246 results on '"LoGrasso, Philip"'
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2. Mechanism of Activation for Zap-70 Catalytic Activity
3. Inhibition of JNK Mitochondrial Localization and Signaling Is Protective against Ischemia/Reperfusion Injury in Rats
4. Blocking c-Jun N-terminal Kinase (JNK) Translocation to the Mitochondria Prevents 6-Hydroxydopamine-induced Toxicity in Vitro and in Vivo
5. Structural Mechanisms of Allostery and Autoinhibition in JNK Family Kinases
6. Enzyme Kinetics and Interaction Studies for Human JNK1β1 and Substrates Activating Transcription Factor 2 (ATF2) and c-Jun N-terminal kinase (c-Jun)
7. Discovery of Potent and Selective Covalent Inhibitors of JNK
8. Mitochondrial c-Jun N-terminal Kinase (JNK) Signaling Initiates Physiological Changes Resulting in Amplification of Reactive Oxygen Species Generation
9. Structure-Activity Relationships and X-ray Structures Describing the Selectivity of Aminopyrazole Inhibitors for c-Jun N-terminal Kinase 3 (JNK3) over p38
10. Comparison of Miniaturized Time-Resolved Fluorescence Resonance Energy Transfer and Enzyme-Coupled Luciferase High-Throughput Screening Assays to Discover Inhibitors of Rho-Kinase II (ROCK-II)
11. Mechanistic characterization for c-jun-N-Terminal Kinase 1α1
12. Kinetics of allopregnanolone formation catalyzed by human 3alpha-hydroxysteroid dehydrogenase type III (AKR1C2)
13. Kinetic mechanism for human Rho-Kinase II (ROCK-II)
14. Activation of JNK3alpha1 requires both MKK4 and MKK7: kinetic characterization of in vitro phosphorylated JNK3alpha1
15. Substituting c-Jun N-terminal kinase-3 (JNK3) ATP-binding site amino acid residues with their p38 counterparts affects binding of JNK- and p38-selective inhibitors
16. Time-resolved Forster resonance energy transfer assays for the binding of nucleotide and protein substrates to p38α protein kinase
17. Molecular basis for p38 protein kinase inhibitor specificity
18. Kinetic mechanism for p38 MAP kinase
19. Interaction and influence of phenylalanine-198 and threonine-199 on catalysis by human carbonic anhydrase III
20. Influence of amino acid replacement at position 198 on catalytic properties of zinc-bound water in human carbonic anhydrase III
21. Advances in pain therapeutics
22. The Structure of JNK3 in Complex with Small Molecule Inhibitors: Structural Basis for Potency and Selectivity
23. Characterization and purification of truncated human Rho-kinase II expressed in Sf-21 cells
24. c-jun-N-Terminal Kinase (JNK) for the Treatment of Amyotrophic Lateral Sclerosis
25. Signalling for survival and death in neurones: the role of stress-activated kinases, JNK and p38
26. p38 Map Kinase Substrate Specificity Differs Greatly for Protein and Peptide Substrates
27. Kinetic mechanism and inhibitor characterization for c-jun-N-terminal kinase 3[alpha]1
28. Pharmacological Inhibition of c-Jun N-terminal Kinase Reduces Food Intake and Sensitizes Leptin’s Anorectic Signaling Actions
29. Synthesis and SAR of novel isoxazoles as potent c-jun N-terminal kinase (JNK) inhibitors
30. Amino acid derived quinazolines as Rock/PKA inhibitors
31. Correction to Design and Synthesis of Highly Potent and Isoform Selective JNK3 Inhibitors: SAR Studies on Aminopyrazole Derivatives
32. Tetrahydroisoquinoline Derivatives As Highly Selective and Potent Rho Kinase Inhibitors
33. c-jun-N-Terminal Kinase (JNK) for the Treatment of Amyotrophic Lateral Sclerosis
34. Synthesis of potent bicyclic bisarylimidazole c-jun N-terminal kinase inhibitors by catalytic C-H bond activation
35. Rho Kinase (ROCK) Inhibitors and Their Therapeutic Potential
36. Serum- and Glucocorticoid-Inducible Kinase 1 Confers Protection in Cell-Based and in In Vivo Neurotoxin Models via the c-Jun N-Terminal Kinase Signaling Pathway
37. Pyridopyrimidinone Derivatives as Potent and Selective c-Jun N-Terminal Kinase (JNK) Inhibitors
38. Bis-aryl Urea Derivatives as Potent and Selective LIM Kinase (Limk) Inhibitors
39. Discovery and optimization of indole and 7-azaindoles as Rho kinase (ROCK) inhibitors (Part-II)
40. Discovery and optimization of indoles and 7-azaindoles as Rho kinase (ROCK) inhibitors (part-I)
41. Synthesis and SAR of novel quinazolines as potent and brain-penetrant c-jun N-terminal kinase (JNK) Inhibitors
42. Synthesis and biological evaluation of 4-quinazolinones as Rho kinase inhibitors
43. Structural Basis and Biological Consequences for JNK2/3 Isoform Selective Aminopyrazoles
44. The development of benzimidazoles as selective rho kinase inhibitors
45. c-jun-N-Terminal Kinase (JNK) for the Treatment of Amyotrophic Lateral Sclerosis
46. Design and Synthesis of Highly Potent and Isoform Selective JNK3 Inhibitors: SAR Studies on Aminopyrazole Derivatives
47. c-jun-N-Terminal Kinase (JNK) for the Treatment of Amyotrophic Lateral Sclerosis
48. Benzothiazoles as Rho-associated kinase (ROCK-II) inhibitors
49. Synthesis and SAR of piperazine amides as novel c-jun N-terminal kinase (JNK) inhibitors
50. Rho kinase inhibitors: a patent review (2012 – 2013)
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