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1. Outbreak of severe community-acquired bacterial infections among children in North Rhine-Westphalia (Germany), October to December 2022

Author

Goretzki, Sarah C., van der Linden, Mark, Itzek, Andreas, Hühne, Tom, Adelmann, Roland O., Ala Eldin, Firas, Albarouni, Mohamed, Becker, Jan-Claudius, Berghäuser, Martin A., Boesing, Thomas, Boeswald, Michael, Brasche, Milian, Brevis Nuñez, Francisco, Camara, Rokya, Deibert, Clara, Dohle, Frank, Dolgner, Jörg, Dziobaka, Jan, Eifinger, Frank, Elting, Natalie, Endmann, Matthias, Engelmann, Guido, Frenzke, Holger, Gappa, Monika, Gharavi, Bahman, Goletz, Christine, Hahn, Eva, Heidenreich, Yvonne, Heimann, Konrad, Hensel, Kai O., Hoffmann, Hans-Georg, Hoppenz, Marc, Horneff, Gerd, Klassen, Helene, Koerner-Rettberg, Cordula, Längler, Alfred, Lenz, Pascal, Lohmeier, Klaus, Müller, Andreas, Niemann, Frank, Paulussen, Michael, Pentek, Falk, Perez, Ruy, Pingel, Markus, Repges, Philip, Rothoeft, Tobias, Rübo, Jochen, Schade, Herbert, Schmitz, Robert, Schonhoff, Peter, Schwade, Jan N., Schwarz, Tobias, Seiffert, Peter, Selzer, Georg, Spille, Uwe, Thiel, Carsten, Thimm, Ansgar, Urgatz, Bartholomäus, van den Heuvel, Alijda, van Hop, Tan, Giesen, Verena, Wirth, Stefan, Wollbrink, Thomas, Wüller, Daniel, Felderhoff-Müser, Ursula, Dohna-Schwake, Christian, Lâm, Thiên-Trí, Claus, Heike, and Bruns, Nora

Published
2024
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2. De novo missense variants in RRAGC lead to a fatal mTORopathy of early childhood

Author

Reijnders, Margot R.F., Seibt, Annette, Brugger, Melanie, Lamers, Ideke J.C., Ott, Torsten, Klaas, Oliver, Horváth, Judit, Rose, Ailsa M.S., Craghill, Isabel M., Brunet, Theresa, Graf, Elisabeth, Mayerhanser, Katharina, Hellebrekers, Debby, Pauck, David, Neuen-Jacob, Eva, Rodenburg, Richard J.T., Wieczorek, Dagmar, Klee, Dirk, Mayatepek, Ertan, Driessen, Gertjan, Bindermann, Robert, Averdunk, Luisa, Lohmeier, Klaus, Sinnema, Margje, Stegmann, Alexander P.A., Roepman, Ronald, Poulter, James A., and Distelmaier, Felix

Published
2023
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3. Impact of Various Surface Treatments on the S-N Curve of Additive Manufactured AlSi12

Author

Greuling, Steffen, Weise, Wolfgang, Fetzer, Dieter, Müller-Lohmeier, Klaus, Speckle, Mattias-Manuel, Correia, José A.F.O., Series Editor, De Jesus, Abílio M.P., Series Editor, Ayatollahi, Majid Reza, Advisory Editor, Berto, Filippo, Advisory Editor, Fernández-Canteli, Alfonso, Advisory Editor, Hebdon, Matthew, Advisory Editor, Kotousov, Andrei, Advisory Editor, Lesiuk, Grzegorz, Advisory Editor, Murakami, Yukitaka, Advisory Editor, Carvalho, Hermes, Advisory Editor, Zhu, Shun-Peng, Advisory Editor, Fernandes, António Augusto, editor, and Calçada, Rui, editor

Published
2019
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4. Outbreak of severe community-acquired bacterial infections from Streptococcus pyogenes, Streptococcus pneumoniae, Neisseria meningitidis, and Haemophilus influenzae among children in North Rhine-Westphalia (Germany), October to December 2022

Author

Goretzki, Sarah C., primary, van der Linden, Mark, additional, Itzek, Andreas, additional, Huehne, Tom, additional, Adelmann, Roland O., additional, Ala Eldin, Firas, additional, Albarouni, Mohamed, additional, Becker, Jan-Claudius, additional, Berghaeuser, Michael A., additional, Boesing, Thomas, additional, Boeswald, Michael, additional, Brasche, Milian, additional, Brevis Nunez, Francisco, additional, Camara, Rokya, additional, Deibert, Clara, additional, Dohle, Frank, additional, Dolgner, Joerg, additional, Dziobaka, Jan, additional, Eifinger, Frank, additional, Elting, Natalie, additional, Endmann, Matthias, additional, Engelmann, Guido, additional, Frenzke, Holger, additional, Gappa, Monika, additional, Gharavi, Bahman, additional, Goletz, Christine, additional, Hahn, Eva, additional, Heidenreich, Yvonne, additional, Heimann, Konrad, additional, Hensel, Kai O., additional, Hoffmann, Hans-Georg, additional, Hoppenz, Marc, additional, Horneff, Gerd, additional, Klassen, Helene, additional, Koerner-Rettberg, Cordula, additional, Laengler, Alfred, additional, Lenz, Pascal, additional, Lohmeier, Klaus, additional, Mueller, Andreas, additional, Niemann, Frank, additional, Paulussen, Michael, additional, Pentek, Falk, additional, Perez, Ruy, additional, Pingel, Markus, additional, Repges, Philip, additional, Rothoeft, Tobias, additional, Ruebo, Jochen, additional, Schade, Herbert, additional, Schmitz, Robert, additional, Schonhoff, Peter, additional, Schwabe, Jan N., additional, Schwarz, Tobias, additional, Seiffert, Peter, additional, Selzer, Georg, additional, Spille, Uwe, additional, Thiel, Carsten, additional, Thimm, Ansgar, additional, Urgatz, Bartholomaeus, additional, van den Heuvel, Alijda, additional, van Hop, Tan, additional, Giesen, Verena, additional, Wirth, Stefan, additional, Wollbrink, Thomas, additional, Wueller, Daniel, additional, Felderhoff-Mueser, Ursula, additional, Dohna-Schwake, Christian, additional, Lam, Thien-Tri, additional, Claus, Heike, additional, and Bruns, Nora, additional

Published
2023
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5. Treated Cases of Retinopathy of Prematurity in Germany

Author

Pfeil, Johanna M., Barth, Teresa, Lagrèze, Wolf A., Lorenz, Birgit, Hufendiek, Karsten, Liegl, Raffael, Breuss, Helge, Bemme, Sebastian, Aisenbrey, Sabine, Glitz, Barbara, Süsskind, Daniela, Gabel-Pfisterer, Ameli, Skevas, Christos, Krohne, Tim U., Kakkassery, Vinodh, Bründer, Marie-Christine, Engelmann, Katrin, Guthoff, Rainer, Walter, Peter, Choritz, Lars, Stahl, Andreas, Michalewicz, Emilia, Baumgarten, Sabine, Lohmann, Tibor, Walter, Peter, Breuß, Helge, Retzlaff, Annekatrin, Bödemann, Melanie, Liegl, Marian, El Moussaoui, Laila, Aisenbrey, Sabine, Saßmannshausen, Marlene, Liegl, Raffael, Engelmann, Katrin, Goldammer, Imke, Fleischer, Ulrike, Ander, Annika, Tietz, Martin, Wienigk, Anja, Li, Jeany Q., Krohne, Tim U., Guthoff, Rainer, Khamees, Ala, Kaya, Sema, Höhn, Thomas, Lohmeier, Klaus, Franzel, Julia, Busik, Valentina, Mais, Christine, Bemme, Sebastian, Khattab, Mohammed, Lauermann, Peer, Meyer, Yulia, Dieks, Jana Katharina, Bründer, Marie-Christine, Grundel, Bastian, Grundel, Milena, Paul, Sebastian, Stahl, Andreas, Tayar, Allam, Heckmann, Matthias, Bahlmann, Hagen, Linnemann, Knud, Skevas, Christos, Hagenau, Felix, Spitzer, Martin, Herden, Jonas, Gröber, Thomas, Haar, Melanie, Mester, Nils, Brockmann, Dorothee, Tode, Jan, Hufendiek, Karsten, Framme, Carsten, Bohnhorst, Bettina, Böhne, Carolin, Peter, Corinna, Pirr, Sabine, Brosig, Anton, Gniesmer, Stefanie, Grisanti, Salvatore, Lüken, Sabine, Piria, Roya, Prasuhn, Michelle, Ranjbar, Mahdy, Rommel, Felix, Schiemenz, Christian, Kakkassery, Vinodh, Heckert, Anni, Choritz, Lars, Glitz, Barbara, Eter, Nicole, Falkenau, Silvia, Gabel-Pfisterer, Ameli, Lindenberg, Ann-Sophie, Mathias, Altmann, Barth, Teresa, Benedikt, Blüml, Isabel, Oberacher-Velten, Patrick, Peters, Herbert, Jägle, Horst, Helbig, Stephan, Döring, Anette, Keller-Wackerbauer, Jochen, Kittel, Holger, Michel, Hugo, Segerer, Sven, Wellmann, Süsskind, Daniela, Partsch, Michael, Völker, Michael, and Hagemann, Ulrike

Abstract

To analyze changes in demographic parameters and retreatment patterns over a 10-year period in a clinical routine setting of infants with retinopathy of prematurity (ROP) requiring treatment documented in the German Retina.net ROP registry.

Published
2024
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6. Assessment of retinopathy of prematurity regression and reactivation using an artificial intelligence–based vascular severity score

Author

Eilts, Sonja K., Pfeil, Johanna M., Poschkamp, Broder, Krohne, Tim U., Eter, Nicole, Barth, Teresa, Guthoff, Rainer, Lagrèze, Wolf, Grundel, Milena, Bründer, Marie-Christine, Busch, Martin, Kalpathy-Cramer, Jayashree, Chiang, Michael F., Chan, R. V. Paul, Coyner, Aaron S., Ostmo, Susan, Campbell, J. Peter, Stahl, Andreas, Pfeil, Johanna M, Bühler, Anima, Daniel, Moritz, Felzmann, Susanne, Gross, Nicolai, Horn, Stefanie, Lagrèze, Wolf A, Molnár, Fanni, Müller, Claudia, Reichl, Sabine, Reiff, Charlotte, Richter, Olga, Stech, Milena, Hentschel, Roland, Stavropolou, Dimitria, Tautz, Juliane, Bartsch, Kerstin, Braunstein, Jennifer, Brinken, Ralf, Brinkmann, Christian Karl, Czauderna, Joanna, Dralle, Wiebke, Gliem, Martin, Goebel, Arno, Heymer, Philipp, Hofmann, Martina, Holz, Frank G, Krohne, Tim U, Kupitz, David, Müller, Philipp, Petrak, Michael, Schmitz, Eva Janine, Schmitz-Valckenberg, Steffen, Schröder, Moritz, Steinberg, Julia, Supé, Julia, Kant, Evelyn, Kunze, Diana, Müller, Andreas, Adorf, Adeline, Alex, Anne, Alten, Florian, Clemens, Christoph R, Falkenau, Silvia, Friedhoff, Caroline, Loos, Desiree Sandra, Mihailovic, Natasa, Termühlen, Julia, Uhlig, Constantin, Hörnig-Franz, Isabell, Rieger-Fackeldey, Esther, Tekaat, Maria, Werner, Claudius, Altmann, Mathias, Blecha, Christiane, Brandl-Rühle, Sabine, Helbig, Horst, Hufendiek, Karsten, Jägle, Herbert, Konrad, Julia, Kopetzky, Eva, Lehmann, Fabian, Oberacher-Velten, Isabel, Keller-Wackerbauer, Annette, Kittel, Jochen, Segerer, Hugo, Ackermann, Phillip, Benga, Jemina, Guthoff, Tanja, Kleinert, Elena, Mayatepek, Ertan, Schrader, Stefan, Völker, Magdalena, Höhn, Thomas, Lohmeier, Klaus, Sabir, Hemmen, Brevis, Francisco, Mönig, Tina, Schwarz, Simone, Ehmer, Angela, Meltendorf, Synke, Schuart, Claudia, Avenarius, Stefan, Böttger, Ralf, Apel, Christoph, Bergmann, Anne, Herrmann, Karsten, Ockert-Schön, Franziska, Wegener, Sabine, Ehrt, Oliver, Nentwich, Martin, Pressler, Angelika, Rudolph, Günther, Genzel-Boroviczeny, Orsolya, Schmidt, Susanne, Münch, Hans-Georg, Thilmany, Claude, Aisenbrey, Sabine, Bruckmann, Anna, Dimopoulos, Spyridon, Hagemann, Ulrike, Inhoffen, Werner, Partsch, Michael, Schrader, Merle, Süsskind, Daniela, Völker, Michael, Bialkowski, Anja, Müller-Hansen, Ingo, Gerberth, Andrea, Hasselbach, Heike Christine, Lindemann, Solveig, Purtskhvanidze, Konstantine, Raffel, Yvonne, Roider, Johann, Schröder, Greta, Szymanek, Beke, Tode, Jan, Bendiks, Meike, Modlich, Simon, Jandeck, Isabel, Gerding, Heinrich, Smith, Lois E H, Eilts, Sonja K., Pfeil, Johanna M., Poschkamp, Broder, Krohne, Tim U., Eter, Nicole, Barth, Teresa, Guthoff, Rainer, Lagrèze, Wolf, Grundel, Milena, Bründer, Marie-Christine, Busch, Martin, Kalpathy-Cramer, Jayashree, Chiang, Michael F., Chan, R. V. Paul, Coyner, Aaron S., Ostmo, Susan, Campbell, J. Peter, Stahl, Andreas, Pfeil, Johanna M, Bühler, Anima, Daniel, Moritz, Felzmann, Susanne, Gross, Nicolai, Horn, Stefanie, Lagrèze, Wolf A, Molnár, Fanni, Müller, Claudia, Reichl, Sabine, Reiff, Charlotte, Richter, Olga, Stech, Milena, Hentschel, Roland, Stavropolou, Dimitria, Tautz, Juliane, Bartsch, Kerstin, Braunstein, Jennifer, Brinken, Ralf, Brinkmann, Christian Karl, Czauderna, Joanna, Dralle, Wiebke, Gliem, Martin, Goebel, Arno, Heymer, Philipp, Hofmann, Martina, Holz, Frank G, Krohne, Tim U, Kupitz, David, Müller, Philipp, Petrak, Michael, Schmitz, Eva Janine, Schmitz-Valckenberg, Steffen, Schröder, Moritz, Steinberg, Julia, Supé, Julia, Kant, Evelyn, Kunze, Diana, Müller, Andreas, Adorf, Adeline, Alex, Anne, Alten, Florian, Clemens, Christoph R, Falkenau, Silvia, Friedhoff, Caroline, Loos, Desiree Sandra, Mihailovic, Natasa, Termühlen, Julia, Uhlig, Constantin, Hörnig-Franz, Isabell, Rieger-Fackeldey, Esther, Tekaat, Maria, Werner, Claudius, Altmann, Mathias, Blecha, Christiane, Brandl-Rühle, Sabine, Helbig, Horst, Hufendiek, Karsten, Jägle, Herbert, Konrad, Julia, Kopetzky, Eva, Lehmann, Fabian, Oberacher-Velten, Isabel, Keller-Wackerbauer, Annette, Kittel, Jochen, Segerer, Hugo, Ackermann, Phillip, Benga, Jemina, Guthoff, Tanja, Kleinert, Elena, Mayatepek, Ertan, Schrader, Stefan, Völker, Magdalena, Höhn, Thomas, Lohmeier, Klaus, Sabir, Hemmen, Brevis, Francisco, Mönig, Tina, Schwarz, Simone, Ehmer, Angela, Meltendorf, Synke, Schuart, Claudia, Avenarius, Stefan, Böttger, Ralf, Apel, Christoph, Bergmann, Anne, Herrmann, Karsten, Ockert-Schön, Franziska, Wegener, Sabine, Ehrt, Oliver, Nentwich, Martin, Pressler, Angelika, Rudolph, Günther, Genzel-Boroviczeny, Orsolya, Schmidt, Susanne, Münch, Hans-Georg, Thilmany, Claude, Aisenbrey, Sabine, Bruckmann, Anna, Dimopoulos, Spyridon, Hagemann, Ulrike, Inhoffen, Werner, Partsch, Michael, Schrader, Merle, Süsskind, Daniela, Völker, Michael, Bialkowski, Anja, Müller-Hansen, Ingo, Gerberth, Andrea, Hasselbach, Heike Christine, Lindemann, Solveig, Purtskhvanidze, Konstantine, Raffel, Yvonne, Roider, Johann, Schröder, Greta, Szymanek, Beke, Tode, Jan, Bendiks, Meike, Modlich, Simon, Jandeck, Isabel, Gerding, Heinrich, and Smith, Lois E H

Published
2023

9. Thin-catheter Surfactant Application for Respiratory Distress Syndrome in Spontaneously Breathing Preterm Infants: A Meta-analysis of Randomized Clinical Trials

Author

Kesler, Hanan, Lohmeier, Klaus, Hoehn, Thomas, Kribs, Angela, Peinemann, Frank, Kesler, Hanan, Lohmeier, Klaus, Hoehn, Thomas, Kribs, Angela, and Peinemann, Frank

Abstract

Background: Surfactant application by a thin catheter represented by the term less invasive surfactant administration (LISA) for respiratory distress syndrome in spontaneously breathing preterm infants was developed as an alternative to endotracheal intubation. Methods: We conducted a meta-analysis to assess the effects of LISA when compared to the so-called intubation-surfactant-extubation (INSURE) and the standard endotracheal intubation and mechanical ventilation (MV). The primary outcome was the composite incidence of death or bronchopulmonary dysplasia at a postmenstrual age of 36 weeks. The secondary outcome was the composite incidence of seven other severe adverse events. On 06 October 2021, we searched randomized clinical trials (RCTs) in PubMed, the Cochrane Library, ClinicalTrials.gov , and the ICTRP Registry. Results: We included 18 RCTs. The pooled data on the primary outcome favored LISA when compared to either INSURE (risk ratio 0.67; 95% CI, 0.51 to 0.88) or MV (risk ratio 0.78; 95% CI, 0.61 to 0.99). The pooled data on the second outcome also favored LISA when compared to INSURE (risk ratio 0.75; 95% CI, 0.60 to 0.94) and MV (risk ratio 0.73; 95% CI, 0.55 to 0.96). Conclusion: The findings showed that surfactant application by non-intubation respiratory support and the use of a thin catheter may decrease the composite risk of death or bronchopulmonary dysplasia. The included data support the view that LISA should be considered the preferred treatment option in eligible infants.

Published
2022

11. Understanding tubing troubles: the environment can have a surprisingly detrimental effect on pneumatic tubing. Here's how to identify and understand the causes

Author

Munzer, Norbert and Muller-Lohmeier, Klaus

Subjects
Business, Engineering and manufacturing industries
Abstract

Pneumatic tubing usually is taken for granted. So when problems occur, they are particularly annoying because tubing often is considered to be a commodity item. But environmental conditions can wreak [...]

Published
2004

12. Comparing alternative ranibizumab dosages for safety and efficacy in retinopathy of prematurity : a randomized clinical trial

Author

Stahl, Andreas, Krohne, Tim U., Eter, Nicole, Oberacher-Velten, Isabel, Guthoff, Rainer, Meltendorf, Synke, Ehrt, Oliver, Aisenbrey, Sabine, Roider, Johann, Gerding, Heinrich, Jandeck, Claudia, Smith, Lois E. H., Walz, Johanna M., Bühler, Anima, Daniel, Moritz, Felzmann, Susanne, Gross, Nicolai, Horn, Stefanie, Lagrèze, Wolf, Molnár, Fanni, Müller, Claudia, Reichl, Sabine, Reiff, Charlotte, Richter, Olga, Stech, Milena, Hentschel, Roland, Stavropolou, Dimitria, Tautz, Juliane, Bartsch, Kerstin, Braunstein, Jennifer, Brinken, Ralf, Brinkmann, Christian Karl, Czauderna, Joanna, Dralle, Wiebke, Gliem, Martin, Goebel, Arno, Heymer, Philipp, Hofmann, Martina, Holz, Frank G., Kupitz, David, Müller, Philipp, Petrak, Michael, Schmitz, Eva Janine, Schmitz-Valckenberg, Steffen, Schröder, Moritz, Steinberg, Julia, Supé, Julia, Kant, Evelyn, Kunze, Diana, Müller, Andreas, Adorf, Adeline, Alex, Anne, Alten, Florian, Clemens, Christoph R., Falkenau, Silvia, Friedhoff, Caroline, Loos, Desiree Sandra, Mihailovic, Natasa, Termühlen, Julia, Uhlig, Constantin, Hörnig-Franz, Isabell, Rieger-Fackeldey, Esther, Tekaat, Maria, Werner, Claudius, Altmann, Mathias, Barth, Theresa, Blecha, Christiane, Brandl-Rühle, Sabine, Helbig, Horst, Hufendiek, Karsten, Jägle, Herbert, Konrad, Julia, Kopetzky, Eva, Lehmann, Fabian, Keller-Wackerbauer, Annette, Kittel, Jochen, Segerer, Hugo, Ackermann, Phillip, Benga, Jemina, Guthoff, Tanja, Kleinert, Elena, Mayatepek, Ertan, Schrader, Stefan, Völker, Magdalena, Höhn, Thomas, Lohmeier, Klaus, Sabir, Hemmen, Brevis, Francisco, Mönig, Tina, Schwarz, Simone, Ehmer, Angela, Schuart, Claudia, Avenarius, Stefan, Böttger, Ralf, Apel, Christoph, Bergmann, Anne, Herrmann, Karsten, Ockert-Schön, Franziska, Wegener, Sabine, Nentwich, Martin, Pressler, Angelika, Rudolph, Günther, Genzel-Boroviczeny, Orsolya, Schmidt, Susanne, Münch, Hans-Georg, Thilmany, Claude, Bruckmann, Anna, Dimopoulos, Spyridon, Hagemann, Ulrike, Inhoffen, Werner, Partsch, Michael, Schrader, Merle, Süsskind, Daniela, Völker, Michael, Bialkowski, Anja, Müller-Hansen, Ingo, Gerberth, Andrea, Hasselbach, Heike Christine, Lindemann, Solveig, Purtskhvanidze, Konstantine, Raffel, Yvonne, Schröder, Greta, Szymanek, Beke, Tode, Jan, Bendiks, Meike, and Modlich, Simon

Subjects
Male, Vascular Endothelial Growth Factor A, medicine.medical_specialty, genetic structures, Bevacizumab, Medizin, Angiogenesis Inhibitors, Pilot Projects, law.invention, 03 medical and health sciences, 0302 clinical medicine, Double-Blind Method, Randomized controlled trial, law, Germany, Ranibizumab, Internal medicine, Clinical endpoint, Humans, Medicine, Retinopathy of Prematurity, Dosing, Original Investigation, Dose-Response Relationship, Drug, business.industry, Standard treatment, Infant, Newborn, Retinopathy of prematurity, Odds ratio, medicine.disease, Treatment Outcome, Pediatrics, Perinatology and Child Health, 030221 ophthalmology & optometry, Female, business, 030217 neurology & neurosurgery, medicine.drug
Abstract

Importance Anti–vascular endothelial growth factor (VEGF) therapies are a novel treatment option in retinopathy of prematurity (ROP). Data on dosing, efficacy, and safety are insufficient. Objective To investigate lower doses of anti-VEGF therapy with ranibizumab, a substance with a significantly shorter systemic half-life than the standard treatment, bevacizumab. Design, Setting, and Participants This randomized, multicenter, double-blind, investigator-initiated trial at 9 academic medical centers in Germany compared ranibizumab doses of 0.12 mg vs 0.20 mg in infants with bilateral aggressive posterior ROP; ROP stage 1 with plus disease, 2 with plus disease, or 3 with or without plus disease in zone I; or ROP stage 3 with plus disease in posterior zone II. Patients were recruited between September 2014 and August 2016. Twenty infants were screened and 19 were randomized. Interventions All infants received 1 baseline ranibizumab injection per eye. Reinjections were allowed in case of ROP recurrence after at least 28 days. Main Outcomes and Measures The primary end point was the number of infants who did not require rescue therapy at 24 weeks. Key secondary end points included time-to-event analyses, progression of physiologic vascularization, and plasma VEGF levels. Stages of ROP were photodocumented and reviewed by an expert committee. Results Nineteen infants with ROP were enrolled (9 [47.4%] female; median [range] postmenstrual age at first treatment, 36.4 [34.7-39.7] weeks), 3 of whom died during the study (1 in the 0.12-mg group and 2 in the 0.20-mg group). Of the surviving infants, 8 (88.9%) (17 eyes [94.4%]) in the 0.12-mg group and 6 (85.7%) (13 eyes [92.9%]) in the 0.20-mg group did not require rescue therapy. Both ranibizumab doses were equally successful in controlling acute ROP (Cochran-Mantel-Haenszel analysis; odds ratio, 1.88; 95% CI, 0.26-13.49;P = .53). Physiologic intraretinal vascularization was superior in the 0.12-mg group. The VEGF plasma levels were not systematically altered in either group. Conclusions and Relevance This pilot study demonstrates that ranibizumab is effective in controlling acute ROP and that 24% of the standard adult dose (0.12 mg) appears equally effective as 40% (0.20 mg). Superior vascularization of the peripheral retina with 0.12 mg of ranibizumab indicates that the lower dose may be favorable. Unchanged plasma VEGF levels point toward a limited systemic drug exposure after ranibizumab. Trial Registration clinicaltrials.gov Identifier:NCT02134457and clinicaltrialsregister.eu Identifier:2013-002539-13.

Published
2018

13. NAXE Mutations Disrupt the Cellular NAD(P)HX Repair System and Cause a Lethal Neurometabolic Disorder of Early Childhood

Author

Kremer, Laura S., Danhauser, Katharina, Herebian, Diran, Petkovic Ramadža, Danijela, Piekutowska-Abramczuk, Dorota, Seibt, Annette, Müller-Felber, Wolfgang, Haack, Tobias B., Płoski, Rafał, Lohmeier, Klaus, Schneider, Dominik, Klee, Dirk, Rokicki, Dariusz, Mayatepek, Ertan, Strom, Tim M., Meitinger, Thomas, Klopstock, Thomas, Pronicka, Ewa, Mayr, Johannes A., Baric, Ivo, Distelmaier, Felix, and Prokisch, Holger

Published
2016
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15. De novo missense variants in RRAGClead to a fatal mTORopathy of early childhood

Author

Reijnders, Margot R.F., Seibt, Annette, Brugger, Melanie, Lamers, Ideke J.C., Ott, Torsten, Klaas, Oliver, Horváth, Judit, Rose, Ailsa M.S., Craghill, Isabel M., Brunet, Theresa, Graf, Elisabeth, Mayerhanser, Katharina, Hellebrekers, Debby, Pauck, David, Neuen-Jacob, Eva, Rodenburg, Richard J.T., Wieczorek, Dagmar, Klee, Dirk, Mayatepek, Ertan, Driessen, Gertjan, Bindermann, Robert, Averdunk, Luisa, Lohmeier, Klaus, Sinnema, Margje, Stegmann, Alexander P.A., Roepman, Ronald, Poulter, James A., and Distelmaier, Felix

Abstract

Mechanistic target of rapamycin (mTOR) complex 1 (mTORC1) regulates cell growth in response to nutritional status. Central to the mTORC1 function is the Rag-GTPase heterodimer. One component of the Rag heterodimer is RagC (Ras-related GTP-binding protein C), which is encoded by the RRAGCgene.

Published
2023
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17. Understanding TUBING TROUBLES.

Author

Münzer, Rorbert and Müller-Lohmeier, Klaus

Subjects
*CHEMICAL processes, *TUBES, *INTERMOLECULAR forces, *POLYMERS, *DIFFUSION, *PNEUMATIC machinery
Abstract

The article focuses on the detrimental effects of the environment on pneumatic tubing. To avoid recurring problems, it is important to know what can go wrong and why. This allows making the right material selection to avoid future problems. Many different types of tubing exist because, a material with good characteristics in one area generally has poor characteristics in others. Any selection of tubing, is a compromise between media resistance, performance, and price. The effect of chemically active substances most likely fits the general idea of media-related damage. A completely different type of damage mechanism occurs in the case of physically active media, where no chemical reaction takes place with the polymer material. These media develop their damaging effect by diffusion into a component and reduce the intermolecular forces within the polymer.

Published
2004

18. Thin-catheter Surfactant Application for Respiratory Distress Syndrome in Spontaneously Breathing Preterm Infants: A Meta-analysis of Randomized Clinical Trials.

Author

Kesler H, Lohmeier K, Hoehn T, Kribs A, and Peinemann F

Subjects
Catheters, Humans, Infant, Infant, Newborn, Infant, Premature, Randomized Controlled Trials as Topic, Surface-Active Agents, Bronchopulmonary Dysplasia, Pulmonary Surfactants, Respiratory Distress Syndrome, Newborn
Abstract

Background: Surfactant application by a thin catheter represented by the term less invasive surfactant administration (LISA) for respiratory distress syndrome in spontaneously breathing preterm infants was developed as an alternative to endotracheal intubation., Methods: We conducted a meta-analysis to assess the effects of LISA when compared to the socalled intubation-surfactant-extubation (INSURE) and the standard endotracheal intubation and mechanical ventilation (MV). The primary outcome was the composite incidence of death or bronchopulmonary dysplasia at a postmenstrual age of 36 weeks. The secondary outcome was the composite incidence of seven other severe adverse events. On 06 October 2021, we searched randomized clinical trials (RCTs) in PubMed, the Cochrane Library, ClinicalTrials.gov, and the ICTRP Registry., Results: We included 18 RCTs. The pooled data on the primary outcome favored LISA when compared to either INSURE (risk ratio 0.67; 95% CI, 0.51 to 0.88) or MV (risk ratio 0.78; 95% CI, 0.61 to 0.99). The pooled data on the second outcome also favored LISA when compared to INSURE (risk ratio 0.75; 95% CI, 0.60 to 0.94) and MV (risk ratio 0.73; 95% CI, 0.55 to 0.96)., Conclusion: The findings showed that surfactant application by non-intubation respiratory support and the use of a thin catheter may decrease the composite risk of death or bronchopulmonary dysplasia. The included data support the view that LISA should be considered the preferred treatment option in eligible infants., (Copyright© Bentham Science Publishers; For any queries, please email at epub@benthamscience.net.)

Published
2022
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