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The polyurea elastomer (PUA) powder modifier was prepared by the method of spraying–initial crushing–fine grinding, and then, the PUA-modified asphalt was produced. The typical functional structure of PUA was identified and characterized. The apparent viscosity of PUA-modified asphalt was tested at different temperatures. The impact of particle size and content of PUA on creep and recovery properties of asphalt at high temperature was investigated through the multiple stress creep recovery test. The mesothermal fatigue behavior of PUA-modified asphalt was evaluated by means of time sweep and linear amplitude sweep. Results indicated that the high elastic properties of PUA materials might depend on the spherical structure inside PUA material. The diameter of functional structure was around 20 µm and presented as 3D ball structure. The increase in PUA particle size would lead to the increase in cracks and folds in the bonding surface PUA modifier could improve by about 50% of the apparent viscosity significantly. Furthermore, PUA modifier could promote the high-temperature rutting resistance and middle-temperature fatigue property of asphalt. The improving effect on R could reach almost 28% and the 0.075 mm could be the best application size of PUA.

The aerodynamic characteristics of the vertical tail of an aircraft are directly related to the size and weight of the vertical tail. Increasing the lift force of the vertical tail using flow control can further reduce the size of the vertical tail,which is of practical significance for reducing the weight of the structure. The computational fluid dynamics(CFD)method is used to perform the numerical simulation for the active flow control of vertical tail using the co-flow jet technique. The influence law of jet momentum coefficient on continuous co-flow jet and the influence law of jet momentum coefficient and the paramaters of jet momentum coefficient,blockage ratio,injection hole number on discrete co-flow jet are studied. The results show that for the continuous co-flow jet,with the increase of jet momentum coefficient,the effectiveness of lift enhancement,drag reduction and separation suppression becomes more significant. For the discrete co-flow jet,the effectiveness of lift enhancement gradually decreases with the increase of the blockage ratio,and the power consumption also decreases at the same time. With the increase of the discrete hole number,the lift enhancement effect first increases and then decreases,and the comprehensive aerodynamic efficiency considering energy consumption is improved.

Objective: The purposes of this study were to explore the pharmacokinetics of perampanel (PER) in children with epilepsy, identify factors that contribute to pharmacokinetic variations among subjects, evaluate the connection between PER exposure and clinical outcome, and establish an evidence‐based approach for tailoring individualized antiepileptic treatment in this specific population. Methods: In this prospective study, PER plasma concentrations and genetic information on metabolic enzymes were obtained from 194 patients younger than 18 years. The disposition kinetics of PER in pediatric patients following oral dosing were characterized using nonlinear mixed effect models. The effective range for the plasma concentration of PER was determined by assessing the efficacy and safety of PER treatment and analyzing the relationship between drug exposure and clinical response. Monte Carlo simulations were then performed to evaluate and optimize the current dosing regimens. Results: The pharmacokinetic profile of PER was adequately described by a one‐compartment model with first‐order absorption and elimination. Body weight, total bilirubin level, and concomitant oxcarbazepine were found to have significant influences on PER pharmacokinetics. Model estimates of apparent clearance and volume of distribution were.016 ±.009 L/h/kg and 1.47 ±.78 L/kg, respectively. The effective range predicted from plasma concentration data in responders was 215–862 μg/L. Dosing scenarios stratified according to essential covariates were proposed through simulation analysis. Significance: In this study, we captured the pharmacokinetic/pharmacodynamic characteristics of PER in pediatric epilepsy patients through analysis of real‐world data and adopted a pharmacometric approach to support an individualized dosing strategy for PER in this specific population. [ABSTRACT FROM AUTHOR]

Ciprofloxacin (CIP), an important representative fluoroquinolone antibiotic, has been frequently detected in water sources, thus threatening aquatic organisms and human health. In this work, a porous three‐component covalent organic polymer (SLEL‐6) was synthesized through multi‐component (MC) reaction systems for adsorptive removal of CIP from aqueous solution, followed by an encapsulation process to achieve SLEL‐6/sodium alginate (SA) beads with boosted adsorption ability, reusability and recyclability. By virtue of the hierarchical porous natures, functional groups as well as π‐rich skeletons, SLEL‐6 and SLEL‐6/SA beads could deal with CIP contamination effectively. Moreover, the adsorption isotherms of CIP by SLEL‐6 and SLEL‐6/SA beads follow the Langmuir model showing high theoretical maximum adsorption capacities of 57.47 and 163.93 mg g−1, respectively. Furthermore, the plausible mechanisms are proposed according to experimental studies of influencing factors, coupled with characterizations before and after adsorption. This work therefore highlighting the immense potential of COP‐based SA composite beads as new‐type globular adsorbents for eliminating fluoroquinolones from aqueous solution. [ABSTRACT FROM AUTHOR]