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Your search keyword '"Loes P C, Hoebers"' showing total 4 results
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4 results on '"Loes P C, Hoebers"'

1. Long‐Term Survival and Angina After Chronic Total Occlusion Percutaneous Coronary Intervention Compared With Medical Therapy: A Meta‐Analysis

Author

Casper F. Coerkamp, Anna van Veelen, Kambis A. Mashayekhi, Sinisa M. Stojkovic, Stefan A. Juricic, Bimmer E. P. M. Claessen, René J. van der Schaaf, Loes P. C. Hoebers, Joelle Elias, and José P. S. Henriques

Subjects
chronic total occlusion, medical therapy, meta‐analysis, percutaneous coronary intervention, Diseases of the circulatory (Cardiovascular) system, RC666-701
Published
2024
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2. No evidence for cardiac dysfunction in Kif6 mutant mice.

Author

Abdul Hameed, Ellen Bennett, Barbara Ciani, Loes P C Hoebers, Roy Milner, Allan Lawrie, Sheila E Francis, and Andrew J Grierson

Subjects
Medicine, Science
Abstract

A KIF6 variant in man has been reported to be associated with adverse cardiovascular outcomes after myocardial infarction. No clear biological or physiological data exist for Kif6. We sought to investigate the impact of a deleterious KIF6 mutation on cardiac function in mice. Kif6 mutant mice were generated and verified. Cardiac function was assessed by serial echocardiography at baseline, after ageing and after exercise. Lipid levels were also measured. No discernable adverse lipid or cardiac phenotype was detected in Kif6 mutant mice. These data suggest that dysfunction of Kif6 is linked to other more complex biological/biochemical parameters or is unlikely to be of material consequence in cardiac function.

Published
2013
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3. No evidence for cardiac dysfunction in Kif6 mutant mice

Author

Allan Lawrie, Sheila E. Francis, Loes P. C. Hoebers, Barbara Ciani, Roy Milner, Abdul G. Hameed, Andrew J. Grierson, and Ellen J. Bennett

Subjects
Cardiac function curve, medicine.medical_specialty, Pathology, Anatomy and Physiology, Mouse, Mutant, Myocardial Infarction, Kinesins, lcsh:Medicine, Biology, medicine.disease_cause, Cardiovascular, Cardiovascular System, Molecular Genetics, Mice, Model Organisms, Internal medicine, medicine, Genetics, Animals, Humans, Myocardial infarction, lcsh:Science, Heart Failure, Clinical Genetics, Mutation, Multidisciplinary, lcsh:R, Heart, Animal Models, medicine.disease, Phenotype, Lipids, Mice, Mutant Strains, Cardiovascular physiology, Endocrinology, Ageing, Echocardiography, Genetics of Disease, KIF6, cardiovascular system, Medicine, lcsh:Q, Research Article
Abstract

A KIF6 variant in man has been reported to be associated with adverse cardiovascular outcomes after myocardial infarction.\ud No clear biological or physiological data exist for Kif6. We sought to investigate the impact of a deleterious KIF6 mutation on\ud cardiac function in mice. Kif6 mutant mice were generated and verified. Cardiac function was assessed by serial\ud echocardiography at baseline, after ageing and after exercise. Lipid levels were also measured. No discernable adverse lipid\ud or cardiac phenotype was detected in Kif6 mutant mice. These data suggest that dysfunction of Kif6 is linked to other more\ud complex biological/biochemical parameters or is unlikely to be of material consequence in cardiac function.

Published
2013

4. Long-term safety and sustained left ventricular recovery: Long-term results of percutaneous left ventricular support with Impella LP2.5 in ST-elevation myocardial infarction

Author

Annemarie E, Engström, Annemarie, Engström, Krischan D, Sjauw, Krischan, Sjauw, Jan, Baan, Maurice, Remmelink, Bimmer E P M, Claessen, Bimmer, Claessen, Wouter J, Kikkert, Wouter, Kikkert, Loes P C, Hoebers, Loes, Hoebers, Marije M, Vis, Marije, Vis, Karel T, Koch, Karel, Koch, Martijn M, Meuwissen, Martijn, Meuwissen, Jan G P, Tijssen, Jan, Tijssen, Robbert J, De Winter, Robbert, De Winter, Jan J, Piek, Jan, Piek, José P S, Henriques, José, Henriques, Cardiology, and Amsterdam Cardiovascular Sciences

Subjects
Aortic valve, Male, medicine.medical_specialty, medicine.medical_treatment, Myocardial Infarction, 030204 cardiovascular system & hematology, Ventricular Function, Left, 03 medical and health sciences, Electrocardiography, 0302 clinical medicine, Internal medicine, medicine, Humans, 030212 general & internal medicine, Myocardial infarction, cardiovascular diseases, Angioplasty, Balloon, Coronary, Impella, Ejection fraction, medicine.diagnostic_test, business.industry, Hemodynamics, Percutaneous coronary intervention, Middle Aged, medicine.disease, 3. Good health, medicine.anatomical_structure, Echocardiography, Ventricular assist device, Aortic Valve, Conventional PCI, Cardiology, cardiovascular system, Female, Heart-Assist Devices, Cardiology and Cardiovascular Medicine, business
Abstract

Aims: Mechanical left ventricular (LV) unloading may reduce infarct size when combined with primary percutaneous coronary intervention (PCI) in patients with ST-elevation myocardial infarction (STEM I). The Impella LP2.5 is a novel percutaneous left ventricular assist device. Although the short-term safety and feasibility of this device have been demonstrated, the long-term effects are unknown. The purpose of the current study was to evaluate the long-term effects of the Impella LP2.5 support on the aortic valve and left ventricular ejection fraction (LVEF). Methods and results: In 2006, 10 patients with anterior STEMI received 3-day support with the Impella LP2.5 after PCI. The control group consisted of 10 comparable patients, treated according to routine care. For the current study, echocardiography was performed and adverse events were recorded. Mean duration of follow-up was 2.9+/-0.6 years in the Impella group and 3.0+/-0.3 years in the control group. No differences in aortic valve abnormalities and LVEF were demonstrated between the groups; nevertheless, LVEF increase from baseline was significantly greater in Impella-treated patients (23.6+/-8.9% versus 6.7+/-7.0%, P=0.008). Conclusions: Three-day support with the Impella LP2.5 is not associated with adverse effects on the aortic valve at long-term follow-up. LVEF was similar in both groups; however, recovery was significantly greater in the Impella group

Published
2011
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