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11. Contributors

Author

Abraham, Theodore P., primary, Acquatella, Harry, additional, Adams, David, additional, Agler, Deborah A., additional, Aichinger, Josef, additional, Ali, Bilal Shaukat, additional, Asirvatham, Samuel J., additional, Bach, David S., additional, Bangalore, Sripal, additional, Bansal, Manish, additional, Baumgartner, Helmut, additional, Bax, Jeroen J., additional, Bierig, S. Michelle, additional, Bleeker, Gabe B., additional, Borden, William B., additional, Burstow, Darryl J., additional, Carerj, Scipione, additional, Chaliki, Hari P., additional, Chan, Kwan-Leung, additional, Chandra, Sonal, additional, Chandrasekaran, Krishnaswamy, additional, Chaowalit, Nithima, additional, Chaudhry, Farooq A., additional, Chung, Namsik, additional, Coon, Patrick D., additional, Curtin, Ronan J., additional, DeCara, Jeanne M., additional, Derumeaux, Geneviève, additional, Dimaano, Veronica Lea J., additional, Dumesnil, Jean G., additional, Ebner, Christian, additional, Eggebrecht, Holger, additional, Erbel, Raimund, additional, Fountain, Rebecca B., additional, Franke, Andreas, additional, Freeman, William K., additional, Garcia, Mario J., additional, García-Fernández, Eulogio, additional, García-Fernandez, Miguel Angel, additional, García-Robles, José Antonio, additional, Goldstein, Steven A., additional, Zamorano Gomez, José Luis, additional, de Diego, José Juan Gómez, additional, Gutierrez-Bernal, Jose Luis, additional, Ha, Jong-Won, additional, Holmes, David R., additional, Horton, Kenneth, additional, Hung, Judy W., additional, Ito, Hiroshi, additional, Jollis, James G., additional, Jost, Christine Attenhofer, additional, Kabicher, Gudrun, additional, Kaul, Sanjiv, additional, Khandheria, Bijoy K., additional, Kirkpatrick, James N., additional, Klein, Allan L., additional, Kort, Smadar, additional, Kronzon, Itzhak, additional, Kurrelmeyer, Karla M., additional, Lang, Roberto M., additional, Lee, Pui, additional, Lennie, Vera, additional, Lester, Steven J., additional, Leung, Dominic Y., additional, Lindner, Jonathan R., additional, Lodato, Joseph A., additional, Lowe, Boris S., additional, Lusk, Joan L., additional, Malouf, Joseph F., additional, Martin, Randolph P., additional, Marwick, Thomas H., additional, Maurer, Gerald, additional, McCarthy, Patrick M., additional, Melgarejo, Ivàn, additional, Michelena, Hector I., additional, Mor-Avi, Victor, additional, Nagueh, Sherif F., additional, Nesser, Hans Joachim, additional, Niel, Johannes, additional, Ommen, Steve R., additional, Pearlman, Alan S., additional, Pellikka, Patricia A., additional, Pérez-David, Esther, additional, Pibarot, Philippe, additional, Picard, Michael H., additional, Pinto, Fausto J., additional, Pollard, Heidi, additional, Polonsky, Tamar S., additional, Porter, Thomas R., additional, Powell, Brian D., additional, Riarte, Jose E., additional, Rigolin, Vera H., additional, Ronderos, Ricardo E., additional, Saric, Muhamed, additional, Sengupta, Partho P., additional, Shah, Dipak P., additional, Shernan, Stanton K., additional, Spencer, Kirk T., additional, Srichai, Monvadi B., additional, Stergiopoulos, Kathleen, additional, Strachan, G. Monet, additional, Sugeng, Lissa, additional, Takeuchi, Masaaki, additional, Thibault, Hélène, additional, Tkalec, Wolfgang, additional, Tunick, Paul A., additional, Umland, Matt M., additional, Vannan, Mani A., additional, Vignon, Philippe, additional, Villarraga, Hector R., additional, Ward, R. Parker, additional, Watanabe, Nozomi, additional, Wei, Kevin, additional, Weissman, Neil J., additional, Winter, Siegmund, additional, Wood, Malissa J., additional, Xie, Feng, additional, Yang, Hyun Suk, additional, Sanborn, Danita M. Yoerger, additional, Zhao, Qiong, additional, Zito, Concetta, additional, and Zoghbi, William A., additional

Published
2011
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12. Roles of IL-1 and TNF in the decreased ileal muscle contractility induced by lipopolisaccharide

Author

Lodato, Robert F., Khan, A. Rizwan, Zembowicz, Malgorzata J., Weisbrodt, Norman W., Pressley, Thomas A., Li, Yong-Fang, Lodato, Joseph A., Zembowicz, Artur, and Moody, Frank G.

Subjects
Interleukin-1 -- Physiological aspects, Tumor necrosis factor -- Physiological aspects, Ileum -- Physiological aspects, Smooth muscle -- Physiological aspects, Endotoxins -- Physiological aspects, Biological sciences
Abstract

Endotoxin impairs smooth muscle contraction, partly through inducible nitric oxide synthase (NOS-II) and increased nitric oxide production. The functions of tumor necrosis factor-alpha (TNF) and interleukin-1 (IL-1) in this process were investigated by utilizing TNF binding protein (TNFbp) and IL-1 receptor antagonist (IL-1ra). Findings indicated that endotoxin-induced increase in NOS-II activity and the reduction in ileal muscle contractility are mediated by TNF and IL-1.

Published
1999

24. Quantitative 3D evaluation of myocardial perfusion during regadenoson stress using multidetector computed tomography.

Author

Mor-Avi, Victor, Kachenoura, Nadjia, Lodato, Joseph A., Chandra, Sonal, Freed, Benjamin H., Newby, Barbara, Lang, Roberto M., and Patel, Amit R.

Abstract

We tested the hypothesis that quantitative 3D analysis of myocardial perfusion from MDCT images obtained during regadenoson stress would more accurately detect the presence of significant coronary artery disease (CAD) than the same analysis when performed on resting MDCT images. Fifty consecutive patients referred for CT coronary angiography (CTCA) underwent additional imaging with regadenoson (0.4mg, Astellas) using prospective gating (256-channel, Philips). Custom software was used to calculate for each myocardial segment an index of severity and extent of perfusion abnormality, Qh, which was compared to perfusion defects predicted by the presence and severity of coronary stenosis on CTCA. In segments supplied by arteries with luminal narrowing >50%, myocardial attenuation was slightly reduced compared to normally perfused segments at rest (91±21 vs. 93±26 HU, NS), and to a larger extent at stress (102±21 vs. 112±20 HU, p<0.05). In contrast, index Qh was significantly increased in these segments at rest (0.40±0.48 vs. 0.26±0.41, p<0.05) and reached a nearly 3-fold difference at stress (0.66±0.74 vs. 0.28±0.51, p<0.05). The addition of regadenoson improved the diagnosis of CAD, as reflected by an increase in sensitivity (from 0.57 to 0.91) and improvement in accuracy (0.65 to 0.77). In conclusion, quantitative 3D analysis of MDCT images allows objective detection of CAD, the accuracy of which is improved by regadenoson stress. [ABSTRACT FROM PUBLISHER]

Published
2012

25. S100A12 Mediates Aortic Wall Remodeling and Aortic Aneurysm.

Author

Bowman, Marion Hofmann, Wilk, Jeannine, Heydemann, Ahike, Kim, Gene, Rehman, Jalees, Lodato, Joseph A., Raman, Jai, and McNally, Elizabeth M.

Subjects
CARRIER proteins, AORTIC aneurysm treatment, VASCULAR smooth muscle, OXIDATIVE stress
Abstract

The article presents a study on the capability of S100A12, a small calcium binding protein, to mediate aortic wall and aortic aneurysm in the U.S. The study intends to determine the role of S100A12 in vascular smooth muscle cells (VSMC). The findings reveal on the capability of the S100A12 to activate the pathogenic pathways by modulating oxidative stress and vascular remodeling in vivo.

Published
2010
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26. Colaboradores

Author

Abraham, Theodore P., Acquatella, Harry, Adams, David, Agler, Deborah A., Aichinger, Josef, Ali, Bilal Shaukat, Asirvatham, Samuel J., Bach, David S., Bangalore, Sripal, Bansal, Manish, Baumgartner, Helmut, Bax, Jeroen J., Bierig, S. Michelle, Bleeker, Gabe B., Borden, William B., Burstow, Darryl J., Carerj, Scipione, Chaliki, Hari P., Chan, Kwan-Leung, Chandra, Sonal, Chandrasekaran, Krishnaswamy, Chaowalit, Nithima, Chaudhry, Farooq A., Chung, Namsik, Coon, Patrick D., Curtin, Ronan J., DeCara, Jeanne M., Derumeaux, Geneviève, Dimaano, Veronica Lea J., Dumesnil, Jean G., Ebner, Christian, Eggebrecht, Holger, Erbel, Raimund, Fountain, Rebecca B., Franke, Andreas, Freeman, William K., Garcia, Mario J., García-Fernández, Eulogio, García-Fernandez, Miguel Angel, García-Robles, José Antonio, Goldstein, Steven A., Zamorano Gomez, José Luis, de Diego, José Juan Gómez, Gutierrez-Bernal, Jose Luis, Ha, Jong-Won, Holmes, David R., Jr., Horton, Kenneth, Hung, Judy W., Ito, Hiroshi, Jollis, James G., Jost, Christine Attenhofer, Kabicher, Gudrun, Kaul, Sanjiv, Khandheria, Bijoy K., Kirkpatrick, James N., Klein, Allan L., Kort, Smadar, Kronzon, Itzhak, Kurrelmeyer, Karla M., Lang, Roberto M., Lee, Pui, Lennie, Vera, Lester, Steven J., Leung, Dominic Y., Lindner, Jonathan R., Lodato, Joseph A., Lowe, Boris S., Lusk, Joan L., Malouf, Joseph F., Martin, Randolph P., Marwick, Thomas H., Maurer, Gerald, McCarthy, Patrick M., Melgarejo, Ivàn, Michelena, Hector I., Mor-Avi, Victor, Nagueh, Sherif F., Nesser, Hans Joachim, Niel, Johannes, Ommen, Steve R., Pearlman, Alan S., Pellikka, Patricia A., Pérez-David, Esther, Pibarot, Philippe, Picard, Michael H., Pinto, Fausto J., Pollard, Heidi, Polonsky, Tamar S., Porter, Thomas R., Powell, Brian D., Riarte, Jose E., Rigolin, Vera H., Ronderos, Ricardo E., Saric, Muhamed, Sengupta, Partho P., Shah, Dipak P., Shernan, Stanton K., Spencer, Kirk T., Srichai, Monvadi B., Stergiopoulos, Kathleen, Strachan, G. Monet, Sugeng, Lissa, Takeuchi, Masaaki, Thibault, Hélène, Tkalec, Wolfgang, Tunick, Paul A., Umland, Matt M., Vannan, Mani A., Vignon, Philippe, Villarraga, Hector R., Ward, R. Parker, Watanabe, Nozomi, Wei, Kevin, Weissman, Neil J., Winter, Siegmund, Wood, Malissa J., Xie, Feng, Yang, Hyun Suk, Sanborn, Danita M. Yoerger, Zhao, Qiong, Zito, Concetta, and Zoghbi, William A.

Published
2012
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27. Quantitative diagnosis of stress-induced myocardial ischemia using analysis of contrast echocardiographic parametric perfusion images

Author

Toledo, Eran, Jacobs, Lawrence D., Lodato, Joseph A., DeCara, Jeanne M., Coon, Patrick, Mor-Avi, Victor, and Lang, Roberto M.

Abstract

Abstract: Aims: Parametric imaging of myocardial perfusion provides useful visual information for the diagnosis of coronary artery disease (CAD). We developed a technique for automated detection of perfusion defects based on quantitative analysis of parametric perfusion images and validated it against coronary angiography. Methods and results: Contrast-enhanced, apical 2-, 3- and 4-chamber images were obtained at rest and with dipyridamole in 34 patients with suspected CAD. Images were analyzed to generate parametric perfusion images of the standard contrast-replenishment model parameters A, β and A·β. Each parametric image was divided into six segments, and mean parameter value (MPV) was calculated for each segment. Segmental MPV ratio between stress and rest was defined as a flow reserve index (FRI). Receiver operating characteristics (ROC) analysis was used in a Study group (N =17) to optimize FRI threshold and the minimal number of abnormal segments per vascular territory (LAD and non-LAD), required for automated detection of stress-induced perfusion defects. The optimized detection algorithm was then tested prospectively in the remaining 17 patients (Test group). LAD and non-LAD stenosis >70% was found in 19 and 17 patients, respectively. In the Study group, FRI threshold was: LAD=0.95 and non-LAD=0.68, minimal number of abnormal segments was four and two, correspondingly. Sensitivity, specificity and accuracy in the Test group were: 75%, 67% and 71% in the LAD, and 75%, 75% and 75% in the non-LAD territories. Conclusion: Automated quantitative analysis of contrast echocardiographic parametric perfusion images is feasible and may aid in the objective detection of CAD. [Copyright &y& Elsevier]

Published
2006
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29. 866-2 Objective detection of stress-induced myocardial ischemia using quantitative analysis of contrast echocardiographic parametric perfusion images.

Author

Toledo, Eran, Lodato, Joseph A, DeCara, Jeanne M, Collins, Keith A, Bednarz, James E, Mor-Avi, Victor, and Lang, Roberto M

Subjects
*DIAGNOSIS, *CORONARY disease, *CONTRAST echocardiography, *MYOCARDIAL perfusion imaging, *VENTRICULAR ejection fraction, *DOPPLER echocardiography, *CARDIAC catheterization
Published
2004
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32. Contributors

Author

Abraham, Theodore P., Acquatella, Harry, Adams, David, Agler, Deborah A., Aichinger, Josef, Ali, Bilal Shaukat, Asirvatham, Samuel J., Bach, David S., Bangalore, Sripal, Bansal, Manish, Baumgartner, Helmut, Bax, Jeroen J., Bierig, S. Michelle, Bleeker, Gabe B., Borden, William B., Burstow, Darryl J., Carerj, Scipione, Chaliki, Hari P., Chan, Kwan-Leung, Chandra, Sonal, Chandrasekaran, Krishnaswamy, Chaowalit, Nithima, Chaudhry, Farooq A., Chung, Namsik, Coon, Patrick D., Curtin, Ronan J., DeCara, Jeanne M., Derumeaux, Geneviève, Dimaano, Veronica Lea J., Dumesnil, Jean G., Ebner, Christian, Eggebrecht, Holger, Erbel, Raimund, Fountain, Rebecca B., Franke, Andreas, Freeman, William K., Garcia, Mario J., García-Fernández, Eulogio, García-Fernandez, Miguel Angel, García-Robles, José Antonio, Goldstein, Steven A., Zamorano Gomez, José Luis, de Diego, José Juan Gómez, Gutierrez-Bernal, Jose Luis, Ha, Jong-Won, Holmes, David R., Jr., Horton, Kenneth, Hung, Judy W., Ito, Hiroshi, Jollis, James G., Jost, Christine Attenhofer, Kabicher, Gudrun, Kaul, Sanjiv, Khandheria, Bijoy K., Kirkpatrick, James N., Klein, Allan L., Kort, Smadar, Kronzon, Itzhak, Kurrelmeyer, Karla M., Lang, Roberto M., Lee, Pui, Lennie, Vera, Lester, Steven J., Leung, Dominic Y., Lindner, Jonathan R., Lodato, Joseph A., Lowe, Boris S., Lusk, Joan L., Malouf, Joseph F., Martin, Randolph P., Marwick, Thomas H., Maurer, Gerald, McCarthy, Patrick M., Melgarejo, Ivàn, Michelena, Hector I., Mor-Avi, Victor, Nagueh, Sherif F., Nesser, Hans Joachim, Niel, Johannes, Ommen, Steve R., Pearlman, Alan S., Pellikka, Patricia A., Pérez-David, Esther, Pibarot, Philippe, Picard, Michael H., Pinto, Fausto J., Pollard, Heidi, Polonsky, Tamar S., Porter, Thomas R., Powell, Brian D., Riarte, Jose E., Rigolin, Vera H., Ronderos, Ricardo E., Saric, Muhamed, Sengupta, Partho P., Shah, Dipak P., Shernan, Stanton K., Spencer, Kirk T., Srichai, Monvadi B., Stergiopoulos, Kathleen, Strachan, G. Monet, Sugeng, Lissa, Takeuchi, Masaaki, Thibault, Hélène, Tkalec, Wolfgang, Tunick, Paul A., Umland, Matt M., Vannan, Mani A., Vignon, Philippe, Villarraga, Hector R., Ward, R. Parker, Watanabe, Nozomi, Wei, Kevin, Weissman, Neil J., Winter, Siegmund, Wood, Malissa J., Xie, Feng, Yang, Hyun Suk, Sanborn, Danita M. Yoerger, Zhao, Qiong, Zito, Concetta, and Zoghbi, William A.

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