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3. Highly efficient on-chip erbium-ytterbium co-doped lithium niobate waveguide amplifiers

Author

Zhang, Yuqi, Luo, Qiang, Zheng, Dahuai, Wang, Shuolin, Liu, Shiguo, Liu, Hongde, Bo, Fang, Kong, Yongfa, and Xu, Jingjun

Subjects
Physics - Optics, Physics - Applied Physics
Abstract

The ability to amplify optical signals is of paramount importance in photonic integrated circuits (PICs). Recently, lithium niobate on insulator (LNOI) has attracted increasing interests as an emerging PIC platform. However, the shortage of active devices on LNOI platform limits the development of optical amplification. Here, we firstly report an efficient waveguide amplifier based on erbium and ytterbium co-doped LNOI by using electron beam lithography and inductively coupled plasma reactive ion etching process. We have demonstrated that the net internal gain in the communication band is 15.70 dB/cm under the pumping of 974 nm continuous laser. Benefiting from the efficient pumping facilitated by energy transfer between ytterbium and erbium ions, signal amplification can be achieved at a low pump power of 0.1 mW. It is currently the most efficient waveguide amplifier under unidirectional pumping reported on the LNOI platform, with an internal conversion efficiency of 10%. This work proposes a new and efficient active device for LNOI integrated optical systems, which may become an important fundamental component of future lithium niobate photonic integration platforms.

Published
2023

10. On-chip erbium-doped lithium niobate microdisk lasers

Author

Luo, Qiang, Hao, ZhenZhong, Yang, Chen, Zhang, Ru, Zheng, DaHuai, Liu, ShiGuo, Liu, HongDe, Bo, Fang, Kong, YongFa, Zhang, GuoQuan, and Xu, JingJun

Subjects
Physics - Optics, Physics - Applied Physics
Abstract

Erbium-doped lithium niobate high-Q microdisk cavities were fabricated in batches by UV exposure, inductively coupled plasma reactive ion etching and chemo-mechanical polishing. The stimulated emission at 1531.6 nm was observed under the pump of a narrow-band laser working at 974 nm in erbium-doped lithium niobate microdisk cavity with threshold down to 400 {\mu}W and a conversion efficiency of 3.1{\times}10^{-4} %, laying the foundation for the LNOI integrated light source research., Comment: 4 pages, 4 figures

Published
2020

19. NUMB dysfunction defines a novel mechanism underlying hyperuricemia and gout.

Author

Chi, Jingwei, Chen, Ying, Li, Changgui, Liu, Shiguo, Che, Kui, Kong, Zili, Guo, Ziheng, Chu, Yanchen, Huang, Yajing, Yang, Libo, Sun, Cunwei, Wang, Yunyang, Lv, Wenshan, Zhang, Qing, Guo, Hui, Zhao, Han, Yang, Zhitao, Xu, Lili, Wang, Ping, and Dong, Bingzi

Subjects
URIC acid, MISSENSE mutation, GENETIC variation, CELL membranes, EPITHELIAL cells, ATP-binding cassette transporters
Abstract

Defective renal excretion and increased production of uric acid engender hyperuricemia that predisposes to gout. However, molecular mechanisms underlying defective uric acid excretion remain largely unknown. Here, we report a rare genetic variant of gout-unprecedented NUMB gene within a hereditary human gout family, which was identified by an unbiased genome-wide sequencing approach. This dysfunctional missense variant within the conserved region of the NUMB gene (NUMBR630H) underwent intracellular redistribution and degradation through an autophagy-dependent mechanism. Mechanistically, we identified the uric acid transporter, ATP Binding Cassette Subfamily G Member 2 (ABCG2), as a novel NUMB-binding protein through its intracellular YxNxxF motif. In polarized renal tubular epithelial cells (RTECs), NUMB promoted ABCG2 trafficking towards the apical plasma membrane. Genetic loss-of-function of NUMB resulted in redistribution of ABCG2 in the basolateral domain and ultimately defective excretion of uric acid. To recapitulate the clinical situation in human gout patients, we generated a NUMBR630H knock-in mouse strain, which showed marked increases of serum urate and decreased uric acid excretion. The NUMBR630H knock-in mice exhibited clinically relevant hyperuricemia. In summary, we have uncovered a novel NUMB-mediated mechanism of uric acid excretion and a functional missense variant of NUMB in humans, which causes hyperuricemia and gout. [ABSTRACT FROM AUTHOR]

Published
2024
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25. JAG1 Variants Confer Genetic Susceptibility to Thyroid Dysgenesis and Thyroid Dyshormonogenesis in 813 Congenital Hypothyroidism in China

Author

Li,Miaomiao, Wang,Xiaoyu, Wang,Fang, Wang,Fengqi, Zhao,Dehua, Liu,Shiguo, Li,Miaomiao, Wang,Xiaoyu, Wang,Fang, Wang,Fengqi, Zhao,Dehua, and Liu,Shiguo

Abstract

Miaomiao Li,1,2 Xiaoyu Wang,1,2 Fang Wang,3 Fengqi Wang,1,2 Dehua Zhao,4 Shiguo Liu1,2 1Department of Medical Genetic, the Affiliated Hospital of Qingdao University, Qingdao, People’s Republic of China; 2Prenatal Diagnosis Center, the Affiliated Hospital of Qingdao University, Qingdao, People’s Republic of China; 3Endocrinology Department, the Affiliated Hospital of Qingdao University, Qingdao, People’s Republic of China; 4Neonatal Screening Center, the Third Affiliated Hospital of Zhengzhou University, Zhengzhou, People’s Republic of ChinaCorrespondence: Dehua Zhao, The Third Affiliated Hospital of Zhengzhou University, Neonatal Screening Center, Zhengzhou, Henan, 450052, People’s Republic of China, Email zhaodehua369@163.com Shiguo Liu, The Affiliated Hospital of Qingdao University, Department of Medical Genetic, Prenatal Diagnosis Center, Qingdao, Shandong, 266003, People’s Republic of China, Email liushiguo@qdu.edu.cnBackground and Objective: Congenital hypothyroidism (CH) is indeed a prevalent neonatal endocrine disorder, affecting approximately 1 in 2000– 3000 newborns worldwide, and 1 in 2400 newborns in China. Despite its high incidence, the genetic causes of CH, particularly those related to thyroid dysgenesis (TD), are still not well understood. However, previous studies have suggested that JAG1 may be a potential susceptibility gene for congenital thyroid defects. To explore the association between JAG1 and CH, we screened JAG1 variants in a large cohort of 813 CH patients.Methods: We performed genetic analysis of JAG1 using next-generation sequencing in 813 CH cases. The pathogenicity of the variants was assessed by bioinformatics softwares, protein sequence conservation analysis, and hydrophobic analysis. Further genetic analysis was conducted targeting 20 CH-related genes in these 25 JAG1 variant carriers.Results: We identified 10 pathogenic missense mutations (p.V45L, p.V272I, p.P552L, p.G610E, p.G852D, p.A891T, p.E1030K, p.R1060W, p.A11

Published
2024

26. Clinical Significance of Detection of ZIC1 Promoter Methylation in Peripheral Blood and Cancer Tissues of Non-small Cell Lung Cancer Patients

Author

XU Yao, LIU Shiguo, ZHANG Chang, ZHANG Li, JIANG Shan, ZHANG Junxia, and PENG Li

Subjects
zic1 methylation, msp, non-small cell lung cancer, lung cancer tissue, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282
Abstract

Objective To investigate the methylation status of ZIC1 gene in peripheral blood and lung cancer tissues of NSCLC patients and its prognostic significance. Methods We took the peripheral blood, cancer tissues and adjacent tissues of 95 NSCLC patients. The peripheral blood of 95 healthy people was taken as control group. MSP was used to compare the detection rate of ZIC1 methylation between peripheral blood and cancer tissues. And we analyzed the correlation of ZIC1 methylation in peripheral blood and cancer tissues with the clinicopathological factors of NSCLC patients. Results The methylation detection rates of ZIC1 in peripheral blood and lung cancer tissues in NSCLC patients were significantly higher than those in peripheral blood of healthy people and adjacent tissues of NSCLC patients (P < 0.05), and the sensitivity and specificity of ZIC1 methylation in the diagnosis of tumor tissues were higher. The positive rate of ZIC1 gene methylation in peripheral blood and tumor tissues of NSCLC patients was significantly correlated with tumor diameter, metastasis, stage and pleural effusion (P < 0.05). Conclusion The methylation of ZIC1 gene is related to the occurrence, development, metastasis and stage of NSCLC. It may be used as a diagnostic and prognostic indicator of NSCLC.

Published
2021
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29. A Novel Ectodysplasin a Gene mutation of X-Linked Hypohidrotic Ectodermal Dysplasia.

Author

Zhuang, Yuan, Zhang, Ru, Li, Miaomiao, Zou, Yaru, Jiang, Shui, Zhang, Yanan, Liu, Shiguo, and Yu, Bo

Subjects
ECTODERMAL dysplasia, SWEAT glands, MEMBRANE proteins, GENETIC mutation, WESTERN immunoblotting
Abstract

Introduction: Hypohidrotic ectodermal dysplasia (HED) is a genetic disorder that influences structures of ectodermal origin, such as teeth, hair, and sweat glands. Compared with autosomal recessive and dominant modes of inheritance, the X-linked HED (XLHED) characterized by Hypodontia/Oligodontia teeth, Absent/sparse hair, Anhidrosis/hypohidrosis, and characteristic facial features, is the most frequent and its primary cause is the mutation of ectodysplasin A (EDA) gene. This research aimed to expound the clinical and molecular features of a Chinese male with XLHED and to summarize and compare several previous findings. Methods: Genomic DNA was obtained from the peripheral blood of the proband and his family members, then Sanger sequencing was used to perform a mutational analysis of EDA. Real-time quantitative PCR and Western blotting were used to detect EDA expression. The transcriptional activity of NF-κB was detected using a luciferase assay. Results: The probandwith XLHED was identified a novel EDA mutation, c.1119G>C(p.M373I), that affected the molecular analysis of transmembrane protein exon8 mutations, inherited from the mother. He showed a severe multiple-tooth loss, with over 20 permanent teeth missing and sparse hair and eyebrows, dry, thin, and itching skin. Furthermore, his sweating function was abnormal to a certain extent. Discussion: The functional study showed that this novel mutant led to a significant decrease in the EDA expression level and transcriptional activity of NF-κB. Our findings extend the range of EDA mutations in XLHED patients, which provides the basis and idea for further exploring the pathogenesis of XLHED. [ABSTRACT FROM AUTHOR]

Published
2024
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37. Mutations in ASH1L confer susceptibility to Tourette syndrome

Author

Liu, Shiguo, Tian, Miaomiao, He, Fan, Li, Jiani, Xie, Hong, Liu, Wenmiao, Zhang, Yeting, Zhang, Ru, Yi, Mingji, Che, Fengyuan, Ma, Xu, Zheng, Yi, Deng, Hao, Wang, Guiju, Chen, Lang, Sun, Xue, Xu, Yinglei, Wang, Jingli, Zang, Yucui, Han, Mengmeng, Wang, Xiuhai, Guan, Hongzai, Ge, Yinlin, Wu, Chunmei, Wang, Haiyan, Liang, Hui, Li, Hui, Ran, Ni, Yang, Zhaochuan, Huang, Huanhuan, Wei, Yanzhao, Zheng, Xueping, Sun, Xiangrong, Feng, Xueying, Zheng, Lanlan, Zhu, Tao, Luo, Wenhan, Chen, Qinan, Yan, Yuze, Huang, Zuzhou, Jing, Zhongcui, Guo, Yixia, Zhang, Xuzhan, Schaaf, Christian P., Xing, Jinchuan, Wang, Chuanyue, Yu, Fuli, and Guan, Ji-Song

Published
2020
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39. The Doping Concentration Optimization of Er-Doped LiNbO3Crystals for LNOI Lasers and Amplifiers

Author

Zhang, Zhongzheng, Wu, Zhaojie, Zhang, Yuqi, Liu, Shiguo, Liu, Hongde, Zheng, Dahuai, Kong, Yongfa, and Xu, Jingjun

Abstract

Photonics on a lithium-niobate-on-insulator (LNOI) has emerged as one of the most attractive fields within integrated optics. Recently, the lasers and amplifiers on LNOI have made a series of breakthroughs and important progress; however, their output efficiencies are still at a low level. In this paper, a series of erbium-doped lithium niobate (Er:LN) crystals were grown from the congruent melts with different concentrations ranging from 0.1 to 4.0 mol % by the Czochralski method. The absorption and emission intensities became stronger with the increase of erbium ion concentration and approached saturation when it is up to 2.0 mol %. Judd–Ofelt and McCumber theories were carried out to discuss the optical characteristics of erbium ions in Er:LN crystals, providing a basis for evaluating the performance of Er:LN devices. Besides, the UV absorption edges and the OH–absorption bands showed that there is a threshold around 2.0–2.65 mol % of erbium ions in Er:LN crystals, indicating a change of defect structures. It was concluded that the optimal doping concentration of erbium ions in Er:LN crystals is about 2.0 mol %, which provides significant guidance for the development of highly efficient LNOI lasers and amplifiers.

Published
2024
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50. Diagnostic value of non-coding RNAs in ovarian cancer

Author

Sun, Ningxia, Liu, Shiguo, and Chen, Aiping

Subjects
Obstetrics and Gynecology
Abstract

The type of primary tumour of the ovary ranks first among all organs in the body. Although the incidence of malignant ovarian tumour ranks third among gynaecological malignancies, it is the most fatal type. A lack of effective diagnostic methods for early ovarian cancer remains, and the efficacy of advanced ovarian cancer is often unsatisfactory; the five-year survival rate of stage III–IV is less than 30%. Non-coding RNA is RNA that does not have protein-coding potential and was once considered as ‘junk DNA’. However, increasing number of studies have shown that the disorder of non-coding RNA is related to a variety of diseases, including the occurrence and development of tumours. We summarised the dysregulated non-coding RNAs (miRNAs, circRNAs, and lncRNAs) reported currently in ovarian cancer and their functional mechanisms, and the clinical value of different types of ncRNAs as diagnostic or predictive markers for ovarian cancer, providing further evidence for non-coding RNAs to be considered as biomarkers of ovarian cancer.

Published
2022

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