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4 results on '"Loh-Shan B. Leung"'

1. Oculometric biomarkers of visuomotor deficits in clinically asymptomatic patients with systemic lupus erythematosus undergoing long-term hydroxychloroquine treatment

Author

Andrew R. Berneshawi, Kimia Seyedmadani, Rahul Goel, Mark R. Anderson, Terence L. Tyson, Yasmin M. Akay, Metin Akay, Loh-Shan B. Leung, and Leland S. Stone

Subjects
pursuit eye movements, saccadic eye movements, visual motion processing, retinal function, surveillance, structure-function analysis, Medicine
Abstract

IntroductionThis study examines a set of oculomotor measurements, or “oculometric” biomarkers, as potential early indicators of visual and visuomotor deficits due to retinal toxicity in asymptomatic Systemic Lupus Erythematosus (SLE) patients on long-term hydroxychloroquine (HCQ) treatment. The aim is to identify subclinical functional impairments that are otherwise undetectable by standard clinical tests and to link them to structural retinal changes.MethodsWe measured oculomotor responses in a cohort of SLE patients on chronic HCQ therapy using a previously established behavioral task and analysis technique. We also examined the relationship between oculometrics, OCT measures of retinal thickness, and standard clinical perimetry measures of visual function in our patient group using Bivariate Pearson Correlation and a Linear Mixed-Effects Model (LMM).ResultsSignificant visual and visuomotor deficits were found in 12 asymptomatic SLE patients on long-term HCQ therapy compared to a cohort of 17 age-matched healthy controls. Notably, six oculometrics were significantly different. The median initial pursuit acceleration was 22%, steady-state pursuit gain 16%, proportion smooth 7%, and target speed responsiveness 31% lower, while catch-up saccade amplitude was 46% and fixation error 46% larger. Excluding the two patients with diagnosed mild toxicity, four oculometrics, all but fixation error and proportion smooth, remained significantly impaired compared to controls. Across our population of 12 patients (24 retinae), we found that pursuit latency, initial acceleration, steady-state gain, and fixation error were linearly related to retinal thickness even when age was accounted for, while standard measures of clinical function (Mean Deviation and Pattern Standard Deviation) were not.DiscussionOur data show that specific oculometrics are sensitive early biomarkers of functional deficits in SLE patients on HCQ that could be harnessed to assist in the early detection of HCQ-induced retinal toxicity and other visual pathologies, potentially providing early diagnostic value beyond standard visual field and OCT evaluations.

Published
2024
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3. Electroretinographic findings in retinal vasculitis

Author

Hashem H Ghoraba, Wataru Matsumiya, Christopher Or, Hassan Khojasteh, Prem Patel, Irmak Karaca, Jonathan Regenold, Moosa Zaidi, Jaclyn Hwang, Sherin Lajevardi, Negin Yavari, Ngoc Trong Tuong Than, Sung Who Park, Amir Akhavanrezayat, Gunay Uludag, Cigdem Yasar, Loh-Shan B Leung, and Quan Dong Nguyen

Subjects
Cellular and Molecular Neuroscience, Ophthalmology, Sensory Systems
Abstract

AimTo describe and correlate electroretinographic responses with clinical and angiographic findings in retinal vasculitis (RV).MethodsMedical records of patients with diagnosis of RV at a tertiary eye centre from December 2017 to May 2021 were reviewed. Cases in which fluorescein angiography (FFA) and full field electroretinography (ffERG) were done within 1 month were included. FFAs were graded according to the Angiography Scoring for Uveitis Working Group from 0 to 40, where 0 is normal. A novel ffERG grading system was implemented where individual waves were graded for timing and amplitude and general ffERG score was determined with 6 being a perfect score.Results20 patients (34 eyes) were included. Mean age was 43.9±19.8 years; 70% were female. Median best-corrected visual acuity was 0.8 (0.08–1). Mean FFA score was 12.6±6.5. Median general ffERG score was 5 (0–6). 68% and 91% of eyes had responses with general ffERG scores ≥5 and 4, respectively. Flicker timing was most commonly affected.FFA scores weakly correlated with delayed photopic cone b-wave and flicker timing (p=0.03 and 0.016, respectively). Vitreous haze moderately correlated with delayed cone b-wave timing (pConclusionIn this study, RV was not frequently associated with severe global retinal dysfunction Higher FFA scores, and vitreous haze grading were weakly, but significantly, correlated with cone-generated ffERG responses.

Published
2022
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4. Contributors

Author

Michael Abràmoff, Gary W. Abrams, Anita Agarwal, Everett Ai, Lloyd M. Aiello, Lloyd Paul Aiello, Daniel M. Albert, Mathew W. Aschbrenner, Marcos Ávila, G. William Aylward, Matthew Bedell, Rubens Belfort, Jean Bennett, Chris Bergstrom, Cagri G. Besirli, Pramod S. Bhende, Susanne Binder, Alan C. Bird, Barbara A. Blodi, Mark S. Blumenkranz, H. Culver Boldt, Norbert Bornfeld, Ferdinando Bottoni, Michael E. Boulton, Sara J. Bowne, Milam A. Brantley, Neil M. Bressler, Susan B. Bressler, Andreas Bringmann, Daniel A. Brinton, Gary C. Brown, Justin C. Brown, Simon Brunner, Ronald A. Bush, Dingcai Cao, Antonio Capone, David Carruthers, Jerry D. Cavallerano, Usha Chakravarthy, Chi-Chao Chan, Waiman Chan, Steven Charles, David G. Charteris, Dong Feng Chen, Jeannie Chen, Youxin Chen, Carol Yim Lui Cheung, Emily Y. Chew, Allen Chiang, Michael F. Chiang, Ian J. Constable, Gabriel Coscas, Alan F. Cruess, Emmett T. Cunningham, Christine A. Curcio, Stephen P. Daiger, Bertil E. Damato, Janet L. Davis, Matthew D. Davis, Shelley Day, Patrick De Potter, Marc D. de Smet, Alastair K. Denniston, Ranjit S. Dhaliwal, Xiaoyan Ding, Diana V. Do, Guorui Dou, William A. Dunn, Justis P. Ehlers, Michael Engelbert, Lisa J. Faia, Benedetto Falsini, Amani A. Fawzi, Sharon Fekrat, Steven E. Feldon, Rodrigo A. Brant Fernandes, Henry A. Ferreyra, Deborah A. Ferrington, Frederick L. Ferris, Paul T. Finger, Steven K. Fisher, Gerald A. Fishman, Monika Fleckenstein, Harry W. Flynn, Andrew C. Fok, Wallace S. Foulds, William R. Freeman, Aurélien Freton, Martin Friedlander, Laura J. Frishman, Arthur D. Fu, Carlos Alexandre de Amorim Garcia Filho, Enrique Garcia-Valenzuela, Alain Gaudric, Mary Gayed, Mohamed A. Genead, Heinrich Gerding, Andrea Giani, Morton F. Goldberg, Dan S. Gombos, Lingam Gopal, Caroline Gordon, Hiroshi Goto, Evangelos S. Gragoudas, Maria B. Grant, W. Richard Green, Ronald G. Gregg, Zdenek Gregor, Giovanni Gregori, Kevin Gregory-Evans, Seanna Grob, Carl Groenewald, Hans E. Grossniklaus, Sandeep Grover, Vamsi K. Gullapalli, Aditi Gupta, Rudolf F. Guthoff, Paul Hahn, Julia A. Haller, J. William Harbour, Christos Haritoglou, Mary E. Hartnett, Barbara S. Hawkins, Shikun He, Martina C. Herwig, Florian M.A. Heussen, David R. Hinton, Frank G. Holz, Samuel K. Houston, Yan-Nian Hui, Mark S. Humayun, Yasushi Ikuno, David Isaac, Tatsuro Ishibashi, Douglas A. Jabs, Glenn J. Jaffe, Lee M. Jampol, Leonard Joffe, Mark Johnson, Mark W. Johnson, Robert N. Johnson, Antonia M. Joussen, Karina Julian, J. Michael Jumper, Peter K. Kaiser, Anselm Kampik, Robert Katamay, Christine N. Kay, Pearse A. Keane, M. Cristina Kenney, Khizer R. Khaderi, Mohamad A. Khodair, Ivana K. Kim, Tae Wan Kim, Bernd Kirchhof, Barbara E.K. Klein, Ronald Klein, Lazaros Konstantinidis, Igor Kozak, Baruch D. Kuppermann, Leanne T. Labriola, Timothy Y. Lai, Dennis S. Lam, Linda A. Lam, Maurice B. Landers, Anne Marie Lane, Erin B. Lavik, James F. Leary, Sun Young Lee, Thomas C. Lee, Loh-Shan B. Leung, David A. Lewis, Geoffrey P. Lewis, Anita Leys, Xiaoxin Li, Sandra Liakopoulos, Chang-Ping Lin, Phoebe Lin, David T. Liu, Nikolas J.S. London, Brandon J. Lujan, Yan Luo, Gerard A. Lutty, Robert MacLaren, Steven Madreperla, Albert M. Maguire, Martin A. Mainster, Nancy C. Mansfield, Arnold M. Markoe, Michael F. Marmor, Daniel F. Martin, Stephen C. Massey, Maureen A. McCall, Tara A. McCannel, J. Allen McCutchan, H. Richard McDonald, Milap P. Mehta, Petra Meier, Shannath Merbs, Travis A. Meredith, Carsten H. Meyer, William F. Mieler, Joan W. Miller, Rukhsana G. Mirza, Sayak K. Mitter, Robert A. Mittra, Yozo Miyake, Carlo Montemagno, Ala Moshiri, Prithvi Mruthyunjaya, Cristina Muccioli, Robert F. Mullins, Toshinori Murata, A. Linn Murphree, Robert P. Murphy, Philip I. Murray, Timothy G. Murray, Manish Nagpal, Perumalsamy Namperumalsamy, Sumit K. Nanda, Quan Dong Nguyen, Robert B. Nussenblatt, Kean T. Oh, Masahito Ohji, Kyoko Ohno-Matsui, Daniel Palanker, Purnima S. Patel, Anna C. Pavlick, David M. Peereboom, Mark E. Pennesi, Jay S. Pepose, Julian D. Perry, Carmen A. Puliafito, Polly A. Quiram, Rajiv Raman, Rajeev S. Ramchandran, Haripriya Vittal Rao, Narsing A. Rao, P. Kumar Rao, Sivakumar R. Rathinam, Franco M. Recchia, Kristin J. Redmond, Thomas A. Reh, Andreas Reichenbach, Robert Ritch, Philip J. Rosenfeld, Gary S. Rubin, Humberto Ruiz-Garcia, Stephen J. Ryan, SriniVas R. Sadda, Alfredo A. Sadun, Taiji Sakamoto, Alapakkam P. Sampath, Andrew P. Schachat, Steffen Schmitz-Valckenberg, Stephen G. Schwartz, Adrienne W. Scott, Jerry Sebag, Johanna M. Seddon, H. Nida Sen, Yasir Jamal Sepah, Sanjay Sharma, Tarun Sharma, Shwu-Jiuan Sheu, Carol L. Shields, Jerry A. Shields, Kei Shinoda, Dhananjay Shukla, Paul A. Sieving, Paolo A.S. Silva, Claudio Silveira, Arun D. Singh, Sylvia B. Smith, Wendy M. Smith, Lucia Sobrin, Akrit Sodhi, Elliott H. Sohn, Gisèle Soubrane, Leigh Spielberg, Sunil K. Srivastava, Oliver Stachs, Giovanni Staurenghi, Paul Sternberg, Edwin M. Stone, Ilene K. Sugino, Lori S. Sullivan, Paul Sullivan, Jennifer K. Sun, Janet S. Sunness, Ramin Tadayoni, Shibo Tang, Hiroko Terasaki, Matthew A. Thomas, John T. Thompson, Gabriele Thumann, Cynthia A. Toth, Michael T. Trese, Julie H. Tsai, Mary E. Turell, Patricia L. Turner, Nitin Udar, J. Niklas Ulrich, Russell N. Van Gelder, Jan C. van Meurs, Daniel Vítor Vasconcelos-Santos, Demetrios G. Vavvas, G. Atma Vemulakonda, Hao Wang, Yusheng Wang, James D. Weiland, Richard G. Weleber, Moody D. Wharam, Louisa Wickham, Peter Wiedemann, Henry E. Wiley, C.P. Wilkinson, David J. Wilson, Thomas J. Wolfensberger, David Wong, Ian Y. Wong, Tien Yin Wong, David M. Wu, Yanors Yandiev, Chang-Hao Yang, Chung-May Yang, Lawrence A. Yannuzzi, Miho Yasuda, Po-Ting Yeh, Zohar Yehoshua, Glenn Yiu, Young Hee Yoon, Hyeong Gon Yu, Alex Yuan, Marco A. Zarbin, Jun Jun Zhang, Kang Zhang, Mingwei Zhao, and Peng Zhou

Published
2013
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