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1. Risk of recurrence after discontinuing anticoagulation in patients with COVID-19- associated venous thromboembolism: a prospective multicentre cohort study

Author

Adarraga, María Dolores, Conesa, Ana Alberich, Aibar, Jesús, Lozano, Alicia Alda, Alfonso, Joaquín, Carrillo, Jesús Alonso, Amado, Cristina, García, María Angelina, Arcelus, Juan Ignacio, Ballaz, Aitor, Barba, Raquel, Hernando, María Barca, Barbagelata, Cristina, Barrón, Manuel, Andrés, Belén Barrón, Chaib, Fahd Beddar, Blanco Molina, María Ángeles, Caballero, Juan Carlos, Castellanos, Gonzalo, Chasco, Leyre, Criado, Juan, de Ancos, Cristina, Toro, Jorge del, Rodríguez, Pablo Demelo, de Juana Izquierdo, Cristina, Díaz Brasero, Ana María, Díaz Peromingo, José Antonio, Silva, Álvaro Dubois, Escribano, Juan Carlos, Falgá, Concepción, Farfán Sedano, Ana Isabel, Aracil, Cleofe Fernández, Capitán, Carmen Fernández, Jiménez, Begoña Fernández, Fernández Reyes, José Luis, Fidalgo, María Ángeles, Francisco, Iria, Gabara, Cristina, Valle, Francisco Galeano, Bragado, Francisco García, Ortega, Alberto García, Sebastián, Olga Gavín, Gil de Gómez, María Allende, Díaz, Aída Gil, Cuervo, Covadonga Gómez, Munera, Adriana González, Grau, Enric, Guirado, Leticia, Gutiérrez, Javier, Blasco, Luis Hernández, Palomares, Luis Jara, Jaras, María Jesús, Jiménez, David, Jiménez, Rafael, Jou, Inés, Joya, María Dolores, Justo, Sara Lainez, Lalueza, Antonio, Lecumberri, Ramón, León Ramírez, José Manuel, Llamas, Pilar, Lobo, José Luis, Jiménez, Luciano López, Miguel, Patricia López, López Núñez, Juan José, Ruiz, Antonio López, López Sáez, Juan Bosco, Lorenzo, Alicia, Lumbierres, Marina, Madridano, Olga, Maestre, Ana, Marchena, Pablo Javier, Marcos, María, Martín del Pozo, Mar, Martos, Francisco Martín, Maza, Jorge Manuel, Mena, Elisabeth, Mercado, Maria Isabel, Moisés, Jorge, Monreal, Manuel, Morales, María del Valle, Navas, Maria Sierra, Nieto, José Antonio, Núñez Fernández, Manuel Jesús, Olid, Mónica, Ortega, Lucía Ordieres, Ortiz, María, Osorio, Jeisson, Otálora, Sonia, Otero, Remedios, Gómez, Nazaret Pacheco, Pagán, Javier, Palomeque, Andrea Catalina, Paredes, Ezequiel, Caballero, Pedro Parra, Pedrajas, José María, Ductor, Cristina Pérez, Pinar, Montserrat Pérez, Peris, María Luisa, Pesce, María Lourdes, Porras, José Antonio, Puchades, Ramón, Cívico, Francisco Rivera, Cobo, Ana Rodríguez, Rosa, Vladimir, Brugera, Marta Romero, Artacho, Pedro Ruiz, Giménez, Nuria Ruiz, Ruiz, Justo Ruiz, Salgueiro, Georgina, Sancho, Teresa, Sendín, Vanesa, Sigüenza, Patricia, Soler, Silvia, Fernández, Susana Suárez, Tirado, Raimundo, Vilar, Ana Torrents, Torres, María Isabel, Santos, Javier Trujillo, Uresandi, Fernando, Valle, Reina, Varona, José Felipe, Villalobos, Aurora, Villares, Paula, Ay, Cihan, Nopp, Stephan, Pabinger, Ingrid, Engelen, Matthias, Vanassche, Thomas, Verhamme, Peter, Bok Yoo, Hugo Hyung, Montenegro, Ana Cristina, Morales, Silvia Natalia, Roa, Jairo, Hirmerova, Jana, Malý, Radovan, Bertoletti, Laurent, Bura-Riviere, Alessandra, Catella, Judith, Chopard, Romain, Couturaud, Francis, Espitia, Olivier, Grange, Claire, Leclercq, Barbara, Le Mao, Raphael, Mahé, Isabelle, Moustafa, Farès, Plaisance, Ludovic, Bartoli, Gabrielle Sarlon, Suchon, Pierre, Versini, Edouard, Schellong, Sebastian, Brenner, Benjamin, Dally, Najib, Tzoran, Inna, Sadeghipour, Parham, Rashidi, Fahrid, Abenante, Alessia, Barillari, Giovanni, Basaglia, Manuela, Bilora, Franca, Bissacco, Daniele, Bortoluzzi, Cristiano, Brandolin, Barbara, Casana, Renato, Ciammaichella, Maurizio, Colaizzo, Donatella, Dentali, Francesco, Di Micco, Pierpaolo, Grandone, Elvira, Imbalzano, Egidio, Deliliers, Daniela Lambertenghi, Negro, Federica, Pesavento, Raffaele, Poz, Alessandra, Prandoni, Paolo, Scarinzi, Paolo, Siniscalchi, Carmine, Taflaj, Beldisa, Tufano, Antonella, Visonà, Adriana, Hong, Ngoc Vo, Zalunardo, Beniamino, Skride, Andris, Kigitovica, Dana, Fonseca, Samuel, Marques, Rafael, Meireles, José, Pinto, Sara Barbosa, Bosevsky, Marijan, Eftimova, Aleksandra, Zdraveska, Marijan, Bounameaux, Henri, Mazzolai, Lucia, Aujayeb, Avinash, Bikdeli, Behnood, Caprini, Joseph, Weinberg, Ido, Bui, Hanh My, Jara-Palomares, Luis, Muriel, Alfonso, Demelo-Rodríguez, Pablo, López-Miguel, Patricia, López-Jiménez, Luciano, and Rivera-Cívico, Francisco

Published
2024
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4. Feasibility of a screening algorithm for chronic thromboembolic pulmonary hypertension: The OSIRIS study

Author

Otero, Remedios, Lobo, José Luis, López, Raquel, Fernández, Carmen, Jiménez, David, Muriel, Alfonso, Alfonso, María, Ballaz, Aitor, Núñez-Ares, Ana, Rodríguez-Matute, Consolación, de Miguel-Díez, Javier, Rodríguez-Chiaradía, Diego Agustín, Alcalde, Mercedes, Elías, Teresa, Jara-Palomares, Luis, Rivas, Agustina, Alonso, Ángel, García-Ortega, Alberto, Sancho, Teresa, Morillo, Raquel, García-Bragado, Fernando, Hernández-Blasco, Luis, Uresandi, Fernando, Madridano, Olga, Agüero, Ramón, and Monreal, Manuel

Published
2023
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5. Risk of recurrence after discontinuing anticoagulation in patients with COVID-19- associated venous thromboembolism: a prospective multicentre cohort study

Author

Jara-Palomares, Luis, primary, Bikdeli, Behnood, additional, Jiménez, David, additional, Muriel, Alfonso, additional, Demelo-Rodríguez, Pablo, additional, Moustafa, Farès, additional, Villalobos, Aurora, additional, López-Miguel, Patricia, additional, López-Jiménez, Luciano, additional, Otálora, Sonia, additional, Peris, María Luisa, additional, Amado, Cristina, additional, Chopard, Romain, additional, Rivera-Cívico, Francisco, additional, Monreal, Manuel, additional, Adarraga, María Dolores, additional, Conesa, Ana Alberich, additional, Aibar, Jesús, additional, Lozano, Alicia Alda, additional, Alfonso, Joaquín, additional, Carrillo, Jesús Alonso, additional, García, María Angelina, additional, Arcelus, Juan Ignacio, additional, Ballaz, Aitor, additional, Barba, Raquel, additional, Hernando, María Barca, additional, Barbagelata, Cristina, additional, Barrón, Manuel, additional, Andrés, Belén Barrón, additional, Chaib, Fahd Beddar, additional, Blanco Molina, María Ángeles, additional, Caballero, Juan Carlos, additional, Castellanos, Gonzalo, additional, Chasco, Leyre, additional, Criado, Juan, additional, de Ancos, Cristina, additional, Toro, Jorge del, additional, Rodríguez, Pablo Demelo, additional, de Juana Izquierdo, Cristina, additional, Díaz Brasero, Ana María, additional, Díaz Peromingo, José Antonio, additional, Silva, Álvaro Dubois, additional, Escribano, Juan Carlos, additional, Falgá, Concepción, additional, Farfán Sedano, Ana Isabel, additional, Aracil, Cleofe Fernández, additional, Capitán, Carmen Fernández, additional, Jiménez, Begoña Fernández, additional, Fernández Reyes, José Luis, additional, Fidalgo, María Ángeles, additional, Francisco, Iria, additional, Gabara, Cristina, additional, Valle, Francisco Galeano, additional, Bragado, Francisco García, additional, Ortega, Alberto García, additional, Sebastián, Olga Gavín, additional, Gil de Gómez, María Allende, additional, Díaz, Aída Gil, additional, Cuervo, Covadonga Gómez, additional, Munera, Adriana González, additional, Grau, Enric, additional, Guirado, Leticia, additional, Gutiérrez, Javier, additional, Blasco, Luis Hernández, additional, Palomares, Luis Jara, additional, Jaras, María Jesús, additional, Jiménez, Rafael, additional, Jou, Inés, additional, Joya, María Dolores, additional, Justo, Sara Lainez, additional, Lalueza, Antonio, additional, Lecumberri, Ramón, additional, León Ramírez, José Manuel, additional, Llamas, Pilar, additional, Lobo, José Luis, additional, Jiménez, Luciano López, additional, Miguel, Patricia López, additional, López Núñez, Juan José, additional, Ruiz, Antonio López, additional, López Sáez, Juan Bosco, additional, Lorenzo, Alicia, additional, Lumbierres, Marina, additional, Madridano, Olga, additional, Maestre, Ana, additional, Marchena, Pablo Javier, additional, Marcos, María, additional, Martín del Pozo, Mar, additional, Martos, Francisco Martín, additional, Maza, Jorge Manuel, additional, Mena, Elisabeth, additional, Mercado, Maria Isabel, additional, Moisés, Jorge, additional, Morales, María del Valle, additional, Navas, Maria Sierra, additional, Nieto, José Antonio, additional, Núñez Fernández, Manuel Jesús, additional, Olid, Mónica, additional, Ortega, Lucía Ordieres, additional, Ortiz, María, additional, Osorio, Jeisson, additional, Otero, Remedios, additional, Gómez, Nazaret Pacheco, additional, Pagán, Javier, additional, Palomeque, Andrea Catalina, additional, Paredes, Ezequiel, additional, Caballero, Pedro Parra, additional, Pedrajas, José María, additional, Ductor, Cristina Pérez, additional, Pinar, Montserrat Pérez, additional, Pesce, María Lourdes, additional, Porras, José Antonio, additional, Puchades, Ramón, additional, Cívico, Francisco Rivera, additional, Cobo, Ana Rodríguez, additional, Rosa, Vladimir, additional, Brugera, Marta Romero, additional, Artacho, Pedro Ruiz, additional, Giménez, Nuria Ruiz, additional, Ruiz, Justo Ruiz, additional, Salgueiro, Georgina, additional, Sancho, Teresa, additional, Sendín, Vanesa, additional, Sigüenza, Patricia, additional, Soler, Silvia, additional, Fernández, Susana Suárez, additional, Tirado, Raimundo, additional, Vilar, Ana Torrents, additional, Torres, María Isabel, additional, Santos, Javier Trujillo, additional, Uresandi, Fernando, additional, Valle, Reina, additional, Varona, José Felipe, additional, Villares, Paula, additional, Ay, Cihan, additional, Nopp, Stephan, additional, Pabinger, Ingrid, additional, Engelen, Matthias, additional, Vanassche, Thomas, additional, Verhamme, Peter, additional, Bok Yoo, Hugo Hyung, additional, Montenegro, Ana Cristina, additional, Morales, Silvia Natalia, additional, Roa, Jairo, additional, Hirmerova, Jana, additional, Malý, Radovan, additional, Bertoletti, Laurent, additional, Bura-Riviere, Alessandra, additional, Catella, Judith, additional, Couturaud, Francis, additional, Espitia, Olivier, additional, Grange, Claire, additional, Leclercq, Barbara, additional, Le Mao, Raphael, additional, Mahé, Isabelle, additional, Plaisance, Ludovic, additional, Bartoli, Gabrielle Sarlon, additional, Suchon, Pierre, additional, Versini, Edouard, additional, Schellong, Sebastian, additional, Brenner, Benjamin, additional, Dally, Najib, additional, Tzoran, Inna, additional, Sadeghipour, Parham, additional, Rashidi, Fahrid, additional, Abenante, Alessia, additional, Barillari, Giovanni, additional, Basaglia, Manuela, additional, Bilora, Franca, additional, Bissacco, Daniele, additional, Bortoluzzi, Cristiano, additional, Brandolin, Barbara, additional, Casana, Renato, additional, Ciammaichella, Maurizio, additional, Colaizzo, Donatella, additional, Dentali, Francesco, additional, Di Micco, Pierpaolo, additional, Grandone, Elvira, additional, Imbalzano, Egidio, additional, Deliliers, Daniela Lambertenghi, additional, Negro, Federica, additional, Pesavento, Raffaele, additional, Poz, Alessandra, additional, Prandoni, Paolo, additional, Scarinzi, Paolo, additional, Siniscalchi, Carmine, additional, Taflaj, Beldisa, additional, Tufano, Antonella, additional, Visonà, Adriana, additional, Hong, Ngoc Vo, additional, Zalunardo, Beniamino, additional, Skride, Andris, additional, Kigitovica, Dana, additional, Fonseca, Samuel, additional, Marques, Rafael, additional, Meireles, José, additional, Pinto, Sara Barbosa, additional, Bosevsky, Marijan, additional, Eftimova, Aleksandra, additional, Zdraveska, Marijan, additional, Bounameaux, Henri, additional, Mazzolai, Lucia, additional, Aujayeb, Avinash, additional, Caprini, Joseph, additional, Weinberg, Ido, additional, and Bui, Hanh My, additional

Published
2024
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8. Statin use and 30‐day mortality in patients with acute symptomatic pulmonary embolism

Author

Siniscalchi, Carmine, Muriel, Alfonso, Suriñach Caralt, Jose Maria, Bikdeli, Behnood, Jiménez, David, Lobo, José Luis, Amado, Cristina, Gil‐Díaz, Aída, Imbalzano, Egidio, Monreal, Manuel, Prandoni, Paolo, Brenner, Benjamin, Farge‐Bancel, Dominique, Barba, Raquel, Di Micco, Pierpaolo, Bertoletti, Laurent, Schellong, Sebastian, Tzoran, Inna, Reis, Abilio, Bosevski, Marijan, Bounameaux, Henri, Malý, Radovan, Verhamme, Peter, Caprini, Joseph A, and Bui, Hanh My

Published
2022
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11. Oxygen therapy in patients with intermediate-risk acute pulmonary embolism: a randomized trial

Author

Barrios, Deisy, primary, Durán, Diego, additional, Rodríguez, Carmen, additional, Moisés, Jorge, additional, Retegui, Ana, additional, Lobo, José Luis, additional, López, Raquel, additional, Chasco, Leyre, additional, Jara-Palomares, Luis, additional, Muriel, Alfonso, additional, Otero-Candelera, Remedios, additional, Ruiz-Artacho, Pedro, additional, Monreal, Manuel, additional, Bikdeli, Behnood, additional, and Jiménez, David, additional

Published
2023
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18. The rationale, design, and methods of a trial to evaluate the efficacy and safety of oxygen therapy in patients with intermediate-risk acute pulmonary embolism.

Author

Durán, Diego, Barrios, Deisy, Moisés, Jorge, Retegui, Ana, Rodríguez, Carmen, Lobo, José L., López-Reyes, Raquel, Chasco, Leyre, Jara-Palomares, Luis, Monreal, Manuel, Bikdeli, Behnood, Jiménez, David, Lobo, José Luis, and AIR investigators

Abstract

Introduction: In patients with intermediate-risk pulmonary embolism (PE), reversal of hypoxic vasoconstriction could constitute a target for treatment that protects the right ventricular (RV) function until endogenous fibrinolysis occurs. The Air versus oxygen for Intermediate-Risk pulmonary embolism (AIR) trial aims to assess the effect of oxygen therapy in patients with intermediate-risk acute PE who do not have hypoxemia at baseline.Methods and Analyses: AIR is a prospective, multicenter, randomized, open-label, parallel-group, proof-of-concept trial. A total of 90 patients hospitalized with intermediate-risk PE and an oxygen saturation of 90% or higher at baseline will be randomized in a 1:1 fashion to receive supplemental oxygen or ambient air. The primary outcome is a RV/LV diameter ratio equal or less than 1.0 on echocardiography measured 48 hours after the start of treatment. Secondary efficacy outcomes are the numerical change in the ratio of the RV to the LV diameter measured 48 hours and 7 days after the start of treatment, with respect to the baseline ratio measured at randomization. Clinical adverse events will be also collected.Results: Enrollment started in July 2019 and is expected to proceed until 2022. Median age of the first 50 patients was 74 years (interquartile range, 61-81), and 50% were female.Conclusions: This multicenter trial will provide information about the value of supplemental oxygen in patients with intermediate-risk acute PE who do not have hypoxemia at baseline. The results will contribute to research that may assist patients with intermediate-risk PE in the future. [ABSTRACT FROM AUTHOR]

Published
2023
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19. Pulmonary Embolism in Patients with COVID-19: Comparison between Different Care Settings.

Author

Buso, Giacomo, Mazzolai, Lucia, Rueda-Camino, José Antonio, Fernández-Capitán, Carmen, Jiménez, David, Bikdeli, Behnood, Lobo, José Luis, Fernández-Reyes, José Luis, Ciammaichella, Maurizio, and Monreal, Manuel

Subjects
COVID-19, PULMONARY embolism, DISEASE relapse, THROMBOEMBOLISM
Abstract

The clinical characteristics and outcomes of patients with coronavirus disease 2019 (COVID-19) who develop pulmonary embolism (PE) in the full spectrum of patient care settings need to be elucidated. The aim of this study was to compare the clinical characteristics, treatment, and 90-day outcomes in patients diagnosed with PE while recovering from COVID-19 in the outpatient setting versus those who were diagnosed with PE while being hospitalized with COVID-19. Data from the international Registro Informatizado de Enfermedad TromboEmbólica (RIETE) registry were used. The major study outcomes were all-cause death, major bleeding, and venous thromboembolism (VTE) recurrences during the first 90 days after PE. From March 2020 to March 2021, 737 patients with COVID-19 experienced acute PE. Of these, 340 (46%) were recovering from COVID-19 as outpatients (267 patients who had been treated at home for COVID-19 and 73 discharged after being hospitalized with COVID-19). Compared with inpatients with COVID-19, those recovering in the outpatient setting upon PE were less likely to be men (odds ratio [OR]: 0.54; 95% confidence interval [CI]: 0.40–0.72) and less likely to have hypertension (OR: 0.55; 95% CI: 0.41–0.74) or diabetes (OR: 0.51; 95% CI: 0.33–0.76). At 90-day follow-up, eight patients (none recovering from COVID-19 as outpatient vs. 2.4% of inpatients with COVID-19) developed recurrent VTE, 34 (1.9 vs. 7.9%) had major bleeding, and 128 (10 vs. 24%) died. On multivariable analysis, inpatients with COVID-19 were at a higher risk of major bleeding (adjusted hazard ratio [HR]: 6.80; 95% CI: 1.52–30.4) or death (adjusted HR: 2.24; 95% CI: 1.40–3.58). In conclusion, using a large multinational registry of patients with COVID-19 who experienced PE, thromboembolic episodes occurring in those recovering from COVID-19 as outpatients were associated with less ominous outcomes than inpatients with COVID-19. [ABSTRACT FROM AUTHOR]

Published
2023
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20. Effect of Prognostic Guided Management of Patients With Acute Pulmonary Embolism According to the European Society of Cardiology Risk Stratification Model

Author

Jiménez, David, Rodríguez, Carmen, Pintado, Beatriz, Pérez, Andrea, Jara-Palomares, Luis, López-Reyes, Raquel, Ruiz-Artacho, Pedro, García-Ortega, Alberto, Bikdeli, Behnood, Lobo, José Luis, IPEP investigators, Instituto de Salud Carlos III, and European Commission

Subjects
Complications, pulmonary embolism, LOS, complications, Pulmonary embolism, prognosis, Mortality, Prognosis, Cardiology and Cardiovascular Medicine, mortality
Abstract

[Background] A recent trial showed that management driven by prognostic assessment was effective in reducing the length of stay (LOS) for acute stable pulmonary embolism (PE). The efficacy and safety of this strategy in each subgroup of risk stratification remains unknown., [Methods] We conducted a post-hoc analysis of the randomized IPEP study to evaluate the effect of a management strategy guided by early use of a prognostic pathway in the low- and intermediate-high risk subgroups defined by the European Society of Cardiology (ESC) model. These subgroups were retrospectively identified in the control arm. The primary outcome was LOS. The secondary outcomes were 30-day clinical outcomes., [Results] Of 249 patients assigned to the intervention group, 60 (24%) were classified as low-, and 30 (12%) as intermediate-high risk. Among 249 patients assigned to the control group, 66 (27%) were low-, and 13 (5%) intermediate-high risk. In the low-risk group, the mean LOS was 2.1 (±0.9) days in the intervention group and 5.3 (±2.9) days in the control group (P < 0.001). In this group, no significant differences were observed in 30-day readmissions (0% vs. 3.0%, respectively), all-cause (0% vs. 0%) and PE-related mortality rates (0% vs. 0%), or severe adverse events (0% vs. 1.5%). In the intermediate-high risk group, the mean LOS was 5.3 (±1.8) days in the intervention group and 6.5 (±2.5) days in the control group (P = 0.08). In this group, no significant differences were observed in 30-day readmissions (3.3% vs. 3.0%, respectively), all-cause (6.7% vs. 7.7%) and PE-related mortality rates (6.7% vs. 7.7%), or severe adverse events (16.7% vs. 15.4%)., [Conclusion] The use of a prognostic assessment and management pathway was effective in reducing the LOS for acute PE without comprising safety across subgroups of risk stratification., This work was funded by the Instituto de Salud Carlos III (PI15/00207) and cofinanced by the European Development Regional Fund “A way to achieve Europe.”

Published
2022

21. Major bleeding in patients with pulmonary embolism presenting with syncope

Author

Maestre, Ana, Escribano, José Carlos, Lobo, José Luis, Jara Palomares, Luis, Jiménez, David, Bikdeli, Behnood, Armestar, Fernando, Bura-Riviere, Alessandra, Lorenzo, Alicia, Monreal, Manuel, RIETE Group, LEO Pharma, Rovi, and Maestre, Ana

Subjects
Pulmonary embolism, syncope, Bleeding, Clinical Biochemistry, Anticoagulants, Hemorrhage, General Medicine, Biochemistry, Syncope, Fibrinolytic Agents, Acute Disease, Humans, Thrombolytic Therapy, Registries, Pulmonary Embolism, Outcome
Abstract

[Introduction] Syncope has been shown to be a risk factor of bleeding in patients receiving thrombolytic therapy for acute pulmonary embolism (PE). Whether syncope predicts bleeding in a broader population of patients with PE remains unknown., [Methods] We used the RIETE registry data to assess whether initial presentation with syncope could predict bleeding in PE patients receiving anticoagulant therapy, and to explore the association between presence of syncope and timing and site of major bleeding events., [Results] Among 45,765 patients with acute PE from March 2001 to January 2021, 6760 (14.8%) had syncope. Patients with syncope were older and more likely to have hypotension, tachycardia, hypoxaemia or elevated troponin levels than those without syncope. They also were more likely to receive thrombolytics. During the first 90 days, 1097 patients (2.4%) suffered major bleeding (gastrointestinal 335, hematoma 271 and intracranial 163) and 3611 died (158 had fatal bleeding). Patients with syncope had a higher rate of major bleeding (odds ratio [OR]: 1.63; 95% CI: 1.41–1.89) and a nonsignificantly higher rate of fatal bleeding (OR: 1.47; 95% CI: 0.99–2.17) than those without syncope. Multivariable analysis confirmed that patients with syncope were at increased risk for major bleeding (adjusted hazard ratio [aHR]: 1.34; 95% CI: 1.15–1.55). On sensitivity analysis, the increased risk for major bleeding was confirmed in patients initially receiving anticoagulant therapy without thrombolytics at 7 days (aHR: 1.47; 95% CI: 1.13–1.91) and 90 days (aHR: 1.33; 95%CI: 1.13–1.56)., [Discussion] Syncope is a predictor of major bleeding events in patients with PE, even among those receiving anticoagulation monotherapy., We express our gratitude to Sanofi Spain, LEO PHARMA and ROVI for supporting this Registry with an unrestricted educational grant.

Published
2022

23. Association Between Preexisting Versus Newly Identified Atrial Fibrillation and Outcomes of Patients With Acute Pulmonary Embolism

Author

Bikdeli, Behnood, primary, Jiménez, David, additional, del Toro, Jorge, additional, Piazza, Gregory, additional, Rivas, Agustina, additional, Fernández‐Reyes, José Luis, additional, Sampériz, Ángel, additional, Otero, Remedios, additional, Suriñach, José María, additional, Siniscalchi, Carmine, additional, Martín‐Guerra, Javier Miguel, additional, Castro, Joaquín, additional, Muriel, Alfonso, additional, Lip, Gregory Y. H., additional, Goldhaber, Samuel Z., additional, Monreal, Manuel, additional, Prandoni, Paolo, additional, Brenner, Benjamin, additional, Farge‐Bancel, Dominique, additional, Barba, Raquel, additional, Di Micco, Pierpaolo, additional, Bertoletti, Laurent, additional, Schellong, Sebastian, additional, Tzoran, Inna, additional, Reis, Abilio, additional, Bosevski, Marijan, additional, Bounameaux, Henri, additional, Malý, Radovan, additional, Verhamme, Peter, additional, Caprini, Joseph A., additional, Bui, Hanh My, additional, Adarraga, María Dolores, additional, Agud, María, additional, Aibar, Jesús, additional, Aibar, Miguel Ángel, additional, Amado, Cristina, additional, Arcelus, Juan Ignacio, additional, Baeza, Carlos, additional, Ballaz, Aitor, additional, Barbagelata, Cristina, additional, Barrón, Manuel, additional, Barrón‐Andrés, Belén, additional, Blanco‐Molina, Ángeles, additional, Botella, Ernesto, additional, Camon, Ana María, additional, Cañas, Inmaculada, additional, Casado, Ignacio, additional, Chasco, Leyre, additional, Criado, Juan, additional, de Ancos, Cristina, additional, de Miguel, Javier, additional, Demelo‐Rodríguez, Pablo, additional, Díaz‐Peromingo, José Antonio, additional, Di Campli, Mario Virgilio, additional, Díez‐Sierra, Javier, additional, Domínguez, Irene Milagros, additional, Escribano, José Carlos, additional, Falgá, Conxita, additional, Farfán‐Sedano, Ana Isabel, additional, Fernández‐Capitán, Carmen, additional, Fernández‐Reyes, Jose Luis, additional, Fidalgo, María Ángeles, additional, Flores, Katia, additional, Font, Carme, additional, Font, Llorenç, additional, Francisco, Iria, additional, Gabara, Cristina, additional, Galeano‐Valle, Francisco, additional, Galindo, David, additional, García, María Angelina, additional, García‐Bragado, Ferrán, additional, García de Herreros, Marta, additional, García‐Hernáez, Raquel, additional, García‐Mullor, María Mar, additional, García‐Raso, Arantxa, additional, Gavín‐Sebastián, Olga, additional, Gil‐Díaz, Aida, additional, Gómez‐Cuervo, Covadonga, additional, Grau, Enric, additional, Guirado, Leticia, additional, Gutiérrez, Javier, additional, Hernández‐Blasco, Luis, additional, Hernando, Elena, additional, Herreros, Miguel, additional, Jara‐Palomares, Luis, additional, Jaras, María Jesús, additional, Jiménez, Rafael, additional, Joya, Maria Dolores, additional, León, José Manuel, additional, Lima, Jorge, additional, Llamas, Pilar, additional, Lobo, José Luis, additional, López‐Jiménez, Luciano, additional, López‐Miguel, Patricia, additional, López‐Núñez, Juan José, additional, López‐Reyes, Raquel, additional, López‐Ruiz, Antonio, additional, López‐Sáez, Juan Bosco, additional, Lorenzo, Alicia, additional, Madridano, Olga, additional, Maestre, Ana, additional, Marchena, Pablo Javier, additional, Martín del Pozo, Mar, additional, Martín‐Martos, Francisco, additional, Mella, Carmen, additional, Mellado, Meritxell, additional, Mercado, Maria Isabel, additional, Moisés, Jorge, additional, del Valle Morales, María, additional, Muñoz‐Blanco, Arturo, additional, Muñoz‐Rivas, Nuria, additional, Navas, María Sierra, additional, Nieto, Jose Antonio, additional, Núñez‐Fernández, Manuel Jesús, additional, Obispo, Berta, additional, Olid, Mónica, additional, Olivares, María Carmen, additional, Orcastegui, José Luis, additional, Ortega‐Michel, Clara, additional, Osorio, Jeisson, additional, Otalora, Sonia, additional, Parra, Pedro, additional, Parra, Virginia, additional, Pedrajas, José María, additional, Pellejero, Galadriel, additional, Porras, José Antonio, additional, Portillo, José, additional, Riera‐Mestre, Antoni, additional, Rivera‐Civico, Francisco, additional, Rodríguez‐Chiaradía, Diego Agustín, additional, Rodríguez‐Cobo, Ana, additional, Rodríguez‐Matute, Consolación, additional, Rogado, Jacobo, additional, Roig, Sonia, additional, Rosa, Vladimir, additional, Ruiz‐Artacho, Pedro, additional, Ruiz‐Giménez, Nuria, additional, Ruiz‐Ruiz, Justo, additional, Ruiz‐Sada, Pablo, additional, Salgueiro, Giorgina, additional, Sánchez‐Martínez, Rosario, additional, Sánchez‐Muñoz‐Torrero, Juan Francisco, additional, Sancho, Teresa, additional, Sirisi, Merçe, additional, Soler, Silvia, additional, Tirado, Raimundo, additional, Torres, María Isabel, additional, Tolosa, Carles, additional, Trujillo‐Santos, Javier, additional, Uresandi, Fernando, additional, Valero, Beatriz, additional, Valle, Reina, additional, Vela, Jerónimo Ramón, additional, Vidal, Gemma, additional, Villares, Paula, additional, Zamora, Carles, additional, Gutiérrez, Paula, additional, Vázquez, Fernando Javier, additional, Engelen, Matthias, additional, Vanassche, Thomas, additional, Hirmerova, Jana, additional, Salgado, Estuardo, additional, Ait Abdallah, Nassim, additional, Bura‐Riviere, Alessandra, additional, Crichi, Benjamin, additional, Debourdeau, Philippe, additional, Olivier, Espitia, additional, Falvo, Nicolas, additional, Galliazzo, Silvia, additional, Helfer, Hélène, additional, Mahé, Isabelle, additional, Moustafa, Farès, additional, Poenou, Geraldine, additional, Braester, Andrei, additional, Bilora, Franca, additional, Bucherini, Eugenio, additional, Ciammaichella, Maurizio, additional, Imbalzano, Egidio, additional, Maida, Rosa, additional, Mastroiacovo, Daniela, additional, Pace, Federica, additional, Pesavento, Raffaele, additional, Pomero, Fulvio, additional, Quintavalla, Roberto, additional, Rocci, Anna, additional, Romualdi, Roberta, additional, Tufano, Antonella, additional, Visonà, Adriana, additional, Zalunardo, Beniamino, additional, Gibietis, Valdis, additional, Kigitovica, Dana, additional, Skride, Andris, additional, Fonseca, Samuel, additional, Martins, Filipa, additional, Meireles, Jose, additional, Mazzolai, Lucia, additional, Bikdeli, Behnood, additional, Tafur, Alfonso J., additional, Ochoa‐Chaar, Cassius Iyad, additional, Weinberg, Ido, additional, and Wilkins, Hannah, additional

Published
2021
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25. WITHDRAWN: Multidisciplinary consensus for the management of pulmonary thromboembolism

Author

Lobo, José Luis, primary, Alonso, Sergio, additional, Arenas, Juan, additional, Domènech, Pere, additional, Escribano, Pilar, additional, Fernández-Capitán, Carmen, additional, Jara-Palomares, Luis, additional, Jiménez, Sonia, additional, Lázaro, María, additional, Lecumberri, Ramón, additional, Monreal, Manuel, additional, Ruiz-Artacho, Pedro, additional, and Jiménez, David, additional

Published
2021
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26. Spanish consensus for the management of pulmonary thromboembolism

Author

Lobo, José Luis, primary, Jiménez, David, additional, Alonso, Sergio, additional, Arenas, Juan, additional, Domènech, Pere, additional, Escribano, Pilar, additional, Fernández-Capitán, Carmen, additional, Jara-Palomares, Luis, additional, Jiménez, Sonia, additional, Lázaro, María, additional, Lecumberri, Ramón, additional, Monreal, Manuel, additional, and Ruiz-Artacho, Pedro, additional

Published
2021
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27. Randomised controlled trial of a prognostic assessment and management pathway to reduce the length of hospital stay in normotensive patients with acute pulmonary embolism

Author

Jiménez, David, primary, Rodríguez, Carmen, additional, León, Francisco, additional, Jara-Palomares, Luis, additional, López-Reyes, Raquel, additional, Ruiz-Artacho, Pedro, additional, Elías, Teresa, additional, Otero, Remedios, additional, García-Ortega, Alberto, additional, Rivas-Guerrero, Agustina, additional, Abelaira, Jaime, additional, Jiménez, Sonia, additional, Muriel, Alfonso, additional, Morillo, Raquel, additional, Barrios, Deisy, additional, Le Mao, Raphael, additional, Yusen, Roger D., additional, Bikdeli, Behnood, additional, Monreal, Manuel, additional, and Lobo, José Luis, additional

Published
2021
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28. Prognostic significance of multidetector CT in normotensive patients with pulmonary embolism: results of the protect study

Author

Jiménez, David, Lobo, José Luis, Monreal, Manuel, Moores, Lisa, Oribe, Mikel, Barrón, Manuel, Otero, Remedios, Nauffal, Dolores, Rabuñal, Ramón, Valle, Reina, Navarro, Carmen, Rodríguez-Matute, Consolación, Álvarez, Celso, Conget, Francisco, Uresandi, Fernando, Aujesky, Drahomir A, Yusen, Roger D, Álvarez, Celso, Abaitúa, Jose María, Abraira, Víctor, Alonso, Ángel, Alonso, Luis Javier, Ballaz, Aitor, Ballester, Marta, Barrón, Manuel, Briongos, Sem, Castañer, Eva, Castro, Olalla, Conget, Francisco, Cuesta, José María, Elías, Teresa, Gómez, Vicente, Gallego, Ignacio, González, Mariano, Gorospe, Luis, Guillaumet, Eva, Iglesias, Concepción, Jiménez, David, López, Francisco, López, Mónica, Lladó, María, Lobo, José Luis, Lucio, Pilar, Marín, Jesús, Martín, María, Monreal, Manuel, Muriel, Alfonso, Nauffal, Dolores, Navarro, Carmen, Oribe, Mikel, Osa, Ana, Otero, Remedios, Pamies, José, Piret, María Victoria, Pozo, Delfina, Prieto, Amador, Rabuñal, Ramón, Rodríguez, Consolación, Rodríguez, Nuria, Rodrigo, Carmen, Santolaria, Miguel Ángel, Serrano, Pilar, Testa, Ana, Uresandi, Fernando, Valle, Reina, Velasco, Sonia, Vicente, Agustina, Vivancos, Jorge, Yusen, Roger D., Zamora, Javier, Zorrilla, Vanesa, de Benito, José Luis, and del Rey, José Manuel

Published
2014
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29. Cancer Histology and Natural History of Patients with Lung Cancer and Venous Thromboembolism.

Author

Ruiz-Artacho, Pedro, Lecumberri, Ramón, Trujillo-Santos, Javier, Font, Carme, López-Núñez, Juan J., Peris, María Luisa, Díaz Pedroche, Carmen, Lobo, José Luis, López Jiménez, Luciano, López Reyes, Raquel, Jara Palomares, Luis, Pedrajas, José María, Mahé, Isabelle, and Monreal, Manuel

Subjects
DISEASE relapse, HEMORRHAGE risk factors, LUNG cancer complications, MORTALITY risk factors, ADENOCARCINOMA, VEINS, SMALL cell carcinoma, LUNG tumors, DISEASE incidence, ANTICOAGULANTS, RISK assessment, CANCER patients, THROMBOEMBOLISM, HISTOLOGY, SQUAMOUS cell carcinoma, DISEASE complications
Abstract

Simple Summary: Cancer is a widely heterogeneous disease, and the natural history of patients with cancer-associated thrombosis may differ according to the cancer site. Lung cancer is the most common malignancy, and a leading cause of death. A number of studies in the literature suggest that patients with adenocarcinoma may have a worse outcome than those with squamous or other types of lung cancer. The aim of the current study was to assess the potential impact of lung cancer histology on the incidence rates of VTE recurrences, major bleeding, or death appearing during the course of anticoagulation, in patients with lung cancer and VTE. Our findings, obtained from a large series of consecutive patients with lung cancer and VTE (482 patients), reveal important differences between patients with adenocarcinoma vs. other histologies in their outcomes during anticoagulation. This might likely help to design better therapeutic strategies for patients with lung cancer. Background: In patients with lung cancer and venous thromboembolism (VTE), the influence of cancer histology on outcome has not been consistently evaluated. Methods: We used the RIETE registry (Registro Informatizado Enfermedad TromboEmbólica) to compare the clinical characteristics and outcomes during anticoagulation in patients with lung cancer and VTE, according to the histology of lung cancer. Results: As of April 2022, there were 482 patients with lung cancer and VTE: adenocarcinoma 293 (61%), squamous 98 (20%), small-cell 44 (9.1%), other 47 (9.8%). The index VTE was diagnosed later in patients with squamous cancer than in those with adenocarcinoma (median, 5 vs. 2 months). In 50% of patients with adenocarcinoma, the VTE appeared within the first 90 days since cancer diagnosis. During anticoagulation (median 106 days, IQR: 45–214), 14 patients developed VTE recurrences, 15 suffered major bleeding, and 218 died: fatal pulmonary embolism 10, fatal bleeding 2. The rate of VTE recurrences was higher than the rate of major bleeding in patients with adenocarcinoma (11 vs. 6 events), and lower in those with other cancer types (3 vs. 9 events). On multivariable analysis, patients with adenocarcinoma had a non-significantly higher risk for VTE recurrences (hazard ratio [HR]: 3.79; 95%CI: 0.76–18.8), a lower risk of major bleeding (HR: 0.29; 95%CI: 0.09–0.95), and a similar risk of mortality (HR: 1.02; 95%CI: 0.76–1.36) than patients with other types of lung cancer. Conclusions: In patients with lung adenocarcinoma, the rate of VTE recurrences outweighed the rate of major bleeding. In patients with other lung cancers, it was the opposite. [ABSTRACT FROM AUTHOR]

Published
2022
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30. Consenso multidisciplinar para el manejo de la tromboembolia de pulmón

Author

Lobo, José Luis, Alonso, Sergio, Arenas, Juan, Domènech, Pere, Escribano, Pilar, Fernández-Capitán, Carmen, Jara-Palomares, Luis, Jiménez, Sonia, Lázaro, María, Lecumberri, Ramón, Monreal, Manuel, Ruiz-Artacho, Pedro, Jiménez, David, and en nombre del Panel Multidisciplinar para el Manejo de la TEP

Subjects
Treatment, Tromboembolia de pulmón, Diagnóstico, Diagnosis, Pulmonary embolism, Pronóstico, Tratamiento, Prognosis
Abstract

We have updated recommendations on 12 controversial topics that were published in the 2013 National Consensus on the diagnosis, risk stratification and treatment of patients with pulmonary embolism (PE). A comprehensive review of the literature was performed for each topic, and each recommendation was evaluated in two teleconferences. For diagnosis, we recommend against using the Pulmonary Embolism Rule Out Criteria (PERC) rule as the only test to rule out PE, and we recommend using a D-dimer cutoff adjusted to age to rule out PE. We suggest using computed tomography pulmonary angiogram as the imaging test of choice for the majority of patients with suspected PE. We recommend using direct oral anticoagulants (over vitamin K antagonists) for the vast majority of patients with acute PE, and we suggest using anticoagulation for patients with isolated subsegmental PE. We recommend against inserting an inferior cava filter for the majority of patients with PE, and we recommend using full-dose systemic thrombolytic therapy for PE patients requiring reperfusion. The decision to stop anticoagulants at 3 months or to treat indefinitely mainly depends on the presence (or absence) and type of risk factor for venous thromboembolism, and we recommend against thrombophilia testing to decide duration of anticoagulation. Finally, we suggest against extensive screening for occult cancer in patients with PE.

Published
2021

34. Manejo clínico de la enfermedad por coronavirus SARS-CoV-2.

Author

Montufar Andrade, Franco Eduardo, primary, Dueñas Castell, Carmelo, additional, Sáenz, Oscar, additional, Ortiz, Guillermo, additional, Garay, Manuel, additional, Díaz Bossa, Claudia Patricia, additional, Quintana Lobo, José Luis, additional, Varón Vega, Fabio, additional, and Matiz, Carlos, additional

Published
2021
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38. Fabricación y evaluación de una cámara climática para el desarrollo de técnicas de bioimpresión 3D

Author

Matamoros Pacheco, Manuel, primary, Sánchez Ortega, Álvaro, additional, Canito Lobo, José Luis, additional, Marcos Romero, Alfonso Carlos, additional, Carrasco Amador, Juan Pablo, additional, Gómez Blanco, Juan Carlos, additional, Mancha Sánchez, Enrique, additional, Sánchez Margallo, Francisco Miguel, additional, and Pagador Carrasco, José Blas, additional

Published
2020
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39. Implications of Abnormal Troponin Levels With Normal Right Ventricular Function in Normotensive Patients With Acute Pulmonary Embolism

Author

Mirambeaux, Rosa, primary, Le Mao, Raphael, additional, Muriel, Alfonso, additional, Pintado, Beatriz, additional, Pérez, Andrea, additional, Velasco, Diurbis, additional, Lobo, José Luis, additional, Barrios, Deisy, additional, Morillo, Raquel, additional, Bikdeli, Behnood, additional, and Jiménez, David, additional

Published
2020
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42. Fabricación y evaluación de una cámara climática para el desarrollo de técnicas de bioimpresión 3D

Author

Matamoros Pacheco, Manuel, Sánchez Ortega, Álvaro, Canito Lobo, José Luis, Marcos Romero, Alfonso Carlos, Carrasco Amador, Juan Pablo, Gómez Blanco, Juan Carlos, Mancha Sánchez, Enrique, Sánchez Margallo, Francisco Miguel, and Pagador Carrasco, José Blas

Subjects
Bioingeniería, Cartilage, Cartílago, Biocamera, Prótesis, Bioprinting, Bioengineering, Prosthesis, Bioimpresión, Biocámara
Abstract

[Resumen] El objetivo del presente trabajo es la optimización de las técnicas de bioimpresión en el campo de la regeneración tisular de cartílago y la generación de prótesis vasculares. En este trabajo se ha realizado el diseño, fabricación y evaluación de un prototipo de cámara climática. El diseño final de la cámara será capaz de albergar en su interior una bioimpresora 3D. El control de temperatura, humedad y CO2 generará una atmósfera controlada, estéril y estanca, para el perfecto desarrollo del proceso de bioimpresión y maduración de tejidos celulares. [Abstract] The objective of this work is the optimization of bioprinting techniques in the field of cartilage tissue regeneration and the generation of vascular grafts. In this work, the design, manufacture and evaluation of a climatic chamber for a 3D bioprinter has been carried out. The control of temperature, humidity and CO2 generate a controlled, sterile and watertight atmosphere, for the perfect development of the process of bioprinting and maturation of bioprinted cellular tissues. Extremadura. Consejería de Economía e Infraestructuras; IB16200

Published
2018

44. Assessment of coexisting deep vein thrombosis for risk stratification of acute pulmonary embolism

Author

Quezada, Carlos Andrés, primary, Bikdeli, Behnood, additional, Barrios, Deisy, additional, Morillo, Raquel, additional, Nieto, Rosa, additional, Chiluiza, Diana, additional, Barbero, Esther, additional, Guerassimova, Ina, additional, García, Aldara, additional, Yusen, Roger D., additional, Jiménez, David, additional, Rodríguez, Consolación, additional, Vivancos, Jorge, additional, Marín, Jesús, additional, Oribe, Mikel, additional, Ballaz, Aitor, additional, Abaitúa, Jose María, additional, Velasco, Sonia, additional, Barrón, Manuel, additional, Lladó, María, additional, Rodrigo, Carmen, additional, Alonso, Luis Javier, additional, Rabuñal, Ramón, additional, Castro, Olalla, additional, Iglesias, Concepción, additional, Testa, Ana, additional, Gómez, Vicente, additional, Gorospe, Luis, additional, Briongos, Sem, additional, del Rey, José Manuel, additional, Álvarez, Celso, additional, Rodríguez, Nuria, additional, Prieto, Amador, additional, Martín, María, additional, Navarro, Carmen, additional, López, Mónica, additional, Castañer, Eva, additional, Guillaumet, Eva, additional, Otero, Remedios, additional, Elías, Teresa, additional, Serrano, Pilar, additional, López, Francisco, additional, Valle, Reina, additional, Piret, María Victoria, additional, Lucio, Pilar, additional, Cuesta, José María, additional, Nauffal, Dolores, additional, Ballester, Marta, additional, Pamies, José, additional, Osa, Ana, additional, Lobo, José Luis, additional, Zorrilla, Vanesa, additional, Pozo, Delfina, additional, Alonso, Ángel, additional, Conget, Francisco, additional, Santolaria, Miguel Ángel, additional, González, Mariano, additional, and de Benito, José Luis, additional

Published
2018
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45. Incidence of Chronic Thromboembolic Pulmonary Hypertension (CTEPH) at six months of a Pulmonary Embolism (PE). OSIRIS Study

Author

López, Raquel, primary, Lobo, José Luis, additional, Jimenez, David, additional, Muriel, Alfonso, additional, Fernández-Capitán, Carmen, additional, Alfonso, María, additional, Ballaz, Aitor, additional, Nuñez, Ana, additional, Rodrigez-Matute, Consolación, additional, de Miguel, Javier, additional, Monreal, Manuel, additional, Agustin, Diego, additional, Alcalde, Mercedes, additional, GarcíA-Bragado, Fernando, additional, HernáNdez, Luis Manuel, additional, Uresandi, Fernando, additional, Aguero, Ramon, additional, Otero Candelera, Remedios, additional, and Del Molino, Fatima, additional

Published
2017
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48. Interobserver reliability of echocardiography for prognostication of normotensive patients with pulmonary embolism.

Author

Kopecna, Dita, Briongos, Sem, Castillo, Hugo, Moreno, Carlos, Recio, Mónica, Navas, Paula, Lobo, José Luis, Alonso-Gomez, Angel, Obieta-Fresnedo, Izaskun, Fernández-Golfin, Covadonga, Zamorano, José Luis, and Jiménez, David

Abstract

Objectives: To evaluate the interobserver reliability of echocardiographic findings of right ventricle (RV) dysfunction for prognosticating normotensive patients with pulmonary embolism (PE). Methods: A central panel of cardiologists evaluated echocardiographic studies of 75 patients included in the PROTECT study for the following signs: RV diameter, RV/left ventricular (LV) diameter ratio, hypokinesis of the RV free wall, and tricuspid plane systolic excursion (TAPSE). Investigators used intraclass correlation to assess agreement between the measurements of the central panel and each of the local cardiologists. Investigators used the single weighted kappa statistic to test for agreement between readers of interpretation of RV enlargement and RV hypokinesis. Results: The two observers had fair agreement (к = 0.45) for RV enlargement assessed by the RV diameter, and good agreement (к = 0.65) for RV enlargement assessed by the RV/LV diameter ratio. The interobserver reliability of the assessment whether hypokinesis of the RV free wall is present was good (к = 0.70), and whether RV dysfunction (assessed by TAPSE measurement) is present was very good (к = 0.86). The intraclass correlation for the RV/LV diameter ratio was fair (0.55; 95% confidence interval [CI], 0.37-0.69), for the RV diameter was good (0.70; 95% CI, 0.56-0.80), and for the TAPSE measurement was very good (0.85; 95% CI, 0.77-0.90). On Bland-Altman analysis, the mean differences for RV diameter, RV/LV diameter ratio and TAPSE measurement were 2.33 (±5.38), 0.06 (±0.23) and 0.08 (±2.20), respectively. Conclusion: TAPSE measurement is the least user dependent and most reproducible echocardiographic finding of RV dysfunction in normotensive patients with PE. [ABSTRACT FROM AUTHOR]

Published
2014
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49. Caracterización físico mecánica de los laminados de bambú Dendrocalamus asper como material sostenible constructivo para proyectos arquitectónicos en el noroccidente de la provincia de Pichincha

Author

Larco Benítez, Myrian Alexandra, Canito Lobo, José Luis, Reyes Rodríguez, Antonio Manuel, and Universidad de Extremadura. Departamento de Expresión Gráfica

Subjects
Bambú dendrocalamus asper laminado, Valores de resistencia, Materiales constructivos sostenibles, 3312.12 Ensayo de Materiales, Resistance values, 3313.04 Material de Construcción, 3305.33 Resistencia de Estructuras, Sustainable building materials, Bamboo dendrocalamus asper laminates, 3312.09 Resistencia de Materiales
Abstract

Los procesos de construcción de proyectos arquitectónicos son los Los procesos de construcción de proyectos arquitectónicos son los responsables de generar un significativo nivel de impacto ambiental. Desde esta perspectiva se vuelve imperioso realizar investigaciones que brinden alternativas de uso de materiales de construcción que ayudan a este propósito. El bambú es un material natural que gracias a sus aracterísticas, a lo largo de todo su ciclo productivo, brinda grandes beneficios medio ambientales, desde bosques con mayor capacidad de absorción del CO2, periodos muy rápidos de crecimiento en los que se encuentra con los niveles de resistencia adecuados para su aprovechamiento como material de construcción. La posibilidad de uso de laminados de bambú en el sector de la construcción, con indicadores de sostenibilidad muy favorecedores, podría constituirse en una alternativa viable que brinde ventajas tales como la modulación para la sistematización de los procesos constructivos optimizando tiempos y costos. Esta investigación tiene como objetivo principal realizar la caracterización físico mecánica de los Laminados de Bambú fabricados con la especie Dendrocalamus Asper (LBDA), que se están produciendo en el Noroccidente de la Provincia de Pichincha en el Ecuador. Los resultados de esta investigación buscan dar respuesta al comportamiento estructural de este material frente a los esfuerzos de compresión, cortante y flexión, determinando así la posibilidad de su uso en proyectos arquitectónicos que apliquen criterios de construcción sostenible. responsables de generar un significativo nivel de impacto ambiental. Desde esta perspectiva se vuelve imperioso realizar investigaciones que brinden alternativas de uso de materiales de construcción que ayudan a este propósito. El bambú es un material natural que gracias a sus características, a lo largo de todo su ciclo productivo, brinda grandes beneficios medio ambientales, desde bosques con mayor capacidad de absorción del CO2, periodos muy rápidos de crecimiento en los que se encuentra con los niveles de resistencia adecuados para su aprovechamiento como material de construcción. La posibilidad de uso de laminados de bambú en el sector de la construcción, con indicadores de sostenibilidad muy favorecedores, podría constituirse en una alternativa viable que brinde ventajas tales como la modulación para la sistematización de los procesos constructivos optimizando tiempos y costos. Esta investigación tiene como objetivo principal realizar la caracterización físico mecánica de los Laminados de Bambú fabricados con la especie Dendrocalamus Asper (LBDA), que se están produciendo en el Noroccidente de la Provincia de Pichincha en el Ecuador. Los resultados de esta investigación buscan dar respuesta al comportamiento estructural de este material frente a los esfuerzos de compresión, cortante y flexión, determinando así la posibilidad de su uso en proyectos arquitectónicos que apliquen criterios de construcción sostenible., The processes of construction of architectural projects are responsible for generating a significant level of environmental impact. From this perspective, it is imperative to carry out research that provides alternatives for the use of construction materials that contribute to reduce such impact. Bamboo is a natural material that thanks to its characteristics - throughout its productive cycle - provides great environmental benefits, from forests with greater ability to absorb CO2 until very fast periods of growth in which it has levels of resistance suitable for use as building material. The possibility of using bamboo laminates in the construction sector, with very favorable sustainability indicators, could constitute a viable alternative that offers advantages such as the use of modules that in turn enable the systematization of the construction processes, thus optimizing time and costs. The main objective of this research is to perform the mechanical physical characterization of Bamboo Laminates made with the species dendrocalamus asper (LBDA), which are being produced in the Northwest of the Province of Pichincha in Ecuador. The results of this research try to respond to the structural behavior of this material in front of the compression, shear and bending strengths, thus determining the possibility of its use in architectural projects that apply sustainable construction criteria.

Published
2017

50. La gestión local en los modelos de planificación urbana y su impacto en el medio ambiente

Author

Mena Mora, Fredy Raúl, Moral García, Francisco Jesús, Canito Lobo, José Luis, and Universidad de Extremadura. Departamento de Expresión Gráfica

Subjects
Environmental quality, Morfología urbana, Planificación urbana, Sostenibilidad, 5401.03 Utilización de la Tierra, Paisaje, 6201.03 Urbanismo, Calidad ambiental, Sustainability, Urban planning, 5404.01 Geografía Urbana, Urban morphology, Landscape, 3305.37 Planificación Urbana
Abstract

La planificación urbana es un aspecto preponderante para la organización del territorio y de las actividades que en él se desarrollan, procesos de ordenamiento que quizás en el contexto ecuatoriano no se ha desarrollado aún con eficiencia, de ahí la necesidad de generar propuestas metodológicas que apunten a la aplicación de estrategias urbanas que busquen optimizar los recursos naturales, más aún si se tiene en cuenta que la ciudad como un ente vivo se apropia de estos bienes generando emisiones y descargas contaminantes al ambiente. Lo que se pretende con este trabajo es realizar un análisis de la situación urbana actual de una ciudad de tamaño medio de la sierra centro del Ecuador, identificando para ello componentes que tradicionalmente se han abordado en los estudios urbanos, como aquellos que se relacionan exclusivamente con el uso y ocupación del suelo, e incluyendo otros elementos que tienen que ver con la calidad ambiental de los recursos agua y aire, el nivel de confort sobre el análisis de la contaminación acústica, el índice de calor urbano y el estudio de la calidad paisajística, como elementos de referencia que pueden ser aplicados en otras ciudades de la región con similares características. Evidenciando una problemática que agobia a ciudades intermedias, que se relacionan con conflictos en el uso del espacio público, la movilidad, el control edilicio, la deficiencia de áreas verdes y el crecimiento de la mancha urbana en función de la dispersión de los asentamientos humanos. Con estos resultados se plantea la construcción de un modelo territorial sostenible sobre la base de la definición de unidades de paisaje que plateen un nuevo ordenamiento urbano que incluya el componente ambiental en su análisis, generando líneas estratégicas que resulten útiles para emprender una gestión municipal centrada en propuestas eficaces y eficientes tendientes a mejorar los procesos de urbanización y la conservación del medio ambiente., The urban planning is a preponderant aspect for the organization of the territory and the activities that are developed in it, processes of ordering that perhaps in the Ecuadorian context has not yet been developed with efficiency, hence the need to generate methodological proposals that point to The application of urban strategies that seek to optimize natural resources, especially considering that the city as a living entity appropriates these godos generating polluting emissions and discharges to the environment. The aim of this work is to analyze the current urban situation of a medium-sized city in the central highlands of Ecuador, identifying for this purpose components that have traditionally been addressed in urban studies, such as those that relate exclusively to The use and occupation of the soil, and including other elements that have to do with the environmental quality of water and air resources, the level of comfort on the analysis of noise pollution, the urban heat index and the study of landscape quality , As reference elements that can be applied in other cities of the region with similar characteristics. Evidenciating a problem that overwhelms intermediate cities, which are related to conflicts in the use of public space, mobility, building control, deficiency of green areas and the growth of the urban spot as a result of the dispersal of human settlements. With these results, the construction of a sustainable territorial model based on the definition of landscape units that create a new urban structure that includes the environmental component in its analysis, generating strategic lines that are useful to undertake a municipal management centered on effective and efficient proposals to improve the processes of urbanization and conservation of the environment.

Published
2017

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