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Prediabetes, as an intermediary stage between normal glucose homeostasis and overt diabetes, affects an estimated 720 million individuals worldwide, highlighting the urgent need for proactive intervention strategies. Continuous glucose monitoring (CGM) emerges as a transformative tool, offering unprecedented insights into glycemic dynamics and facilitating tailored therapeutic interventions. This perspective scores the clinical significance of even slightly elevated fasting blood glucose levels and the critical role of early intervention. CGM technology provides real-time, continuous data on glucose concentrations, surpassing the constraints of conventional monitoring methods. Both retrospectively analyzed and real-time CGM systems offer valuable tools for glycemic management, each with unique strengths. The integration of CGM into routine care can detect early indicators of type 2 diabetes, inform the development of personalized intervention strategies, and foster patient engagement and empowerment. Despite challenges such as cost and the need for effective utilization through training and education, CGM's potential to revolutionize prediabetes management is evident. Future research should focus on refining CGM algorithms, exploring personalized intervention strategies, and leveraging wearable technology and artificial intelligence advancements to optimize glycemic control and patient well-being. [ABSTRACT FROM AUTHOR]

Myofascial as a holistic structure emphasizes a holistic approach to intervention and treatment of fascial-related disorders such as neck pain (NP), low back pain (LBP), and knee pain. There are currently adverse effects of medication for diseases related to myofascial. Traditional Chinese rehabilitation exercise (TCRE) is a practical approach to traditional Chinese medicine and is a valuable option for intervening in myofascial-related pain. This article found some research evidence for Baduanjin, Wuqinxi, and Yijinjing in clinical studies of myofascial chain-related pain. The article summarizes the current evidence and finds that TCRE can enhance limb movement function through breathing and slow movements, increase joint movement and flexibility, and reduce joint pathology and stress-induced pain. As for future directions, focus on TCRE in improving the health of older adults and treating long-COVID syndrome, and integrate robotic and TCRE training to frame safe and effective exercise models. Relevant studies have already been registered in the Clinical Trials Registry, and some clinical study protocols have been published. TCRE can be an alternative nonpharmacological rehabilitation therapy to alleviate chronic rheumatic pain symptoms and augment public health management. [ABSTRACT FROM AUTHOR]

This document is a response to a letter from Hao et al regarding a study on Traditional Chinese Rehabilitation Exercise (TCRE) and its potential applicability in different populations. The authors express gratitude for the recognition of their work and clarify that their focus on older adults and diseases associated with aging is due to the concentrated distribution of existing research data and the prevalent demand in clinical practice. They acknowledge the limited research on TCRE in young populations and attribute it to young people's preference for modern activities over traditional exercises. However, they emphasize the importance of investigating TCRE's efficacy and potential in different age groups and express agreement with the suggestion to strengthen research on TCRE in young populations. The authors also express their willingness to collaborate with other scholars to explore the application value of TCRE in a broader demographic. [Extracted from the article]

This article discusses a study on acupoints for headache with blood stasis syndrome. The authors acknowledge the importance of the study but also identify areas that need further exploration and refinement. They suggest that the inclusion criteria, exclusion criteria, and quality assessment methods should be explicitly outlined to improve research transparency. They also recommend providing more details on the data mining techniques used and the validation procedures. Additionally, the authors propose further analysis of the significance and implications of the observed acupoint combinations and suggest refining future research directions. Overall, the article has academic value and practical implications in the field of acupuncture, but the authors believe that enhancements can further elevate its quality and influence. [Extracted from the article]

Early diagnosis of hepatic cancer is a major public health challenge. While changes in serum N-glycans have been observed as patients progress from liver fibrosis/cirrhosis to hepatocellular carcinoma (HCC), the predictive performance of N-glycans is yet to be determined for HCC early diagnosis as well as differential diagnosis from liver fibrosis/cirrhosis. In a total sample of 247 patients with hepatitis B virus-related liver disease, we characterized and compared the serum N-glycans in very early/early and intermediate/advanced stages of HCC and those with liver fibrosis/cirrhosis. Additionally, we performed a retrospective timeline analysis of the serum N-glycans 6 and 12 months before a diagnosis of the very early/early stage of HCC (EHCC). A predictive model was built, named hereafter as Glycomics-EHCC, incorporating the glycan peaks (GPs) 1, 2, and 4. The model showed a larger area under the receiver operating characteristic curve compared with a traditional model with the α-fetoprotein (0.936 vs. 0.731, respectively). The Glycomics-EHCC model had a sensitivity of 84.6% and specificity of 85.0% at a cutoff value of -0.39 to distinguish EHCC from liver fibrosis/cirrhosis. Moreover, the Glycomics-EHCC model was able to forecast a future EHCC diagnosis with a sensitivity and specificity over 90% and 85%, respectively, using the serum N-glycan biosignatures 6 or 12 months earlier when the patients were suffering from liver fibrosis/cirrhosis before being diagnosed with EHCC. This serum glycomic biosignature model warrants further clinical studies in independent population samples and offers promise to forecast EHCC and its differential diagnosis from liver fibrosis/cirrhosis.

Objective: To investigate the levels of hepatitis B virus (HBV) total DNA and covalently closed circular (ccc) DNA in liver transplant recipients due to HBV-associated liver diseases and detemaine their clinical significance., Methods: Sixty patients undergoing liver transplantation (LT) due to HBV-associated liver diseases were enrolled for the study. Levels of HBV total and ccc DNA in plasma, liver and PBMCs were measured by RT-PCR., Results: The ratio of male:female participants was 48:12. The mean age was 52.98+/-9.40 years old, and the median duration post-LT was 72 (25-128) months. 59 of the patients had no detectable HBV DNA in plasma.Four patients had detectable levels of total HBV DNA in PBMCs, but no detectable ccc DNA. Five patients had detectable levels of total HBV DNA in liver, and two of those also had detectable levels of ccc DNA. One patients who had detectable HBV DNA in PBMCs suffered HBV recurrence., Conclusion: The liver transplant recipients with detectable levels of HBV total and ccc DNA in PBMCs and liver should be considered high risk for HBV recurrence following LT.