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412 results on '"Liu, Xiaole"'

1. Analysis of Bee Population and the Relationship with Time

Author

Li, Muyang, Liu, Xiaole, Qi, Chen, Liu, Lexuan, Yang, Kai, Celebi, Emre, Series Editor, Chen, Jingdong, Series Editor, Gopi, E. S., Series Editor, Neustein, Amy, Series Editor, Liotta, Antonio, Series Editor, Di Mauro, Mario, Series Editor, and Meng, Lei, editor

Published
2024
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5. The evolution of computational research in a data-centric world

Author

Deshpande, Dhrithi, Chhugani, Karishma, Ramesh, Tejasvene, Pellegrini, Matteo, Shiffman, Sagiv, Abedalthagafi, Malak S., Alqahtani, Saleh, Ye, Jimmie, Liu, Xiaole Shirley, Leek, Jeffrey T., Brazma, Alvis, Ophoff, Roel A., Rao, Gauri, Butte, Atul J., Moore, Jason H., Katritch, Vsevolod, and Mangul, Serghei

Published
2024
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9. A novel Algorithm for Hydrostatic-mechanical Mobile Machines with a Dual-Clutch Transmission

Author

Xiang, Yusheng, Li, Ruoyu, Brach, Christine, Liu, Xiaole, and Geimer, Marcus

Subjects
Electrical Engineering and Systems Science - Systems and Control
Abstract

Mobile machines using a hydrostatic transmission is highly efficient under lower working-speed condition but less capable at higher transport velocities. To enhance overall efficiency, we have improved the powertrain design by combining a hydrostatic transmission with a dual-clutch transmission (DCT). Compared with other mechanical gearboxes, the DCT avoids the interruption of torque transmission in the process of shifting without sacrificing more transmission efficiency. However, there are some problems of unstable torque transmission during the shifting process, and an excessive torque drop occurring at the end of the gear shift, which result in a poor drive comfort. To enhance the performance of the novel structural possibility of powertrain design, we designed a novel control strategy for the motor torque and the clutch torques during the shifting process. The controller's task is tracking the target drive torque and completing the gear shift as quickly as possible with acceptable smoothness requirements. In the process of the controller design, a specific control algorithm is firstly designed for a 10 ton wheel loader. The model-based simulation has validated the control effect. As a result, the control strategy employing clutch and motor torque control to achieve a smooth shifting process is feasible since drive torque is well tracked, and highly dynamical actuators are not required. Furthermore, only two calibration parameters are designed to adjust the control performance systematically. The novel control strategy is generalized for other mobile machines with different sizes., Comment: 8 pages, 10 figures

Published
2020

10. Realtime Estimation of IEEE 802.11p for Mobile working Machines Communication respecting Delay and Packet Loss

Author

Xiang, Yusheng, Su, Tianqing, Liu, Xiaole, and Geimer, Marcus

Subjects
Computer Science - Networking and Internet Architecture
Abstract

The fleet management of mobile working machines with the help of connectivity can increase not only safety but also productivity. However, rare mobile working machines have taken advantage of V2X. Moreover, no one published the simulation results that are suitable for evaluating the performance of the ad-hoc network at a working site on the highway where is congested, with low mobility, and without building. In this paper, we suggested that IEEE 802.11p should be implemented for fleet management, at least for the first version. Furthermore, we proposed an analytical model for machines to estimate the ad-hoc network performance, i.e., the delay and the packet loss probability in real-time based on the simulation results we made in ns3. The model of this paper can be further used for determining when shall ad-hoc or cellular network be used in the corresponding scenarios., Comment: 6 pages, 6 figures

Published
2020

18. All-optical targeted drug delivery and real-time detection of a single cancer cell

Author

Liu Xiaole, Yuan Jie, Wu Dong, Zou Xiaobin, Zheng Qing, Zhang Weina, and Lei Hongxiang

Subjects
optical tweezers, raman detection, drug delivery, Physics, QC1-999
Abstract

Targeted drug delivery and real-time detection both play an important role for studying the specificity of a single cancer cell and the development of anticancer drugs. However, a method that simultaneously enables safe and efficient targeted drug delivery and noninvasive, free-label cell detection is highly desirable but challenging. Here, we report an all-optical method that combines fiber optical tweezers with laser Raman microspectroscopy, which can achieve targeted drug delivery to a single cancer cell using optical manipulation in vitro quickly and accurately by a tapered fiber probe, and simultaneously record the corresponding active characteristics of the targeted cancer cell under the contact of delivered drug through a Raman spectrometer. Using the method, drug delivery and release can be flexibly controlled by turning on/off the trapping laser beam propagating in the fiber, which can avoid the complex systems and is highly autonomous and controllable. Moreover, the detection of cell activity does not require any dye calibration and processing, and it is noninvasive. In addition, for a single suspension cell, optical trapping of the cell using another fiber tip can overcome the low efficiency of targeted drug delivery and the poor stability of the Raman spectrum caused by Brownian motion of the cell. This all-optical method provides a promising approach to conduct pharmacologic studies with the reaction of cancer cell and drugs at the level of a single cell.

Published
2019
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19. Comparative analysis of metazoan chromatin organization

Author

Ho, Joshua WK, Jung, Youngsook L, Liu, Tao, Alver, Burak H, Lee, Soohyun, Ikegami, Kohta, Sohn, Kyung-Ah, Minoda, Aki, Tolstorukov, Michael Y, Appert, Alex, Parker, Stephen CJ, Gu, Tingting, Kundaje, Anshul, Riddle, Nicole C, Bishop, Eric, Egelhofer, Thea A, Hu, Sheng'en Shawn, Alekseyenko, Artyom A, Rechtsteiner, Andreas, Asker, Dalal, Belsky, Jason A, Bowman, Sarah K, Chen, Q Brent, Chen, Ron A-J, Day, Daniel S, Dong, Yan, Dose, Andrea C, Duan, Xikun, Epstein, Charles B, Ercan, Sevinc, Feingold, Elise A, Ferrari, Francesco, Garrigues, Jacob M, Gehlenborg, Nils, Good, Peter J, Haseley, Psalm, He, Daniel, Herrmann, Moritz, Hoffman, Michael M, Jeffers, Tess E, Kharchenko, Peter V, Kolasinska-Zwierz, Paulina, Kotwaliwale, Chitra V, Kumar, Nischay, Langley, Sasha A, Larschan, Erica N, Latorre, Isabel, Libbrecht, Maxwell W, Lin, Xueqiu, Park, Richard, Pazin, Michael J, Pham, Hoang N, Plachetka, Annette, Qin, Bo, Schwartz, Yuri B, Shoresh, Noam, Stempor, Przemyslaw, Vielle, Anne, Wang, Chengyang, Whittle, Christina M, Xue, Huiling, Kingston, Robert E, Kim, Ju Han, Bernstein, Bradley E, Dernburg, Abby F, Pirrotta, Vincenzo, Kuroda, Mitzi I, Noble, William S, Tullius, Thomas D, Kellis, Manolis, MacAlpine, David M, Strome, Susan, Elgin, Sarah CR, Liu, Xiaole Shirley, Lieb, Jason D, Ahringer, Julie, Karpen, Gary H, and Park, Peter J

Subjects
Biochemistry and Cell Biology, Biological Sciences, Immunization, Human Genome, Genetics, 1.1 Normal biological development and functioning, Underpinning research, Generic health relevance, Animals, Caenorhabditis elegans, Cell Line, Centromere, Chromatin, Chromatin Assembly and Disassembly, DNA Replication, Drosophila melanogaster, Enhancer Elements, Genetic, Epigenesis, Genetic, Heterochromatin, Histones, Humans, Molecular Sequence Annotation, Nuclear Lamina, Nucleosomes, Promoter Regions, Genetic, Species Specificity, General Science & Technology
Abstract

Genome function is dynamically regulated in part by chromatin, which consists of the histones, non-histone proteins and RNA molecules that package DNA. Studies in Caenorhabditis elegans and Drosophila melanogaster have contributed substantially to our understanding of molecular mechanisms of genome function in humans, and have revealed conservation of chromatin components and mechanisms. Nevertheless, the three organisms have markedly different genome sizes, chromosome architecture and gene organization. On human and fly chromosomes, for example, pericentric heterochromatin flanks single centromeres, whereas worm chromosomes have dispersed heterochromatin-like regions enriched in the distal chromosomal 'arms', and centromeres distributed along their lengths. To systematically investigate chromatin organization and associated gene regulation across species, we generated and analysed a large collection of genome-wide chromatin data sets from cell lines and developmental stages in worm, fly and human. Here we present over 800 new data sets from our ENCODE and modENCODE consortia, bringing the total to over 1,400. Comparison of combinatorial patterns of histone modifications, nuclear lamina-associated domains, organization of large-scale topological domains, chromatin environment at promoters and enhancers, nucleosome positioning, and DNA replication patterns reveals many conserved features of chromatin organization among the three organisms. We also find notable differences in the composition and locations of repressive chromatin. These data sets and analyses provide a rich resource for comparative and species-specific investigations of chromatin composition, organization and function.

Published
2014

20. Host immune signatures as predictors of response to immunotherapy-based regimens in patients with metastatic renal cell carcinoma (mRCC)

Author

Saad, Eddy, primary, Labaki, Chris, additional, Saliby, Renée-Maria, additional, Bakouny, Ziad, additional, Song, Li, additional, Wall, McKenzy, additional, Pan, Wenting, additional, Semaan, Karl, additional, Eid, Marc, additional, Gwo-Shu, Mary Lee, additional, Braun, David, additional, Liu, Xiaole Shirley, additional, and Choueiri, Toni, additional

Published
2023
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28. Effects of serratus anterior plane block and thoracic paravertebral nerve block on analgesia, immune function and serum tumor markers in patients after thoracoscopic radical resection of lung cancer

Author

Liu, Xiaole and An, Jing

Subjects
thoracoscopic radical resection, lung cancer, serratus anterior plane block, immune function, serum tumor marker
Abstract

We aimed to assess the effects of serratus anterior plane block (SAPB) and thoracic paravertebral nerve block (TPVB) on analgesia, immune function and serum tumor markers in patients after thoracoscopic radical resection of lung cancer. A total of 132 patients enrolled from February 2019 to November 2020 were prospectively selected and randomly divided into 3 groups (n=44). Control group received general anesthesia. After induction of general anesthesia, TPVB or SAPB group was given TPVB or SAPB. Their clinical data, operation conditions, Visual Analogue Scale (VAS) score, immune function, serum tumor markers and adverse reactions were compared. TPVB and SAPB groups had lower dosage of sufentanil during operation, later time of first pressing patient-controlled intravenous analgesia (PCA) pump after operation and smaller number of pressing PCA pump within 48 h after operation than those of control group (P0.05). SAPB and TPVB can markedly improve postoperative analgesic effect, enhance immune function and decrease serum tumor marker levels in patients receiving thoracoscopic radical resection of lung cancer, without increasing adverse reactions. However, TPVB may puncture the pleura.

Published
2022

29. Data from Enhanced Efficacy of Simultaneous PD-1 and PD-L1 Immune Checkpoint Blockade in High-Grade Serous Ovarian Cancer

Author

Wan, Changxin, primary, Keany, Matthew P., primary, Dong, Han, primary, Al-Alem, Linah F., primary, Pandya, Unnati M., primary, Lazo, Suzan, primary, Boehnke, Karsten, primary, Lynch, Katherine N., primary, Xu, Rui, primary, Zarrella, Dominique T., primary, Gu, Shengqing, primary, Cejas, Paloma, primary, Lim, Klothilda, primary, Long, Henry W., primary, Elias, Kevin M., primary, Horowitz, Neil S., primary, Feltmate, Colleen M., primary, Muto, Michael G., primary, Worley, Michael J., primary, Berkowitz, Ross S., primary, Matulonis, Ursula A., primary, Nucci, Marisa R., primary, Crum, Christopher P., primary, Rueda, Bo R., primary, Brown, Myles, primary, Liu, Xiaole Shirley, primary, and Hill, Sarah J., primary

Published
2023
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30. Supplementary Table 4 from Enhanced Efficacy of Simultaneous PD-1 and PD-L1 Immune Checkpoint Blockade in High-Grade Serous Ovarian Cancer

Author

Wan, Changxin, primary, Keany, Matthew P., primary, Dong, Han, primary, Al-Alem, Linah F., primary, Pandya, Unnati M., primary, Lazo, Suzan, primary, Boehnke, Karsten, primary, Lynch, Katherine N., primary, Xu, Rui, primary, Zarrella, Dominique T., primary, Gu, Shengqing, primary, Cejas, Paloma, primary, Lim, Klothilda, primary, Long, Henry W., primary, Elias, Kevin M., primary, Horowitz, Neil S., primary, Feltmate, Colleen M., primary, Muto, Michael G., primary, Worley, Michael J., primary, Berkowitz, Ross S., primary, Matulonis, Ursula A., primary, Nucci, Marisa R., primary, Crum, Christopher P., primary, Rueda, Bo R., primary, Brown, Myles, primary, Liu, Xiaole Shirley, primary, and Hill, Sarah J., primary

Published
2023
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31. Supplementary Table 5 from Enhanced Efficacy of Simultaneous PD-1 and PD-L1 Immune Checkpoint Blockade in High-Grade Serous Ovarian Cancer

Author

Wan, Changxin, primary, Keany, Matthew P., primary, Dong, Han, primary, Al-Alem, Linah F., primary, Pandya, Unnati M., primary, Lazo, Suzan, primary, Boehnke, Karsten, primary, Lynch, Katherine N., primary, Xu, Rui, primary, Zarrella, Dominique T., primary, Gu, Shengqing, primary, Cejas, Paloma, primary, Lim, Klothilda, primary, Long, Henry W., primary, Elias, Kevin M., primary, Horowitz, Neil S., primary, Feltmate, Colleen M., primary, Muto, Michael G., primary, Worley, Michael J., primary, Berkowitz, Ross S., primary, Matulonis, Ursula A., primary, Nucci, Marisa R., primary, Crum, Christopher P., primary, Rueda, Bo R., primary, Brown, Myles, primary, Liu, Xiaole Shirley, primary, and Hill, Sarah J., primary

Published
2023
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32. Supplementary Table 2 from Enhanced Efficacy of Simultaneous PD-1 and PD-L1 Immune Checkpoint Blockade in High-Grade Serous Ovarian Cancer

Author

Wan, Changxin, primary, Keany, Matthew P., primary, Dong, Han, primary, Al-Alem, Linah F., primary, Pandya, Unnati M., primary, Lazo, Suzan, primary, Boehnke, Karsten, primary, Lynch, Katherine N., primary, Xu, Rui, primary, Zarrella, Dominique T., primary, Gu, Shengqing, primary, Cejas, Paloma, primary, Lim, Klothilda, primary, Long, Henry W., primary, Elias, Kevin M., primary, Horowitz, Neil S., primary, Feltmate, Colleen M., primary, Muto, Michael G., primary, Worley, Michael J., primary, Berkowitz, Ross S., primary, Matulonis, Ursula A., primary, Nucci, Marisa R., primary, Crum, Christopher P., primary, Rueda, Bo R., primary, Brown, Myles, primary, Liu, Xiaole Shirley, primary, and Hill, Sarah J., primary

Published
2023
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33. Supplementary Table 1 from Enhanced Efficacy of Simultaneous PD-1 and PD-L1 Immune Checkpoint Blockade in High-Grade Serous Ovarian Cancer

Author

Wan, Changxin, primary, Keany, Matthew P., primary, Dong, Han, primary, Al-Alem, Linah F., primary, Pandya, Unnati M., primary, Lazo, Suzan, primary, Boehnke, Karsten, primary, Lynch, Katherine N., primary, Xu, Rui, primary, Zarrella, Dominique T., primary, Gu, Shengqing, primary, Cejas, Paloma, primary, Lim, Klothilda, primary, Long, Henry W., primary, Elias, Kevin M., primary, Horowitz, Neil S., primary, Feltmate, Colleen M., primary, Muto, Michael G., primary, Worley, Michael J., primary, Berkowitz, Ross S., primary, Matulonis, Ursula A., primary, Nucci, Marisa R., primary, Crum, Christopher P., primary, Rueda, Bo R., primary, Brown, Myles, primary, Liu, Xiaole Shirley, primary, and Hill, Sarah J., primary

Published
2023
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34. Supplementary Materials from Enhanced Efficacy of Simultaneous PD-1 and PD-L1 Immune Checkpoint Blockade in High-Grade Serous Ovarian Cancer

Author

Wan, Changxin, primary, Keany, Matthew P., primary, Dong, Han, primary, Al-Alem, Linah F., primary, Pandya, Unnati M., primary, Lazo, Suzan, primary, Boehnke, Karsten, primary, Lynch, Katherine N., primary, Xu, Rui, primary, Zarrella, Dominique T., primary, Gu, Shengqing, primary, Cejas, Paloma, primary, Lim, Klothilda, primary, Long, Henry W., primary, Elias, Kevin M., primary, Horowitz, Neil S., primary, Feltmate, Colleen M., primary, Muto, Michael G., primary, Worley, Michael J., primary, Berkowitz, Ross S., primary, Matulonis, Ursula A., primary, Nucci, Marisa R., primary, Crum, Christopher P., primary, Rueda, Bo R., primary, Brown, Myles, primary, Liu, Xiaole Shirley, primary, and Hill, Sarah J., primary

Published
2023
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35. Supplementary Table 3 from Enhanced Efficacy of Simultaneous PD-1 and PD-L1 Immune Checkpoint Blockade in High-Grade Serous Ovarian Cancer

Author

Wan, Changxin, primary, Keany, Matthew P., primary, Dong, Han, primary, Al-Alem, Linah F., primary, Pandya, Unnati M., primary, Lazo, Suzan, primary, Boehnke, Karsten, primary, Lynch, Katherine N., primary, Xu, Rui, primary, Zarrella, Dominique T., primary, Gu, Shengqing, primary, Cejas, Paloma, primary, Lim, Klothilda, primary, Long, Henry W., primary, Elias, Kevin M., primary, Horowitz, Neil S., primary, Feltmate, Colleen M., primary, Muto, Michael G., primary, Worley, Michael J., primary, Berkowitz, Ross S., primary, Matulonis, Ursula A., primary, Nucci, Marisa R., primary, Crum, Christopher P., primary, Rueda, Bo R., primary, Brown, Myles, primary, Liu, Xiaole Shirley, primary, and Hill, Sarah J., primary

Published
2023
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