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Your search keyword '"Livia C. Liporagi-Lopes"' showing total 4 results
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4 results on '"Livia C. Liporagi-Lopes"'

1. Corrigendum: Home-based exercise program in the indeterminate form of Chagas disease (PEDI-CHAGAS study): a study protocol for a randomized clinical trial

Author

Mauro F. F. Mediano, Leonardo G. Ribeiro, Rudson S. Silva, Isis G. G. Xavier, Marcelo C. Vieira, Tatiana R. Gonçalves, Vitor B. Paravidino, Juliana P. Borges, Luiz Fernando Rodrigues Junior, Henrique S. Costa, Michel S. Reis, Livia C. Liporagi-Lopes, Pablo Martinez-Amezcua, Paula S. Silva, Gilberto M. Sperandio Da Silva, Andrea S. Sousa, Marcelo T. Holanda, Henrique H. Veloso, Fernanda M. Carneiro, Flavia Mazzoli-Rocha, Andrea R. Costa, Roberto M. Saraiva, Fernanda S. N. S. Mendes, Luiz Henrique C. Sangenis, and Alejandro M. Hasslocher-Moreno

Subjects
physical activity, exercise training, mental health, fitness, chagas disease, quality of life, Medicine (General), R5-920
Published
2023
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2. Home-based exercise program in the indeterminate form of Chagas disease (PEDI-CHAGAS study): A study protocol for a randomized clinical trial

Author

Mauro F. F. Mediano, Leonardo G. Ribeiro, Rudson S. Silva, Isis G. G. Xavier, Marcelo C. Vieira, Tatiana R. Gonçalves, Vitor B. Paravidino, Juliana P. Borges, Luiz Fernando Rodrigues Junior, Henrique S. Costa, Michel S. Reis, Livia C. Liporagi-Lopes, Pablo Martinez-Amezcua, Paula S. Silva, Gilberto M. Sperandio Da Silva, Andrea S. Sousa, Marcelo T. Holanda, Henrique H. Veloso, Fernanda M. Carneiro, Flavia Mazzoli-Rocha, Andrea R. Costa, Roberto M. Saraiva, Fernanda S. N. S. Mendes, Luiz Henrique C. Sangenis, and Alejandro M. Hasslocher-Moreno

Subjects
physical activity, exercise training, mental health, fitness, Chagas disease, quality of life, Medicine (General), R5-920
Abstract

BackgroundChagas disease (CD) is a neglected endemic disease with worldwide impact due to migration. Approximately 50–70% of individuals in the chronic phase of CD present the indeterminate form, characterized by parasitological and/or serological evidence of Trypanosoma cruzi infection, but without clinical signs and symptoms. Subclinical abnormalities have been reported in indeterminate form of CD, including pro-inflammatory states and alterations in cardiac function, biomarkers and autonomic modulation. Moreover, individuals with CD are usually impacted on their personal and professional life, making social insertion difficult and impacting their mental health and quality of life (QoL). Physical exercise has been acknowledged as an important strategy to prevent and control numerous chronic-degenerative diseases, but unexplored in individuals with the indeterminate form of CD. The PEDI-CHAGAS study (which stands for “Home-Based Exercise Program in the Indeterminate Form of Chagas Disease” in Portuguese) aims to evaluate the effects of a home-based exercise program on physical and mental health outcomes in individuals with indeterminate form of CD.Methods and designThe PEDI-CHAGAS is a two-arm (exercise and control) phase 3 superiority randomized clinical trial including patients with indeterminate form of CD. The exclusion criteria are

Published
2023
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4. Bionized Nanoferrite Particles Alter the Course of Experimental Cryptococcus neoformans Pneumonia

Author

Livia C. Liporagi Lopes, Preethi Korangath, Samuel R. Dos Santos Junior, Kathleen L. Gabrielson, Robert Ivkov, and Arturo Casadevall

Subjects
Inflammation, Pharmacology, Mice, Infectious Diseases, Tumor Necrosis Factor-alpha, Cryptococcus neoformans, Animals, Experimental Therapeutics, Pharmacology (medical), Cryptococcosis
Abstract

Cryptococcosis is a devastating fungal disease associated with high morbidity and mortality even when treated with antifungal drugs. Bionized nanoferrite (BNF) nanoparticles are powerful immunomodulators, but their efficacy for infectious diseases has not been investigated. Administration of BNF nanoparticles to mice with experimental cryptococcal pneumonia altered the outcome of infection in a dose response manner as measured by colony forming units and survival. The protective effects were higher at lower doses, with reductions in IL-2, IL-4 and TNF-α, consistent with immune modulation whereby reductions in inflammation translate into reduced host damage, clearance of infection and longer survival.

Published
2022
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