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312 results on '"Liu, Ze‐Xian"'

13. Selective Organ‐Targeting Hafnium Oxide Nanoparticles with Multienzyme‐Mimetic Activities Attenuate Radiation‐Induced Tissue Damage (Adv. Mater. 19/2024)

Author

Liu, Dingxin, primary, Cao, Fei, additional, Xu, Zhifeng, additional, Zhao, Chunhua, additional, Liu, Zekun, additional, Pang, Jiadong, additional, Liu, Ze‐Xian, additional, Moghiseh, Mahdieh, additional, Butler, Anthony, additional, Liang, Shaoxia, additional, Fan, Weijun, additional, and Yang, Jiang, additional

Published
2024
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23. Residual circulating tumor DNA after adjuvant chemotherapy effectively predicts recurrence of stage II‐III gastric cancer

Author

Yuan, Shu‐Qiang, primary, Nie, Run‐Cong, additional, Huang, You‐Sheng, additional, Chen, Ying‐Bo, additional, Wang, Si‐Yu, additional, Sun, Xiao‐Wei, additional, Li, Yuan‐Fang, additional, Liu, Ze‐Kun, additional, Chen, Yan‐Xing, additional, Yao, Yi‐Chen, additional, Xu, Yu, additional, Qiu, Hai‐Bo, additional, Liang, Yao, additional, Wang, Wei, additional, Liu, Ze‐Xian, additional, Zhao, Qi, additional, Xu, Rui‐Hua, additional, Zhou, Zhi‐Wei, additional, and Wang, Feng, additional

Published
2023
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25. AMPKα1 confers survival advantage of colorectal cancer cells under metabolic stress by promoting redox balance through the regulation of glutathione reductase phosphorylation

Author

Wang, Ying-Nan, Lu, Yun-Xin, Liu, Jie, Jin, Ying, Bi, Hui-Chang, Zhao, Qi, Liu, Ze-Xian, Li, Ying-Qin, Hu, Jia-Jia, Sheng, Hui, Jiang, Yi-Ming, Zhang, Chao, Tian, Feng, Chen, Yang, Pan, Zhi-Zhong, Chen, Gong, Zeng, Zhao-Lei, Liu, Kai-Yan, Ogasawara, Marcia, Yun, Jin-Ping, Ju, Huai-Qiang, Feng, Jian-Xiong, Xie, Dan, Gao, Song, Jia, Wei-Hua, Kopetz, Scott, Xu, Rui-Hua, and Wang, Feng

Published
2020
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26. Long noncoding RNA Regulating ImMune Escape regulates mixed lineage leukaemia protein‐1‐H3K4me3‐mediated immune escape in oesophageal squamous cell carcinoma

Author

Liu, Jia, primary, Zhou, Wei‐Yi, additional, Luo, Xiao‐Jing, additional, Chen, Yan‐Xing, additional, Wong, Chau‐Wei, additional, Liu, Ze‐Xian, additional, Bo Zheng, Jia‐, additional, Yu Mo, Hai‐, additional, Chen, Jun‐Quan, additional, Li, Jia‐Jun, additional, Zhong, Ming, additional, Xu, Yu‐Hong, additional, Zhang, Qi‐Hua, additional, Pu, Heng‐Ying, additional, Wu, Qi‐Nian, additional, Jin, Ying, additional, Wang, Zi‐Xian, additional, Xu, Rui‐Hua, additional, and Luo, Hui‐Yan, additional

Published
2023
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28. Inflammatory cytokine-regulated tRNA-derived fragment tRF-21 suppresses pancreatic ductal adenocarcinoma progression

Author

Pan, Ling, Huang, Xudong, Liu, Ze-Xian, Ye, Ying, Li, Rui, Zhang, Jialiang, Wu, Guandi, Bai, Ruihong, Zhuang, Lisha, Wei, Lusheng, Li, Mei, Zheng, Yanfen, Su, Jiachun, Deng, Junge, Deng, Shuang, Zeng, Lingxing, Zhang, Shaoping, Wu, Chen, Che, Xu, Wang, Chengfeng, Chen, Rufu, Lin, Dongxin, and Zheng, Jian

Subjects
Cytokines -- Health aspects, Transfer RNA -- Health aspects, Pancreatic cancer -- Development and progression -- Genetic aspects -- Care and treatment, Health care industry
Abstract

The tumorigenic mechanism for pancreatic ductal adenocarcinoma (PDAC) is not clear, although chronic inflammation is implicated. Here, we identified an inflammatory cytokine-regulated transfer RNA- derived (tRNA-derived) fragment, tRF-21VBY9PYKHD (tRF-21), as a tumor suppressor in PDAC progression. We found that the biogenesis of tRF-21 could be inhibited by leukemia inhibitory factor and IL-6 via the splicing factor SRSF5. Reduced tRF- 21 promoted AKT2/1-mediated heterogeneous nuclear ribonucleoprotein L (hnRNP L) phosphorylation, enhancing hnRNP L to interact with dead-box helicase 17 (DDX17) to form an alternative splicing complex. The provoked hnRNP L-DDX17 activity preferentially spliced Caspase 9 and mH2A1 pre-mRNAs to form Caspase9b and mH2A1.2, promoting PDAC cell malignant phenotypes. The tRF-21 levels were significantly lower in PDACs than in normal tissues, and patients with low tRF-21 levels had a poor prognosis. Treatment of mouse PDAC xenografts or patient-derived xenografts (PDXs) with tRF-21 mimics repressed tumor growth and metastasis. These results demonstrate that tRF-21 has a tumor-suppressive effect and is a potential therapeutic agent for PDAC., Introduction Pancreatic ductal adenocarcinoma (PDAC) is the most lethal malignancy, with a 5-year survival rate of less than 9% (1, 2). Most PDAC tumors are already in an advanced stage [...]

Published
2021
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30. Supplementary Figures from The Macrophage-Associated LncRNA MALR Facilitates ILF3 Liquid–Liquid Phase Separation to Promote HIF1α Signaling in Esophageal Cancer

Author

Liu, Jia, primary, Liu, Ze-Xian, primary, Li, Jia-Jun, primary, Zeng, Zhao-Lei, primary, Wang, Jin-Hong, primary, Luo, Xiao-Jing, primary, Wong, Chau-Wei, primary, Zheng, Jia-Bo, primary, Pu, Heng-Ying, primary, Mo, Hai-Yu, primary, Sheng, Hui, primary, Wu, Qi-Nian, primary, Li, Hao, primary, Wan, Gang, primary, Li, Bo, primary, Wang, De-shen, primary, Xu, Rui-Hua, primary, and Ju, Huai-Qiang, primary

Published
2023
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31. Supplementary Table 1 from The Macrophage-Associated LncRNA MALR Facilitates ILF3 Liquid–Liquid Phase Separation to Promote HIF1α Signaling in Esophageal Cancer

Author

Liu, Jia, primary, Liu, Ze-Xian, primary, Li, Jia-Jun, primary, Zeng, Zhao-Lei, primary, Wang, Jin-Hong, primary, Luo, Xiao-Jing, primary, Wong, Chau-Wei, primary, Zheng, Jia-Bo, primary, Pu, Heng-Ying, primary, Mo, Hai-Yu, primary, Sheng, Hui, primary, Wu, Qi-Nian, primary, Li, Hao, primary, Wan, Gang, primary, Li, Bo, primary, Wang, De-shen, primary, Xu, Rui-Hua, primary, and Ju, Huai-Qiang, primary

Published
2023
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32. Supplementary Table 3 from The Macrophage-Associated LncRNA MALR Facilitates ILF3 Liquid–Liquid Phase Separation to Promote HIF1α Signaling in Esophageal Cancer

Author

Liu, Jia, primary, Liu, Ze-Xian, primary, Li, Jia-Jun, primary, Zeng, Zhao-Lei, primary, Wang, Jin-Hong, primary, Luo, Xiao-Jing, primary, Wong, Chau-Wei, primary, Zheng, Jia-Bo, primary, Pu, Heng-Ying, primary, Mo, Hai-Yu, primary, Sheng, Hui, primary, Wu, Qi-Nian, primary, Li, Hao, primary, Wan, Gang, primary, Li, Bo, primary, Wang, De-shen, primary, Xu, Rui-Hua, primary, and Ju, Huai-Qiang, primary

Published
2023
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33. Data from The Macrophage-Associated LncRNA MALR Facilitates ILF3 Liquid–Liquid Phase Separation to Promote HIF1α Signaling in Esophageal Cancer

Author

Liu, Jia, primary, Liu, Ze-Xian, primary, Li, Jia-Jun, primary, Zeng, Zhao-Lei, primary, Wang, Jin-Hong, primary, Luo, Xiao-Jing, primary, Wong, Chau-Wei, primary, Zheng, Jia-Bo, primary, Pu, Heng-Ying, primary, Mo, Hai-Yu, primary, Sheng, Hui, primary, Wu, Qi-Nian, primary, Li, Hao, primary, Wan, Gang, primary, Li, Bo, primary, Wang, De-shen, primary, Xu, Rui-Hua, primary, and Ju, Huai-Qiang, primary

Published
2023
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34. Supplementary Movie 1 from The Macrophage-Associated LncRNA MALR Facilitates ILF3 Liquid–Liquid Phase Separation to Promote HIF1α Signaling in Esophageal Cancer

Author

Liu, Jia, primary, Liu, Ze-Xian, primary, Li, Jia-Jun, primary, Zeng, Zhao-Lei, primary, Wang, Jin-Hong, primary, Luo, Xiao-Jing, primary, Wong, Chau-Wei, primary, Zheng, Jia-Bo, primary, Pu, Heng-Ying, primary, Mo, Hai-Yu, primary, Sheng, Hui, primary, Wu, Qi-Nian, primary, Li, Hao, primary, Wan, Gang, primary, Li, Bo, primary, Wang, De-shen, primary, Xu, Rui-Hua, primary, and Ju, Huai-Qiang, primary

Published
2023
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35. Supplementary Table 2 from The Macrophage-Associated LncRNA MALR Facilitates ILF3 Liquid–Liquid Phase Separation to Promote HIF1α Signaling in Esophageal Cancer

Author

Liu, Jia, primary, Liu, Ze-Xian, primary, Li, Jia-Jun, primary, Zeng, Zhao-Lei, primary, Wang, Jin-Hong, primary, Luo, Xiao-Jing, primary, Wong, Chau-Wei, primary, Zheng, Jia-Bo, primary, Pu, Heng-Ying, primary, Mo, Hai-Yu, primary, Sheng, Hui, primary, Wu, Qi-Nian, primary, Li, Hao, primary, Wan, Gang, primary, Li, Bo, primary, Wang, De-shen, primary, Xu, Rui-Hua, primary, and Ju, Huai-Qiang, primary

Published
2023
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36. Supplementary Methods from The Macrophage-Associated LncRNA MALR Facilitates ILF3 Liquid–Liquid Phase Separation to Promote HIF1α Signaling in Esophageal Cancer

Author

Liu, Jia, primary, Liu, Ze-Xian, primary, Li, Jia-Jun, primary, Zeng, Zhao-Lei, primary, Wang, Jin-Hong, primary, Luo, Xiao-Jing, primary, Wong, Chau-Wei, primary, Zheng, Jia-Bo, primary, Pu, Heng-Ying, primary, Mo, Hai-Yu, primary, Sheng, Hui, primary, Wu, Qi-Nian, primary, Li, Hao, primary, Wan, Gang, primary, Li, Bo, primary, Wang, De-shen, primary, Xu, Rui-Hua, primary, and Ju, Huai-Qiang, primary

Published
2023
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39. Pan‐cancer landscape of tumour endothelial cells pinpoints insulin receptor as a novel antiangiogenic target and predicts immunotherapy response.

Author

Zheng, Yongqiang, Pan, Yi‐Qian, Liao, Kun, Yu, Kai, Wu, Qinian, Chen, Yanxing, Deng, Yuqing, Sun, Hui, Pu, Hengying, Ju, Huai‐Qiang, Xu, Rui‐Hua, and Liu, Ze‐Xian

Subjects
INSULIN receptors, ENDOTHELIAL cells, NEOVASCULARIZATION inhibitors, IMMUNOTHERAPY, TUMORS
Abstract

This article presents a study on tumour endothelial cells (TECs) and their role in tumour development and angiogenesis. The researchers created a pan-cancer TEC atlas using single-cell sequencing data from 381 samples. They identified different clusters of TECs and found that angiogenic components were elevated in tumours compared to normal endothelial cells. They also discovered two novel tip EC clusters, INSR+ tip ECs and PGF+ tip ECs, which were associated with angiogenesis. The study provides valuable insights into the mechanisms of tumour angiogenesis and suggests potential antiangiogenic targets for future therapies. Additionally, the article discusses the role of the insulin receptor (INSR) in angiogenesis, specifically in tumor endothelial cells (TECs). The study found that INSR is expressed exclusively in tumor ECs and is correlated with classical EC markers in multiple cancers, indicating its role as an angiogenic marker. In vitro and in vivo experiments demonstrated that INSR enhances angiogenic capacity, making it a promising antiangiogenic target. Furthermore, the study found that mature venous ECs expressing MHC-II molecules are associated with a better response to immunotherapy. The findings contribute to the development of innovative antiangiogenic agents. [Extracted from the article]

Published
2023
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41. Supplementary Methods, Figures and Tables from MYC-Activated LncRNA MNX1-AS1 Promotes the Progression of Colorectal Cancer by Stabilizing YB1

Author

Wu, Qi-Nian, primary, Luo, Xiao-Jing, primary, Liu, Jia, primary, Lu, Yun-Xin, primary, Wang, Yun, primary, Qi, Jingjing, primary, Liu, Ze-Xian, primary, Huang, Qi-Tao, primary, Liu, Ze-Kun, primary, Lu, Jia-Bin, primary, Jin, Ying, primary, Pu, Heng-Ying, primary, Hu, Pei-Shan, primary, Zheng, Jia-Bo, primary, Zeng, Zhao-Lei, primary, Ju, Huai-Qiang, primary, Xie, Dan, primary, Zhao, Qi, primary, and Xu, Ruihua, primary

Published
2023
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42. Data from Clonal Mutations Activate the NF-κB Pathway to Promote Recurrence of Nasopharyngeal Carcinoma

Author

You, Rui, primary, Liu, You-Ping, primary, Lin, De-Chen, primary, Li, Qing, primary, Yu, Tao, primary, Zou, Xiong, primary, Lin, Mei, primary, Zhang, Xiao-Long, primary, He, Gui-Ping, primary, Yang, Qi, primary, Zhang, Yi-Nuan, primary, Xie, Yu-Long, primary, Jiang, Rou, primary, Wu, Chen-Yan, primary, Zhang, Chao, primary, Cui, Cheng, primary, Wang, Jing-Qi, primary, Wang, Yue, primary, Zhuang, Ai-Hua, primary, Guo, Gui-Fang, primary, Hua, Yi-Jun, primary, Sun, Rui, primary, Yun, Jing-Ping, primary, Zuo, Zhi-Xiang, primary, Liu, Ze-Xian, primary, Zhu, Xiao-Feng, primary, Kang, Tie-Bang, primary, Qian, Chao-Nan, primary, Mai, Hai-Qiang, primary, Sun, Ying, primary, Zeng, Mu-Sheng, primary, Feng, Lin, primary, Zeng, Yi-Xin, primary, and Chen, Ming-Yuan, primary

Published
2023
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45. Supplementary Data from Clonal Mutations Activate the NF-κB Pathway to Promote Recurrence of Nasopharyngeal Carcinoma

Author

You, Rui, primary, Liu, You-Ping, primary, Lin, De-Chen, primary, Li, Qing, primary, Yu, Tao, primary, Zou, Xiong, primary, Lin, Mei, primary, Zhang, Xiao-Long, primary, He, Gui-Ping, primary, Yang, Qi, primary, Zhang, Yi-Nuan, primary, Xie, Yu-Long, primary, Jiang, Rou, primary, Wu, Chen-Yan, primary, Zhang, Chao, primary, Cui, Cheng, primary, Wang, Jing-Qi, primary, Wang, Yue, primary, Zhuang, Ai-Hua, primary, Guo, Gui-Fang, primary, Hua, Yi-Jun, primary, Sun, Rui, primary, Yun, Jing-Ping, primary, Zuo, Zhi-Xiang, primary, Liu, Ze-Xian, primary, Zhu, Xiao-Feng, primary, Kang, Tie-Bang, primary, Qian, Chao-Nan, primary, Mai, Hai-Qiang, primary, Sun, Ying, primary, Zeng, Mu-Sheng, primary, Feng, Lin, primary, Zeng, Yi-Xin, primary, and Chen, Ming-Yuan, primary

Published
2023
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48. Data from MYC-Activated LncRNA MNX1-AS1 Promotes the Progression of Colorectal Cancer by Stabilizing YB1

Author

Wu, Qi-Nian, primary, Luo, Xiao-Jing, primary, Liu, Jia, primary, Lu, Yun-Xin, primary, Wang, Yun, primary, Qi, Jingjing, primary, Liu, Ze-Xian, primary, Huang, Qi-Tao, primary, Liu, Ze-Kun, primary, Lu, Jia-Bin, primary, Jin, Ying, primary, Pu, Heng-Ying, primary, Hu, Pei-Shan, primary, Zheng, Jia-Bo, primary, Zeng, Zhao-Lei, primary, Ju, Huai-Qiang, primary, Xie, Dan, primary, Zhao, Qi, primary, and Xu, Ruihua, primary

Published
2023
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49. A Cyclodiaryliodonium NOX Inhibitor for the Treatment of Pancreatic Cancer Via Enzyme‐activatable Targeted Delivery by Sulfated Glycosaminoglycan Derivatives

Author

Pang, Jiadong, primary, Zhu, Daqian, additional, Liu, Yang, additional, Liu, Dingxin, additional, Zhao, Chunhua, additional, Zhang, Jianeng, additional, Li, Shengping, additional, Liu, Ze‐Xian, additional, Li, Xiaobing, additional, Huang, Peng, additional, Wen, Shijun, additional, and Yang, Jiang, additional

Published
2023
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50. Near-Infrared Phototheranostic Iron Pyrite Nanocrystals Simultaneously Induce Dual Cell Death Pathways via Enhanced Fenton Reactions in Triple-Negative Breast Cancer

Author

Zhao, Chunhua, primary, Liu, Zekun, additional, Chang, Chia-Che, additional, Chen, Yi-Chia, additional, Zhang, Qize, additional, Zhang, Xiao-Dong, additional, Andreou, Chrysafis, additional, Pang, Jiadong, additional, Liu, Ze-Xian, additional, Wang, Di-Yan, additional, Kircher, Moritz F., additional, and Yang, Jiang, additional

Published
2023
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