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179 results on '"Liu, Xi-Wang"'

7. Untargeted and Targeted Metabolomics Reveal the Underlying Mechanism of Aspirin Eugenol Ester Ameliorating Rat Hyperlipidemia via Inhibiting FXR to Induce CYP7A1

Author

Lu Xiao-Rong, Ma Ning, Liu Xi-Wang, Li Shi-Hong, Qin Zhe, Bai Li-Xia, Yang Ya-Jun, and Li Jian-Yong

Subjects
aspirin eugenol ester, hyperlipidemia, metabolomics, bile acids, cholesterol, Therapeutics. Pharmacology, RM1-950
Abstract

Hyperlipidemia is an important lipid disorder and a risk factor for health. Aspirin eugenol ester (AEE) is a novel synthetic compound which is made up of two chemical structural units from aspirin and eugenol. Therapeutic effect of AEE on hyperlipidemia has been confirmed in animal model. But the action mechanism of AEE on hyperlipidemia is still poorly understood. In this study, we investigated the effects of AEE on liver and feces metabolic profile through UPLC-Q-TOF/MS-based untargeted metabolomics in hyperlipidemia hamster induced with high fat diet (HFD), and the effects of AEE on the expression of genes and proteins related to cholesterol and bile acid (BA) in HFD-induced hyperlipidemia SD rat. The concentrations of 26 bile acids (BAs) in the liver from hyperlipidemia SD rat were also quantified with the application of BA targeted metabolomics. The results of untargeted metabolomics showed that the underlying mechanism of AEE on hyperlipidemia was mainly associated with amino acid metabolism, glutathione metabolism, energy metabolism, BA metabolism, and glycerophospholipid metabolism. AEE induced the expression of the BA-synthetic enzymes cholesterol 7α-hydroxylase (CYP7A1) by the inhibition of BA nuclear receptor farnesoid X receptor (FXR) in liver, which resulted in accelerating the conversion of cholesterol into bile acids and excrete in feces. The results of BA targeted metabolomics showed that AEE elevated the glycine-conjugated BA level and decreased the tauro-conjugated BA level. In conclusion, this study found that AEE decreased FXR and increased CYP7A1 in the liver, which might be the possible molecular mechanisms and targets of AEE for anti-hyperlipidemia therapies.

Published
2021
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44. Efficacy and safety of Ban Huang oral liquid for treating bovine respiratory diseases

Author

Li, Bing, Zhou, Xu-Zheng, Niu, Jian-Rong, Wei, Xiao-Juan, Li, Jian-Yong, Yang, Ya-Jun, Liu, Xi-Wang, Cheng, Fu-Sheng, and Zhang, Ji-Yu

Subjects
Ban Huang oral liquid, Mycoplasma bovis, minimum inhibitory concentration, safety, clinical efficacy
Abstract

Background: Ban Huang oral liquid was developed as a veterinary compound preparation by the Lanzhou Institute of Husbandry and Pharmaceutical Sciences of the Chinese Academy of Agricultural Sciences (CAAS). The purpose of this study was to determine whether the oral liquid preparation of traditional Chinese medicine, Ban Huang, is safe and effective for treating respiratory diseases in cattle.Materials and Methods: Acute oral toxicity experiments were conducted in Wistar rats and Kunming mice via oral administration. The minimum inhibitory concentration of the drug against Mycoplasma bovis in vitro with the double dilution method was 500 mg/mL, indicating good sensitivity. The results of laboratory pathogen testing, analysis of clinical symptoms, and analysis of pathological anatomy were combined to diagnose bovine respiratory diseases in 147 Simmental cattle caused by mixed infections of M. bovis, bovine respiratory syncytial virus, bovine parainfluenza virus type 3, and Mannheimia haemolytica. These cattle were randomly divided into three groups: drug treatment group 1 (treated via Tilmicosin injection), drug treatment group 2 (treated with Shuang Huang Lian oral liquid combined with Tilmicosin injection), and drug treatment group 3 (treated with Ban Huang oral liquid combined with Tilmicosin injection). Treatment effects were observed within 7 days.Results: The results showed no toxicity and a maximum tolerated dose greater than 20 g/kg BW. For the 87 cattle in drug-treatment group, the cure rate was 90.80%, whereas the response rate was 94.25%. The cure rate of drug treatment group was increased by 14.13% in comparison with that of drug control group 1 and by 7.47% in comparison with that of drug control group 2 (both P < 0.05).Conclusion: This study demonstrates that Ban Huang oral liquid is a safe and effective treatment for bovine respiratory diseases, especially for mixed infection caused by M. bovis, bacteria, and viruses.Keywords: Ban Huang oral liquid, Mycoplasma bovis, minimum inhibitory concentration, safety, clinical efficacy

Published
2017

50. Real Time Three-Dimensional Transthoracic Echocardiography Evaluation in a Patient with Congenital Pulmonary Vein Stenosis

Author

Jiang Guo-ping, Liu Xi-Wang, Li Jian-hua, Ye Jing-Jing, Xu Wei-ze, and Shu Qiang

Subjects
medicine.medical_specialty, business.industry, medicine.medical_treatment, medicine.disease, Pulmonary vein, Stenosis, Internal medicine, medicine, Cardiology, Congenital pulmonary vein stenosis, Radiology, Nuclear Medicine and imaging, Radiology, Cardiology and Cardiovascular Medicine, business, Cardiac catheterization
Abstract

Although real time three-dimensional transthoracic echocardiography (RD-3DTTE) has been used in children with complex congenital heart diseases, the benefit of RD-3DTTE as a vision of the pulmonary veins still requires further evaluation. We present here, a 3-year-old girl with a stenosis of the left upper pulmonary vein (LUPV). Excellent images were obtained rapidly by RD-3DTTE that successfully visualized the narrowing at the junction of the LUPV. The result was demonstrated by MRI, cardiac catheterization, and operation. RD-3DTTE is a feasible and promising technique in evaluating pulmonary veins in children. (Echocardiography 2010;27:E109-E111)

Published
2010

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