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5. Heteroleptic/Heterometallic Sierpiński Triangle with Room Temperature Fluorescence Emission and Photocatalytic Amine Oxidation Activity

Author

Jiang, Zhilong, primary, Liu, Weiya, additional, Wang, Jun, additional, Chen, Bangtang, additional, Wu, Zihao, additional, Fu, Fan, additional, Miao, Rui, additional, Ouyang, Ting, additional, Lv, Wenzhi, additional, Huang, Yongchao, additional, Liu, Die, additional, Liu, Zhao-Qing, additional, Chen, Mingzhao, additional, and Wang, Pingshan, additional

Published
2023
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8. The Marriage of Sierpiński Triangles and Platonic Polyhedra

Author

Wang, Jun, primary, Jiang, Zhilong, additional, Liu, Weiya, additional, Wu, Zihao, additional, Miao, Rui, additional, Fu, Fan, additional, Yin, Jia‐Fu, additional, Chen, Bangtang, additional, Dong, Qiangqiang, additional, Zhao, He, additional, Li, Kaixiu, additional, Wang, Guotao, additional, Liu, Die, additional, Yin, Panchao, additional, Li, Yiming, additional, Chen, Mingzhao, additional, and Wang, Pingshan, additional

Published
2022
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15. The Marriage of Sierpiński Triangles and Platonic Polyhedra.

Author

Wang, Jun, Jiang, Zhilong, Liu, Weiya, Wu, Zihao, Miao, Rui, Fu, Fan, Yin, Jia‐Fu, Chen, Bangtang, Dong, Qiangqiang, Zhao, He, Li, Kaixiu, Wang, Guotao, Liu, Die, Yin, Panchao, Li, Yiming, Chen, Mingzhao, and Wang, Pingshan

Subjects
POLYHEDRA, PLATONIC solids, TANDEM mass spectrometry, MICROENCAPSULATION, MATHEMATICAL complexes, TETRAHEDRA, TRIANGLES
Abstract

Fractal structures with self‐similarity are of fundamental importance in the fields of aesthetic, chemistry and mathematics. Here, by taking advantage of constructs the rational geometry‐directed precursor design, we report the construction of two fascinating Platonic solids, the Sierpiński tetrahedron ST‐T and the Sierpiński octahedron ST‐O, in which each possesses a fractal Sierpiński triangle on their independent faces. These two discrete complexes are formed in near‐quantitative yield from the multi‐component self‐assembly of truncated Sierpiński triangular kernel L1 with tribenzotriquinacene‐based hexatopic and anthracene‐based tetratopic terpyridine ligands (L3 and L4) in the presence of metal ions, respectively. The enhanced stabilities of the 3D discrete structures were investigated by gradient tandem mass spectrometry (gMS2). This work provides new constructs for the imitation of complex virus assemblies and for the molecular encapsulation of giant guest molecules. [ABSTRACT FROM AUTHOR]

Published
2023
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27. Glycemic impact of a diet and lifestyle intervention on diabetics and prediabetics during treatment for non-muscle invasive bladder cancer

Author

Chestnut, Connor, primary, Smelser, Woodson, additional, Dum, Travis, additional, Bechtel, Misty, additional, Hand, Lauren, additional, Michel, Carrie, additional, Bawajeeh, Areej, additional, Zohreh, Sepideh, additional, Liu, Weiya, additional, Anant, Shrikant, additional, Robbins, David, additional, Holzbeierlein, Jeffrey M., additional, Hamilton-Reeves, Jill, additional, and Lee, Eugene K., additional

Published
2019
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28. Tumor M2-PK: A novel urine marker of bladder cancer

Author

Liu, Weiya, primary, Woolbright, Benjamin L., additional, Pirani, Karim, additional, Didde, Ryan, additional, Abbott, Erika, additional, Kaushik, Gaurav, additional, Martin, Paige, additional, Hamilton-Reeves, Jill, additional, Taylor, John A., additional, Holzbeierlein, Jeffrey M., additional, Anant, Shrikant, additional, and Lee, Eugene K., additional

Published
2019
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31. Glycemic impact of a diet and lifestyle intervention on diabetics and prediabetics during treatment for non-muscle invasive bladder cancer.

Author

Chestnut, Connor, Smelser, Woodson, Dum, Travis, Bechtel, Misty, Hand, Lauren, Michel, Carrie, Bawajeeh, Areej, Zohreh, Sepideh, Liu, Weiya, Anant, Shrikant, Robbins, David, Holzbeierlein, Jeffrey M., Hamilton-Reeves, Jill, and Lee, Eugene K.

Subjects
DISEASE relapse prevention, ACCELEROMETERS, BEHAVIOR modification, BLADDER tumors, BLOOD sugar monitoring, BODY weight, CANCER patients, CANCER invasiveness, CLINICAL trials, DIET, EXERCISE, FASTING, GLYCOSURIA, GLYCOSYLATED hemoglobin, HEALTH behavior, LONGITUDINAL method, LOW-carbohydrate diet, TYPE 2 diabetes, NUTRITION counseling, PATIENT compliance, PREDIABETIC state, SELF-evaluation, WALKING, PILOT projects, TREATMENT effectiveness, EVALUATION of human services programs, DESCRIPTIVE statistics, GLYCEMIC control
Abstract

Introduction: Patients with Type II Diabetes Mellitus (DM2) have increased risk of recurrence and progression of non-muscle invasive bladder cancer (NMIBC). Glucose control through lifestyle intervention is an uninvestigated, attractive strategy to decrease risk of cancer recurrence. We test the feasibility of a diet and exercise program and its glycemic impact in patients with DM2 and NMIBC. Materials/methods: Five participants with NMIBC and pre-diabetes or DM2 were recruited for a pilot, prospective clinical trial. Each participant received dietary counseling for 16 sessions during clinical visits. The intervention included a carbohydrate-restricted (CR) diet (<130 grams per day), 30 min, walking 5×/wk, and 5000 steps daily. Diet compliance was measured with 24-hour diet recall. Exercise was monitored with accelerometer and self-report. Results: Five participants enrolled and two participants completed the 12-month intervention. Adherence was 60% to CR diet and 84% to exercise goals. Participants reduced carbohydrate consumption by 44%. Participants showed reductions in fasting blood glucose, HbA1c, glucosuria, fasting blood insulin, and body weight, and increased euglycemia on continuous glucose monitoring. Conclusions: Adherence to a CR diet and exercise goals is feasible in patients with NMIBC and DM2 and also leads improved glucose control. A phase-II trial on bladder cancer-specific outcomes is warranted. [ABSTRACT FROM AUTHOR]

Published
2020
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33. Structure-guided design of an Hsp90β N-terminal isoform-selective inhibitor

Author

Khandelwal, Anuj, primary, Kent, Caitlin N., additional, Balch, Maurie, additional, Peng, Shuxia, additional, Mishra, Sanket J., additional, Deng, Junpeng, additional, Day, Victor W., additional, Liu, Weiya, additional, Subramanian, Chitra, additional, Cohen, Mark, additional, Holzbeierlein, Jeffery M., additional, Matts, Robert, additional, and Blagg, Brian S. J., additional

Published
2018
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44. Trefoil-shaped metallacycle and metallacage viaheteroleptic self-assembly

Author

Jiang, Zhilong, Zhao, He, Wang, Jun, Chen, Bangtang, Lv, Wenzhi, Li, Yiming, Dong, Qiangqiang, Liu, Die, Liu, Weiya, Wang, Min, Fu, Fan, Hwang, Seok-Ho, Chen, Mingzhao, and Wang, Pingshan

Abstract

Template-oriented multi-component synthesis method has been proven to be an exceedingly reasonable and excellent method for the synthesis of giant two-dimensional (2D) and three-dimensional (3D) supramolecules, but designing and constructing heteroleptic and controllable self-assembly without unexpected by-products remains a challenge. Here we report two discrete trefoil-shaped metallacycle S1and metallacage S2by heteroleptic self-assembly using one hexaphenylbenzene core ligand and two capping ligands. The 2D trefoil-shaped metallacycle S1could resemble the emblem of the classic ‘Mitsubishi’ motif. The use of template-oriented ligand and bent spacer ligand promotes the quantitative formation of the desired 3D trefoil-shaped metallacage S2. The formed metallacage S2possesses a molecular weight up to 36 kDa, diameter 6.6 nm and height 3.0 nm. All supramolecular coordination complexes were fully characterized by NMR spectroscopy (1H NMR, 2D COSY, 2D NOESY, 2D DOSY), high-resolution electrospray ionization mass spectrometry ESI-MS, ESI-TWIM-MS, TEM and AFM.

Published
2023
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45. KU675, a Concomitant Heat-Shock Protein Inhibitor of Hsp90 and Hsc70 that Manifests Isoform Selectivity for Hsp90αin Prostate Cancer Cells▪

Author

Liu, Weiya, Vielhauer, George A., Holzbeierlein, Jeffrey M., Zhao, Huiping, Ghosh, Suman, Brown, Douglas, Lee, Eugene, and Blagg, Brian S.J.

Abstract

The 90-kDa heat-shock protein (Hsp90) assists in the proper folding of numerous mutated or overexpressed signal transduction proteins that are involved in cancer. Inhibiting Hsp90 consequently is an attractive strategy for cancer therapy as the concomitant degradation of multiple oncoproteins may lead to effective antineoplastic agents. Here we report a novel C-terminal Hsp90 inhibitor, designated KU675, that exhibits potent antiproliferative and cytotoxic activity along with client protein degradation without induction of the heat-shock response in both androgen-dependent and -independent prostate cancer cell lines. In addition, KU675 demonstrates direct inhibition of Hsp90 complexes as measured by the inhibition of luciferase refolding in prostate cancer cells. In direct binding studies, the internal fluorescence signal of KU675 was used to determine the binding affinity of KU675 to recombinant Hsp90α, Hsp90β, and Hsc70 proteins. The binding affinity (Kd) for Hsp90αwas determined to be 191 μM, whereas the Kdfor Hsp90βwas 726 μM, demonstrating a preference for Hsp90α. Western blot experiments with four different prostate cancer cell lines treated with KU675 supported this selectivity by inducing the degradation of Hsp90α-dependent client proteins. KU675 also displayed binding to Hsc70 with a Kdvalue at 76.3 μM, which was supported in cellular by lower levels of Hsc70-specific client proteins on Western blot analyses. Overall, these findings suggest that KU675 is an Hsp90 C-terminal inhibitor, as well as a dual inhibitor of Hsc70, and may have potential use for the treatment of cancer.

Published
2015
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46. Physicochemical changes in phosphorylase kinase induced by its cationic activator Mg2+.

Author

Liu, Weiya, Nadeau, Owen W., Sage, Jessica, and Carlson, Gerald M.

Abstract

For over four decades free Mg2+ ions, that is, those in excess of MgATP, have been reported to affect a wide variety of properties of phosphorylase kinase (PhK), including its affinity for other molecules, proteolysis, chemical crosslinking, phosphorylation, binding to certain monoclonal antibodies, and activity, which is stimulated. Additionally, for over three decades Mg2+ has been known to act synergistically with Ca2+, another divalent activator of PhK, to affect even more properties of the enzyme. During all of this time, however, no study has been performed to determine the overall effects of free Mg2+ ions on the physical properties of PhK, even though the effects of Ca2+ ions on PhK's properties are well documented. In this study, changes in the physicochemical properties of PhK induced by Mg2+ under nonactivating (pH 6.8) and activating (pH 8.2) conditions were investigated by circular dichroism spectroscopy, zeta potential analyses, dynamic light scattering, second derivative UV absorption, negative stain electron microscopy, and differential chemical crosslinking. The effects of the activator Mg2+ on some of the properties of PhK measured by these techniques were found to be quite different at the two pH values, and displayed both differences and similarities with the effects previously reported to be induced by the activator Ca2+ (Liu et al., Protein Sci 2008;17:2111-2119). The similarities may reflect the fact that both cations are activators, and foremost among their similarities is the dramatically less negative zeta potential induced by their binding to PhK. [ABSTRACT FROM AUTHOR]

Published
2013
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