1. C1q and mobility score in predicting sarcopenia in an Australian cohort of cancer surgery patients.
- Author
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Senanayake T, Loh EJ, Carroll R, Chan V, and Smith SR
- Subjects
- Humans, Aged, Complement C1q, Prospective Studies, Australia epidemiology, Biomarkers, Retrospective Studies, Sarcopenia diagnosis, Sarcopenia diagnostic imaging, Colorectal Neoplasms surgery
- Abstract
Background: Sarcopenia has been shown to have significant adverse health outcomes in a range of patient populations. Particularly, sarcopenic patients having cancer surgery are a unique group who demonstrate poorer post-operative outcomes. Currently, the gold standard in diagnosing sarcopenia is through the use of computed tomography. However, the widespread use of imaging to diagnose patients with sarcopenia is neither cost-effective nor practical. Identifying a serum biomarker or a simple mobility scoring system as an alternative diagnostic tool may aid in identifying more patients at risk of sarcopenia. C1q, a novel biomarker, has previously been shown to correlate with sarcopenia. Similarly, we sought to explore whether mobility scores may provide a useful surrogate marker for sarcopenia., Methods: This was a prospective cohort study of patients who presented for colorectal cancer surgery between the dates of 6/10/2016 and 4/10/2017 at John Hunter Hospital. Computed tomography was utilized to calculate the psoas area at the L3 spinal level. Pre-operative blood samples were obtained for C1q analysis and de Morton Mobility Index (DEMMI) was also performed., Results: A total of 51 patients were included in the study. The median age of the patients were 69 years old. We did not demonstrate a correlation between serum C1q and DEMMI scores with psoas area., Conclusion: Our findings suggest that neither C1q nor DEMMI scores are correlated with psoas area in a colorectal cancer population., (© 2022 Royal Australasian College of Surgeons.)
- Published
- 2022
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