1. Engineered vascular grafts lend unique insight to pathophysiology of aortic aneurysms.
- Author
-
Naegeli KM and Niklason LE
- Subjects
- Humans, Animals, Induced Pluripotent Stem Cells metabolism, Myocytes, Smooth Muscle metabolism, Myocytes, Smooth Muscle pathology, Loeys-Dietz Syndrome genetics, Loeys-Dietz Syndrome pathology, Tissue Engineering, Aortic Aneurysm pathology, Aortic Aneurysm physiopathology, Blood Vessel Prosthesis
- Abstract
Yang et al.
1 generate tissue engineered blood vessels from hiPSC-derived smooth muscle cells harboring a mutation found in Loeys-Dietz syndrome. In vitro and in vivo data from these vessels provide new insight into the molecular physiology of aortic aneurysms and may create a paradigm for understanding a suite of vascular diseases., Competing Interests: Declaration of interests L.E.N. is founder and CEO of Humacyte Global, Inc., and serves on its board of directors. K.M.N. is an employee and shareholder of Humacyte Global, Inc. Humacyte Global owns, co-owns, or exclusively licenses 111 patents (including 15 within the United States) within 17 patent families related to tissue-engineered constructs and blood vessels and derivations thereof., (Copyright © 2024 Elsevier Inc. All rights reserved.)- Published
- 2024
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