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［Objective］To address the issue of cutterhead damage and subsequent work stoppages caused by unidentified obstructions during the construction of Zhengzhou Metro Line 3 tunnel, it is essential to study comprehensive construction methods for shield receiving in water-rich silty sand stratum. ［Method］A comprehensive construction plan for shield receiving is introduced, incorporating techniques such as the double-ring freezing method, active dewatering, mining methods, and shield empty push construction. The temperature variation characteristics of freezing and key construction technologies are analyzed using on-site monitoring data. ［Result & Conclusion］The comprehensive construction plan is proven to be safe and effective for dealing with shield receiving in water-rich silty sand stratum conditions. Adopting double-ring freezing method combined with active dewatering could effectively prevent issues related to water and sand inflows in mining method tunnels. During the steam thawing process of the inner ring freezing wall, the temperature of the outer ring freezing wall increases by approximately 5 ℃. When employing the shield empty push method through a mining method tunnel that is not fully thawed, the maximum shield thrust is 26 500 kN, which is less than the theoretical value of shield push resistance. At this point, the ground displacement and tunnel deformation all meet control requirements. During shield empty pushing, the temperature at the interface between shield casing and partially thawed inner ring soil remains around 3 ℃. When crossing the frozen zone using the mining method, different levels of land subsidence are observed near the tunnel, while the soil layer subsidence trend far away from the tunnel remains relatively stable.

In the blended conductive rubbers, good dispersion of conductive fillers and great interfacial bonding with the substrate are the keys to achieving excellent mechanical and electromagnetic shielding properties. It is found that compared with octyltriethoxysilane (A137), 3-methacryloxypropyl-trimethoxysilane (A174) and vinyltriethoxysilane (A151) with a double bond reduce the curing degree of the blends. The vinyl methyl silicone rubber/nickel-coated graphite (VMQ/NCG) composites modified by A137 shows poor tensile properties, while the composites modified by A174 shows inferior electrical properties. The presence of physical adsorption and chemical adsorption on the surface of NCG modified by A151, which effectively enhances the dispersibility of NCG and interfacial bonding strength with rubber, so that the material exhibits excellent comprehensive properties. When the content of A151 is 3% and modified by dry method, the tensile strength of VMQ/NCG composites can reach 1.6 MPa, the elongation at break can reach 162%, and the volume resistivity can reach 0.05 Ω·cm.

Aiming at the intelligent design of combat systems, we proposed a conceptual framework and application methods of Agent based on artificial intelligence technology. First, we analyze the concept of Agent and discusse the important significance of studying Agent in the combat system. Then, we introduce the research framework of artificial intelligence based on Agent, and multiple application methods of Agent in combat systems. Finally, we analyze the development trends of Agent technology and the risks and challenges that its combat applications may face.

Oil-gas interfacial tension is an important parameter for analyzing the mixing degree of oil and gas phases and influencing the minimum mixing pressure of oil and gas and the development effect of gas injection during gas flooding for enhanced oil recovery. Aiming at n-octane （C8）， which is the main component of shale oil， the changing rules of interfacial tension and interfacial microscopic characteristics of pure CO2 and mixed gases （CO2， CH4， N2） with n-octane were investigated by molecular dynamics simulation. Additionally， the effects of external factors such as temperature， pressure， and gas components on interfacial characteristics were also taken into account. The results show that with the increase in gas-phase pressure， the mixing degree of gas and n-octane increases， and the microscopic features such as interfacial thickness， roughness， and relative adsorption are enhanced， resulting in a gradual decrease in the interfacial tension between the oil and gas. The interfacial tension shows opposite trends with temperature in different pressure intervals. The interfacial tension declines as the temperature rises in low pressure intervals. While the interfacial tension grows as the temperature rises in high pressure intervals. Compared with pure CO2， the addition of CH4 and N2 increases the interfacial tension between the mixed gases and the oil， of which N2 has a greater effect on the oil-gas interfacial tension. At the same time， CH4 and N2 weaken the microscopic features such as the oil-gas interfacial thickness and relative adsorption. The relative adsorption of CO2 is the largest， followed by CH4 and the smallest N2 in the ternary CO2+CH4+N2/C8 system， which proves that the interactions between the three gases and the oil are from the strong to the weak， i.e.， CO2CH4N2. In addition， the relative adsorption of all the systems is greater than zero. As the adsorption is larger， the interfacial tension decreases faster with the increasing pressure， which is in agreement with Gibbs’ adsorption theory.

Catalysts for warm cloud seeding have significant potential for applications in warm cloud catalytic precipitation and fog elimination. In recent years, numerous innovative materials have been developed, each with the potential to be used in warm cloud catalysis. However, a universally recognized ideal formulation has not yet been established. It is necessary to conduct a scientific analysis on the performance of various hygroscopic catalysts under consistent experimental conditions.Therefore, 9 types of typical powdered hygroscopic catalysts are collected, and experiments involving fog chamber and static testing of catalysts are conducted at CMA Key Laboratory of Cloud-precipitation Physics and Weather Modification in May 2023. Fog elimination capabilities and hygroscopic characteristics of various catalysts are comprehensively evaluated and compared. Results indicate that, under the same fog conditions, salt type catalysts demonstrate the shortest time to eliminate fog, and porous composite materials (PCM-100 and PCM-10) are also effective, while fog elimination effects of modified starch, molecular sieves, organic bentonite and sodium bentonite are not obvious after seeding. In static detection, under normal temperature and humidity conditions, CaCl2 exhibits the strongest static hygroscopicity, followed by porous composite materials such as PCM-100 and PCM-10. Composite salt catalysts exhibit strong hygroscopic absorption, whereas the static hygroscopic absorption capacity of other catalysts is not as pronounced. In high humidity conditions, bentonite and molecular sieve catalysts still do not exhibit moisture absorption characteristics. The hygroscopic abilities of CaCl2, PCM-100, and PCM-10 are significantly higher than those of other catalysts. The performance of various catalysts in the fog chamber experiment and static detection is basically consistent.Microstructures of various catalysts with strong hygroscopic properties do not show significant changes after 30 minutes. PCM-10 primarily exists in the form of liquid droplets after standing for 5 minutes and can continue to provide hydration. PCM-100 remains in irregular crystal form after 5 minutes and transforms into droplets after 30 minutes. CaCl2 absorbs moisture rapidly under the microscope, initially existing as liquid droplets for 5 minutes. Subsequently, there are no significant changes, primarily small droplets. Complex salts always form crystals, while the size of liquid droplets formed is larger.It should be noted that, although the hygroscopicity and the ability of fog elimination of various catalysts are important indicators, the dispersibility, corrosiveness and ease of preparation and storage of the catalyst are also important parameters of whether they can be used as efficient warm cloud catalysts. Follow-up research and evaluation of various catalysts will be conducted.

ObjectiveTo explore how the joint-teaching mode of tomographic-radiologic anatomy and topographic anatomy in a way of case-based learning (CBL) promotes the education of medical students.MethodsAccording to the principle of systematic random sampling, the students of the eight-year pilot class of clinical medicine and the graduate students majoring in medical imaging were randomly assigned to the joint teaching group and the control group. They respectively received the joint-teaching of tomographic and topographic anatomy based on CBL and the traditional teaching of topographic anatomy. At the end of the course, both groups of students had a theoretical knowledge test and a course evaluation.ResultsA total of 68 students were recruited in this study, including 39 students from the 2022 grade of eight-year pilot class of clinical medicine in Peking Union Medical College and 29 first-year master students majoring in medical imaging. There were 34 students in the joint teaching group (20 from the 8-year pilot class and 14 from the master's program) and 34 students in the control group (19 from the 8-year pilot class and 15 from the master's program). The average knowledge test scores and course evaluation scores in the four dimensions of "improving the mastery of anatomy knowledge", "improving the interest in anatomy", "improving the recognition of radiologic knowledge", and "improving the clinical comprehensive ability" were significantly higher in the joint teaching group than in the control group (all P < 0.05). In the subgroup analysis, the average knowledge test scores of the students from the 8-year pilot class and master's program in the joint teaching group were respectively higher than those in the control group. In addition, joint teaching could significantly improve the radiologic cognition and comprehensive clinical ability of the students from the 8-year pilot class, while students from the master's program may benefit more in anatomy knowledge and clinical application.ConclusionsThe case-based joint-teaching mode can promote the mastery of anatomy knowledge, radiologic cognition and comprehensive clinical ability of medical students from different academic systems.

Paroxysmal nocturnal hemoglobinuria (PNH) is an acquired clonal hematopoietic stem cell disease caused by abnormal expression of glycosylphosphatidylinositol (GPI) on the cell membrane due to mutations in the phosphatidylinositol glycan class A(PIGA) gene. It is commonly characterized by intravascular hemolysis, repeated thrombosis, and bone marrow failure, as well as multiple systemic involvement symptoms such as renal dysfunction, pulmonary hypertension, swallowing difficulties, chest pain, abdominal pain, and erectile dysfunction. Due to the rarity of PNH and its strong heterogeneity in clinical manifestations, multidisciplinary collaboration is often required for diagnosis and treatment. Peking Union Medical College Hospital, relying on the rare disease diagnosis and treatment platform, has invited multidisciplinary clinical experts to form a unified opinion on the diagnosis and treatment of PNH, and formulated the Expert Consensus of Multidisciplinary Diagnosis and Treatment for Paroxysmal Nocturnal Hemoglobinuria (2024), with the hope of promoting the standardization of PNH diagnosis and treatment.

Jiyang shale oil resources have enormous potential. However， there is a lack of systematic understanding of seepage mechanism and development laws in the multi-scale spaces after fracturing due to the influence of complex geological conditions， making it difficult to achieve large-scale beneficial development. In order to clarify the formation mechanism of the development law of Jiyang shale oil， the multi-scale fracture characteristics of Jiyang shale oil were analyzed. The formation mechanism and combination mode of fracture networks after fracturing were studied using physical experiments and numerical simulations. In addition， seepage mechanisms in multi-medium spaces were researched， including the stress sensitivity of multi-scale fractures， nonlinear flow in multi-scale pores and fractures， and imbibition displacement of pore-fracture systems. According to the differences in the distribution of multi-scale fracture networks and their flow laws after fracturing， a three-zone flow pattern of “easy flow-slow flow-difficult flow” for shale oil was established. Finally， the flow characteristics and production laws of Jiyang shale oil at different flow stages were clarified. The research results indicated that the developed bedding fractures could improve the physical properties of reservoirs， enhance imbibition displacement efficiency， and reduce start-up pressure gradient. During the elastic development stage， the flow channels reduce， and the fracture network conductivity decreases as the formation pressure declines， resulting in significant stress sensitivity. In the development process of Jiyang shale oil， the initial flow state is mainly dominated by linear flow and elliptical flow of fractures supplied by the easy flow zone. In the middle stage of development， the slow flow zone supplies energy to the easy flow zone， and the flow state changes to elliptical flow in the formation. Moreover， the shale oil in the difficult flow zone is gradually produced， and the flow state changes to boundary-controlled flow in the later stage of development. Due to the influence of geological conditions and production systems， there are significant differences in the energy change， water cut decrease， and production change law of different horizontal wells. Reasonably optimizing the shut-in time and production system can ensure imbibition displacement efficiency， efficiently utilize formation energy， and improve shale oil production capacity.

In order to realize the effective development of shale oil with low maturity in continental faulted basins in Jiyang Depression， systematic evaluations have been carried out simultaneously in Boxing， Niuzhuang， and Minfeng sags since 2019， based on the 10 000 meters of systematic coring and more than 100 000 core tests. Significant breakthroughs have been made in single well evaluation and stereoscopic development of well groups. A pilot test of eight wells in three layers was conducted in Boxing Sag， and the first 100 000-ton shale oil development well group of SINOPEC was built. A large-platform stereoscopic development test of well groups was carried out with 20 wells in five layers， and all wells were put into production in Niuzhuang Sag. A comprehensive overall evaluation and stereoscopic development test was launched in Minfeng Sag， following the mode of “overall deployment of a large platform and step-by-step implementation of a small well group.” Peak daily oil production exceeded one hundred tons in 28 wells， including Wells FYP1 and FY1-1HF ternary-element （storage， fracture， and pressure） storage and flow theory of shale oil in Jiyang Depression was proposed. The technologies of shale oil development， stereoscopic fine evaluation of development sweet spots， integrated modeling and numerical simulation， and stereoscopic development optimization were developed. A theoretical and technical system of stereoscopic development of shale oil in continental faulted basins with Shengli characteristics was initially constructed. It effectively supported the construction of the shale oil national demonstration area in Jiyang Depression， Shengli Oilfield.

Abstract Introduction In the current study, we screened for highly sensitive and specific predictors of premature birth, with the aim to establish an sPTB prediction model that is suitable for women in China and easy to operate and popularize, as well as to establish a sPTB prediction scoring system for early, intuitive, and effective assessment of premature birth risk. Methods A total of 685 pregnant women with a single pregnancy during the second trimester (16–26 weeks) were divided into premature and non-premature delivery groups based on their delivery outcomes. Clinical and ultrasound information were collected for both groups, and risk factors that could lead to sPTB in pregnant women were screened and analyzed using a cut-off value. A nomogram was developed to establish a prediction model and scoring system for sPTB. In addition, 119 pregnant women who met the inclusion criteria for the modeling cohort were included in the external validation of the model. The accuracy and consistency of the model were evaluated using the area under the receiver operating characteristic (ROC) and C-calibration curves. Results Multivariate logistic regression analysis showed a significant correlation (P

Against the background of the increasing separation of natural and human geography, gradual disintegration of the comprehensive disciplinary characteristics of geography, and weakening of the social influence of geographers, the domestic geography community has recently been discussing the possibility of integrating natural and human geography and the possible paths for doing so. In response, this study proposes an analysis framework of Ecological Economic Geography conducive to the integration of physical and human geography. Furthermore, this study advocates a focus on the dynamic change of "human" as a giant system with complex links of economy, technology, and institutional systems, and its two-way feedback relationship with the ecosystem. By exploring the coupling and regulation mechanisms of human and natural systems in the context of environmental and technological change, this study seeks the best answer to human sustainable development in the comprehensive balance. To clarify the research perspective and ideas of Ecological Economic Geography, we select the following three cases: i) the centennial evolution of the ecological economic system of Mulberry-dyke and Fish-pond System, ii) the systematic cascade of the "digital-energy-water" in data centers, and iii) the humanistic perspective of ecological restoration planning. With a focus on the analytical framework of the "pattern-process-relationship-pathway," this study proposes four research topics on which Ecological Economic Geography needs to focus, specifically, the coupling pattern of ecosystems and economic systems, process and impact of different factor flows between different systems, regional complexity of ecological and economic coupling systems, and sustainable development pathway of the ecological economic system. Accordingly, the development of Ecological Economic Geography may strengthen the mutual collaboration between scholars of the natural world and the humanities, promote the integration of geographic disciplines, and enhance the ability of geography to solve extensive problems.

Objective To effectively prevent lining damage and water leakage in tunnels, research is carried out on minimizing lining structure bending moment for tunnel cross-section in upper-soft lower-hard composite strata. Method Soft soil-hard soil and soil-rock two types of loading modes for composite strata tunnel lining structures are proposed based on composite strata tunnel surrounding rock pressure characteristics and reasonable assumptions. Following the ideal optimization approach for a zero bending moment composite strata tunnel, a semi-structural mechanics model of tunnel cross-section is established. The rational axis equation of the zero bending moment tunnel cross-section and the analytical expressions of diameters at both composite strata boundary lines and the horizontal tunnel cross-section mid-line are calculated. The process of minimizing bending moment in composite strata tunnel cross-section is outlined briefly. Result & Conclusion The rational axis of the zero bending moment cross-section in soft soil-hard soil tunnel is pear-shaped, while in soil-rock tunnel, it is horseshoe-shaped. In practical engineering, based on the rational axis equation of tunnel cross-section, key parameters for tunnel cross-section design can be determined through comprehensive evaluation and weighted averaging method. This approach enables the design of new tunnel cross-sections in upper-soft and lower-hard strata, aiming to minimize lateral deformation in composite strata tunnels.

SiCf/SiC composites were prepared by melt infiltration（MI）process，chemical vapor infiltration combined with precursor infiltration and pyrolysis（CVI+PIP）process and precursor infiltration and pyrolysis（PIP）process，respectively. The microstructures，compositions and properties of SiCf/SiC composites prepared by different processes before and after water-oxygen corrosion at 1300 ℃ were characterized by scanning electron microscopy and its accompanying EDS and X-ray diffractometer. The results show that the distributions of oxygen elements of the fracture surface is obviously different in the composites prepared by different processes，and the phases after corrosion are closely related to the preparation processes. The strength retention rate and modulus retention rate of SiCf/SiC composites prepared by MI process are 84% and 76% after water oxygen corrosion at 1300 ℃ for 50 hours. The strength retention rate of SiCf/SiC composites prepared by CVI+PIP is 64%，and the modulus is increased by 6%. The SiCf/SiC composites prepared by PIP process has a strength retention rate of 49% and a modulus increase of 17%. The composite materials prepared by MI process show oxidation mass gain，while the composite materials prepared by CVI+PIP and PIP process show oxidation mass loss，which are mainly related to its microstructures and compositions.

Study region: The three headwaters of Tarim river, south of the Xinjiang Province, China. Study focus: Temporal runoff concentration variations are crucial for water resources utilization and management, particularly in arid regions. In this study, the runoff concentration in the Tarim River Basin is studied based on analysis of the trend, abrupt changes, and periodicity, identifying key extreme climate indices influencing the Gini-runoff coefficient and predicting its future changes under three Shared Socioeconomic Pathways (SSPs). New hydrological insights for the region: From 1962–2020, the Gini-runoff coefficient decreased by 8.3 %, while annual runoff increased by 14.2 %. This is attributed to temperature changes, escalating hydrological risk uncertainty. The anomaly of low geopotential high fields and Central Asian anticyclones have caused an increase in total cloud cover (TCC) and precipitation, and a decrease in the Daily Temperature Range (DTR). Increasing of Warm nights (TN90), Maximum Tmax (TXx), and Hot nights (TR) have enhanced the warm-season runoff. However, the climatic impact on warm-season runoff is less pronounced than that in the cold season, which led to the runoff concentration decline. Changes in hydro-junction regulation led to decrease of Gini-runoff coefficient by 12.11 % from 2001 to 2020 along the Hotan river. Under the three SSP scenarios, the average Gini-runoff coefficient for the Aksu and Hotan rivers are expected to decrease by 3.3 % and 2.6 %, respectively.

The Internet plus nursing service program is being piloted in China, which has become a new home nursing service model led by nurses. To enable safe and effective homecare service delivery, nurses working in the program need a high level of competency. However, the content of these core competencies and the training needs of nurses for Internet plus nursing services are still unknown.

Objective To investigate the mechanism by which G protein-coupled estrogen receptor (GPER) reduces retinal neovascularisation in oxygen-induced retinopathy (OIR) in newborn mice. Methods A total of 42 newborn mice were randomly divided into normoxic control group (n=11), OIR group (n=11), G-1(GPER agonist) group (n=10), and solvent control group (n=10).On postnatal day 17(P17), the distribution of GPER in the retina of mice in the normoxic control group was observed by immunofluorescence staining on frozen sections of the eyeballs.The mice of the G-1 group and solvent control group were given by intraperitoneal injection 50 μg/(kg·d) G-1 or corn oil solvent from P12 to P15.Immunofluorescence staining of retinal spreads at P17 was performed to observe the expression of retinal vascular marker IB4 and astrocyte marker glia fibrilary acidic protein (GFAP).Western blotting was used to quantify the expression of retinal vascular endothelial growth factor A (VEGFA), GFAP, and inflammatory factors TNF-α, IGF-1, and IL1-β. Results GPER was present throughout the retina and co-stained with the astrocyte marker GFAP in the ganglion cell layer (GCL).Compared with the normoxic control group, the retinas of mice in the OIR group showed neovascular and avascular areas, and the expression of VEGFA and GFAP was significantly increased (P < 0.05).Compared with the solvent control group, the retinal neovascularisation was reduced in the G-1 group, and the expression levels of VEGFA, GFAP, TNF-α, IGF-1, and IL1-β proteins were decreased significantly (P < 0.05). Conclusion GPER inhibits astrocyte activity, reduces VEGFA expression and release of inflammatory factors, and then decreases retinal neovascularisation in OIR mice.

Magnesium alloy is widely used in the aerospace field due to its low density，high specific strength，high damping and good thermal conductivity. However，its low elastic modulus limits its reliable application in large thin-walled components. Aiming at the problem to improve the modulus properties of magnesium-based materials，this paper briefly introduces the main factors affecting the modulus of the alloy，compares the advantages，disadvantages and application scope of relevant calculation models such as equal stress-strain model，rule of mixture，Halpin-Tsai model and two-phase composite model，summarizes the current situation and progress of the research on the modulus properties of magnesium-based materials，and reviews the two major ways of modulus improvement of magnesium-based materials and the mechanism of performance improvement. Based on the integrated computational material engineering，the integrated development strategy of high-strength and high-modulus magnesium-based materials for atomic-lattice scale analogy high-modulus aluminum alloy development and machine learning assisted optimization experimental design is proposed.

The transmission of point cloud video streaming requires the scheduling of various computing and transmission resources. Existing research rarely considers the energy consumption issues caused by the computing tasks of terminal display devices. To solve this problem, a point cloud video streaming transmission scheme assisted by mobile edge computing (MEC) was proposed, which offloaded part of computing tasks to the MEC server based on the access bandwidth and point cloud video content. A joint optimization model was established in this scheme to maximize the quality of user’s viewing experience and minimize the energy consumption of terminal device under the constraints of network resources, terminal and edge computing resources. Experimental results show that the proposed scheme can improve the viewing quality of users and reduce the energy consumption of terminal equipment compared with the contrast scheme under different conditions.

[ Objective ] VQ proteins are plant-specific proteins with the conserved VQ motifs ( Fxxh- VQxhTG ), which play an important role in plant growth and development as well as in response to abiotic stresses. The role of the VQ gene family in litchi ( Litchi chinensis ) had not been systematically studied. We identified the LcVQ gene family members as well as their expression patterns in different tissues of ly- chee and their responses to abiotic stresses. This laid a foundation for studying its stress-resistant mecha- nism. [ Methods ] The sequences of LcVQ genes were obtained from the L . chinensis genome using bioin- formatics methods , and their physicochemical properties , subcellular localizations , gene structures , and conserved motifs were analyzed ; a phylogenetic tree was constructed using MEGA 6.0 to analyze the phy- logenetic relationships of the VQ proteins in L . chinensis , Arabidopsis , and Oryza sativa ; the responses to various abiotic stresses were verified by the quantitative real-time PCR ( qRT-PCR ) . [ Results ] A total of 18 LcVQ genes were identified from L . chinensis genome , named as LcVQ1 - 18 , which were clustered into 9 subgroups. They were widely distributed on 11 of 15 chromosomes of lychee. The amino acid num- bers of LcVQ proteins were ranged from 111 to 427 , and molecular weights from 12.48 kD to 45.49 kD. Subcellular localizations showed that except for LcVQ15 and LcVQ17 were localized at the cytoplasm , all other LcVQ proteins were localized at the nucleus. The LcVQ promoters contained a large number of growth and development , plant hormone , and stress-responsiveness related response elements. The LcVQ genes expression was varied at different tissues , which was divided into universal expression and specific expression. Under the treatment of low temperature , high temperature , drought , and salt stress , we found that 4 , 3 , 3 , and 4 LcVQ genes were significantly up-regulated at 3 hours of treatment , respective- ly , indicating that these genes could respond to the abiotic stresses. [ Conclusion ] There are 18 VQ mem- bers in the L . chinensis genome with typical VQ binding domains and participate in different stress re- sponses.

In order to understand the quality of local sorghum in Chongqing and provide theoretical and applied guidance for the development of local sorghum industry, 12 main sorghum varieties in Chongqing were collected in the experiment. The physical and chemical components of the two main sorghum varieties in the northeast and northwest were measured and analyzed by principal component analysis, and their components and uses were correlated. At the same time, the digestibility of sorghum starch was determined to screen out the anti-digestible sorghum varieties. The results showed that there were significant differences in the physical and chemical properties of 16 sorghum varieties (P

Three-cycle minimum surface structures show excellent lightweight and energy absorption capabilities, and additive manufacturing techniques provide a unique degree of freedom for lattice structure design. Therefore, in this study, three-period minimum surface (TPMS) structures of Schwarz-P boron steel alloys were prepared by Selective Laser Melting (SLM) technique. By investigating the effect of lattice structure design, we have analyzed the deformation behavior, mechanical properties and energy absorption capacity under compression. In addition, tensile properties and fracture morphology were analyzed to gain insight into the performance characteristics of these structures, and the effect of structural design on hardness was explored. The results of the study show that the structural design has a small effect on the microstructure and hardness. Under compressive loading, the P (0.5 1) structure exhibits a uniform deformation behavior, while the other four structures show a crushing deformation pattern. In particular, the P (0.5 1) structure exhibits excellent compressive performance, with an energy absorption work per unit mass as high as 296.2 J/mm^3, and its stiffness reaches 1627 MPa. Meanwhile, the P (0.35 1) structure exhibits excellent tensile performance with the tensile strength of 687 MPa. The morphological analysis of the tensile fracture reveals that the fracture mainly occurs in the strut nodes, and it mainly exhibits ductile tensile fracture.

ObjectiveTo analyze the correlation between preoperative hypoproteinemia and the risk of perioperative allogeneic erythrocyte transfusion in ovarian cancer patients undergoing cytoreductive surgery.MethodsOvarian cancer patients who underwent cytoreductive surgery at Peking Union Medical College Hospital from January 2014 to December 2018 were retrospectively included. Clinical data such as the patients' general information, preoperative plasma albumin, American Society of Anesthesiologists(ASA) classification, intraoperative bleeding volume, operation time, perioperative (intraoperative and within 3 d postoperatively)allogeneic red blood cell transfusion were collected, and the correlation between preoperative hypoproteinemia (plasma albumin < 35 g/L) and the risk of allogeneic red blood cell infusion was analyzed by using multivariate Logistic regression.ResultsA total of 1001 ovarian cancer patients who met the inclusion and exclusion criteria were enrolled, of which 64 (6.4%) had preoperative hypoproteinemia and 481(48.1%) received perioperative allogeneic red blood cell transfusion. The rate of perioperative allogeneic red blood cell transfusion was higher in the patients with hypoproteinemia than in those without hypoproteinemia [84.4% (54/64) vs. 45.6% (427/937), P < 0.001]. Multivariate Logistic regression analysis corrected for confounders such as ASA classification, intraoperative bleeding volume, and operative time found that preoperative hypoproteinemia was significantly associated with the risk of perioperative allogeneic red blood cell transfusion (OR=5.68, 95% CI: 2.56-13.57, P < 0.001).ConclusionPreoperative hypoalbuminemia could be associated with the increased risk of perioperative transfusion in patients undergoing cytoreductive surgery for ovarian cancer.

Objective To investigate the value of the magnetic resonance neurography three-dimensional sampling perfection with application optimized contrasts by using different flip angle evolution (3D-SPACE) in displaying the neoplasms of the lumbosacral plexus. Methods MRI 3D-SPACE images of 16 cases with neoplasm in the lumbosacral plexus collected during January 2018 to December 2023 were retrospectively analyzed. All cases were confirmed by pathology. The maximum diameter of the tumors was measured and the number of lesions was counted. The location of the involved lumbosacral plexus was observed and the number of the involved nerves was counted. The relationship between the tumors and nerves was evaluated. Results Ten cases were of single lesion and 6 cases were of multiple lesions. The average maximum diameter of tumors was （57.1±37.2）mm. Single nerve involved was detected in 5 cases while multiple nerves involved were in 11 cases. The relationship between the tumor and nerve was divided into three types. The tumor grew along the nerve in 5 cases. The nerves were compressed by the tumors in 5 cases, and were invaded and surrounded in 6 cases. Conclusions MRI 3D-SPACE can reveal the location and numbers of the tumor, displaying the relationship between the tumor and nerve clearly and intuitively, which is important for localization and diagnosis of the neoplastm in the lumbosacral plexus.

Objective The northern margin fault zone of the Qaidam Basin is a regional active fault zone in the northern part of the Qinghai-Tibet Plateau, forming the boundary fault of the northern Qaidam Basin and the Qilian Mountains. Studying its late Quaternary paleoseismic activity is of great significance for understanding the seismic recurrence cycle and seismic hazard of the northern margin fault zone of the Qaidam Basin. Methods Through geological survey, remote sensing interpretation, trench excavation, OSL geological dating, and analysis of paleoseismic events, the paleoseismic events of the northern margin fault of the Qaidam Basin (Xitieshan-Amunikeshan section) were studied. Conclusion The study reveals that the trench profiles exposed five relatively reliable paleoseismic events, with occurrence times of approximately 60 years ago for Event E1, 3.1±0.3 to 3.4±0.3 ka for Event E2, 7.5±0.3 to 8.1±0.3 ka for Event E3, 10.1±0.4 to 11.4±0.4 ka for Event E4, and 12.1±0.4 to 12.8±0.4 ka for Event E5. Using the paleoseismic incremental limiting method, the seismic recurrence cycle of the northern margin fault of the Qaidam Basin (Xitieshan-Amunikeshan section) is estimated to be 2.6 to 3.4 ka. The most recent event departure time for the Amunikeshan section is 60 years ago, and for the Xitieshan section, it is 3.1±0.3 ka, suggesting a higher likelihood of destructive earthquakes in the future for the Xitieshan section compared to the Amunikeshan section of the northern margin fault of the Qaidam Basin. Significance This result can provide a better understanding of the paleoseismic events, recurrence intervals, and other aspects of the northern margin fault of the Qaidam Basin, which has guiding significance for seismic forecasting, prediction, and evaluation of future seismic hazards of this fault.

Cooling water accounts for the majority of water usage in power plants. With the aggravation of water scarce all over the world, adaptive actions to optimize cooling system and improve water efficiency of cooling process are required. This review aims to provide a comprehensive insight of the issues involving water saving of cooling system for power plants. Limitation of current cooling technologies were firstly discussed. Then some retrofits and optimization of system designs that could significantly help to reduce water and energy consumption in power plant were presented. The possibity, complexities and challenges of some non-traditional water supplies such as reclaimed water and seawater recirculating cooling for power plant applications were introduced. The key technologies of water treatment and monitoring for water quality control were also illustrated and the water-saving effect brought by advanced technology was introduced. Finally, opportunities and challenges of management for cooling system were suggested.

Inflammatory bowel disease (IBD) is a debilitating condition that can lead to life-threatening complications. Macrophages are crucial in IBD management because they secrete various cytokines and regulate tissue repair. Macrophage-derived angiogenin (ANG) has been shown to be essential for limiting colonic inflammation, but its upstream regulatory pathway and role in macrophages remain unclear. Here we show that ANG expression is up-regulated in macrophages during colitis treatment or upon lipopolysaccharides (LPS) treatment. Mechanistically, LPS activates Toll-like receptor 4 (TLR4) to initiate NF-κB translocation from the cytoplasm to the nucleus, where it binds to the ANG promoter and enhances its transcriptional activity, leading to increased ANG expression. Interestingly, our data also reveal that the deletion of ANG in macrophages has no adverse effect on key macrophage functions, such as phagocytosis, chemotaxis, and cell survival. Our findings establish a “LPS-TLR4-NF-κB-ANG” regulatory axis in inflammatory disorders and confirm that ANG controls inflammation in a paracrine manner, highlighting the importance of ANG as a key mediator in the complex network of inflammatory processes.

Electromagnetic interference (EMI) shielding rubber effectively fills gaps in electronic devices to prevent electromagnetic (EM) leakage. However, research on the potential application of EMI shielding rubber in the field of space is limited. This study explores the optimal amount of silver-coated aluminum powder (SCA) in SCA/ methyl vinyl silicone rubber (MVQ) composites to balance the electrical and mechanical properties of EMI shielding rubber. The EMI shielding effectiveness (SE) of 41.8 vol% SCA/MVQ composite exceeded 90 dB in the frequency range between 100 and 1,200 MHz with a compression set of only 14%. To address the outgassing characteristics of silicone rubber in a vacuum environment, both pre-heating and post-heating treatments for reducing rubber volatility are explored, proving that silicone rubber followed by 4 h of post-heating treatment at 200°C, is an appropriate solution to reduce silicone rubber volatility, leading to the SCA/MVQ composite with a total mass loss of only 0.2%, and a collected volatile condensable material of only 0.02%. In addition, high reliability is crucial for EMI shielding materials. SCA/MVQ composite exhibits excellent adaptability to vacuum temperature cycles, with the EMI SE maintained at 90 dB after cycles. At room temperature, after 30 days of storage, the EMI SE of the composite remains at 90 dB. These findings indicate that SCA/MVQ composites exhibit broad potential applications in the field of EM sealing for aerospace electronic devices.

Secondary prevention of skin cancer consists in early detection of malignant lesions through patients’ mole self-examination and medical examination. The objective of this study was to assess the self-reported frequency of mole examination in a large, representative sample of the adult general population of 17 countries from all continents. Of a total of 17,001 participants, 4.8% had their moles checked by a dermatologist more than once a year, 11.3% once a year, 8.4% every 2–3 years, 12.4% once in a while, 10.3% once in lifetime, and 52.6% of participants had never performed a mole examination. Egypt was the country with the highest prevalence of people who performed a moles check more than once a year (15.9%), followed by Brazil and the USA. A higher frequency of mole checks was associated with sex (man vs woman), higher education, higher income, fair phototype, history of skin cancer, medical insurance, and sun-protective behaviours. Despite recommendations by health providers, it appears that the frequency of mole checks in the general population is still low. It is necessary for dermatologists to keep informing at-risk populations about the importance of moles check, with particular care regarding categories that less frequently adhere to secondary prevention measures.

Objective To analyze relationship between autonomic nervous function and cognitive function in elderly patients with Parkinson's disease (PD). Methods A total of 130 elderly patients with PD admitted to The Affiliated Brain Hospital of Nanjing Medical University from January 2020 to December 2022 were included. Hoehn‑Yahr staging was used to evaluate stage of the disease, Unified Parkinson's Disease Rating Scale Ⅲ (UPDRS Ⅲ) was used to evaluate the severity of motor disorders, Scales for Outcomes in Parkinson's Disease ‑ Autonomic (SCOPA ‑ AUT) was used to evaluate autonomic nervous function, Mini‑Mental State Examination (MMSE) and Montreal Cognitive Assessment (MoCA) were used to evaluate cognitive function, Non‑Μotor Symptoms Scale (NMSS) was used to evaluate the severity of nonmotor symptoms. Results According to whether the patients were accompanied by Alzheimer's disease (AD), they were divided into a group with AD (n = 82) and a group without AD (n = 48). The proportion of Hoehn‑Yahr staging 3 to 5 (χ2 = 5.689, P = 0.017), UPDRSⅢ score (t = 21.490, P = 0.000), SCOPA‑AUT score (t = 21.330, P = 0.000), dysregulation of body temperature (χ2 = 8.512, P = 0.004), urinary dysfunction (χ2 = 17.270, P = 0.000), gastrointestinal dysfunction (χ2 = 24.471, P = 0.000), dysregulation of pupil (χ2 = 5.299, P = 0.021), cardiovascular dysfunction (χ2 = 15.355, P = 0.000) and NMSS score (t = 32.309, P = 0.000) in the group with AD were higher than those in the group without AD, the MMSE (t = 4.730, P = 0.000) and MoCA (t = 6.840, P = 0.000) total scores and subtype scores (P = 0.000, for all) in the group with AD were lower than those in the group without AD. Correlation analysis showed that the SCOPA‑AUT score of PD patients with AD was negatively correlated with MMSE and MoCA total scores and subtype scores (P = 0.000, for all). Conclusions The autonomic dysfunction of elderly PD patients with AD is more serious, and the autonomic nervous function is closely related to cognitive function.

The exothermic behaviors of butanol, butyraldehyde, butanone, and butyric acid with nitric acid were studied by adiabatic accelerating rate calorimeter(ARC), and the test results were compared and analyzed, and the system risk was evaluated by THI index method. The results show that under the condition of the zero oxygen balance, butyraldehyde-HNO3 system has the most obvious self-exothermic. When the butyraldehyde content is only 0.14 g, the adiabatic temperature of the system rises to 118.4 ℃ and the heat release amount is 776.6 J/g; butanol-HNO3 system begins to emit heat at about 40.2 ℃, and the highest temperature in the exothermic stage of self-reaction reaches 145.7 ℃ and the maximum pressure reaches about 34 bar(1 bar=105 Pa). Butanone-HNO3 system releases heat from 50 ℃ to 136 ℃, and the amount of heat released is 564.0 J/g. No exothermic point is observed in butyric acid-HNO3 system in the temperature range of less than 140.0 ℃. With the increase of nitric acid concentration(2.0→6.0 mol/L), the risk of butanol-HNO3 system increases from medium to high level. The risks of reaction systems of butanol, butyraldehyde, butanone and butyric acid with 4.0 mol/L HNO3 are at higher, higher, middle and middle levels.

Nickel-based superalloy is an essential material to prepare hot-end components in aero-engines and gas turbines，due to its excellent mechanical properties under high temperature. Additive manufacturing（AM） is one of the most important techniques to fabricate superalloy components with complex geometry. In this paper，the research progress of microstructure and defects of AMed superalloy is reviewed. Based on the existing literature，tensile properties of GH3536，GH3625 and GH4169 are summarized. Typical applications of AMed superalloy components in aero-engines and gas turbines are presented. Finally，for the problems in existing investigations，it is suggested that the future research can focus on materials design，heat treatment/hot isostatic pressure process optimization，single crystal preparation，real-time monitoring technique development and internal surface treatment technique innovation.

Background and Purpose: Accurate differentiation of pancreatic ductal adenocarcinoma (PDAC) from mass-forming chronic pancreatitis (MFCP) is clinically significant. The application of dual-layer spectral detector CT (DLCT) in pancreas has been explored. This study aimed to investigate the value of DLCT in distinguishing resectable PDAC from MFCP. Methods: We retrospectively collected data of 33 patients with resectable PDAC and 19 patients with MFCP admitted to Fudan University Shanghai Cancer Center from September 1, 2021 to May 31, 2023. Prior to surgery, patients underwent enhanced DLCT scans, including arterial phase (AP), parenchymal phase (PP) and venous phase (VP). DLCT quantitative parameters, including attenuation enhancement fraction (AEF), lesion-to-parenchyma ratio (LPR) and iodine enhancement fraction (IEF) were calculated. Difference analysis was conducted using independent sample t-test or chi-square test. Univariate and multivariate analyses were performed using binary logistic regression. Receiver operating characteristic (ROC) curves were used for performance evaluation. P

Black phosphorus (BP) has garnered significant interest in the field of biomedicine because of its exceptional degradability. The oxidation product of BP phosphate has been utilized in numerous studies for the purpose of repairing bone defects and inducing apoptosis and autophagy in cancer cells. Nevertheless, this process has drawbacks in terms of low yield and a slow rate of phosphate production. In this study, we found that the oxidation rate of BP was increased 120-fold and the yield proportion of phosphate BP product was increased from 30% to 85% with the presence of less than 0.1% copper ions (Cu2+) in the reaction system. The enhancement was attributed to the fact that the presence of Cu2+ promoted the bonding of oxygen on the BP surface and then the desorption of phosphate molecules from the BP surface. This study offers a novel perspective on the process of BP oxidation and introduces innovative concepts for the development of biological drug delivery systems capable of rapid decomposition.

【Objective】 This study delves into the mechanisms underlying the damage and failure of concrete linings in hydraulic channels in cold regions in Northern China that are prone to freeze-thaw, wind and sand erosion. 【Method】 We prepared concrete samples, in line with canal system engineering standards, using solid waste fly ash and silicon powder sourced from Inner Mongolia. Our investigation focused on the freeze-thaw-wind-sand erosion of the concrete lining when it is laid in different directions and the consequential impact on its service life. 【Result】 ①Wind-sand erosion exacerbates freeze-thaw damage in the concrete lining within. The extent of slurry erosion on the channel concrete surface intensifies with the increase in erosion angle. The most severe surface damage occurs when the wind-sand erosion angle was 90°, accelerating surface slurry shedding and internal damage, which is twice as severe as when the angle was 30°. ②The degradation of the eroded surface showed a distinctive fractal pattern. The combined effects of freeze-thaw-wind-sand erosion initiated small pores which then propagated to larger pores. ③Based on material decay and grey theory, we proposed an GM (1,1) grey model to predict the relative dynamic elastic modulus and a model to predict of serve life of the concrete under cycled freeze-thaw erosion under various wind-sand erosion angles. 【Conclusion】 The service life of the hydraulic concrete lining diminishes as the wind-sand erosion angle increases, with a substantial reduction to 25.83 years when exposed to 90° wind-sand erosion.

Ginseng and American ginseng need to be covered and protected against cold in winter to survive, and covering and uncovering date has great influences on safe overwintering and seedling emergence. To determine the optimal time, field experiments are conducted at Fusong of Jilin Province from November 2021 to June 2022. Effects of different covering dates on the soil temperature in the overwintering layer and seedling emergence rate of ginseng and American ginseng are studied through different experiment themes. For some cases they are covered in stages in early winter and simultaneously uncovered in spring, and there are also other cases when the ginseng and American ginseng are covered simultaneously in early winter and uncovered step by step in spring. Results show that the emergence rate of ginseng and American ginseng decreases with the delay of coverage date. When 5 cm soil temperature is 0℃, the coverage date for cold prevention is the best, with the highest emergence rate of ginseng and American ginseng. Below -12℃, most or all of American ginseng is frozen to death. When the instantaneous 5 cm soil temperature drops to -14℃, the emergence rate of ginseng still reaches 75%. The emergence rate of ginseng seedlings in other treatments above this temperature coverage is mostly over 86%. When the soil temperature is -7℃ or above, the emergence rate of ginseng seedlings is above 97%. The emergence rate of ginseng seedlings covered by snow is 91%. The soil temperature fluctuates between -14℃ and -8℃, and all uncovered ginseng with an extreme minimum of -16℃ is frozen to death. When ginseng seedlings emerge, the soil temperature of 5-20 cm is around 8-9℃, slightly higher than that of American ginseng. Covering with high insulation fibers to prevent cold, the later the cover is removed, the lower the soil temperature becomes, and the later the seedlings emerge. The date of uncovering affects the progress of seedling emergence, but has little correlation with the emergence rate. The optimal date of uncovering needs to be analyzed further. On frost prone areas in early spring, combined with climate prediction, the emergence progress can be adjusted by uncovering date to avoid spring freezing damage.

Advanced differentiated thyroid carcinoma (ADTC) lacks effective treatment options, and has a poor prognosis, which is an urgent clinical problem to be resolved. Targeted multikinase inhibitor(MKI) has been approved for the treatment of radioiodine refractory differentiated thyroid carcinoma, and have recently been recommended as a preoperative neoadjuvant therapy agents for locally ADTC. Although radioiodine therapy is the standard postoperative treatment for ADTC, it has certain limitations. MKI combined with radioiodine therapy is expected to become a new strategy of treatment for ADTC.

This paper summarized the palliative care practice for a patient diagnosed with malignant melanoma and schizophrenia. The patient had developed exfoliative dermatitis after receiving envolizumab treatment for malignant melanoma. The palliative care practice mainly included controlling the symptoms of exfoliative-induced dermatitis to improve comfort, finding psychological problems and mental disorders and then giving timely intervention, improving the strength of social support, paying attention to patients' spiritual needs and providing spiritual comfort, etc. According to the changes of the patient at different stages of illness, personalized palliative care program was formulated to help patient effectively control symptoms, relieve pain, increase comfort, provide care from physical, psychological, social and spiritual aspects, and improve the quality of life. (总结1例恶性黑色素瘤合并精神分裂症患者使用恩沃利单抗导致剥脱性皮炎的安宁疗护实践过程, 主要包括控制剥脱性皮炎症状, 提高舒适度; 发现心理问题及精神障碍, 及时给予干预; 充分发挥社会支持系统作用, 提高社会支持力度; 关注患者精神需求, 给予精神慰藉等方面。针对患者病情不同阶段的变化, 制定个性化的安宁疗护方案, 帮助患者有效控制症状、缓解痛苦、增加舒适度, 从身体、心理、社会、精神等提供全人照护, 提高生命质量。)

Abstract Pulmonary fibrosis (PF) is a severe chronic interstitial lung disease with high mortality, and there is currently a lack of definite and effective treatment methods. Studies have found that gentiopicroside, a secoiridoid glycoside compound derived from plants of the Gentiana genus, can significantly improve pulmonary inflammation and fibrosis lesions in mice with pulmonary fibrosis. However, the mechanism of its anti-fibrotic effect is unclear. Therefore, in this study, we employed network pharmacology's virtual computer technology to investigate the potential mechanism underlying the anti-pulmonary fibrosis effect of Gentianae Radix et Rhizome (Longdan in Chinese, GRR). Our findings offer valuable theoretical insights and serve as a guiding reference for future experimental investigations. A total of 10 active compounds and 920 drug-target proteins were identified from the TCMSP database. The compound-target-pathway-disease network showed that GRR could potentially treat PF by regulating the MDM2, ERBB2 and VEGFA, signaling pathways through its key targets, including AKT1, TNF, and MAPK1. The protein‒protein interaction network revealed that these targets had strong interactions with each other, indicating a potential synergistic effect of GRR in treating PF. The GO and KEGG enrichment analyses further supported the potential anti-pulmonary fibrosis mechanisms of GRR, including regulating the inflammatory response, ECM-receptor interaction, and TGF-beta signaling pathways. Our study provides a systematic analysis of the potential anti-pulmonary fibrosis mechanisms of GRR based on network pharmacology. These findings could contribute to the development of novel treatments for PF and provide a basis for further experimental studies.

[Objective] The spatial-temporal variation of terrestrial vegetation coverage in Lugu Lake Wetland Nature Reserve in Sichuan Province during 2000—2020 was analyzed in order to provide a reference for the construction and management of the reserve. [Methods] MODIS data from June to September of 2000—2020 for the Lugu Lake Wetland Nature Reserve in Sichuan Province was the data source. Correlation analysis methods such as pixel dichotomy and Theil-SenMedian trend analysis were combined to determine the spatial-temporal variation characteristics of vegetation coverage and their response to climate. [Results] ① The overall terrestrial vegetation coverage of Lugu Lake Wetland Nature Reserve in Sichuan Province slightly increased from 2000 to 2020, and increased at a rate of 0.09/10 yr. ② Vegetation coverage of the protected area was low in the lake area and the surrounding areas, and higher in the north and south areas. The spatial variation of vegetation coverage of the protected area increased overall but decreased locally. ③ The climate of the reserve (from June to September) tended to be “warmer and drier”, and fractional vegetation coverage was mainly positively correlated with temperature and precipitation. The influence of temperature was greater than that of precipitation. The specific influencing factors had spatial differences. [Conclusion] From 2000 to 2020, the vegetation coverage of the Lugu Lake Wetland Nature Reserve in Sichuan Province was good, and the vegetation coverage slightly increased over time. Temperature was the main climate factor affecting vegetation coverage. Topography and human activities, meanwhile, had some effects on the vegetation coverage of the reserve to a certain extent.

A large number of power electronic devices and nonlinear loads are connected to the coal mine power grid, causing a large amount of current harmonics and reactive power in the coal mine power grid. It seriously endangers the power quality of the coal mine power grid. The traditional coal mine power quality control strategies mostly use proportional integral (PI) regulators to control static synchronous compensator (STATCOM) to achieve harmonic suppression and reactive power compensation. But their parameters are difficult to adjust and their dynamic response is slow. In order to solve the above problems, a STATCOM control strategy based on modulated model predictive control (M2PC) is proposed. Firstly, the ip-iq method is used to detect the harmonic current and reactive current in the power grid as the reference current for M2PC. Secondly, based on the reference current and STATCOM mathematical model, the duty cycle and sector cost function of the two effective vectors and zero vectors for each sector is calculated. Thirdly, by minimizing the cost function, the optimal sector and the duty cycle of the two optimal effective vectors and zero vectors corresponding to that sector are obtained. Finally, according to the space vector modulation (SVM) method, switching pulses are allocated to achieve a fixed switching frequency. It thereby controls STATCOM to emit compensation current to offset harmonic and reactive currents in the power grid. The simulation and experimental results show that before the adopting of M2PC based STATCOM, the grid side current distortion is severe, the reactive power fluctuation on the grid side is large. The power factor on the grid side fluctuates and is less than 1. After the adopting of M2PC based STATCOM, the total harmonic distortion rate (THD) of the grid side current is significantly reduced due to STATCOM compensating for the harmonic current on the grid side. Moreover, due to STATCOM compensating for the required reactive power of the load, the reactive power on the grid side remains basically 0. The power factor on the grid side remains stable at 1, effectively improving power quality.

The deformation of open-pit mine slopes is influenced by various factors such as geological structure, hydrogeological conditions, mining activities, etc., making the prediction model complex. It is difficult to accurately capture all influencing factors. At present, a large number of monitoring devices are deployed around the slope of open-pit mines to record real-time displacement data of open-pit mine slopes. The data has the features of high-dimensional, temporal correlation, and nonlinear. Traditional slope stability analysis methods cannot effectively predict slope deformation without knowing other conditions and only data, it is necessary to use a data-based model to predict the displacement data of open-pit mine slopes in advance for slope stability analysis. In order to solve the above problems, a deformation prediction model for open-pit mine slopes based on the golden jackal optimized multilayer perception machine (GJO-MLP) is proposed. Each agent in GJO is independent of each other and can accelerate the training process of optimizing MLP through parallel computing. GJO can combine the nonlinear modeling and feature extraction capabilities of MLP, making the optimized MLP more advantageous in dealing with complex problems. To test the feasibility and effectiveness of GJO-MLP, GJO-MLP is compared and analyzed with ant colony algorithm optimization based MLP (ACO-MLP), gravity search algorithm optimization based MLP (GSA-MLP), and differential evolution algorithm optimization based MLP (DE-MLP). The simulation results on six datasets show that under the same experimental conditions, GJO-MLP shows better optimization performance compared to the other three algorithms. The slope deformation prediction model based on GJO-MLP is applied to the slope deformation prediction of Baorixile open-pit mine and Huapingzi slope deformation prediction. The results show that under the same conditions, compared to the other three algorithms, the slope deformation prediction model based on GJO-MLP not only show better predictive performance in predicting slope deformation data, but also has better feasibility and robustness.

Accident tolerant fuel can improve the safety of nuclear reactor core and strengthen the ability of nuclear reactor to withstand serious accidents. Coated particle dispersed fuel has become a hot research topic in accident tolerant fuel in recent years, due to its high thermal conductivity and good radiation resistance stability. Coated particle dispersed fuel consists of threedimensional isotropic coated particles as the fuel phase and silicon carbide as the matrix phase, adopting the fuel form of coated particle dispersed in the silicon carbide matrix. However, due to the low selfdiffusion rate of SiC, it is difficult to achieve high densification by solid phase sintering, which is only controlled by diffusion. The existing sintering process mainly involves adding sintering aids or generating liquid glass phase to assist in the sintering of SiC powder. Spark plasma sintering (SPS) process can activate powder particles and promote sintering, and has been widely used in nuclear ceramic sintering in recent years. This article used SPS to prepare coated particle dispersed fuel pellets, and studied the influence of sintering process parameters on the density of the coated particle dispersed fuel pellets, such as the amount of sintering additive addition, maximum sintering temperature, maximum sintering pressure, and holding time. It is found that the best process parameters for SPS sintering of coated particle dispersed fuel pellet is 7% of sintering additive addition, holding 15 minutes at 1 850 ℃ and 45 MPa. Under such process parameter, the relative density of pellet can reach 98.5% of theoretical density. In addition, the sintering mechanism of coated particle dispersed fuel was studied and it is found that the sintering of coated particle dispersed fuel can be divided into five stages. Phase detection, metallographic detection and microstructure characterization analysis of the coated particle dispersed fuel pellets were carried out. The XRD examination results indicate that after sintering, the coated particle dispersed fuel pellet is pure β phase, which indicate that SPS rapid sintering can better control the phase transition. The metallographic examination results indicate that there is no obvious contact between TRISO particles in the coated particle dispersed fuel pellet obtained under the optimal process conditions. The SEM examination results show that the overall integrity of TRISO particles is good, indicating that the structure of TRISO particles dose not break during the sintering process. In the thermal shock test, there are no penetrating micro-cracks on the surface of the fuel pellet after a thermal shock, which maintain good integrity.

Optimizing insulation technique plays a vital role in developing high performance magnetic powder core. Uniform dense titanium dioxide insulation layer was successfully coated on atomized Fe-Si-Al powder through hydrolysis of tetrabutyl titanate and the effect of water content on insulation quality was systematically investigated. The influences of titanium oxide insulation layer on electromagnetic properties of corresponding powder cores were also discussed. The results show that when the mass of water is increased from 10% to 40% of Fe-Si-Al powder, the insulation layer on particle surface first grows thicker and then becomes loose. High water content favors quick hydrolysis and condensation, while too large volumes of water leads to excessively high hydrolysis rate, which is adverse to the uniform growth and crystallization of titanium dioxide insulation layer. It is proven that uniform and dense insulation layer would contribute to the increase of resistivity under the premise of high density of powder core, which is conducive to the suppression of eddy current and frequency stability of permeability. When the mass of water is 20% of Fe-Si-Al powder, the prepared corresponding powder core has the optimal overall performance, the permeability is as high as 82, the resistivity is up to 1022.35 kΩ·cm and the core loss is as low as 77.63 mW/cm3 (at 100 kHz and 50 mT).

Abstract Background Panax ginseng cultivated under the forest is popular because its shape and effective ingredients are similar to wild ginseng. The growth of P. ginseng in the larch forest is generally better than in the broad-leaved forest, and the incidence rate of diseases is low. Therefore, the selection of forest species is one of the basic factors in the successful cropping of P. ginseng. Methods Illumina HiSeq high-throughput sequencing was used to analyze the 16S rRNA/ITS gene sequence of P. ginseng rhizosphere soil under larch forest to study the rhizosphere microbiome's diversity and community composition structure. Results The species classification and richness of rhizosphere bacterial and fungal communities in the same-aged P. ginseng were similar. Consistent with the soil system of commonly cultivated crops, Proteobacteria, Actinobacteriota, Acidobacteriota, Verrucomicrobiota, Chloroflexi, and Basidiomycota, Ascomycota were the dominant phylum of bacteria and fungi, respectively. Compared with the soil without planting P. ginseng, the diversity of microorganisms and community structure of continuous planting for 2 years, 5 years, and 18 years of P. ginseng rhizosphere soil had little change. The accumulation levels of Ilyonectria, Fusarium, Gibberella, and Cylindrocarpon were not significantly increased with planting P. ginseng and the increased age of cropping P. ginseng. Conclusions The results of this study showed that the soil function of the larch forest was good, which provided a theoretical basis for the land selection and soil improvement of cultivating P. ginseng under the larch forest.

Gridding method and black box method were used to acquire and analyze real-time monitoring of moisture content in heat-drying sludge. The properties and calculation methods of hot and humid air in heat-drying system were discussed to study the relationship of moisture discharge rate, drying time and sludge moisture content in the return air inlet. The latest honey badger algorithm (HBA) was tried and introduced to optimize the support vector machine (SVM). HBA-SVM regression model was established, and then compared with the regression model of SVM optimized by particle swarm optimization (PSO) and genetic algorithm (GA). Results showed that the return air inlet moisture discharge rate and sludge moisture content were non-linearly reduced with drying time, and the reduction rate of moisture discharge was slightly higher than that of moisture content. The coefficient of determination (R^2) and root mean square error (RMSE) of HBA-SVM were 0.996 5 and 0.979 2, respectively, and lower dispersion and higher accuracy were achieved. By transplanting the model into the embedded system and verified by site testing, the comprehensive prediction accuracy reached more than 90%. It is concluded that the low dispersion of the prediction value and high prediction accuracy are obtained by applying the HBA-SVM regression model, which is an effective method that can be used to monitor the actual sludge moisture content.

ObjectiveTo observe the effect of electroacupuncture (EA) prestimulation with mental tri-needles on the inflammatory response of hippocampus in aged rats with perioperative neurocognitive disorders (PND).MethodsA total of 24 aged male SD rats were randomly divided into control group, anesthesia group, operation group and acupuncture group, with 6 cases in each group. The acupuncture group received EA prestimulation with mental tri-needles, and the other groups didn't receive any intervention. The aged PND rat model was established by intramedullary nailing surgery for femoral neck fracture in the operation group and the acupuncture group. Open field experiment and water maze test were used to evaluate the cognitive function; ELISA method was used to detect interleukin (IL)-1β, IL-6 and tumor necrosis factor (TNF)-α in the plasma; HE staining was used to observe the cell morphology of hippocampal tissue; TUNEL staining was used to observe the apoptosis of hippocampal tissue; Western blot and real-time fluorescence quantitative PCR were used to detect the protein content and mRNA expression of IL-1β, IL-6 and TNF-α in hippocampal tissue.Results(1) Cognitive function: compared with the control group and the anesthesia group, the time of staying in the central quadrant, the number of crossings of the quadrant, the number of standing ups, the total distance of swimming, the swimming speed and the number of platform crossings in the operation group significantly decreased, and the latency and the time of staying in the target quadrant were significantly prolonged (PPPPPPPPP

[Obiective] The spatial distribution pattern of waterfowl ecological corridors in Dongguan City, Guangdong Province were studied in order to provide a realistic basis for its ecological restoration. [Methods] We considered waterfowl as the key species of Dongguan City. The research was carried out by using the minimal cumulative resistance (MCR) model , the centrality principle of habitat and connection, and the circuit theory based on water data and resistance surface composition data of Dongguan City. [Results] A total of 26 ecological corridors with a total length of 259.91 km were constructed in Dongguan City, of which six, fifteen, and five were important, more important and generally important ecological corridors respectively, and the important and general ecological corridors were centrally distributed, while the more important ecological corridors were dispersed. The spatial locations of the key obstacles were characterized as areas with serious anthropogenic disturbances. [Conclusion] In the perspective of spatial layout of ecological corridors, the main purpose is to optimize the urban background conditions and maintain the balance of the entire urban ecological space. In the perspective of corridor connectivity enhancement, it is suggested to give full play to the self-generated ecological function of the corridor as a guide to ensure the continuity of the overall corridor network space. In terms of restoration of obstacles, the intensity of human activities should be reduced to alleviate the obstruction of waterbirds passing through the corridor.