Search

Rapid tissue reconstruction in acute and chronic injuries are challengeable, the inefficient repair mainly due to the difficulty in simultaneous promoting the regeneration of peripheral nerves and vascular, which are closely related. Main clinical medication strategy of tissue repair depends on different cytokines to achieve nerves, blood vessels or granulation tissue regeneration, respectively. However, their effect is still limited to single aspect with biorisk exists upon long-time use. Herein, for the first time, we have demonstrated that NA isolated from Malania oleifera has potential to simultaneously promote both neurogenesis and angiogenesis in vitro and in vivo. First, NA was identified by NMR and FTIR structural characterization analysis. In a model of oxidative stress in neural cells induced by hydrogen peroxide, the cells viability of RSC96 and PC12 were protected from oxidative stress injury by NA. Similarly, based on the rat wound healing model, effective blood vessel formation and wound healing can be observed in tissue staining under NA treatment. In addition, according to the identification of nerve and vascular related markers in the wound tissue, the mechanism of NA promoting nerve regeneration lies in the upregulation of the secretion NGF, NF-200 and S100 protein, and NA treatment was also able to up-regulate VEGF and CD31 to directly promote angiogenesis during wound healing. This study provides an important candidate drug molecules for acute or chronic wound healing and nerve vascular synchronous regeneration. [ABSTRACT FROM AUTHOR]

Most rotators and stators of motors or generators as well as the cores of transformers are produced by laminated plates of electric steel to reduce the energy loss caused by eddy current. Therefore, it is essential to predict as well as improve the shearing quality of the electric steel plates and thus help increase the efficiency of the machines. Most investigations overlook the planar anisotropy in the numerical analysis of the shearing process. The simplified 2-D analysis was adopted instead of the 3-D analysis. In this work, DEFORM 3D analysis is used which takes into account the anisotropy of the plate material. Normalized Cockcroft & Latham damage criterion is used in determining the occurrence of fracture during the shearing. The result shows that the 3-D analysis predicts well in the burnish depth while roughly in rollover due to insufficient resolution of the element size. The 2-D analysis tends to underestimate the burnish depth attributed to the improper selection of lower critical damage values and predicts scattered rollover.

A new scheme of a double-variable-curvature microlens (DVCM) employing a single-step grinding technique with fully automated fabrication for efficient coupling between high-power 980-nm laser diodes and single-mode fibers is proposed and demonstrated. The grinded fiber endface exhibited a double-variable curvature in the major axis, and was clearly observed for both major and minor axes after slight fusion polish. The perfect aspherical shape of the DVCM results in less grinding offset of 0.2 \mum and better curvature radii control that leads to high average coupling efficiency of 83%. This clearly indicates that the performance of the DVCM can achieve high average coupling efficiency better than any other grinding techniques to form asymmetric microlenses. The versatility in double-variable-curvature design, fully automated fabrication, and the excellent performance of aspherical microlens makes the proposed DVCM extremely attractive for use in many lightwave interconnection applications. [ABSTRACT FROM PUBLISHER]