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1. Rates and Predictors of Treatment Failure in Staphylococcus aureus Prosthetic Joint Infections According to Different Management Strategies: A Multinational Cohort Study—The ARTHR-IS Study Group

Author

Espíndola, Reinaldo, Vella, Venanzio, Benito, Natividad, Mur, Isabel, Tedeschi, Sara, Zamparini, Eleonora, Hendriks, Johannes G. E., Sorlí, Luisa, Murillo, Oscar, Soldevila, Laura, Scarborough, Mathew, Scarborough, Claire, Kluytmans, Jan, Ferrari, Mateo Carlo, Pletz, Mathias W., Mcnamara, Iain, Escudero-Sanchez, Rosa, Arvieux, Cedric, Batailler, Cecile, Dauchy, Frédéric-Antoine, Liu, Wai-Yan, Lora-Tamayo, Jaime, Praena, Julia, Ustianowski, Andrew, Cinconze, Elisa, Pellegrini, Michele, Bagnoli, Fabio, Rodríguez-Baño, Jesús, and del Toro, Maria Dolores

Published
2022
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2. Posttraumatic and OA-related lesions in the knee at baseline and 2 years after traumatic meniscal injury: secondary analysis of a randomized controlled trial

Author

van der Graaff, Sabine J.A., primary, Oei, Edwin H.G., additional, Reijman, Max, additional, Steenbekkers, Lars, additional, van Middelkoop, Marienke, additional, van der Heijden, Rianne A., additional, Meuffels, Duncan E., additional, Eijgenraam, Susanne M., additional, van Es, Eline M., additional, Jan Hofstee, Dirk, additional, Yang, Kiem Gie Auw, additional, Noorduyn, Julia C.A., additional, van Arkel, Ewoud R.A., additional, van den Brand, Igor C.J.B., additional, Janssen, Rob P.A., additional, Liu, Wai-Yan, additional, and Bierma-Zeinstra, Sita M.A., additional

Published
2024
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4. Preoperative and perioperative risk factors, and risk score development for prosthetic joint infection due to Staphylococcus aureus: a multinational matched case-control study

Author

Cuperus, Nienke, Manfré, Giuseppe, Zamparini, Eleonora, Verhagen, Stéphanie, Horcajada, Juan P., Junyent, Joan Gómez, Alier, Albert, Soldevila, Laura, van Rijen, Miranda, Romme, Jannie, Ankert, Juliane, Whitehouse, Celia, Jones, Adrian, Cobo, Javier, Moreno, Javier, Meheut, Anne, Gledel, Claire, Perreau, Pauline, van Wensen, Remco J.A., Lindergard, Gabriella, Espindola, Reinaldo, Vella, Venanzio, Benito, Natividad, Mur, Isabel, Tedeschi, Sara, Rossi, Nicolò, Hendriks, Johannes G.E., Sorlí, Luisa, Murillo, Oscar, Scarborough, Mathew, Scarborough, Claire, Kluytmans, Jan, Ferrari, Mateo Carlo, Pletz, Mathias W., Mcnamara, Iain, Escudero-Sanchez, Rosa, Arvieux, Cedric, Batailler, Cecile, Dauchy, Frédéric-Antoine, Liu, Wai-Yan, Lora-Tamayo, Jaime, Praena, Julia, Ustianowski, Andrew, Cinconze, Elisa, Pellegrini, Michele, Bagnoli, Fabio, Rodríguez-Baño, Jesús, and Del Toro, Maria Dolores

Published
2022
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7. Preoperative and perioperative risk factors, and risk score development for prosthetic joint infection due to Staphylococcus aureus: a multinational matched case-control study

Author

Espindola, Reinaldo, primary, Vella, Venanzio, additional, Benito, Natividad, additional, Mur, Isabel, additional, Tedeschi, Sara, additional, Rossi, Nicolò, additional, Hendriks, Johannes G.E., additional, Sorlí, Luisa, additional, Murillo, Oscar, additional, Scarborough, Mathew, additional, Scarborough, Claire, additional, Kluytmans, Jan, additional, Ferrari, Mateo Carlo, additional, Pletz, Mathias W., additional, Mcnamara, Iain, additional, Escudero-Sanchez, Rosa, additional, Arvieux, Cedric, additional, Batailler, Cecile, additional, Dauchy, Frédéric-Antoine, additional, Liu, Wai-Yan, additional, Lora-Tamayo, Jaime, additional, Praena, Julia, additional, Ustianowski, Andrew, additional, Cinconze, Elisa, additional, Pellegrini, Michele, additional, Bagnoli, Fabio, additional, Rodríguez-Baño, Jesús, additional, Del Toro, Maria Dolores, additional, Cuperus, Nienke, additional, Manfré, Giuseppe, additional, Zamparini, Eleonora, additional, Verhagen, Stéphanie, additional, Horcajada, Juan P., additional, Junyent, Joan Gómez, additional, Alier, Albert, additional, Soldevila, Laura, additional, van Rijen, Miranda, additional, Romme, Jannie, additional, Ankert, Juliane, additional, Whitehouse, Celia, additional, Jones, Adrian, additional, Cobo, Javier, additional, Moreno, Javier, additional, Meheut, Anne, additional, Gledel, Claire, additional, Perreau, Pauline, additional, van Wensen, Remco J.A., additional, and Lindergard, Gabriella, additional

Published
2022
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10. Arthroscopic partial meniscectomy versus physical therapy for traumatic meniscal tears in a young study population: a randomised controlled trial

Author

van der Graaff, Sabine J A, primary, Eijgenraam, Susanne M, additional, Meuffels, Duncan E, additional, van Es, Eline M, additional, Verhaar, Jan A N, additional, Hofstee, Dirk Jan, additional, Auw Yang, Kiem Gie, additional, Noorduyn, Julia C A, additional, van Arkel, Ewoud R A, additional, van den Brand, Igor C J B, additional, Janssen, Rob P A, additional, Liu, Wai-Yan, additional, Bierma-Zeinstra, Sita M A, additional, and Reijman, Max, additional

Published
2022
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11. Effectiveness and cost-effectiveness of dynamic bracing versus standard care alone in patients suffering from osteoporotic vertebral compression fractures: protocol for a multicentre, two-armed, parallel-group randomised controlled trial with 12 months of follow-up

Author

Weber, Annemarijn, primary, Huysmans, Stephanie M D, additional, van Kuijk, Sander M J, additional, Evers, Silvia M A A, additional, Jutten, Elisabeth M C, additional, Senden, Rachel, additional, Paulus, Aggie T G, additional, van den Bergh, Joop P W, additional, de Bie, Rob A, additional, Merk, Johannes M R, additional, Bours, Sandrine P G, additional, Hulsbosch, Mark, additional, Janssen, Esther R C, additional, Curfs, Inez, additional, van Hemert, Wouter L W, additional, Schotanus, Martijn G M, additional, de Baat, Paul, additional, Schepel, Niek C, additional, den Boer, Willem A, additional, Hendriks, Johannes G E, additional, Liu, Wai-Yan, additional, Kleuver, Marinus de, additional, Pouw, Martin H, additional, van Hooff, Miranda L, additional, Jacobs, Eva, additional, and Willems, Paul C P H, additional

Published
2022
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15. Subjects With COPD Walk With Less Consistent Organization of Movement Patterns of the Lower Extremity

Author

Liu, Wai-Yan and Liu, Wai-Yan

Abstract

BACKGROUND: The inherent stride-to-stride fluctuations during walking are altered in the aging population and could provide insight into gait impairments and falls in patients with COPD. Stride-to-stride fluctuations are quantified two ways: variability of the fluctuations (eg, standard deviation), and movement patterns within the fluctuations. Our objective was to investigate stride-to-stride fluctuations by evaluating the variability and movement patterns of lower limb joints in subjects with COPD compared to subjects without COPD as control subjects. METHODS: In this cross-sectional study, 22 subjects with COPD (age 63 +/- 9 y; FEV1 54 +/- 19% predicted) and 22 control subjects (age 62 +/- 9 y; FEV1 95 +/- 18% predicted) walked for 3 min on a treadmill while their gait was recorded. The amount of variability (ie, standard deviation and coefficient of variation) and movement patterns (ie, predictability and consistency in organization) were quantified for the range of motion and joint angle of the hip, knee, and ankle, at 3 walking speeds (ie, self-selected, fast, and slow). General linear mixed models were used for analysis. RESULTS: Control subjects had more consistent organization of the hip and knee joint movement patterns compared to subjects with COPD (P = .02 and P = .02, respectively). Further, control subjects adapted to speed changes by demonstrating more consistent organization of movement patterns with faster speeds, whereas subjects with COPD did not. At the fast walking speed, subjects with COPD demonstrated less consistent organization of knee and hip joint movement patterns as compared to control subjects without COPD (P = .03 and P = .005, respectively). The amount of variability did not differ between groups. CONCLUSIONS: Although subjects with COPD did not demonstrate decreased amount of variability, their hip and knee joint movement patterns were less consistent in organization during walking. Reduced consistency in organization of movement

Published
2020

19. Rates and Predictors of Treatment Failure in Staphylococcus aureusProsthetic Joint Infections According to Different Management Strategies: A Multinational Cohort Study—The ARTHR-IS Study Group

Author

Espíndola, Reinaldo, Vella, Venanzio, Benito, Natividad, Mur, Isabel, Tedeschi, Sara, Zamparini, Eleonora, Hendriks, Johannes G. E., Sorlí, Luisa, Murillo, Oscar, Soldevila, Laura, Scarborough, Mathew, Scarborough, Claire, Kluytmans, Jan, Ferrari, Mateo Carlo, Pletz, Mathias W., Mcnamara, Iain, Escudero-Sanchez, Rosa, Arvieux, Cedric, Batailler, Cecile, Dauchy, Frédéric-Antoine, Liu, Wai-Yan, Lora-Tamayo, Jaime, Praena, Julia, Ustianowski, Andrew, Cinconze, Elisa, Pellegrini, Michele, Bagnoli, Fabio, Rodríguez-Baño, Jesús, and del Toro, Maria Dolores

Abstract

Staphylococcus aureusis one of the most virulent bacteria and frequently causes prosthetic joint infections.

Published
2022
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26. Rates and Predictors of Treatment Failure in Staphylococcus aureus Prosthetic Joint Infections According to Different Management Strategies: A Multinational Cohort Study—The ARTHR-IS Study Group

Author

Reinaldo, Espíndola, Venanzio, Vella, Natividad, Benito, Isabel, Mur, Sara, Tedeschi, Eleonora, Zamparini, Johannes G E, Hendriks, Luisa, Sorlí, Oscar, Murillo, Laura, Soldevila, Mathew, Scarborough, Claire, Scarborough, Jan, Kluytmans, Mateo Carlo, Ferrari, Mathias W, Pletz, Iain, Mcnamara, Rosa, Escudero-Sanchez, Cedric, Arvieux, Cecile, Batailler, Frédéric-Antoine, Dauchy, Wai-Yan, Liu, Jaime, Lora-Tamayo, Julia, Praena, Andrew, Ustianowski, Elisa, Cinconze, Michele, Pellegrini, Fabio, Bagnoli, Jesús, Rodríguez-Baño, Maria Dolores, Del Toro, Gabriella, Lindergard, Hospital Universitario Virgen Macarena [Séville], GlaxoSmithKline [Siena, Italy] (GSK), Hospital de la Santa Creu i Sant Pau, University of Bologna/Università di Bologna, Alma Mater Studiorum Università di Bologna [Bologna] (UNIBO), Department of Orthopaedic Surgery and Trauma, Maxima MC, parent, IMIM-Hospital del Mar, Generalitat de Catalunya, Institut d'Investigació Biomèdica de Bellvitge [Barcelone] (IDIBELL), John Radcliffe Hospital [Oxford University Hospital], Amphia Ziekenhuis = Amphia Hospital [Breda, The Netherlands] (AZ=AH), Humanitas Clinical and Research Center [Rozzano, Milan, Italy], Jena University Hospital [Jena], Norfolk and Norwich University Hospital, Hospital Universitario Ramón y Cajal [Madrid], Universidad de Alcalá - University of Alcalá (UAH), Hôpital Sud [CHU Rennes], CHU Pontchaillou [Rennes], Laboratoire de Biomécanique et Mécanique des Chocs (LBMC UMR T9406 ), Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Université Gustave Eiffel, Centre Hospitalier Universitaire de Bordeaux (CHU de Bordeaux), Catharina Hospital, Hospital Universitario HM Sanchinarro [Madrid, Spain], Hospital Universitario Virgen del Rocío [Sevilla], North Manchester General Hospital, This work was supported by the Innovative Medicines Initiative Joint Undertaking (grant agreement No. 115523), COMBACTE-NET consortium (European Union FP7/2007–2013 and GlaxoSmithKline Biologicals SA, as EFPIA partner). European Development Regional Fund ‘‘A way to achieve Europe’’, Operative Program Intelligence Growth 2014-2020. The study sponsor is also funding the journal’s Rapid Service Fee., European Project: 115523,EC:FP7:SP1-JTI,IMI-JU-06-2012,COMBACTE(2013), European Commission, GlaxoSmithKline, European Federation of Pharmaceutical Industries and Associations, Red Española de Investigación en Patología Infecciosa, Instituto de Salud Carlos III, Ministerio de Ciencia, Innovación y Universidades (España), Espíndola, Reinaldo, Vella, Venanzio, Benito, Natividad, Mur, Isabel, Tedeschi, Sara, Zamparini, Eleonora, Hendriks, Johannes G E, Sorlí, Luisa, Murillo, Oscar, Soldevila, Laura, Scarborough, Mathew, Scarborough, Claire, Kluytmans, Jan, Ferrari, Mateo Carlo, Pletz, Mathias W, Mcnamara, Iain, Escudero-Sanchez, Rosa, Arvieux, Cedric, Batailler, Cecile, Dauchy, Frédéric-Antoine, Liu, Wai-Yan, Lora-Tamayo, Jaime, Praena, Julia, Ustianowski, Andrew, Cinconze, Elisa, Pellegrini, Michele, Bagnoli, Fabio, Rodríguez-Baño, Jesú, and Del Toro, Maria Dolores

Subjects
STAPHYLOCOCCUSAUREUS, Microbiology (medical), Staphylococcus aureus, Prosthetic joint infection, Infectious Diseases, Functional failure, [SDV.MHEP.MI]Life Sciences [q-bio]/Human health and pathology/Infectious diseases, Clinical failure, Outcome
Abstract

[Introduction] Guidelines have improved the management of prosthetic joint infections (PJI). However, it is necessary to reassess the incidence and risk factors for treatment failure (TF) of Staphylococcus aureus PJI (SA-PJI) including functional loss, which has so far been neglected as an outcome., [Methods] A retrospective cohort study of SA-PJI was performed in 19 European hospitals between 2014 and 2016. The outcome variable was TF, including related mortality, clinical failure and functional loss both after the initial surgical procedure and after all procedures at 18 months. Predictors of TF were identified by logistic regression. Landmark analysis was used to avoid immortal time bias with rifampicin when debridement, antibiotics and implant retention (DAIR) was performed., [Results] One hundred twenty cases of SA-PJI were included. TF rates after the first and all surgical procedures performed were 32.8% and 24.2%, respectively. After all procedures, functional loss was 6.0% for DAIR and 17.2% for prosthesis removal. Variables independently associated with TF for the first procedure were Charlson ≥ 2, haemoglobin 30 kg/m2 and delay of DAIR, while rifampicin use was protective. For all procedures, the variables associated with TF were haemoglobin, [Conclusions] TF remains common in SA-PJI. Functional loss accounted for a substantial proportion of treatment failures, particularly after prosthesis removal. Use of rifampicin after DAIR was associated with a protective effect. Among the risk factors identified, anaemia and obesity have not frequently been reported in previous studies., [Trial registration] This study is registered at clinicaltrials.gov, registration no. NCT03826108., This work was supported by the Innovative Medicines Initiative Joint Undertaking (grant agreement No. 115523), COMBACTE-NET consortium (European Union FP7/2007–2013 and GlaxoSmithKline Biologicals SA, as EFPIA partner). R.E, L.S, O. M, R. E-S, J. L–T, J. P, J. R-B and MD. del T are members of the Spanish Network for Research in Infectious Diseases (REIPI), supported by Plan Nacional de I + D + i 2013‐2016 and Instituto de Salud Carlos III, Subdirección General de Redes y Centros de Investigación Cooperativa, Ministerio de Ciencia, Innovación y Universidades, Spanish Network for Research in Infectious Diseases (REIPI RD16/0016/0001; 0002; 0005; 0009; 0011; 0015), co‐ financed by European Development Regional Fund “A way to achieve Europe”, Operative Program Intelligence Growth 2014‐2020.

Published
2022

27. Cost-effectiveness of arthroscopic partial meniscectomy versus physical therapy for traumatic meniscal tears in patients aged under 45 years.

Author

van der Graaff SJA, Reijman M, Meuffels DE, Koopmanschap MA, Eijgenraam SM, van Es EM, Hofstee DJ, Auw Yang KG, Noorduyn JCA, van Arkel ERA, van den Brand ICJB, Janssen RPA, Liu WY, and Bierma-Zeinstra SMA

Subjects
Humans, Cost-Benefit Analysis, Quality of Life, Physical Therapy Modalities, Arthroscopy adverse effects, Menisci, Tibial surgery, Meniscectomy adverse effects, Osteoarthritis, Knee surgery, Osteoarthritis, Knee etiology
Abstract

Aims: The aim of this study was to evaluate the cost-effectiveness of arthroscopic partial meniscectomy versus physical therapy plus optional delayed arthroscopic partial meniscectomy in young patients aged under 45 years with traumatic meniscal tears., Methods: We conducted a multicentre, open-labelled, randomized controlled trial in patients aged 18 to 45 years, with a recent onset, traumatic, MRI-verified, isolated meniscal tear without knee osteoarthritis. Patients were randomized to arthroscopic partial meniscectomy or standardized physical therapy with an optional delayed arthroscopic partial meniscectomy after three months of follow-up. We performed a cost-utility analysis on the randomization groups to compare both treatments over a 24-month follow-up period. Cost utility was calculated as incremental costs per quality-adjusted life year (QALY) gained of arthroscopic partial meniscectomy compared to physical therapy. Calculations were performed from a healthcare system perspective and a societal perspective., Results: A total of 100 patients were included: 49 were randomized to arthroscopic partial meniscectomy and 51 to physical therapy. In the physical therapy group, 21 patients (41%) received delayed arthroscopic partial meniscectomy during follow-up. Over 24 months, patients in the arthroscopic partial meniscectomy group had a mean 0.005 QALYs lower quality of life (95% confidence interval -0.13 to 0.14). The cost-utility ratio was €-160,000/QALY from the healthcare perspective and €-223,372/QALY from the societal perspective, indicating that arthroscopic partial meniscectomy incurs additional costs without any added health benefit., Conclusion: Arthroscopic partial meniscectomy is arthroscopic partial meniscectomy is unlikely to be cost-effective in treating young patients with isolated traumatic meniscal tears compared to physical therapy as a primary health intervention. Arthroscopic partial meniscectomy leads to a similar quality of life, but higher costs, compared to physical therapy plus optional delayed arthroscopic partial meniscectomy., Competing Interests: D. E. Meuffels and M. A. Koopmanschap report an institutional grant from Zon MW, paid to Erasmus MC, related to this study., (© 2023 van der Graaff et al.)

Published
2023
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28. Subjects With COPD Walk With Less Consistent Organization of Movement Patterns of the Lower Extremity.

Author

Liu WY, Schmid KK, Meijer K, Spruit MA, and Yentes JM

Subjects
Adult, Aged, Ankle Joint physiopathology, Biomechanical Phenomena, Case-Control Studies, Cross-Sectional Studies, Exercise Test, Female, Gait, Hip Joint physiopathology, Humans, Knee Joint physiopathology, Male, Middle Aged, Walking Speed, Lower Extremity physiopathology, Pulmonary Disease, Chronic Obstructive physiopathology, Walking
Abstract

Background: The inherent stride-to-stride fluctuations during walking are altered in the aging population and could provide insight into gait impairments and falls in patients with COPD. Stride-to-stride fluctuations are quantified two ways: variability of the fluctuations (eg, standard deviation), and movement patterns within the fluctuations. Our objective was to investigate stride-to-stride fluctuations by evaluating the variability and movement patterns of lower limb joints in subjects with COPD compared to subjects without COPD as control subjects., Methods: In this cross-sectional study, 22 subjects with COPD (age 63 ± 9 y; FEV 1 54 ± 19% predicted) and 22 control subjects (age 62 ± 9 y; FEV 1 95 ± 18% predicted) walked for 3 min on a treadmill while their gait was recorded. The amount of variability (ie, standard deviation and coefficient of variation) and movement patterns (ie, predictability and consistency in organization) were quantified for the range of motion and joint angle of the hip, knee, and ankle, at 3 walking speeds (ie, self-selected, fast, and slow). General linear mixed models were used for analysis., Results: Control subjects had more consistent organization of the hip and knee joint movement patterns compared to subjects with COPD ( P = .02 and P = .02, respectively). Further, control subjects adapted to speed changes by demonstrating more consistent organization of movement patterns with faster speeds, whereas subjects with COPD did not. At the fast walking speed, subjects with COPD demonstrated less consistent organization of knee and hip joint movement patterns as compared to control subjects without COPD ( P = .03 and P = .005, respectively). The amount of variability did not differ between groups., Conclusions: Although subjects with COPD did not demonstrate decreased amount of variability, their hip and knee joint movement patterns were less consistent in organization during walking. Reduced consistency in organization of movement patterns may be a contributing factor to falls and mobility problems experienced by patients with COPD., (Copyright © 2020 by Daedalus Enterprises.)

Published
2020
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