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Background This study aims to determine whether palliative bypass surgery (choledochojejunostomy and gastrojejunostomy), which has a lower incidence of complications and mortality, remains an option for elderly patients with resectable periampullary carcinoma. Methods The clinical data of elderly patients with resectable periampullary carcinoma who had been admitted to Qilu Hospital and had undergone palliative bypass surgery in recent years was collected. Factors concerning these patients, including surgical duration, intraoperative haemorrhage, the incidence of complications, mortality, and survival rate, were compared to those in patients who had received radical surgery. Results Surgical duration, intraoperative haemorrhage, the incidence of complications, pancreatic fistula, abdominal infections, pneumonia, and postoperative hospital stay were found to be more apparent in patients in the radical surgery group than in patients in the palliative bypass surgery group and the difference was statistically significant (P

// Liu Enyu 1, * , Wang Na 2, * , Zhao Chuanzong 1 , Wang Ben 1 , Wu Xiaojuan 3 , Wang Yan 3 , Li Zequn 1, 4 , Hong Jianguo 1 , Wang Jiayong 1 , Liang Benjia 1, 4 , Peng Cheng 1 , Zhu Min 1 , Zhang Zongli 1 1 Department of General Surgery, Qilu Hospital of Shandong University, Jinan 250012, Shandong, P.R. China 2 Department of Dermatology, Shandong Provinical Institute of dermatology and venereology, Jinan 250012, Shandong, P.R. China 3 Department of Pathology, School of Medicine, Shandong University, Jinan 250012, Shandong, P.R. China 4 Key Laboratory of Cardiovascular Remodeling and Function Research, Chinese Ministry of Education and Public Health, Jinan 250012, Shandong, P.R. China * The First two authors have contributed equally to this work Correspondence to: Liu Enyu, email: liuenyu120@sina.com Zhang Zongli, email: zhangzongli120@sina.com Zhu Min, email: zhuminqilu@sina.com Keywords: gallbladder cancer, integrin β6, pStat-3, immunohistochemistry, tumorigenesis Received: April 28, 2016 Accepted: November 01, 2016 Published: January 02, 2017 ABSTRACT Background: Both phosphorylated signal transducer and activator of transcription 3(pStat-3) and integrin αvβ6 can play vital role in the development and progression of cancer. However, little is known about their expression correlation and clinical significance in gallbladder cancer(GBC). Objective : The aim of our present study was to investigate the expression of pStat-3 and integrin αvβ6, two proteins’ correlation and their clinical significance in GBC tissues. Results: The expression of pStat-3 and integrin αvβ6 were both significantly associated with T stage, lymph node metastasis status, TNM stage (P=0.008, P=0.000, P=0.000 and P=0.036, P=0.001,P=0.000,respectively). IHC and Western blot showed their expressions in GBC tissues were higher than that in paraneoplastic tissues. Moderate positive correlation existed between the two proteins (r =0.349, P

A facile energy-saving route is developed for fabricating Sb2Te3-Te nanocomposites and nanosized Te powders. The fabrication route not only avoids using organic chemicals, but also keeps the energy consumption to a minimum. The fabrication procedure involves two steps. Energetic precursors of nanosized powders of Sb and Te are produced at room temperature followed by hot pressing at 400°C under 70 MPa for 1 h. The resulting Sb2Te3-Te nanocomposite exhibits enhanced power factor. The dimensionless figure of merit zT value of the Sb2Te3-Te nanocomposite is 0.29 at 475 K.

It is well known that both eukaryotic initiation factor 4E (eIF4E) and integrin αvβ6 can contribute to malignant behavior of colon cancer. We have found that integrin αvβ6 and eIF4E were co-expressed and positively correlated in colon cancer tissues. Recently, deregulation of the protein synthesis apparatus has begun to gain attention as a major participant in cancer development and progression. However, the regulation of integrin β6 expression at translational level has never been investigated before. In present study, gene-silencing technique for eIF4E by small interfering RNA (siRNA) was used in all the subsequent experiments, in order to investigate whether eIF4E could translationally regulate expression of integrin β6 in colon cancer SW480 and HT-29 cell lines. Additionally, the subsequent effects of eIF4E knockdown on cellular malignant behavior were observed. siRNA in SW480 and HT-29 transfectants. Subsequently, protein expression of β6 was markedly suppressed, while mRNA expression of β6 showed no significant variation before and after eIF4E RNA interfering. Therefore, it could be seen that eIF4E could upregulate the expression of β6, without effect on β6 mRNA expression. More importantly, after treated with eIF4E siRNA, cellular migratory capacity on fibronectin of HT-29 and β6-transfected SW480 as well as their survival to 5-FU was decreased distinctly. Expression of integrin β6 could be translationally regulated by eIF4E, which subsequently contributed to tumor malignancy through enhancing cellular migration, survival, anti-apoptosis, and chemoresistance of colon cancer in vitro. Thus, targeting eIF4E in integrin αvβ6 expressing tumors can be a potential therapeutic strategy for patients with colon cancer.