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377 results on '"Lo, Su‐Shun"'

6. Yin Yang 1 is a target of microRNA-34 family and contributes to gastric carcinogenesis

Author

Wang, An-Ming, Huang, Tzu-Ting, Hsu, Kai-Wen, Huang, Kuo-Hung, Fang, Wen-Liang, Yang, Muh-Hwa, Lo, Su-Shun, Chi, Chin-Wen, Lin, Jing-Jer, and Yeh, Tien-Shun

Subjects
Biotechnology, Stem Cell Research - Nonembryonic - Non-Human, Genetics, Stem Cell Research, Rare Diseases, Cancer, Aetiology, 2.1 Biological and endogenous factors, 3' Untranslated Regions, Animals, Blotting, Western, Cell Line, Tumor, Cell Movement, Cell Proliferation, Cell Survival, Gene Expression Regulation, Neoplastic, Humans, Mice, Inbred BALB C, Mice, Nude, MicroRNAs, RNA Interference, Reverse Transcriptase Polymerase Chain Reaction, Stomach Neoplasms, Tumor Burden, Xenograft Model Antitumor Assays, YY1 Transcription Factor, Oncology and Carcinogenesis
Abstract

Gastric cancer is the second leading cause of cancer-related death worldwide. Herein, we investigated the role of transcription factor Yin Yang 1 (YY1), a multi-functional protein, in tumorigenesis of gastric cancer cells. Results showed that YY1 contributed to gastric carcinogenesis of SC-M1 cells including growth, viability, and abilities of colony formation, migration, invasion, and tumorsphere formation. Levels of pluripotency genes CD44, Oct4, SOX-2, and Nanog were also up-regulated by YY1 in SC-M1 cells. Additionally, the 3'-untranslated region (3'-UTR) of YY1 mRNA was the target of microRNA-34 (miR-34) family consisting of miR-34a, miR-34b, and miR-34c. Overexpression of miR-34 family suppressed carcinogenesis through down-regulation of YY1 in NUGC-3 gastric cancer cells scarcely expressing miR-34 family. Alternatively, knockdown of miR-34 family promoted tumorigenesis via up-regulation of YY1 in SC-M1 and AZ521 gastric cancer cells with higher levels of miR-34 family. The miR-34 family also affected tumorsphere ultra-structure and inhibited the xenografted tumor growth as well as lung metastasis of SC-M1 cells through YY1. Expressions of miR-34a and miR-34c in gastric cancer tissues of patients were lower than those in normal tissues. Taken together, these results suggest that miR-34 family-YY1 axis plays an important role in the control of gastric carcinogenesis.

Published
2014

12. The impact of preoperative waiting time in Stage II–III gastric or gastroesophageal junction cancer: A population‐based cohort study.

Author

Yen, Chih‐Chieh, Yang, Yi‐Hsin, Ku, Hsiu‐Ying, Hu, Huang‐Ming, Lo, Su‐Shun, Chang, Hung‐Chi, Chao, Yee, Chen, Jen‐Shi, Wang, Hsiu‐Po, Wang, Tsang‐En, Bai, Li‐Yuan, Wu, Ming‐Shiang, Yen, Chia‐Jui, Chen, Li‐Tzong, and Shan, Yan‐Shen

Subjects
ESOPHAGOGASTRIC junction, COHORT analysis, STOMACH cancer, ENDOSCOPIC surgery, PREOPERATIVE period, ESOPHAGEAL cancer, GASTROPARESIS, GASTRIC bypass
Abstract

Background: Gastrectomy remains the curative option in gastric cancer. However, the growing concern that preoperative waiting jeopardizes survival has not been fully addressed. The present population‐based cohort study aimed to clarify the impact of preoperative waiting time (PreWT). Methods: We included patients with clinical Stage II–III gastric cancer who received curative surgery from 2008 to 2017 of Taiwan Cancer Registry. PreWT was defined as the time from endoscopic diagnosis to surgery. The prognostic impact on overall survival (OS) was evaluated with Cox and restricted cubic spline regressions. Results: A total of 3059 patients with a median age of 68 years were evaluated. The median PreWT was 16 days (interquartile range, 11–24 days), and patients with a shorter PreWT were younger, had a more advanced disease and received adjuvant therapies. Despite a shorter OS occurring with prolonged PreWT (median OS by PreWT [days]: 7–13, 2.7 years; 14–20, 3.1 years; 21–27, 3.0 years; 28–34, 4.7 years; 35–31, 3.7 years; 42–48, 3.4 years; 49–118, 2.8 years; p = 0.029), the differences were not significant after adjustment. The Cox and restricted cubic spline regressions showed that prolonged PreWT was not a significant prognostic factor for OS (p = 0.719). Conclusions: The population‐based study suggests that a PreWT of 49–118 days does not independently correlate with a poor prognosis in Stage II–III gastric cancer. The study provides rationale for a window period for preoperative therapies and patient optimization. The population‐based study suggests that preoperative waiting within an acceptable range dose not impact the survival in Stage II–III gastric or gastroesophageal junction cancer. [ABSTRACT FROM AUTHOR]

Published
2023
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14. The clinicopathological and genetic differences among gastric cancer patients with no recurrence, early recurrence, and late recurrence after curative surgery

Author

Chen, Meng-Chao, primary, Su, Hsuan-Yu, additional, Su, Yen-Hao, additional, Huang, Kuo-Hung, additional, Fang, Wen-Liang, additional, Lin, Chii-Wann, additional, Chen, Ming-Huang, additional, Chao, Yee, additional, Lo, Su-Shun, additional, Fen-Yau Li, Anna, additional, and Wu, Chew-Wun, additional

Published
2022
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