normal. Results – All the significant abnormalities were found using MRI scans. Significant abnormalities were identified in 4 primary headache patients (0.58%) and 5 healthy controls (0.73%); the rate of significant abnormalities was not significant different between both groups (P >.05). Conclusions – The present study found that neuroimaging was unnecessary for the primary headache patients. [ABSTRACT FROM AUTHOR]

Published
2019
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