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17 results on '"Liu, Wei Shuai"'

8. Celiac Plexus Block After Stereotactic Body Radiotherapy Improves Pain Relief in Locally Advanced Pancreatic Cancer

Author

Ji,Kai, Shao,Yue-Juan, Hao,Jian-Lei, Cheng,Xian-Jiang, Guan,Bing-Qing, Liu,Wei-Shuai, Chen,Lei, Wang,Xin, Song,Yong-Chun, Wang,Kun, and Wang,Ping

Subjects
Journal of Pain Research
Abstract

Kai Ji,1 Yue-Juan Shao,1 Jian-Lei Hao,1 Xian-Jiang Cheng,1 Bing-Qing Guan,1 Wei-Shuai Liu,1 Lei Chen,1 Xin Wang,2 Yong-Chun Song,2 Kun Wang,1 Ping Wang2 1Department of Pain Relief, Tianjin Medical University Cancer Institute and Hospital, National Clinical Research Center for Cancer, Key Laboratory of Cancer Prevention and Therapy, Tianjin, and Tianjin’s Clinical Research Center for Cancer, Tianjin, People’s Republic of China; 2Department of Radiotherapy, Tianjin Medical University Cancer Institute and Hospital, National Clinical Research Center for Cancer, Key Laboratory of Cancer Prevention and Therapy, Tianjin, and Tianjin’s Clinical Research Center for Cancer, Tianjin, People’s Republic of ChinaCorrespondence: Ping Wang Email wangping@tjmuch.comPurpose: This study evaluated the analgesic effect of stereotactic body radiotherapy (SBRT) in combination with celiac plexus block (CPB), relative to SBRT alone, in locally advanced pancreatic cancer (LAPC) patients.Patients and Methods: We reviewed medical records of all patients with LAPC, who received SBRT between 1 January 2017 to 31 August 2019 at our center. The average numeric rating scale (NRS) of ≥ 3 was used in all patients at admission. We recorded average and worst NRS in a 24-hour period, and daily narcotic doses before SBRT, followed by weekly for 1 month and monthly for 3 months.Results: A total of 23 patients in the SBRT group and 12 under SBRT+CPB who met the inclusion criteria were enrolled. All patients in the SBRT+CPB group received CPB within 10 days after SBRT. Pain intensity and narcotic consumption were comparable in both groups at initial assessment. However, a significant decrease (P < 0.05) in average NRS was recorded in the SBRT+CPB group relative to SBRT at 2, 3 and 4 weeks after SBRT. A comparison of daily narcotic consumption with baseline values showed a significant decrease in the SBRT+CPB group at 3 and 4 weeks after SBRT (P < 0.05), while no significant differences were observed in the SBRT group.Conclusion: CPB after SBRT appears to be an effective therapeutic option in patients with LAPC and warrants further evaluation with increased number of patients in prospective clinical trials.Keywords: cancer pain, celiac plexus block, stereotactic body radiotherapy, locally advanced pancreatic cancer

Published
2020

11. 3D macro-micro-mesoporous FeC2O4/graphene hydrogel electrode for high-performance 2.5 V aqueous asymmetric supercapacitors.

Author

Liu, Wei-shuai, Song, Yu-qing, Wang, Heng, Wang, Hong-fei, and Yan, Li-feng

Abstract

Distinguished from commonly used Fe2O3 and Fe3O4, a three-dimensional multilevel macro-micro-mesoporous structure of FeC2O4/graphene composite has been prepared as binder-free electrode for supercapacitors. The as-prepared materials are composed of macroporous graphene and microporous/mesoporous ferrous oxalate. Generally, the decomposition voltage of water is 1.23 V and the practical voltage window limit is about 2 V for asymmetric supercapacitors in aqueous electrolytes. When FeC2O4/rGO hydrogel was used as the negative electrode and a pure rGO hydrogel was used as the positive electrode, the asymmetrical supercapacitor voltage window raised to 1.7 V in KOH (1.0 mol/L) electrolyte and reached up to 2.5 V in a neutral aqueous Na2SO4 (1.0 mol/L) electrolyte. Correspondingly it also exhibits a high performance with an energy density of 59.7 Wh/kg. By means of combining a metal oxide that owns micro-mesoporous structure with graphene, this work provides a new opportunity for preparing high-voltage aqueous asymmetric supercapacitors without addition of conductive agent and binder. [ABSTRACT FROM AUTHOR]

Published
2018
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17. Dmrt1 regulates the immune response by repressing the TLR4 signaling pathway in goat male germline stem cells.

Author

Wei YD, Du XM, Yang DH, Ma FL, Yu XW, Zhang MF, Li N, Peng S, Liao MZ, Li GP, Bai CL, Liu WS, and Hua JL

Subjects
Animals, Cells, Cultured, Gene Expression Regulation drug effects, Gene Knockdown Techniques, Goats, Inflammation metabolism, Lipopolysaccharides toxicity, Male, NF-kappa B, Seminiferous Tubules, Sertoli Cells metabolism, Toll-Like Receptor 4 genetics, Transcription Factors genetics, Adult Germline Stem Cells metabolism, Immunity, Innate physiology, Signal Transduction physiology, Toll-Like Receptor 4 metabolism, Transcription Factors metabolism
Abstract

Double sex and mab-3-related transcription factor 1 (Dmrt1), which is expressed in goat male germline stem cells (mGSCs) and Sertoli cells, is one of the most conserved transcription factors involved in sex determination. In this study, we highlighted the role of Dmrt1 in balancing the innate immune response in goat mGSCs. Dmrt1 recruited promyelocytic leukemia zinc finger (Plzf), also known as zinc finger and BTB domain-containing protein 16 (Zbtb16), to repress the Toll-like receptor 4 (TLR4)-dependent inflammatory signaling pathway and nuclear factor (NF)-κB. Knockdown of Dmrt1 in seminiferous tubules resulted in widespread degeneration of germ and somatic cells, while the expression of proinflammatory factors were significantly enhanced. We also demonstrated that Dmrt1 stimulated proliferation of mGSCs, but repressed apoptosis caused by the immune response. Thus, Dmrt1 is sufficient to reduce inflammation in the testes, thereby establishing the stability of spermatogenesis and the testicular microenvironment.

Published
2021
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