1. Concise Total Synthesis and Antifungal Activities of Fusaric Acid, a Natural Product.
- Author
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Huang, Bin Bin, Liu, Ya Yi, Zhu, Peng Fei, Jiang, Yi Cheng, and Ouyang, Ming-An
- Subjects
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NATURAL products , *PHYTOPATHOGENIC fungi , *PATHOGENIC fungi , *HERBICIDES , *INSECTICIDES , *FUNGICIDES , *ANTIFUNGAL agents , *ISOQUINOLINE alkaloids - Abstract
The total synthesis of a natural product alkaloid fusaric acid (FA), which exhibits herbicide, fungicide, insecticide and even diverse notable pharmacological activities, was accomplished in four steps using commercially available materials. The synthesis, based on a unified and flexible strategy using 6-bromonicotinaldehyde as a common intermediate, is concise, convergent, practical and can be carried out on a two-gram scale. This approach could be readily applicable to the synthesis of its analogues. In addition, FA had a wide range of inhibitory activities against 14 plant pathogenic fungi in this study, which demonstrated that as a leading compound, and it has great potential to be further developed as an agricultural fungicide. [ABSTRACT FROM AUTHOR]
- Published
- 2020
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