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1. The Brussels consensus for non-invasive ICP monitoring when invasive systems are not available in the care of TBI patients (the B-ICONIC consensus, recommendations, and management algorithm)

Author

Robba, Chiara, Picetti, Edoardo, Vásquez-García, Sebastián, Abulhasan, Yasser B., Ain, Amelia, Adeleye, Amos O., Aries, Marcel, Brasil, Sérgio, Badenes, Rafael, Bertuccio, Alessandro, Bouzat, Pierre, Bustamante, Luis, Calabro’, Lorenzo, Njimi, Hassane, Cardim, Danilo, Citerio, Giuseppe, Czosnyka, Marek, Geeraerts, Thomas, Godoy, Daniel A., Hirzallah, Mohammad I., Devi, Bhagavatula Indira, Jibaja, Manuel, Lochner, Piergiorgio, Mijangos Méndez, Julio C., Meyfroidt, Geert, Munusamy, Thangaraj, Portilla, Juan Pinedo, Prabhakar, Hemanshu, Rasulo, Frank, Sánchez Parra, Diana M., Sarwal, Aarti, Shrestha, Gentle S., Shukla, Dhaval P., Sung, Gene, Tirsit, Abenezer, Vásquez, Franly, Videtta, Walter, Wang, Yu Lin, Paiva, Wellingson S., Taccone, Fabio Silvio, and Rubiano, Andres M.

Published
2025
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4. Prognosis and management of acute symptomatic seizures: a prospective, multicenter, observational study

Author

Herzig-Nichtweiß, Julia, Salih, Farid, Berning, Sascha, Malter, Michael P., Pelz, Johann O., Lochner, Piergiorgio, Wittstock, Matthias, Günther, Albrecht, Alonso, Angelika, Fuhrer, Hannah, Schönenberger, Silvia, Petersen, Martina, Kohle, Felix, Müller, Annekatrin, Gawlitza, Alexander, Gubarev, Waldemar, Holtkamp, Martin, and Vorderwülbecke, Bernd J.

Published
2023
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7. Decline in the number of patients with meningitis in German hospitals during the COVID-19 pandemic

Author

Völk, Stefanie, Pfirrmann, Markus, Koedel, Uwe, Pfister, Hans-Walter, Lang, Thomas, Scheibe, Franziska, Salih, Farid, Herzig-Nichtweiss, Julia, Zimmermann, Julian, Alonso, Angelika, Wittstock, Matthias, Totzeck, Andreas, Schramm, Patrick, Schirotzek, Ingo, Onur, Oezguer A., Pelz, Johann Otto, Ottomeyer, Caroline, Luger, Sebastian, Barlinn, Kristian, Binder, Tobias, Wöbker, Gabriele, Reimann, Gernot, Urbanek, Christian, Heckelmann, Jan, Lochner, Piergiorgio, Berghoff, Martin, Schönenberger, Silvia, Neumann, Bernhard, Niesen, Wolf-Dirk, Dohmen, Christian, Huttner, Hagen B., Günther, Albrecht, and Klein, Matthias

Published
2022
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9. Neurologic manifestations of COVID-19 in critically ill patients: results of the prospective multicenter registry PANDEMIC

Author

Dimitriadis, Konstantinos, Meis, Jan, Neugebauer, Hermann, Barlinn, Kristian, Neumann, Bernhard, Gahn, Georg, Lochner, Piergiorgio, Knier, Benjamin, Lindemann, Sarah, Sühs, Kurt Wolfram, Szabo, Kristina, Pfefferkorn, Thomas, Schirotzek, Ingo, Freilinger, Tobias, Burc, Bassa, Günther, Albrecht, Wittstock, Matthias, Schramm, Patrick, Reimann, Gernot, Godau, Jana, Nagy, Gabor, Koenig, Fatima B., Essig, Fabian, Klinker, Hartwig, Hartmann, Christian, Schmidbauer, Moritz L., Steinberg, Tim, Lefterova, Lora, Klose, Christina, and Bösel, Julian

Published
2022
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16. Premorbid frailty, stress hyperglycemia ratio, and functional outcome in patients with acute ischemic stroke.

Author

Zedde, Marialuisa, Lattanzi, Simona, Pilotto, Andrea, Janitschke, Daniel, Stögbauer, Jakob, Merzou, Fatma, Pascarella, Rosario, Padovani, Alessandro, Morotti, Andrea, and Lochner, Piergiorgio

Subjects
STROKE patients, ISCHEMIC stroke, GLYCOSYLATED hemoglobin, BLOOD sugar, STROKE units
Abstract

Background: Frailty, defined as multidimensional prognostic index (MPI), has been recently identified as strong predictor of disability and mortality in the elderly with acute ischemic stroke (AIS). The stress hyperglycemia ratio (SHR) is a recently introduced biomarker significantly associated with poor outcome in AIS. Objectives: This study aimed to investigate in what extent frailty, measured by MPI, and SHR affects the 3-months outcome of patients > 65 years-old with AIS. Methods: Consecutive patients with AIS >65 years-old who underwent intravenous thrombolysis (IVT) from 2015 to 2019 were enrolled in a German and an Italian Stroke Unit. The SHR was calculated by dividing the fasting plasma glucose at admission with glycated hemoglobin. Demographics and clinical premorbid data, stroke-related variables, including baseline and post-treatment NIHSS score were included in a logistic regression model. The 3-months functional outcome was evaluated by using modified Rankin scale (mRS); good outcome was defined as mRS 0–2, poor as mRS ≥ 3. Results: One hundred and fifty-five AIS patients were enrolled in the study. Median MPI was 0.19 [0.13–0.31]; 118 (76.1%) patients were classified as "robust" and 37 (23.9%) as "frail." In regression analysis, age, NIHSS, and MPI demonstrated as the most significant predictor of 3-months good outcome in the whole cohort. In robust patients, SHR values were significantly associated with the outcome. Conclusions: MPI is associated with the 3-months outcome in our cohort, in particular with good outcome. Conversely, SHR seems to be associated with a 3-months poor outcome in "robust" patients but not in frail patients. [ABSTRACT FROM AUTHOR]

Published
2024
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17. Optic Nerve Sheath Diameter Point-of-Care Ultrasonography Quality Criteria Checklist: An International Consensus Statement on Optic Nerve Sheath Diameter Imaging and Measurement*.

Author

Hirzallah, Mohammad I. M, Lochner, Piergiorgio, Hafeez, Muhammad Ubaid, Lee, Andrew G., Krogias, Christos, Dongarwar, Deepa MS, Hartman, Nicholas D., Ertl, Michael, Robba, Chiara, Malojcic, Branko, Valaikiene, Jurgita, Sarwal, Aarti, Hakimi, Ryan DO, MS, and Schlachetzki, Felix

Subjects
*DELPHI method, *OPTIC nerve, *ULTRASONIC imaging, *POSTURE, *INTRACRANIAL pressure
Abstract

OBJECTIVES: To standardize optic nerve sheath diameter (ONSD) point-of-care ultrasonography (POCUS) and improve its research and clinical utility by developing the ONSD POCUS Quality Criteria Checklist (ONSD POCUS QCC). DESIGN: Three rounds of modified Delphi consensus process and three rounds of asynchronous discussions. SETTING: Online surveys and anonymous asynchronous discussion. SUBJECTS: Expert panelists were identified according to their expertise in ONSD research, publication records, education, and clinical use. A total of 52 panelists participated in the Delphi process. INTERVENTIONS: None. MEASUREMENTS AND MAIN RESULTS: Three Delphi rounds and three asynchronous discussion rounds generated consensus on quality criteria (QC). This started with 29 QC in addition to other QC proposed by expert panelists. The QC items were categorized into probe selection, safety, body position, imaging, measurement, and research considerations. At the conclusion of the study, 28 QC reached consensus to include in the final ONSD POCUS QCC. These QC were then reorganized, edited, and consolidated into 23 QC that were reviewed and approved by the panelists. CONCLUSIONS: ONSD POCUS QCC standardizes ONSD ultrasound imaging and measurement based on international consensus. This can establish ONSD ultrasound in clinical research and improve its utility in clinical practice. [ABSTRACT FROM AUTHOR]

Published
2024
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19. Incidence of early poststroke seizures during reperfusion therapies in patients with acute ischemic stroke: An observational prospective study: (TESI study: “Trombolisi/Trombectomia e crisi Epilettiche precoci nello Stroke Ischemico”)

Author

Belcastro, Vincenzo, Brigo, Francesco, Ferlazzo, Edoardo, Gasparini, Sara, Mastroianni, Giovanni, Cianci, Vittoria, Lattanzi, Simona, Silvestrini, Mauro, Versino, Maurizio, Banfi, Paola, Carimati, Federico, Grampa, Giampiero, Lochner, Piergiorgio, Gigli, Gian Luigi, Bax, Francesco, Merlino, Giovanni, Valente, Mariarosaria, Vidale, Simone, and Aguglia, Umberto

Published
2020
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23. Implications for driving based on the risk of seizures after ischaemic stroke

Author

Schubert, Kai Michael, primary, Bicciato, Giulio, additional, Sinka, Lucia, additional, Abraira, Laura, additional, Santamarina, Estevo, additional, Álvarez-Sabín, José, additional, Ferreira-Atuesta, Carolina, additional, Katan, Mira, additional, Scherrer, Natalie, additional, Terziev, Robert, additional, Döhler, Nico, additional, Erdélyi-Canavese, Barbara, additional, Felbecker, Ansgar, additional, Siebel, Philip, additional, Winklehner, Michael, additional, von Oertzen, Tim J, additional, Wagner, Judith N, additional, Gigli, Gian Luigi, additional, Nilo, Annacarmen, additional, Janes, Francesco, additional, Merlino, Giovanni, additional, Valente, Mariarosaria, additional, Zafra-Sierra, María Paula, additional, Mayor-Romero, Luis Carlos, additional, Conrad, Julian, additional, Evers, S, additional, Lochner, Piergiorgio, additional, Roell, Frauke, additional, Brigo, Francesco, additional, Bentes, Carla, additional, Peralta, Rita, additional, Pinho e Melo, Teresa, additional, Keezer, Mark R, additional, Duncan, John Sidney, additional, Sander, Josemir W, additional, Tettenborn, Barbara, additional, Koepp, Matthias, additional, and Galovic, Marian, additional

Published
2024
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24. Statin Therapy in Ischemic Stroke Patients with Atrial Fibrillation: Efficacy and Safety Outcomes

Author

Marvardi, Michele, primary, Ferrante, Mario, additional, Paciaroni, Maurizio, additional, Abdul-Rahim, Azmil H, additional, Tsivgoulis, Georgios, additional, Seiffge, David J, additional, Engelter, Stefan T, additional, Lyrer, Philippe A., additional, Polymeris, Alexandros A, additional, Dittrich, Tolga D, additional, Cancelloni, Virginia, additional, Zietz, Annaelle, additional, De Marchis, Gian Marco, additional, Putaala, Jukka, additional, Strbian, Daniel, additional, Tomppo, Liisa, additional, Michel, Patrik, additional, Strambo, Davide, additional, Salerno, Alexander, additional, Vanacker, Peter, additional, Zuurbier, Susanna M., additional, Yperzeele, Laetitia, additional, Loos, Caroline MJ, additional, Cappellari, Manuel, additional, Emiliani, Andrea, additional, Zedde, Marialuisa, additional, Becattini, Cecilia, additional, Pascarella, Rosario, additional, Dawson, Jesse, additional, Cronshaw, Robert, additional, Schirinzi, Erika, additional, Del Sette, Massimo, additional, Stretz, Christoph, additional, Kala, Narendra Sharma, additional, Schomer, Ashley, additional, Mac Grory, Brian, additional, Jayaraman, Mahesh V, additional, Yaghi, Shadi, additional, Furie, Karen L., additional, Masotti, Luca, additional, Grifoni, Elisa, additional, Toni, Danilo, additional, Risitano, Angela, additional, Falcou, Anne A, additional, Petraglia, Luca, additional, Lotti, Enrico Maria, additional, Pavolucci, Lucia, additional, Lochner, Piergiorgio, additional, Silvestrelli, Giorgio, additional, Ciccone, Alfonso, additional, Alberti, Andrea, additional, Venti, Michele, additional, Leone De Magistris, Ilaria, additional, Mosconi, Maria Giulia, additional, Giustozzi, Michela, additional, Kargiotis, Odysseas, additional, Rocco, Alessandro, additional, Diomedi, Marina, additional, Marcheselli, Simona, additional, Antonenko, Kateryna, additional, Rota, Eugenia, additional, Tassinari, Tiziana, additional, Saia, Valentina, additional, Palmerini, Francesco, additional, Aridon, Paolo, additional, Arnao, Valentina, additional, Monaco, Serena, additional, Cottone, Salvatore, additional, Baldi, Antonio, additional, D'Amore, Cataldo, additional, Ageno, Walter, additional, Pegoraro, Samuela, additional, Ntaios, George, additional, Adamou, Anastasia, additional, Sagris, Dimitrios, additional, Giannopoulos, Sotirios, additional, Kosmidou, Maria, additional, Ntais, Evangelos, additional, Romoli, Michele, additional, Pantoni, Leonardo, additional, Rosa, Silvia, additional, Bertora, Pierluigi, additional, Chiti, Alberto, additional, Canavero, Isabella, additional, Saggese, Carlo Emanuele, additional, Plocco, Maurizio, additional, Giorli, Elisa, additional, Palaiodimou, Lina, additional, Bakola, Eleni, additional, Bandini, Fabio, additional, Gasparro, Antonio, additional, Terruso, Valeria, additional, Mannino, Marina, additional, Pezzini, Alessandro, additional, Ornello, Raffaele, additional, Sacco, Simona, additional, Popovic, Nemanja, additional, Scoditti, Umberto, additional, Genovese, Antonio, additional, Flomin, Yuriy, additional, Mancuso, Michelangelo, additional, D'agliano, Roberto, additional, Baldini, Marco, additional, Ulivi, Leonardo, additional, Giannini, Nicola, additional, Vadikolias, Konstantinos, additional, Liantinioti, Chrysoula, additional, Chondrogianni, Maria, additional, Halvatsiotis, Panagiotis, additional, Karagkiozi, Efstathia, additional, Athanasakis, George, additional, Makaritsis, Konstantinos, additional, lanari, alessia, additional, Tatlisumak, Turgut, additional, Acciarresi, Monica, additional, Lorenzini, Gianni, additional, Tassi, Rossana, additional, Guideri, Francesca, additional, Acampa, Maurizio, additional, Martini, Giuseppe, additional, Sohn, Sung-Il, additional, Mumoli, Nicola, additional, Cararra, Davide, additional, Maccarrone, Miriam, additional, Galati, Franco, additional, Gourbali, Vanessa, additional, Orlandi, Giovanni, additional, Giuntini, Martina, additional, Corea, Francesco, additional, Bellesini, Marta, additional, Karapanayiotides, Theodore, additional, Csiba, Laszlo, additional, Szabo, Lilla, additional, Imberti, Davide, additional, Pieroni, Alessio, additional, Barlinn, Kristian, additional, Pallesen, Lars-Peder, additional, Barlinn, Jessica, additional, Doronin, Boris, additional, Volodina, Vera Alexandrovna, additional, Agnelli, Giancarlo, additional, Deleu, Dirk, additional, Bonetti, Bruno, additional, Gentile, Luana, additional, Reale, Giuseppe, additional, Caliandro, Pietro, additional, Morotti, Andrea, additional, Vannucchi, Vieri, additional, Padroni, Marina, additional, Letteri, Federica, additional, Magoni, Mauro, additional, Tiseo, Cindy, additional, Rigatelli, Alberto, additional, Zauli, Aurelia, additional, Bossi, Francesco, additional, and Caso, Valeria, additional

Published
2024
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27. Implications for driving based on the risk of seizures after ischaemic stroke

Author

Schubert, Kai Michael; https://orcid.org/0000-0003-1438-7544, Bicciato, Giulio; https://orcid.org/0000-0002-2956-0189, Sinka, Lucia, Abraira, Laura, Santamarina, Estevo; https://orcid.org/0000-0003-1915-0335, Álvarez-Sabín, José, Ferreira-Atuesta, Carolina, Katan, Mira; https://orcid.org/0000-0002-9265-8066, Scherrer, Natalie, Terziev, Robert; https://orcid.org/0000-0003-1311-5475, Döhler, Nico, Erdélyi-Canavese, Barbara, Felbecker, Ansgar; https://orcid.org/0000-0001-9073-6617, Siebel, Philip, Winklehner, Michael, von Oertzen, Tim J, Wagner, Judith N; https://orcid.org/0000-0002-0776-6821, Gigli, Gian Luigi, Nilo, Annacarmen, Janes, Francesco, Merlino, Giovanni, Valente, Mariarosaria, Zafra-Sierra, María Paula, Mayor-Romero, Luis Carlos, Conrad, Julian, Evers, S, Lochner, Piergiorgio, Roell, Frauke, Brigo, Francesco; https://orcid.org/0000-0003-0928-1577, Bentes, Carla; https://orcid.org/0000-0003-2399-7678, et al, Schubert, Kai Michael; https://orcid.org/0000-0003-1438-7544, Bicciato, Giulio; https://orcid.org/0000-0002-2956-0189, Sinka, Lucia, Abraira, Laura, Santamarina, Estevo; https://orcid.org/0000-0003-1915-0335, Álvarez-Sabín, José, Ferreira-Atuesta, Carolina, Katan, Mira; https://orcid.org/0000-0002-9265-8066, Scherrer, Natalie, Terziev, Robert; https://orcid.org/0000-0003-1311-5475, Döhler, Nico, Erdélyi-Canavese, Barbara, Felbecker, Ansgar; https://orcid.org/0000-0001-9073-6617, Siebel, Philip, Winklehner, Michael, von Oertzen, Tim J, Wagner, Judith N; https://orcid.org/0000-0002-0776-6821, Gigli, Gian Luigi, Nilo, Annacarmen, Janes, Francesco, Merlino, Giovanni, Valente, Mariarosaria, Zafra-Sierra, María Paula, Mayor-Romero, Luis Carlos, Conrad, Julian, Evers, S, Lochner, Piergiorgio, Roell, Frauke, Brigo, Francesco; https://orcid.org/0000-0003-0928-1577, Bentes, Carla; https://orcid.org/0000-0003-2399-7678, and et al

Abstract

Background: In addition to other stroke-related deficits, the risk of seizures may impact driving ability after stroke. Methods: We analysed data from a multicentre international cohort, including 4452 adults with acute ischaemic stroke and no prior seizures. We calculated the Chance of Occurrence of Seizure in the next Year (COSY) according to the SeLECT$_{2.0}$prognostic model. We considered COSY<20% safe for private and <2% for professional driving, aligning with commonly used cut-offs. Results: Seizure risks in the next year were mainly influenced by the baseline risk-stratified according to the SeLECT$_{2.0}$score and, to a lesser extent, by the poststroke seizure-free interval (SFI). Those without acute symptomatic seizures (SeLECT$_{2.0}$0–6 points) had low COSY (0.7%–11%) immediately after stroke, not requiring an SFI. In stroke survivors with acute symptomatic seizures (SeLECT$_{2.0}$3–13 points), COSY after a 3-month SFI ranged from 2% to 92%, showing substantial interindividual variability. Stroke survivors with acute symptomatic status epilepticus (SeLECT$_{2.0}$7–13 points) had the highest risk (14%–92%). Conclusions: Personalised prognostic models, such as SeLECT$_{2.0}$, may offer better guidance for poststroke driving decisions than generic SFIs. Our findings provide practical tools, including a smartphone-based or web-based application, to assess seizure risks and determine appropriate SFIs for safe driving.

Published
2024

31. European society of neurosonology and cerebral haemodynamic stroke focus cardiac ultrasound (S-FoCUS)

Author

Licenik, Radim, primary, Pagola, Jorge, additional, Pereira, Marcelo Balestro, additional, Hasan, Muhammad, additional, Juega, Jesús, additional, Lelyuk, Vladimir, additional, Limbu, Dipraj, additional, Lochner, Piergiorgio, additional, Lopez-Dequidt, Iria, additional, Montellano, Phelipe, additional, Muñoz, Roberto, additional, Luksic, Vlatka Reskovic, additional, Saeed, Sahrai, additional, and Zviagina, Liliia, additional

Published
2023
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36. Risk Factors for Intracerebral Hemorrhage in Patients With Atrial Fibrillation on Non–Vitamin K Antagonist Oral Anticoagulants for Stroke Prevention

Author

Paciaroni, Maurizio, Agnelli, Giancarlo, Giustozzi, Michela, Caso, Valeria, Toso, Elisabetta, Angelini, Filippo, Canavero, Isabella, Micieli, Giuseppe, Antonenko, Kateryna, Rocco, Alessandro, Diomedi, Marina, Katsanos, Aristeidis H., Shoamanesh, Ashkan, Giannopoulos, Sotirios, Ageno, Walter, Pegoraro, Samuela, Putaala, Jukka, Strbian, Daniel, Sallinen, Hanne, Mac Grory, Brian C., Furie, Karen L., Stretz, Christoph, Reznik, Michael E., Alberti, Andrea, Venti, Michele, Mosconi, Maria Giulia, Vedovati, Maria Cristina, Franco, Laura, Zepponi, Giorgia, Romoli, Michele, Zini, Andrea, Brancaleoni, Laura, Riva, Letizia, Silvestrelli, Giorgio, Ciccone, Alfonso, Zedde, Maria Luisa, Giorli, Elisa, Kosmidou, Maria, Ntais, Evangelos, Palaiodimou, Lina, Halvatsiotis, Panagiotis, Tassinari, Tiziana, Saia, Valentina, Ornello, Raffaele, Sacco, Simona, Bandini, Fabio, Mancuso, Michelangelo, Orlandi, Giovanni, Ferrari, Elena, Pezzini, Alessandro, Poli, Loris, Cappellari, Manuel, Forlivesi, Stefano, Rigatelli, Alberto, Yaghi, Shadi, Scher, Erica, Frontera, Jennifer A., Masotti, Luca, Grifoni, Elisa, Caliandro, Pietro, Zauli, Aurelia, Reale, Giuseppe, Marcheselli, Simona, Gasparro, Antonio, Terruso, Valeria, Arnao, Valentina, Aridon, Paolo, Abdul-Rahim, Azmil H., Dawson, Jesse, Saggese, Carlo Emanuele, Palmerini, Francesco, Doronin, Boris, Volodina, Vera, Toni, Danilo, Risitano, Angela, Schirinzi, Erika, Del Sette, Massimo, Lochner, Piergiorgio, Monaco, Serena, Mannino, Marina, Tassi, Rossana, Guideri, Francesca, Acampa, Maurizio, Martini, Giuseppe, Lotti, Enrico Maria, Padroni, Marina, Pantoni, Leonardo, Rosa, Silvia, Bertora, Pierluigi, Ntaios, George, Sagris, Dimitrios, Baldi, Antonio, D’Amore, Cataldo, Mumoli, Nicola, Porta, Cesare, Denti, Licia, Chiti, Alberto, Corea, Francesco, Acciarresi, Monica, Flomin, Yuriy, Popovic, Nemanja, and Tsivgoulis, Georgios

Published
2021
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39. Anticoagulation in acute ischemic stroke patients with mechanical heart valves: To bridge or not with heparin. The ESTREM study

Author

Paciaroni, Maurizio, primary, Caso, Valeria, additional, Romoli, Michele, additional, Becattini, Cecilia, additional, Salerno, Alexander, additional, Rapillo, Costanza, additional, Simonnet, Fanny, additional, Strambo, Davide, additional, Canavero, Isabella, additional, Zedde, Marialuisa, additional, Pascarella, Rosario, additional, Sohn, Sung-Il, additional, Sacco, Simona, additional, Ornello, Raffaele, additional, Barlinn, Kristian, additional, Schoene, Daniela, additional, Rahmig, Jan, additional, Mosconi, Maria Giulia, additional, Leone De Magistris, Ilaria, additional, Alberti, Andrea, additional, Venti, Michele, additional, Silvestrelli, Giorgio, additional, Ciccone, Alfonso, additional, Padroni, Marina, additional, Laudisi, Michele, additional, Zini, Andrea, additional, Gentile, Luana, additional, Kargiotis, Odysseas, additional, Tsivgoulis, Georgios, additional, Tassi, Rossana, additional, Guideri, Francesca, additional, Acampa, Maurizio, additional, Masotti, Luca, additional, Grifoni, Elisa, additional, Rocco, Alessandro, additional, Diomedi, Marina, additional, Karapanayiotides, Theodore, additional, Engelter, Stefan T, additional, Polymeris, Alexandros A, additional, Zietz, Annaelle, additional, Bandini, Fabio, additional, Caliandro, Pietro, additional, Reale, Giuseppe, additional, Moci, Marco, additional, Zauli, Aurelia, additional, Cappellari, Manuel, additional, Emiliani, Andrea, additional, Gasparro, Antonio, additional, Terruso, Valeria, additional, Mannino, Marina, additional, Giorli, Elisa, additional, Toni, Danilo, additional, Andrighetti, Marco, additional, Falcou, Anne, additional, Palaiodimou, Lina, additional, Ntaios, George, additional, Sagris, Dimitrios, additional, Karagkiozi, Efstathia, additional, Adamou, Anastasia, additional, Halvatsiotis, Panagiotis, additional, Flomin, Yuriy, additional, Scoditti, Umberto, additional, Genovese, Antonio, additional, Popovic, Nemanja, additional, Pantoni, Leonardo, additional, Mele, Francesco, additional, Molitierno, Nicola, additional, Lochner, Piergiorgio, additional, Pezzini, Alessandro, additional, Del Sette, Massimo, additional, Sassos, Davide, additional, Giannopoulos, Sotirios, additional, Kosmidou, Maria, additional, Ntais, Evangelos, additional, Lotti, Enrico Maria, additional, Mastrangelo, Vincenzo, additional, Chiti, Alberto, additional, Naldi, Andrea, additional, Vanacker, Peter, additional, Ferrante, Mario, additional, Volodina, Vera, additional, Mancuso, Michelangelo, additional, Giannini, Nicola, additional, Baldini, Marco, additional, Vadikolias, Kostantinos, additional, Kitmeridou, Sofia, additional, Saggese, Carlo Emanuele, additional, Tassinari, Tiziana, additional, Saia, Valentina, additional, and Michel, Patrik, additional

Published
2023
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40. Association of Mortality and Risk of Epilepsy With Type of Acute Symptomatic Seizure After Ischemic Stroke and an Updated Prognostic Model

Author

Sinka, Lucia, primary, Abraira, Laura, additional, Imbach, Lukas L., additional, Zieglgänsberger, Dominik, additional, Santamarina, Estevo, additional, Álvarez-Sabín, José, additional, Ferreira-Atuesta, Carolina, additional, Katan, Mira, additional, Scherrer, Natalie, additional, Bicciato, Giulio, additional, Terziev, Robert, additional, Simmen, Cyril, additional, Schubert, Kai Michael, additional, Elshahabi, Adham, additional, Baumann, Christian R., additional, Döhler, Nico, additional, Erdélyi-Canavese, Barbara, additional, Felbecker, Ansgar, additional, Siebel, Philip, additional, Winklehner, Michael, additional, von Oertzen, Tim J., additional, Wagner, Judith N., additional, Gigli, Gian Luigi, additional, Serafini, Anna, additional, Nilo, Annacarmen, additional, Janes, Francesco, additional, Merlino, Giovanni, additional, Valente, Mariarosaria, additional, Zafra-Sierra, María Paula, additional, Bayona-Ortiz, Hernan, additional, Conrad, Julian, additional, Evers, Stefan, additional, Lochner, Piergiorgio, additional, Roell, Frauke, additional, Brigo, Francesco, additional, Bentes, Carla, additional, Peralta, Ana Rita, additional, Pinho e Melo, Teresa, additional, Keezer, Mark R., additional, Duncan, John S., additional, Sander, Josemir W., additional, Tettenborn, Barbara, additional, Koepp, Matthias J., additional, and Galovic, Marian, additional

Published
2023
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45. Causes and Risk Factors of Cerebral Ischemic Events in Patients With Atrial Fibrillation Treated With Non–Vitamin K Antagonist Oral Anticoagulants for Stroke Prevention: The RENo Study

Author

Paciaroni, Maurizio, Agnelli, Giancarlo, Caso, Valeria, Silvestrelli, Giorgio, Seiffge, David Julian, Engelter, Stefan, De Marchis, Gian Marco, Polymeris, Alexandros, Zedde, Maria Luisa, Yaghi, Shadi, Michel, Patrik, Eskandari, Ashraf, Antonenko, Kateryna, Sohn, Sung-Il, Cappellari, Manuel, Tassinari, Tiziana, Tassi, Rossana, Masotti, Luca, Katsanos, Aristeidis H., Giannopoulos, Sotirios, Acciarresi, Monica, Alberti, Andrea, Venti, Michele, Mosconi, Maria Giulia, Vedovati, Maria Cristina, Pierini, Patrizia, Giustozzi, Michela, Lotti, Enrico Maria, Ntaios, George, Kargiotis, Odysseas, Monaco, Serena, Lochner, Piergiorgio, Bandini, Fabio, Liantinioti, Chrysoula, Palaiodimou, Lina, Abdul-Rahim, Azmil H., Lees, Kennedy, Mancuso, Michelangelo, Pantoni, Leonardo, Rosa, Silvia, Bertora, Pierluigi, Galliazzo, Silvia, Ageno, Walter, Toso, Elisabetta, Angelini, Filippo, Chiti, Alberto, Orlandi, Giovanni, Denti, Licia, Flomin, Yuriy, Marcheselli, Simona, Mumoli, Nicola, Rimoldi, Alexandra, Verrengia, Elena, Schirinzi, Erika, Del Sette, Massimo, Papamichalis, Panagiotis, Komnos, Apostolos, Popovic, Nemanja, Zarkov, Marija, Rocco, Alessandro, Diomedi, Marina, Giorli, Elisa, Ciccone, Alfonso, Mac Grory, Brian C., Furie, Karen L., Bonetti, Bruno, Saia, Valentina, Guideri, Francesca, Acampa, Maurizio, Martini, Giuseppe, Grifoni, Elisa, Padroni, Marina, Karagkiozi, Efstathia, Perlepe, Kalliopi, Makaritsis, Konstantinos, Mannino, Marina, Maccarrone, Miriam, Ulivi, Leonardo, Giannini, Nicola, Ferrari, Elena, Pezzini, Alessandro, Doronin, Boris, Volodina, Vera, Baldi, Antonio, D’Amore, Cataldo, Deleu, Dirk, Corea, Francesco, Putaala, Jukka, Santalucia, Paola, Nardi, Katiuscia, Risitano, Angela, Toni, Danilo, and Tsivgoulis, Georgios

Published
2019
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46. The Venular Side of Cerebral Amyloid Angiopathy: Proof of Concept of a Neglected Issue

Author

Zedde, M, Grisendi, I, Assenza, F, Vandelli, G, Napoli, M, Moratti, C, Lochner, P, Seiffge, D, Piazza, F, Valzania, F, Pascarella, R, Zedde, Marialuisa, Grisendi, Ilaria, Assenza, Federica, Vandelli, Gabriele, Napoli, Manuela, Moratti, Claudio, Lochner, Piergiorgio, Seiffge, David J, Piazza, Fabrizio, Valzania, Franco, Pascarella, Rosario, Zedde, M, Grisendi, I, Assenza, F, Vandelli, G, Napoli, M, Moratti, C, Lochner, P, Seiffge, D, Piazza, F, Valzania, F, Pascarella, R, Zedde, Marialuisa, Grisendi, Ilaria, Assenza, Federica, Vandelli, Gabriele, Napoli, Manuela, Moratti, Claudio, Lochner, Piergiorgio, Seiffge, David J, Piazza, Fabrizio, Valzania, Franco, and Pascarella, Rosario

Abstract

Small vessel diseases (SVD) is an umbrella term including several entities affecting small arteries, arterioles, capillaries, and venules in the brain. One of the most relevant and prevalent SVDs is cerebral amyloid angiopathy (CAA), whose pathological hallmark is the deposition of amyloid fragments in the walls of small cortical and leptomeningeal vessels. CAA frequently coexists with Alzheimer's Disease (AD), and both are associated with cerebrovascular events, cognitive impairment, and dementia. CAA and AD share pathophysiological, histopathological and neuroimaging issues. The venular involvement in both diseases has been neglected, although both animal models and human histopathological studies found a deposition of amyloid beta in cortical venules. This review aimed to summarize the available information about venular involvement in CAA, starting from the biological level with the putative pathomechanisms of cerebral damage, passing through the definition of the peculiar angioarchitecture of the human cortex with the functional organization and consequences of cortical arteriolar and venular occlusion, and ending to the hypothesized links between cortical venular involvement and the main neuroimaging markers of the disease.

Published
2023

47. Mechanical thrombectomy for in-hospital stroke: data from the Italian Registry of Endovascular Treatment in Acute Stroke.

Author

Naldi, Andrea, Pracucci, Giovanni, Cavallo, Roberto, Saia, Valentina, Boghi, Andrea, Lochner, Piergiorgio, Casetta, Ilaria, Sallustio, Fabrizio, Zini, Andrea, Fainardi, Enrico, Cappellari, Manuel, Tassi, Rossana, Bracco, Sandra, Bigliardi, Guido, Vallone, Stefano, Nencini, Patrizia, Bergui, Mauro, Mangiafico, Salvatore, and Toni, Danilo

Subjects
REPORTING of diseases, STROKE, CONFIDENCE intervals, MULTIVARIATE analysis, COMPARATIVE studies, THROMBECTOMY, HOSPITAL care, DESCRIPTIVE statistics, ENDOVASCULAR surgery, ODDS ratio
Abstract

Background The benefit, safety, and time intervals of mechanical thrombectomy (MT) in patients with in-hospital stroke (IHS) are unclear. We sought to evaluate the outcomes and treatment times for IHS patients compared with out-of-hospital stroke (OHS) patients receiving MT. Methods We analyzed data from the Italian Registry of Endovascular Treatment in Acute Stroke (IRETAS) between 2015 and 2019. We compared the functional outcomes (modified Rankin Scale (mRS) scores) at 3 months, recanalization rates, and symptomatic intracranial hemorrhage (sICH) after MT. Time intervals from stroke onset-to-imaging, onset-to-groin, and onset-to-end MT were recorded for both groups, as were door- to-imaging and door-to-groin for OHS. A multivariate analysis was performed. results Of 5619 patients, 406 (7.2%) had IHS. At 3 months, IHS patients had a lower rate of mRS 0-2 (39% vs 48%, P<0.001) and higher mortality (30.1% vs 19.6%, P<0.001). Recanalization rates and sICH were similar. Time intervals (min, median (IQR)) from stroke onset-to-imaging, onset-to-groin, and onset-to-end MT were favorable for IHS (60 (34-106) vs 123 (89-188.5); 150 (105-220) vs 220 (168-294); 227 (164-303) vs 293 (230-370); all P<0.001), whereas OHS had lower door-to-imaging and door-to-groin times compared with stroke onset-to-imaging and onset-to-groin for IHS (29 (20-44) vs 60 (34-106), P<0.001; 113 (84-151) vs 150 (105-220); P<0.001). After adjustment, IHS was associated with higher mortality (aOR 1.77, 95% CI 1.33 to 2.35, P<0.001) and a shift towards worse functional outcomes in the ordinal analysis (aOR 1.32, 95% CI 1.06 to 1.66, P=0.015). Conclusion Despite favorable time intervals for MT, IHS patients had worse functional outcomes than OHS patients. Delays in IHS management were detected. [ABSTRACT FROM AUTHOR]

Published
2023
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