42 results on '"Loaëc, Nadège"'
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2. Alternative splicing of BCL-x is controlled by RBM25 binding to a G-quadruplex in BCL-x pre-mRNA
3. Novel cationic bis(acylhydrazones) as modulators of Epstein–Barr virus immune evasion acting through disruption of interaction between nucleolin and G-quadruplexes of EBNA1 mRNA
4. Exploration of the imidazo[1,2-b]pyridazine scaffold as a protein kinase inhibitor
5. Alternative splicing of BCL-x is controlled by RBM25 binding to a G-quadruplex in BCL-x pre-mRNA.
6. 5-Substituted 3-chlorokenpaullone derivatives are potent inhibitors of Trypanosoma brucei bloodstream forms
7. TRPC6 channel translocation into phagosomal membrane augments phagosomal function
8. Synthesis and molecular modelling studies of 8-arylpyrido[3′,2′:4,5]thieno[3,2-d]pyrimidin-4-amines as multitarget Ser/Thr kinases inhibitors
9. Type I arginine methyltransferases are intervention points to unveil the oncogenic Epstein-Barr virus to the immune system
10. A homozygous splice variant in ATP5PO, disrupts mitochondrial complex V function and causes Leigh syndrome in two unrelated families
11. 9- and 11-substituted 4-azapaullones are potent and selective inhibitors of African trypanosoma
12. Identification of 8-Hydroxyquinoline Derivatives That Decrease Cystathionine Beta Synthase (CBS) Activity
13. Synthesis and biological evaluation of N-aryl-7-methoxybenzo[b]furo[3,2-d]pyrimidin-4-amines and their N-arylbenzo[b]thieno[3,2-d]pyrimidin-4-amine analogues as dual inhibitors of CLK1 and DYRK1A kinases
14. Synthesis and biological evaluation of N-arylbenzo[b]thieno[3,2-d]pyrimidin-4-amines and their pyrido and pyrazino analogues as Ser/Thr kinase inhibitors
15. Exploring kinase inhibition properties of 9<em>H</em>-pyrimido[5,4-<em>b</em>]- and [4,5-<em>b</em>]indol-4-amine derivatives
16. Exploring Kinase Inhibition Properties of 9H-pyrimido[5,4-b]- and [4,5-b]indol-4-amine Derivatives
17. Sneaking Out for Happy Hour: Yeast-Based Approaches to Explore and Modulate Immune Response and Immune Evasion
18. Indole-3-Carbonitriles as DYRK1A Inhibitors by Fragment-Based Drug Design
19. Sneaking Out for Happy Hour: Yeast-Based Approaches to Explore and Modulate Immune Response and Immune Evasion
20. Synthesis and preliminary in vitro kinase inhibition evaluation of new diversely substituted pyrido[3,4-g]quinazoline derivatives
21. Discovery of pyrido[3,4-g]quinazoline derivatives as CMGC family protein kinase inhibitors: Design, synthesis, inhibitory potency and X-ray co–crystal structure
22. Molecular structures of cdc2-like kinases in complex with a new inhibitor chemotype
23. A new mouse model of ARX dup24 recapitulates the patients’ behavioral and fine motor alterations
24. Correction of cognitive deficits in mouse models of Down syndrome by a pharmacological inhibitor of DYRK1A
25. Marine-Derived 2-Aminoimidazolone Alkaloids. Leucettamine B-Related Polyandrocarpamines Inhibit Mammalian and Protozoan DYRK & CLK Kinases
26. Identification of CLK1 Inhibitors by a Fragment-linking Based Virtual Screening
27. Synthesis of Bioactive 2-(arylamino)thiazolo[5,4-f]-quinazolin-9-ones via the Hügershoff Reaction or Cu- Catalyzed Intramolecular C-S Bond Formation
28. Synthesis of novel 7-substituted pyrido[2′,3′:4,5]furo[3,2-d]pyrimidin-4-amines and their N-aryl analogues and evaluation of their inhibitory activity against Ser/Thr kinases
29. Synthesis of Bioactive 2-(Arylamino)thiazolo[5,4-f]-quinazolin-9-ones via the Hügershoff Reaction or Cu- Catalyzed Intramolecular C-S Bond Formation
30. Synthesis of Thiazolo[5,4-f]quinazolin-9(8H)-ones as Multi-Target Directed Ligands of Ser/Thr Kinases
31. Modulating Innate and Adaptive Immunity by (R)-Roscovitine: Potential Therapeutic Opportunity in Cystic Fibrosis
32. Novel Adociaquinone Derivatives from the Indonesian Sponge Xestospongia sp.
33. 10-Iodo-11H-indolo[3,2-c]quinoline-6-carboxylic Acids Are Selective Inhibitors of DYRK1A
34. Identification of CLK1 Inhibitors by a Fragment-linking Based Virtual Screening.
35. Acridone Alkaloids from Glycosmis chlorosperma as DYRK1A Inhibitors
36. Synthesis, Resolution, and Biological Evaluation of Atropisomeric (aR)- and (aS)-16-Methyllamellarins N: Unique Effects of the Axial Chirality on the Selectivity of Protein Kinases Inhibition
37. Novel Adociaquinone Derivatives from the Indonesian Sponge Xestospongia sp.
38. Impact of meriolins, a new class of cyclin-dependent kinase inhibitors, on malignant glioma proliferation and neo-angiogenesis.
39. Synthesis,Resolution, and Biological Evaluation ofAtropisomeric (aR)- and (aS)-16-MethyllamellarinsN: Unique Effects of the Axial Chirality on the Selectivity of ProteinKinases Inhibition.
40. Acridone Alkaloids from Glycosmis chlorospermaas DYRK1A Inhibitors
41. CDK Inhibitors Roscovitine and CR8 Trigger Mcl-1 Down-Regulation and Apoptotic Cell Death in Neuroblastoma Cells
42. Exploring Kinase Inhibition Properties of 9 H -pyrimido[5,4- b ]- and [4,5- b ]indol-4-amine Derivatives.
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