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2. Outcomes and survival of tracheostomised patients during the COVID-19 pandemic in a third level hospital

Author

Mesalles-Ruiz, Marta, Hamdan, Miriam, Huguet-Llull, Gabriel, Penella, Anna, Portillo, Alejandro, Bagudà, Eva, Capelleras, Marta, Caballero, José Maria, Golet, Mireia, Fulla, Marta, Bartel, Ricardo, Cisa, Enric, Cruellas, Francesc, Tornero, Jordi, Lares, Henry Rafael, Farré, Anna, Skufca, Javier, Nogués, Julio, Mañós, Manuel, and Gonzàlez-Compta, Xavier

Published
2022
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4. Outcome of 1890 tracheostomies for critical COVID-19 patients: a national cohort study in Spain

Author

Martin-Villares, Cristina, Perez Molina-Ramirez, Carmen, Bartolome-Benito, Margarita, Bernal-Sprekelsen, Manuel, Perez-Fernandez, Aranzazu, Alcantara-Armenteros, Sara, Monjas-Cánovas, Irene, Sancho-Mestre, Manuela, Alemán-Lopez, Oscar, Deola-Trasserra, M Dolors, Villarraga-Cova, Vanessa, Carreras-Alcaraz, Azor, Montaner-Sala, Esther, Sota-Eguizabal, Esther, Tolosa, Aihnoa, De la Iglesia, Belen, Garcia-Sardon, Rafael, Diez, Laura, Lehrer, Eduardo, Aviles-Jurado, Francisco Xavier, Tudela-Cabello, Kiara, Huguet-Llull, Gabriel, Mesalles-Ruíz, Marta, Jimenez-Montoya, Ramon, Navazo-Eguïa, Ana, Galindo-Torres, Blanca, Fernandez-Pello, Marta, Rodriguez-Prado, Nuria, Salazar, Carmen, Ramos, Francisco, Amor-Dorado, Juan Carlos, Faubel-Serra, Marta, Nuñez-Carrasco, Valery, Agüero-Medina, Adriana, Carlos-Villatoro, Juan, Lopez-Diu, Roser, Gonzalez-Melgan, Selvyn, Uzcanga-Lacabe, María, Cardier-Suárez, Marisela, Úbeda-Fernández, Esther, Alañon-Fernández, Miguel Ángel, Sanchez-Herrero, Carlos, Municio-Martin, Jose Antonio, Pascua-Gomez, Luis, Andrino-Martin, Sergio, Ayala-Mejias, Sandra, Molina-Gil, Bárbara, De Abajo-Larriba, Jorge, Piñeiro-Aguín, Zenaida, Gil-Carcedo, Elisa, Herrero-Agustín, Javier, Freijanes-Otero, Jorge, Cuetos-Azcona, Mario, Garcia-Fernandez, Alfredo, Jimenez-Huerta, Ignacio, Babarro-Fernández, Rosa, Junjgohann-Jofre, Felipe, Martel-Lopez, Antonio, Martin-Sanchez, Maria Dolores, Benitez-del Rosario, Jesus, Luorido, Diana, Granda, Monica, Tejeda, Jose Miguel, Martinez Ruiz-Coello, Antonio, Almodovar-Iniesta, Antonio, Bonnin, Jesus, Chao-Vietes, Jacobo, Hernández-Garcia, Estefanía, Plaza, Guillermo, Villacampa-Auba, Jose Miguel, Campos-Gonzalez, Alfonso, Casqueiro, Jose Carlos, Baguena-Campos, Lucia, Encinas-Vicente, Alberto, Rubio-Yanguas, Raul, Lowy-Benoliel, Alejandro, Poletti-Serafini, Daniel, Pasamontes-Pingarron, Juan Antonio, Aristegui-Ruiz, Miguel, Hernando-Cuñado, Monica, Souviron-Encabo, Rosalia, Martinez-Guirado, Tomas, Fernandez-Fernandez, Mario, Gonzalez-Orus, Ricardo, Molina-Montes, Beatriz, De la Fuente-Hernandez, Raquel, Crovato-Rojas, Jesús, Ruminot, Cristian, Laguado, Daniella, Acosta, Hander, Hernández-Garcia, María José, Zuaza-Gonzalez, Alejandro, Domingo-Carrasco, Carlos, Valor-García, Cristina, Lopez-Martin, Javier, Mogollon-Cano, Tomas, Meler-Claramonte, Carla, Flores-Martín, Juan Carlos, Arzok del Toro, Juanjo, Garcia-Piñero, Alfonso, Muñoz-Fernandez, Noelia, del Palacio, Antonio, Mateos-Serrano, Blanca, Garcia-Lopez, Isabel, Rodrigañez-Riesco, Laura, Aragon, Paula, Rivera, Teresa, Eisenberg-Plaza, Gustavo, Fernandez-Robledo, Inmaculada, Prada-Pendolero, Jorge, Alvarez-Alvarez, Ignacio, Puente-Verez, Maria, Quintana-Sanjuas, Ana, Parente-Arias, Pablo, García-Cordoba, Francisco, Garcia-Purriños, Francisco Jose, Morales-Angulo, Carmelo, Rodriguez-Rondon, Simara, Lopez-Lopez, Diana, Fernandez-Liesa, Rafael, Lázaro-Sánchez, Amaya, Alonso-Alonso, I, Rusiecka, Michalina, Ramirez, Rosa Delia, Vila, Javier, Bellmunt-Fontanet, Angela, Montoro-Martinez, Victoria, Piqueras, Francisco, Novoa-Morales, Vania, Simonetti, Gabriela, Guillen-Lozada, Enrique, Velasco, Maria Jesus, Alonso-Castiñeira, Ignacio, Hernandez, Maria, Rovira-Ramos, Carlota, Diaz-Argüello, Juan Jose, Escamilla-Carpintero, Yolanda, Torrico-Roman, Pablo, Calvo-Navarro, Carlos, Viza-Puiggros, Ignacio, Vaduva, Cristina, Higuera-Lucas, Juan, Tato, Jose Ignacio, Rivera-Rodriguez, Teresa, Rodriguez-Contreras, Diego, Caravaca-Garcia, Antonio, Ayala, Alejandra, Morales-Puebla, José Manuel, Ruiz-Escudero, Carlos, Lozano-Reina, E, Maza-Solano, Juan Manuel, Alfaro-Garcia, Jorge, Sanchez, Fatima, Montes-Jovellar, Luordes, Medina, Mar, Barbera, Rafael, Marco-Garrido, Alfonso, Cremades-Navalon, Isabel, García-Callejo, Javier, Bastida, C Garcia, Gutierrez-Fonseca, Raimundo, Muñoz-Herrera, Angel, Calvo, Marta, Rosal-Fraga, Carmen, Iglesias-Moreno, Mari Cruz, Gimeno-Hernández, Jesus, Vázquez-Romero, Cristina A, Alzate-Amaya, Fabian, Palomino, Laura, Alcaraz, Marta, Romeu-Figuerola, Coia, Foglia-Fernandez, Maria, Dios-Loureiro, Cristina, Gonzalez-Guijarro, Isabel, Vera-Llao, Rafael, Sancho-Calvo, Rosa, Ramos-Fernandez, Jesus Jose, Lasso-delaVega, Mar, Martinez-Pascual, Paula, Dominguez-Ovejas, Silvia, Morera-Senra, Eduardo, Alba-Mesquida, Jacoba, Bonilla, Alfonso, Martinez-Subias, Javier, Martinez-Salazar, Jesus M, Martinez-Lapeña, Antonio, Corrales-Millan, Rocio, Ruiz, Rosario, Mata, Nieves, Espinosa, Alfredo, Cianci-Jaimes, Laura Gerarda, Zapater-Latorre, Enrique, Alba-Garcia, Jose Ramon, Oishi-Konari, Miriam Natsuki, Pallares-Marti, Beatriz, Rubio-Fernandez, Andrea, Santos-Pérez, Jaime, Idigora-Planas, Albert, Sanchez-Barrueco, Alvaro, Alcala-Rueda, Ignacio, Jara-Rubio, Ruben, Lozano, Estefanía, Tirado-Zamora, Isabel, Coscaron-Blanco, Enrique, Suarez-Ortega, Soledad, Gil-Grasa, Guillermo, Lavilla-Martin de Valmaseda, Maria Jose, Sebastian, Jose Miguel, Nijim, Hazem, Dominguez-Calvo, Jesus, Gonzalez-Gimeno, Maria Jose, Carvajal-Urueña, Ana, Anel, Luis, and Gonzalo-Orden, Manuel

Subjects
medicine.medical_specialty, Percutaneous, medicine.medical_treatment, law.invention, Cohort Studies, 03 medical and health sciences, Tracheostomy, Mechanical ventilation, 0302 clinical medicine, law, medicine, Humans, Weaning, Intensive care unit, 030223 otorhinolaryngology, Retrospective Studies, SARS-CoV-2, business.industry, General surgery, COVID-19, General Medicine, Respiration, Artificial, Otorhinolaryngology, Spain, 030220 oncology & carcinogenesis, Cohort, Observational study, Neurosurgery, business, Head and Neck
Abstract

Background The question of an optimal strategy and outcomes in COVID-19 tracheostomy has not been answered yet. The critical focus in our case study is to evaluate the outcomes of tracheostomy on intubated COVID-19 patients. Methods A multicentric prospective observational study of 1890 COVID-19 patients undergoing tracheostomy across 120 hospitals was conducted over 7 weeks in Spain (March 28 to May 15, 2020). Data were collected with an innovative approach: instant messaging via WhatsApp. Outcome measurements: complications, achieved weaning and decannulation and survival. Results We performed 1,461 surgical (81.3%) and 429 percutaneous tracheostomies. Median timing of tracheostomy was 12 days (4–42 days) since orotracheal intubation. A close follow-up of 1616/1890 (85.5%) patients at the cut-off time of 1-month follow-up showed that in 842 (52.1%) patients, weaning was achieved, while 391 (24.2%) were still under mechanical ventilation and 383 (23.7%) patients had died from COVID-19. Decannulation among those in whom weaning was successful (n = 842) was achieved in 683 (81%) patients. Conclusion To the best of our knowledge, this is the largest cohort of COVID-19 patients undergoing tracheostomy. The critical focus is the unprecedented amount of tracheostomies: 1890 in 7 weeks. Weaning could be achieved in over half of the patients with follow-up. Almost one out of four tracheotomized patients died from COVID-19.

Published
2020

5. Effect of CYP3A4, CYP3A5, MDR1 and POR Genetic Polymorphisms in Immunosuppressive Treatment in Chilean Kidney Transplanted Patients

Author

Contreras-Castillo, Stephania, primary, Plaza, Anita, additional, Stojanova, Jana, additional, Navarro, Gustavo, additional, Carmona, Rodolfo, additional, Corvalán, Fernando, additional, Cerpa, Leslie, additional, Sandoval, Christopher, additional, Muñoz, Daniel, additional, Leiva, Marina, additional, Castañeda, Luis E., additional, Farias, Nayaret, additional, Alvarez, Carolina, additional, Llull, Gabriel, additional, Mezzano, Sergio, additional, Ardiles, Leopoldo, additional, Varela, Nelson, additional, Rodríguez, María S., additional, Flores, Claudio, additional, Cayún, Juan Pablo, additional, Krall, Paola, additional, and Quiñones, Luis A., additional

Published
2021
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6. Outcomes and survival of tracheostomised patients during the COVID-19 pandemic in a third level hospital

Author

Mesalles-Ruiz, Marta, primary, Hamdan, Miriam, additional, Huguet-Llull, Gabriel, additional, Penella, Anna, additional, Portillo, Alejandro, additional, Bagudà, Eva, additional, Capelleras, Marta, additional, Caballero, José Maria, additional, Golet, Mireia, additional, Fulla, Marta, additional, Bartel, Ricardo, additional, Cisa, Enric, additional, Cruellas, Francesc, additional, Tornero, Jordi, additional, Lares, Henry Rafael, additional, Farré, Anna, additional, Skufca, Javier, additional, Nogués, Julio, additional, Mañós, Manuel, additional, and Gonzàlez-Compta, Xavier, additional

Published
2021
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7. Risk of contagion of SARS-CoV-2 among otorhinolaryngologists in Spain during the 'Two waves'

Author

Martin-Villares, Cristina, Bernal-Sprekelsen, Manuel, Molina-Ramirez, Carmen Perez, Bartolome-Benito, Margarita, Aristegui-Ruiz, M., Agüero-Medina, Adriana, Tolosa, Aihnoa, Maturana, Aitor Zabala-Lopezde, Idigora-Planas, Albert, Codina-Aroca, Alberto, Encinas-Vicente, Alberto, Sanchez-Tudela, Alberto, Ayala, Alejandra, Lowy-Benoliel, Alejandro, Zuaza-Gonzalez, Alejandro, Bonilla-Perez, Alfonso, Campos-Gonzalez, Alfonso, Garcia-Piñero, Alfonso, Marco-Garrido, Alfonso, Garcia-Fernandez, Alfredo, Trinidad, Almudena, Sanchez-Barrueco, Alvaro, Lázaro-Sánchez, Amaya, Piñeiro, Z, Navazo-Eguïa, Ana, Quintana-Sanjuas, Ana, Rubio-Fernandez, Andrea, Moreno-Juara, Angel, Muñoz-Herrera, Angel, Bellmunt-Fontanet, Angela, Almodovar-Iniesta, Antonio, Caravaca-Garcia, Antonio, del Palacio, Antonio, Martel-Lopez, Antonio, Martinez-Lapeña, Antonio, MartinezRuiz-Coello, Antonio, Perez-Fernandez, Aranzazu, Carreras-Alcaraz, Azor, Molina-Gil, Bárbara, Molina-Montes, Beatriz, Pallares-Marti, Beatriz, De la Iglesia, Belen, Galindo-Torres, Blanca, Mateos-Serrano, Blanca, Garcia-Bastida, C., Meler-Claramonte, Carla, Calvo-Navarro, Carlos, Domingo-Carrasco, Carlos, Escobar-Sanchez, Carlos, Sanchez-Herrero, Carlos, Rovira-Ramos, Carlota, Morales-Angulo, Carmelo, Rosal-Fraga, Carmen, Salazar, Carmen, Orus, Cesar, Romeu-Figuerola, Coia, Ruminot, Cristian, Vázquez-Romero, Cristina A., Dios-Loureiro, Cristina, Valor-García, Cristina, Poletti-Serafini, Daniel, Laguado, Daniella, Lopez-Lopez, Diana, Luorido, Diana, Rodriguez-Contreras, Diego, Morera-Serna, Eduardo, Gil-Carcedo, Elisa, Coscaron-Blanco, Enrique, Guillén-Lozada, Enrique, Zapater-Latorre, Enrique, Hernández-Garcia, Estefanía, Lozano, Estefanía, Montane-Sala, Esther, Sota-Eguizabal, Esther, Úbeda-Fernández, Esther, Alzate-Amaya, Fabian, Sanchez-Fernandez, Fatima, Junjgohann-Jofre, Felipe, García-Cordoba, Francisco, Garcia-Purriños, Francisco Jose, Ramos, Francisco, Huguet-Llull, Gabriel, Simonetti, Gabriela, Gil-Grasa, Guillermo, Plaza, Guillermo, Eisenberg-Plaza, Gustavo, Acosta, Hander, Alonso-Alonso, I., Alcala-Rueda, Ignacio, Alvarez-Alvarez, Ignacio, Jimenez-Huerta, Ignacio, Viza-Puiggros, Ignacio, Clemente, Ignacio, Fernandez-Robledo, Inmaculada, Monjas-Cánovas, Irene, Castillo-Lopez, Irma Yolanda, Cremades-Navalon, Isabel, Garcia-Lopez, Isabel, Gonzalez-Guijarro, Isabel, Tirado-Zamora, Isabel, Alba-Mesquida, Jacoba, Chao-Vietes, Jacobo, Santos-Pérez, Jaime, García, Javier, Herrero-Agustín, Javier, Lopez-Martin, Javier, Martinez-Subias, Javier, Vila, Javier, Rosario, Jesus Benitez-del, Crovato-Rojas, Jesús, Gimeno-Hernández, Jesus, Dominguez-Calvo, Jesus Ignacio, Ramos-Fernandez, Jesus Jose, Martinez-Salazar, Jesus M., Alfaro-Garcia, Jorge, De Abajo-Larriba, Jorge, Freijanes-Otero, Jorge, Prada-Pendolero, Jorge, Municio-Martin, Jose Antonio, Casqueiro, Jose Carlos, Tato, Jose Ignacio, Sebastian, Jose Miguel, Tejeda, Jose Miguel, Villacampa-Auba, Jose Miguel, Morales, JManuel, Alba-Garcia, Jose Ramon, Dalmau, Josep, Pasamontes-Pingarron, Juan Antonio, Amor-Dorado, Juan Carlos, Flores-Martín, Juan Carlos, Carlos-Villatoro, Juan, Higuera-Lucas, Juan, Toro, Juan Jose Artazkoz-del, Diaz-Argüello, Juan Jose, Tudela-Cabello, Kiara, Rubio-Yanguas, L., Cianci-Jaimes, Laura Gerarda, Palomino, Laura, Rodrigañez-Riesco, Laura, Montes-Jovellar, Lourdes, Baguena-Campos, Lucia, Pascua-Gomez, Luis, Deola-Trasserra, MDolors, Cueva-Díaz, Jenifer, Sancho-Mestre, Manuela, Lasso-delaVega, Mar, Medina, Mar, Iglesias-Moreno, Mari Cruz, Martin-Sanchez, Maria Dolores, Foglia-Fernandez, María, Velasco, Maria Jesus, Jesús-Dominguez, Maria, Hernández-Garcia, María José, de Valmaseda, Maria Jose Lavilla-Martin, Gonzalez-Gimeno, Maria José, Puente-Verez, Maria, Uzcanga-Lacabe, María, Cuetos-Azcona, Mario, Fernandez-Fernandez, Mario, Vazquez, Mariano Andres, Cardier-Suárez, Marisela, Alcaraz, Marta, Calvo, Marta, Estévez, M., Faubel-Serra, Marta, Fernandez-Pello, Marta, Mesalles-Ruíz, Marta, Rusiecka, Michalina, Alañon-Fernández, Miguel Ángel, Oishi-Konari, Miriam Natsuki, Granda, Monica, Hernando-Cuñado, Monica, Muñoz-Fernandez, Noelia, Rodriguez-Prado, Nuria, Alemán-Lopez, Oscar, Parente-Arias, Pablo, Torrico-Roman, Pablo, Aragon, Paula, Martinez-Pascual, Paula, Barbera, Rafael, Fernandez-Liesa, Rafael, Garcia-Sardon, Rafael, Gutierrez-Fonseca, Raimundo, Jimenez-Montoya, Ramon, De la Fuente-Hernandez, Raquel, Raquelortiz-Rodrigo, Gonzalez-Orus, Ricardo, Corrales-Millan, Rocio, Ramirez, Rosa Delia, Fernandez, Rosa Babarro, Sancho-Calvo, Rosa, Souviron-Encabo, Rosalia, Almela-Cortes, Rosana, Ruiz-Gomez, Rosario, Lopez-Diu, Roser, Jara-Rubio, Ruben, Alcantara-Armenteros, Sara, Tamboura, Sara, Santos-Santos, Saturnino, Gonzalez-Melgan, Selvyn, Andrino-Martin, Sergio, Dominguez-Ovejas, Silvia, Rodriguez-Rondon, Simara, Suarez-Ortega, Soledad, Rivera, Teresa, Rivera-Rodriguez, Teresa, Martinez-Guirado, Tomas, Mogollon-Cano, Tomas, Nuñez-Carrasco, Valery, Villarraga-Cova, Vanessa, Montoro-Martinez, Victoria, and Escamilla-Carpintero, Yolanda

Subjects
medicine.medical_specialty, Coronavirus disease 2019 (COVID-19), Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), Short Communication, Population, Communicable diseases, 03 medical and health sciences, Otolaryngology, 0302 clinical medicine, Otorrinolaringologia, Pandemic, Otolaryngologists, medicine, Mortalitat, Humans, Mortality, 030223 otorhinolaryngology, education, Pandemics, education.field_of_study, business.industry, SARS-CoV-2, COVID-19, General Medicine, Malalties infeccioses, medicine.disease, Pneumonia, Morbiditat, Otorhinolaryngology, Spain, 030220 oncology & carcinogenesis, Emergency medicine, Cohort, Observational study, Morbidity, business
Abstract

Introduction The aim of our study was to obtain data about the contagion rate among Otolaryngologists in Spanish ENT Departments and about the clinical outcomes in positive otolaryngologists. As a secondary objective, we aim to assess the rate of contagion in the first and the second Covid-19 wave in Spain among Otorhinolaryngologists and the regional distribution by ENT-Departments. Methods Study design and population: This is a prospective observational study in a cohort of 975 Otolaryngologists from 87 ENT Departments conducted from March 25 to November 17 in our collaborative group, COVID ORL ESP. COVID‐19 polymerase chain reaction (PCR) was the diagnostic standard. Hospitalization and/or intensive care admission and mortality was recorded as non-identified data. Results Data collected from 975 otolaryngologist from 87 Departments resulted in 157 (16.5%) otolaryngologists testing positive for SARS-CoV-19 by RT-PCR. Important geographic differences in contagion are reported. A total of 136 (86.6%) otolaryngologists were tested positive during the first wave and 21 (13.3%) during the second wave. At the last cut-off point of the study only 30/87 ENT Departments (34.5%) remained COVID19-free and 5 Departments reported more than 50% staff members testing positive. The majority of positive tested otolaryngologists (126/157; 80.2%) had only mild or no symptoms, 17 developed moderate symptoms (10.8%) and 3 had pneumonia not requiring hospitalization (2%). Five colleagues were admitted at hospital, 4 required ICU (2.5%) and 2 colleges died from COVID-19. Conclusions During the first wave of the SARS-CoV-19 pandemic otolaryngologists in Spain have been overall the group suffering the highest rate of contagion, particularly during the first month. Subsequently, the Spanish Ministry of Health should include otorhinolaryngologists as a high-risk group in airborne pandemics.

Published
2021

8. Pharmacogenetic Associations Between Atazanavir/UGT1A1*28 and Efavirenz/rs3745274 (CYP2B6) Account for Specific Adverse Reactions in Chilean Patients Undergoing Antiretroviral Therapy

Author

Poblete, Daniela, primary, Bernal, Fernando, additional, Llull, Gabriel, additional, Archiles, Sebastian, additional, Vasquez, Patricia, additional, Chanqueo, Leonardo, additional, Soto, Nicole, additional, Lavanderos, María A., additional, Quiñones, Luis A., additional, and Varela, Nelson M., additional

Published
2021
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11. Pharmacogenetic Associations Between Atazanavir/ UGT1A1*28 and Efavirenz/rs3745274 (CYP2B6) Account for Specific Adverse Reactions in Chilean Patients Undergoing Antiretroviral Therapy.

Author

Poblete, Daniela, Bernal, Fernando, Llull, Gabriel, Archiles, Sebastian, Vasquez, Patricia, Chanqueo, Leonardo, Soto, Nicole, Lavanderos, María A., Quiñones, Luis A., and Varela, Nelson M.

Subjects
EFAVIRENZ, ATAZANAVIR, ANTIRETROVIRAL agents, PHARMACOGENOMICS, HIV-positive persons, DRUG side effects, NON-nucleoside reverse transcriptase inhibitors, PATIENT compliance
Abstract

Background: Efavirenz (EFV), a non-nucleoside reverse transcriptase inhibitor, and atazanavir (ATV), a protease inhibitor, are drugs widely used in antiretroviral therapy (ART) for people living with HIV. These drugs have shown high interindividual variability in adverse drug reactions (ADRs). UGT1A1*28 and CYP2B6 c.516G>T have been proposed to be related with higher toxicity by ATV and EFV, respectively. Objective: To study the association between genetic polymorphisms and ADRs related to EFV or ATV in patients living with HIV treated at a public hospital in Chile. Methods: Epidemiologic, case–control, retrospective, observational study in 67 adult patients under EFV or ATV treatment was conducted, in the San Juan de Dios Hospital. Data were obtained from patients' medical records. Genotype analyses were performed using rtPCR for rs887829 (indirect identification of UGT1A1*28 allele) and rs3745274 (CYP2B6 c.516G>T), with TaqMan® probes. The association analyses were performed with univariate logistic regression between genetic variants using three inheritance models (codominant, recessive, and dominant). Results: In ATV-treated patients, hyperbilirubinemia (total bilirubin >1.2 mg/dl) had the main incidence (61.11%), and moderate and severe hyperbilirubinemia (total bilirubin >1.9 mg/dl) were statistically associated with UGT1A1*28 in recessive and codominant inheritance models (OR = 16.33, p = 0.028 and OR = 10.82, p = 0.036, respectively). On the other hand, in EFV-treated patients adverse reactions associated with CNS toxicity reached 34.21%. In this respect, nightmares showed significant association with CYP2B6 c.516G>T, in codominant and recessive inheritance models (OR = 12.00, p = 0.031 and OR = 7.14, p = 0.042, respectively). Grouped CNS ADRs (nightmares, insomnia, anxiety, and suicide attempt) also showed a statistically significant association with CYP2B6 c.516G > T in the codominant and recessive models (OR = 30.00, p = 0.011 and OR = 14.99, p = 0.021, respectively). Conclusion: Our findings suggest that after treatment with ATV or EFV, UGT1A1*28 and CYP2B6 c.516G>T influence the appearance of moderate-to-severe hyperbilirubinemia and CNS toxicity, respectively. However, larger prospective studies will be necessary to validate these associations in our population. Without a doubt, improving adherence in patients living with HIV is a critical issue to the success of therapy. Hence, validating and applying international pharmacogenetic recommendations in Latin American countries would improve the precision of ART: a fundamental aspect to achieve the 95–95–95 treatment target proposed by UNAIDS. [ABSTRACT FROM AUTHOR]

Published
2021
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13. Dehiscence of the lamina papyracea of the ethmoid bone.

Author

Huguet Llull G, Mesalles Ruiz M, and González Compta X

Subjects
Adipose Tissue diagnostic imaging, Aged, Hernia etiology, Humans, Male, Oculomotor Muscles diagnostic imaging, Tomography, X-Ray Computed, Ethmoid Bone diagnostic imaging, Hernia diagnostic imaging, Orbit diagnostic imaging
Published
2019
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