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2. The Experience of COPD Patients in Lockdown Due to the COVID-19 Pandemic

Author

Pleguezuelos E, Del Carmen A, Moreno E, Ortega P, Vila X, Ovejero L, Serra-Prat M, Palomera E, Garnacho-Castaño MV, Loeb E, Farago G, and Miravitlles M

Subjects
copd, lockdown, covid-19, Diseases of the respiratory system, RC705-779
Abstract

Eulogio Pleguezuelos,1,2 Amin Del Carmen,1 Eva Moreno,3 Pilar Ortega,4 Xavier Vila,4 Laura Ovejero,4 Mateu Serra-Prat,5 Elisabet Palomera,5 Manuel Vicente Garnacho-Castaño,6 Eduardo Loeb,7 Georgina Farago,7 Marc Miravitlles7 1Physical Medicine and Rehabilitation Department, Hospital de Mataró, Barcelona, Spain; 2Department of Experimental Science and Healthcare, Faculty of Health Sciences, Universitat Pompeu Fabra, Barcelona, Spain; 3Physical Medicine and Rehabilitation Department, Hospitalet General Hospital, L´Hospitalet de Llobregat, Barcelona, Spain; 4Pneumology Department, Hospital de Mataró Mataró, Barcelona, Spain; 5Research Unit, Consorci Sanitari del Maresme, Barcelona, Spain; 6TGRI-AFIRS, Department of Physical Activity and Sports Science, School of Health Sciences, Tecno Campus, Universitat Pompeu Fabra, Barcelona, Spain; 7Pneumology Department, Hospital Universitari Vall d’Hebron, Vall d’Hebron Institut de Recerca (VHIR), Vall d’Hebron Barcelona Hospital Campus, CIBER de Enfermedades Respiratorias (CIBERES), Barcelona, SpainCorrespondence: Eulogio PleguezuelosHospital de Mataró, C/Cirera s/n 08302, Mataró, Barcelona, SpainTel +34 93.7417728Fax +34 93.7417717Email epleguezuelos@csdm.catPurpose: On March 16, 2020, the Spanish government declared a state of alarm due to the rapid spread of coronavirus disease 2019 (COVID-19). Patients with chronic obstructive pulmonary disease (COPD) were restricted to remain confined at home, and medical visits were cancelled for 3 months. The impact of this lockdown on the manifestations of COPD and the quality-of-life of these patients has not been explored.Patients and Methods: One hundred patients with COPD were interviewed by telephone from May 2– 18, 2020. The interviews included questions about the lockdown, missed medical appointments, fears of the disease, possible COVID-19 infection, and exacerbations of COPD suffered during this period and their management. In addition, the COPD Assessment Test, the Hospital Anxiety and Depression, and the 5-Dimension Euro Quality-of-Life questionnaires were administered.Results: Sixty-four (64%) patients claimed to have strictly complied with the lockdown, and only 42 (42%) stated they had left home at least once during lockdown. Only one patient (1%) was hospitalized due to COVID-19, and 13 (13%) patients presented an exacerbation of COPD self-managed at home with no admissions due to exacerbation of COPD during this period. A medical consultation or complementary test was cancelled in 90% of the patients, but 61% had a medical telephone visit with a high degree of satisfaction (mean 9.3/10). Most patients declared that their feeling regarding lung disease and general health was similar or even better during lockdown (82% and 81%, respectively).Conclusion: Our results indicate that in general lockdown had a low impact on COPD patients. Only one patient was affected by COVID-19, but moderate exacerbations of COPD were not infrequent. Although many medical visits and test were cancelled, patients were very satisfied with the medical telephone visits.Keywords: COPD, lockdown, COVID-19

Published
2020

11. Nitric Oxide Synthase activity in major depressive episodes before and after antidepressant treatment: Results of a large case-control treatment study

Author

Loeb, E., primary, El Asmar, K., additional, Trabado, S., additional, Gressier, F., additional, Colle, R., additional, Rigal, A., additional, Martin, S., additional, Verstuyft, C., additional, Fève, B., additional, Chanson, P., additional, Becquemont, L., additional, and Corruble, E., additional

Published
2020
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15. Nitric Oxide Synthase activity in major depressive episodes before and after antidepressant treatment: Results of a large case-control treatment study.

Author

Loeb, E., El Asmar, K., Trabado, S., Gressier, F., Colle, R., Rigal, A., Martin, S., Verstuyft, C., Fève, B., Chanson, P., Becquemont, L., and Corruble, E.

Subjects
*ANTIDEPRESSANTS, *RESEARCH, *NITRIC-oxide synthases, *CONFIDENCE intervals, *LIQUID chromatography, *ARGININE, *CASE-control method, *MEDICAL cooperation, *MENTAL depression, *DESCRIPTIVE statistics, *ODDS ratio, *DATA analysis software, *PHARMACODYNAMICS
Abstract

Background: Nitric oxide synthase (NOS) activity, an enzyme potentially involved in the major depressive episodes (MDE), could be indirectly measured by the L-Citrulline/L-Arginine ratio (L-Cit/L-Arg). The aim of this study was: (1) to compare the NOS activity of patients with a MDE to that of healthy controls (HC); (2) to assess its change after antidepressant treatment. Methods: A total of 460 patients with a current MDE in a context of major depressive disorder (MDD) were compared to 895 HC for NOS activity (L-Cit/L-Arg plasma ratio). L-Arg and L-Cit plasma levels were measured using a MS-based liquid chromatography method. Depressed patients were assessed at baseline, and after 3 and 6 months of antidepressant treatment for depression severity and clinical response. Results: Depressed patients had a lower NOS activity than HC at baseline [0.31 ± 0.09 v. 0.38 ± 0.12; 95% confidence interval (CI) −0.084 to −0.062, p < 0.0001]. Lower NOS activity at baseline predicted a higher response rate [odds ratio (OR) = 29.20; 95% CI 1.58–536.37; p = 0.023]. NOS activity in depressed patients increased significantly up to 0.34 ± 0.08 after antidepressant treatment (Est = 0.0034; 95% CI 0.0002–0.0067; p = 0.03). Conclusions: Depressed patients have a decreased NOS activity that improves after antidepressant treatment and predicts drug response. NOS activity may be a promising biomarker for MDE in a context of MDD. [ABSTRACT FROM AUTHOR]

Published
2022
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17. Afstammingsrecht ongeacht gerichtheid of geslacht

Author

Waaldijk, C., Loeb, E., Martens, C., Oostrom, N. van, Vollebregt, L., Loeb, E., Martens, C., Oostrom, N. van, and Vollebregt, L.

Subjects
Co-mothers, Presumption of maternity, Lesbian parents, Same-sex parenting, Presumption of paternity, Acknowledgement of a child
Abstract

This article criticises the new Dutch provisions (in force since 1 April 2014) that make it possible for a woman to become the second mother of the child of her female partner without having to go through an adoption procedure. The author argues that it would have been better - and possible - to make no distinction at all between a child born to a woman with a female partner and a child born to a woman with a male partner. He proposes a new provision for the Civil Code that would be both gender neutral and orientation neutral. The married or registered partner of the birth mother should automatically become the second legal parent of the child, unless another person - with permission of both partners - will have formally acknowledged the child before its birth. When this article was included in this Liber Amicorum (online at rechtwijs.nl/jcvslxla), the editors left out the footnotes by mistake. A copy of the article including the footnotes is available in the Leiden University Repository.

Published
2014

19. Reconstitution of Cellular Immunity in Hodgkin’s Disease with Transfer Factor

Author

Khan, A., Hill, J. M., Loeb, E., MacLellan, A., Hill, N. O., Allfrey, V. G., editor, Allgöwer, M., editor, Bauer, K. H., editor, Berenblum, I., editor, Bergel, F., editor, Bernhard, J., editor, Bernhard, W., editor, Blokhin, N. N., editor, Bock, H. E., editor, Bucalossi, P., editor, Chaklin, A. V., editor, Chorazy, M., editor, Cunningham, G. J., editor, Dargent, M., editor, Della Porta, G., editor, Denoix, P., editor, Dulbecco, R., editor, Eagle, H., editor, Eker, E., editor, Good, R. A., editor, Grabar, P., editor, Hamperl, H., editor, Harris, R. J. C., editor, Hecker, E., editor, Herbeuval, R., editor, Higginson, J., editor, Hueper, W. C., editor, Isliker, H., editor, Kieler, J., editor, Klein, G., editor, Koprowski, H., editor, Koss, L. G., editor, Martz, G., editor, Mathé, G., editor, Mühlbock, O., editor, Nakahara, W., editor, Old, L. J., editor, Potter, V. R., editor, Sabin, A. B., editor, Sachs, L., editor, Saxén, E. A., editor, Schmidt, C. G., editor, Spiegelman, S., editor, Szybalski, W., editor, Tagnon, H., editor, Taylor, R. M., editor, Tissières, A., editor, Uehlinger, E., editor, Wissler, R. W., editor, Rentchnick, P., editor, Mathé, Georges, editor, and Oldham, Robert K., editor

Published
1974
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20. Further Clinical Experience with cis-Platinum (II) Diamminedichloride

Author

Hill, J. M., Loeb, E., MacLellan, A. S., Hill, N. O., Khan, A., Kogler, J., Allfrey, V. G., editor, Allgöwer, M., editor, Bauer, K. H., editor, Berenblum, I., editor, Bergel, F., editor, Bernard, J., editor, Bernhard, W., editor, Blokhin, N. N., editor, Bock, H. E., editor, Braun, W., editor, Bucalossi, P., editor, Chaklin, A. V., editor, Chorazy, M., editor, Cunningham, G. J., editor, Dargent, M., editor, Porta, G. Della, editor, Denoix, P., editor, Dulbecco, R., editor, Eagle, H., editor, Eker, R., editor, Good, R. A., editor, Grabar, P., editor, Hamperl, H., editor, Harris, R. J. C., editor, Hecker, E., editor, Herbeuval, R., editor, Higginson, J., editor, Hueper, W. C., editor, Isliker, H., editor, Kieler, J., editor, Klein, G., editor, Koprowski, H., editor, Koss, L. G., editor, Martz, G., editor, Mathé, G., editor, Mühlbock, O., editor, Nakahara, W., editor, Old, L. J., editor, Potter, V. R., editor, Sabin, A. B., editor, Sachs, L., editor, Saxén, E. A., editor, Schmidt, C. G., editor, Spiegelman, S., editor, Szybalski, W., editor, Tagnon, H., editor, Taylor, R. M., editor, Tissières, A., editor, Uehlinger, E., editor, Wissler, R. W., editor, Rentchnick, P., editor, Connors, T. A., editor, and Roberts, J. J., editor

Published
1974
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22. Output Units of Motor Behavior: An Experimental and Modeling Study

Author

Loeb, E. P., Giszter, S. F., Mussa-Ivaldi, F. A., Saltiel, P., and Bizzi, E.

Subjects
Models, Measurement, Cognition -- Measurement -- Models, Motor skills -- Models -- Measurement, Motor ability -- Models -- Measurement
Abstract

* Cognitive approaches to motor control typically concern sequences of discrete actions without taking into account the stunning complexity of the geometry and dynamics of the muscles. This begs the [...]

Published
2000

25. MANAGEMENT OF VIRAL INFECTIONS WITH TRANSFER FACTOR

Author

Khan, A., primary, Nagata, K., additional, Hill, N.O., additional, Hansen, B., additional, Antonetti, A., additional, Hill, J.M., additional, Pardue, A.S., additional, Loeb, E., additional, Tate, G., additional, and Brodrick, J., additional

Published
1979
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34. Living conditions among people with activity limitations in Zimbabwe. A representative regional survey

Author

Eide, Arne Henning, Nhiwathiwa, Sekai, Muderedzi, Jennifer, and Loeb, E Mitch

Abstract

This research report provides results from a study on living conditions among people with and without activity limitations in Matabeleland, Manicaland and Midlands, Zimbabwe. The study began in 2001 and was completed in 2003. Living conditions among people with activity limitations in Zimbabwe. A representative regional survey.

Published
2003

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