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1. In vivo white matter microstructure in adolescents with early-onset psychosis: a multi-site mega-analysis

Author

Barth, Claudia, Kelly, Sinead, Nerland, Stener, Jahanshad, Neda, Alloza, Clara, Ambrogi, Sonia, Andreassen, Ole A, Andreou, Dimitrios, Arango, Celso, Baeza, Inmaculada, Banaj, Nerisa, Bearden, Carrie E, Berk, Michael, Bohman, Hannes, Castro-Fornieles, Josefina, Chye, Yann, Crespo-Facorro, Benedicto, de la Serna, Elena, Díaz-Caneja, Covadonga M, Gurholt, Tiril P, Hegarty, Catherine E, James, Anthony, Janssen, Joost, Johannessen, Cecilie, Jönsson, Erik G, Karlsgodt, Katherine H, Kochunov, Peter, Lois, Noemi G, Lundberg, Mathias, Myhre, Anne M, Pascual-Diaz, Saül, Piras, Fabrizio, Smelror, Runar E, Spalletta, Gianfranco, Stokkan, Therese S, Sugranyes, Gisela, Suo, Chao, Thomopoulos, Sophia I, Tordesillas-Gutiérrez, Diana, Vecchio, Daniela, Wedervang-Resell, Kirsten, Wortinger, Laura A, Thompson, Paul M, and Agartz, Ingrid

Subjects
Brain Disorders, Serious Mental Illness, Pediatric, Biomedical Imaging, Clinical Research, Neurosciences, Mental Health, Schizophrenia, Mental health, Good Health and Well Being, Female, Humans, Male, Adolescent, White Matter, Diffusion Tensor Imaging, Brain, Psychotic Disorders, Anisotropy, Biological Sciences, Medical and Health Sciences, Psychology and Cognitive Sciences, Psychiatry
Abstract

Emerging evidence suggests brain white matter alterations in adolescents with early-onset psychosis (EOP; age of onset

Published
2023

2. List of contributors

Author

Mirshahi, Reza, primary, Fallon, Julia, additional, Acar, Burak, additional, Acharya, Isha, additional, Agarwal, Aniruddha, additional, Agrawal, Kushal, additional, Ahsanuddin, Sofia, additional, Alforja, Socorro, additional, Aljneibi, Shaikha, additional, Arévalo, J. Fernando, additional, Ayachit, Apoorva, additional, Ayachit, Guruprasad, additional, Baek, Jiwon, additional, Bandello, Francesco, additional, Baumal, Caroline R., additional, Bernal-Morales, Carolina, additional, Bertelli, Pietro M., additional, Bharath, Abhinaya, additional, Biswas, Jyotirmay, additional, Blindbæk, Søren Leer, additional, Bonhomme, Gabrielle, additional, Bonilla, Alan Chew, additional, Bonnin, Sophie, additional, Borrelli, Enrico, additional, Bousquet, Elodie, additional, Caranfa, Jonathan T., additional, Cassoux, Nathalie, additional, Chatziralli, Irini, additional, Checchin, Lisa, additional, Chhablani, Jay, additional, Chotcomwongse, Peranut, additional, Choudhry, Netan, additional, Chui, Toco, additional, Cruz-Pimentel, Miguel, additional, Eandi, Chiara M., additional, El Moussawi, Zeinab, additional, Errera, Marie-Helene, additional, Espejo-Arjona, Francisco, additional, Eyre, Jessica, additional, Falavarjani, Khalil Ghasemi, additional, Gallego-Pinazo, Roberto, additional, Gaudric, Alain, additional, Gonzalez, Monica P., additional, Grauslund, Jakob, additional, Guduric-Fuchs, Jasenka, additional, Guerra, Ricardo Leitão, additional, Gutiérrez-Bonet, Rosa, additional, Handa, Ashit, additional, Iovino, Claudio, additional, Jones, Anthony A., additional, Joshi, Shrinivas, additional, Kim, Judy E., additional, Kodjikian, Laurent, additional, Kulikov, Alexey N., additional, Labay-Tejado, Sara, additional, Ledesma-Gil, Gerardo, additional, Lippincott, John K., additional, Lois, Noemi, additional, Lupidi, Marco, additional, Mainster, Martin A., additional, Malaise, Denis, additional, Maltsev, Dmitrii S., additional, Mammo, Danny A., additional, Mangla, Rubble, additional, Mansour, Hana A., additional, Mansour, Ahmad M., additional, Mariotti, Cesare, additional, Matet, Alexandre, additional, Mathis, Thibaud, additional, Medina, Reinhold J., additional, Melo, Isabela Martins, additional, Menendez-Acebal, Covadonga, additional, Micevych, Paul S., additional, Montesel, Andrea, additional, Montolío-Marzo, Santiago, additional, Muni, Rajeev H., additional, Muñoz-Solano, Javier, additional, Muzi, Alessio, additional, Neto, Laurentino Biccas, additional, Ong, Joshua, additional, Ong, Sally S., additional, Orr, Samantha, additional, Özdek, Şengül, additional, Pacques, Michel, additional, Pappelis, Konstantinos, additional, Pathak, Varun, additional, Pattathil, Niveditha, additional, Pearce, Thomas M., additional, Penha, Fernando M., additional, Pichi, Francesco, additional, Poireir, Matthieu, additional, Prabhu, Vishma, additional, Querques, Giuseppe, additional, Rachitskaya, Aleksandra V., additional, Rahimi Ardali, Kimia, additional, Raval, Vishal, additional, Raval, Nilesh, additional, Reddy, Nikitha Gurram, additional, Reibaldi, Michele, additional, Reid, Emma, additional, Ricardi, Federico, additional, Rosen, Richard, additional, Rosier, Laurence, additional, Ruamviboonsuk, Paisan, additional, Ruiz-Medrano, Jorge, additional, Ruiz-Moreno, José M., additional, Sacconi, Riccardo, additional, Santina, Ahmad, additional, Sarraf, David, additional, Schwartz, Carol E., additional, Scott, Adrienne W., additional, Shaheen, Abdulla R., additional, Silpa-archa, Sukhum, additional, Singh, Sumit Randhir, additional, Sivalingam, Meera D., additional, Sridhar, Jayanth, additional, Stewart, Jay M., additional, Stitt, Alan W., additional, Tadarati, Mongkol, additional, Thariat, Juliette, additional, Turgut, Burak, additional, Venkatesh, Ramesh, additional, Vergmann, Anna Stage, additional, Vidal-Oliver, Lourdes, additional, Vujosevic, Stela, additional, Wakabayashi, Taku, additional, Wang, Kristine, additional, Wu, Lihteh, additional, Wu, Andres, additional, Wu, Max, additional, Yonekawa, Yoshihiro, additional, Zarnegar, Arman, additional, Zarranz-Ventura, Javier, additional, Zeydanli, Ece Ozdemir, additional, Zhang, Xinyuan, additional, and Zucchiatti, Ilaria, additional

Published
2024
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3. Retinal vascular regeneration

Author

Pathak, Varun, primary, Bertelli, Pietro M., additional, Guduric-Fuchs, Jasenka, additional, Eyre, Jessica, additional, Reid, Emma, additional, Lois, Noemi, additional, Stitt, Alan W., additional, and Medina, Reinhold J., additional

Published
2024
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4. Accelerated Cortical Thinning in Schizophrenia Is Associated With Rare and Common Predisposing Variation to Schizophrenia and Neurodevelopmental Disorders

Author

González-Peñas, Javier, Díaz-Caneja, Covadonga M., Costas, Javier, Gurriarán, Xaquín, Andreu-Bernabeu, Álvaro, Fañanas, Lourdes, Rosa de la Cruz, Araceli, Arias, Bárbara, Bobes, Julio, Pinto, Ana González, Crespo-Facorro, B., Martorell, L., Vilella, Elisabet, Muntané, Gerard, Moltó, María Dolores, Escartí, María José, Rivero, Olga, Parellada, Mara, Moreno, Carmen, Arango, Celso, Alloza, Clara, Brouwer, Rachel, González-Lois, Noemí, Gallego, Ana Guil, de Hoyos, Lucía, Romero-García, Rafael, Fañanás, Lourdes, González-Pinto, Ana, Crespo-Facorro, Benedicto, Martorell, Lourdes, Arrojo, Manuel, Gutiérrez-Zotes, Alfonso, Perez-Rando, Marta, Buimer, Elizabeth, van Haren, Neeltje, Cahn, Wiepke, O’Donovan, Michael, Kahn, René S., Pol, Hilleke Hulshoff, Janssen, Joost, and Schnack, Hugo

Published
2024
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6. Scleral Buckle, Vitrectomy, or Combined Surgery for Inferior Break Retinal Detachment: Systematic Review and Meta-Analysis

Author

Abdullatif, Abdussalam M., Ajlan, Radwan, Bonnar, Jonathan, Capone, Antonio, Colyer, Marcus, Dell’Omo, Roberto, Eliott, Dean, Emerson, Geoff, Gupta, Omesh, Hsu, Jason, Joseph, Daniel P., Lois, Noemi, Matinez-Castillo, Vicente, McCullough, Philip, Mohalhal, Ahmed A., Mura, Marco, Regillo, Carl, Rezende, Flavio A., Romano, Mario R., Ryan, Ed, Starr, Matthew, Tan, Chin Han, Von Fricken, Manfred, Wickham, Louisa, Williamson, Tom, Wright, David M., and Yonekawa, Yoshihiro

Published
2023
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8. The Effect of Macular Hole Duration on Surgical Outcomes: An Individual Participant Data Study of Randomized Controlled Trials

Author

Qu, Jinfeng, Zhao, Mingwei, Sadda, Srinivas, Manasa, Sreekumar, Agarwal, Divya, Kumar, Atul, Kakkar, Prateek, Bourgault, Serge, Tourville, Eric, Velez-Montoya, Raul, Hernandez-Da Mota, Sergio E., Ramirez-Estudillo, J. Abel, Nawrocki, Jerzy, Nawrocka, Zofia Anna, Lange, Clemens, Bainbridge, James, Yorston, David, Alberti, Mark, Cour, Morten la, Christensen, Ulrik, Ho Alvin, Kwok Kwan, Murphy, Declan C., Al-Zubaidy, Mo, Lois, Noemi, Scott, Neil, and Steel, David H.

Published
2023
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9. Structural covariance predictors of clinical improvement at 2-year follow-up in first-episode psychosis

Author

García-Rizo, Clemente, González-Díaz, Jairo M., Pina-Camacho, Laura, Rodríguez-Toscano, Elisa, Zorrilla, Iñaki, Lopez-Pena, Purificación, De-la-Cámara, Concepción, Modrego-Pardo, Pedro, Escartí, Mª. Jose, Nacher, Juan, Vázquez, Guillermo, Cristeto, Sílvia, Valli, Isabel, Torrent, Carla, Baeza, Imma, de la Serna, Elena, Menchón, J.M., Martínez-Zalacaín, Ignacio, Sáiz, Pilar A., González-Blanco, Leticia, Rodriguez-Jimenez, Roberto, Sanchez-Pastor, Luis, Usall, Judith, Butjosa, Anna, Pomarol-Clotet, Edith, Salvador, Raymond, Saiz-Masvidal, Cristina, Contreras, Fernando, Soriano-Mas, Carles, Mezquida, Gisela, Díaz-Caneja, Covadonga M., Vieta, Eduard, Amoretti, Silvia, Lobo, Antonio, González-Pinto, Ana, Janssen, Joost, Sagué-Vilavella, Maria, Castro-Fornieles, Josefina, Bergé, Daniel, Bioque, Miquel, Lois, Noemi G., Parellada, Mara, and Bernardo, Miguel

Published
2023
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10. Heterogeneity of morphometric similarity networks in health and schizophrenia

Author

Janssen, Joost, primary, Gallego, Ana Guil, additional, Díaz-Caneja, Covadonga M., additional, Lois, Noemi Gonzalez, additional, Janssen, Niels, additional, González-Peñas, Javier, additional, Macias, Pedro, additional, Buimer, Elizabeth, additional, van Haren, Neeltje, additional, Arango, Celso, additional, Kahn, Rene, additional, Hulshoff Pol, Hilleke, additional, and Schnack, Hugo, additional

Published
2024
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12. Vitrectomy, subretinal Tissue plasminogen activator and Intravitreal Gas for submacular haemorrhage secondary to Exudative Age-Related macular degeneration (TIGER): study protocol for a phase 3, pan-European, two-group, non-commercial, active-control, observer-masked, superiority, randomised controlled surgical trial

Author

Jackson, Timothy L., Bunce, Catey, Desai, Riti, Hillenkamp, Jost, Lee, Chan Ning, Lois, Noemi, Peto, Tunde, Reeves, Barnaby C., Steel, David H., Edwards, Rhiannon T., van Meurs, Jan C., Wafa, Hatem, and Wang, Yanzhong

Published
2022
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15. Scleral Buckle, Vitrectomy, or Combined Surgery for Inferior Break Retinal Detachment

Author

Bonnar, Jonathan, primary, Tan, Chin Han, additional, McCullough, Philip, additional, Wright, David M., additional, Williamson, Tom, additional, Lois, Noemi, additional, Abdullatif, Abdussalam M., additional, Ajlan, Radwan, additional, Bonnar, Jonathan, additional, Capone, Antonio, additional, Colyer, Marcus, additional, Dell’Omo, Roberto, additional, Eliott, Dean, additional, Emerson, Geoff, additional, Gupta, Omesh, additional, Hsu, Jason, additional, Joseph, Daniel P., additional, Matinez-Castillo, Vicente, additional, Mohalhal, Ahmed A., additional, Mura, Marco, additional, Regillo, Carl, additional, Rezende, Flavio A., additional, Romano, Mario R., additional, Ryan, Ed, additional, Starr, Matthew, additional, Von Fricken, Manfred, additional, Wickham, Louisa, additional, and Yonekawa, Yoshihiro, additional

Published
2023
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20. Reply

Author

Reid, Gerard A., McDonagh, Niamh, Wright, David M., Yek, John T. O., Essex, Rohan W., and Lois, Noemi

Published
2020
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24. Large-scale analysis of structural brain asymmetries in schizophrenia via the ENIGMA consortium

Author

Schijven, Dick, primary, Postema, Merel C., additional, Fukunaga, Masaki, additional, Matsumoto, Junya, additional, Miura, Kenichiro, additional, de Zwarte, Sonja M. C., additional, van Haren, Neeltje E. M., additional, Cahn, Wiepke, additional, Hulshoff Pol, Hilleke E., additional, Kahn, René S., additional, Ayesa-Arriola, Rosa, additional, Ortiz-García de la Foz, Víctor, additional, Tordesillas-Gutierrez, Diana, additional, Vázquez-Bourgon, Javier, additional, Crespo-Facorro, Benedicto, additional, Alnæs, Dag, additional, Dahl, Andreas, additional, Westlye, Lars T., additional, Agartz, Ingrid, additional, Andreassen, Ole A., additional, Jönsson, Erik G., additional, Kochunov, Peter, additional, Bruggemann, Jason M., additional, Catts, Stanley V., additional, Michie, Patricia T., additional, Mowry, Bryan J., additional, Quidé, Yann, additional, Rasser, Paul E., additional, Schall, Ulrich, additional, Scott, Rodney J., additional, Carr, Vaughan J., additional, Green, Melissa J., additional, Henskens, Frans A., additional, Loughland, Carmel M., additional, Pantelis, Christos, additional, Weickert, Cynthia Shannon, additional, Weickert, Thomas W., additional, de Haan, Lieuwe, additional, Brosch, Katharina, additional, Pfarr, Julia-Katharina, additional, Ringwald, Kai G., additional, Stein, Frederike, additional, Jansen, Andreas, additional, Kircher, Tilo T. J., additional, Nenadić, Igor, additional, Krämer, Bernd, additional, Gruber, Oliver, additional, Satterthwaite, Theodore D., additional, Bustillo, Juan, additional, Mathalon, Daniel H., additional, Preda, Adrian, additional, Calhoun, Vince D., additional, Ford, Judith M., additional, Potkin, Steven G., additional, Chen, Jingxu, additional, Tan, Yunlong, additional, Wang, Zhiren, additional, Xiang, Hong, additional, Fan, Fengmei, additional, Bernardoni, Fabio, additional, Ehrlich, Stefan, additional, Fuentes-Claramonte, Paola, additional, Garcia-Leon, Maria Angeles, additional, Guerrero-Pedraza, Amalia, additional, Salvador, Raymond, additional, Sarró, Salvador, additional, Pomarol-Clotet, Edith, additional, Ciullo, Valentina, additional, Piras, Fabrizio, additional, Vecchio, Daniela, additional, Banaj, Nerisa, additional, Spalletta, Gianfranco, additional, Michielse, Stijn, additional, van Amelsvoort, Therese, additional, Dickie, Erin W., additional, Voineskos, Aristotle N., additional, Sim, Kang, additional, Ciufolini, Simone, additional, Dazzan, Paola, additional, Murray, Robin M., additional, Kim, Woo-Sung, additional, Chung, Young-Chul, additional, Andreou, Christina, additional, Schmidt, André, additional, Borgwardt, Stefan, additional, McIntosh, Andrew M., additional, Whalley, Heather C., additional, Lawrie, Stephen M., additional, du Plessis, Stefan, additional, Luckhoff, Hilmar K., additional, Scheffler, Freda, additional, Emsley, Robin, additional, Grotegerd, Dominik, additional, Lencer, Rebekka, additional, Dannlowski, Udo, additional, Edmond, Jesse T., additional, Rootes-Murdy, Kelly, additional, Stephen, Julia M., additional, Mayer, Andrew R., additional, Antonucci, Linda A., additional, Fazio, Leonardo, additional, Pergola, Giulio, additional, Bertolino, Alessandro, additional, Díaz-Caneja, Covadonga M., additional, Janssen, Joost, additional, Lois, Noemi G., additional, Arango, Celso, additional, Tomyshev, Alexander S., additional, Lebedeva, Irina, additional, Cervenka, Simon, additional, Sellgren, Carl M., additional, Georgiadis, Foivos, additional, Kirschner, Matthias, additional, Kaiser, Stefan, additional, Hajek, Tomas, additional, Skoch, Antonin, additional, Spaniel, Filip, additional, Kim, Minah, additional, Kwak, Yoo Bin, additional, Oh, Sanghoon, additional, Kwon, Jun Soo, additional, James, Anthony, additional, Bakker, Geor, additional, Knöchel, Christian, additional, Stäblein, Michael, additional, Oertel, Viola, additional, Uhlmann, Anne, additional, Howells, Fleur M., additional, Stein, Dan J., additional, Temmingh, Henk S., additional, Diaz-Zuluaga, Ana M., additional, Pineda-Zapata, Julian A., additional, López-Jaramillo, Carlos, additional, Homan, Stephanie, additional, Ji, Ellen, additional, Surbeck, Werner, additional, Homan, Philipp, additional, Fisher, Simon E., additional, Franke, Barbara, additional, Glahn, David C., additional, Gur, Ruben C., additional, Hashimoto, Ryota, additional, Jahanshad, Neda, additional, Luders, Eileen, additional, Medland, Sarah E., additional, Thompson, Paul M., additional, Turner, Jessica A., additional, van Erp, Theo G. M., additional, and Francks, Clyde, additional

Published
2023
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26. Targeting QKI-7 in vivo restores endothelial cell function in diabetes

Author

Yang, Chunbo, Eleftheriadou, Magdalini, Kelaini, Sophia, Morrison, Thomas, González, Marta Vilà, Caines, Rachel, Edwards, Nicola, Yacoub, Andrew, Edgar, Kevin, Moez, Arya, Ivetic, Aleksandar, Zampetaki, Anna, Zeng, Lingfang, Wilkinson, Fiona L., Lois, Noemi, Stitt, Alan W., Grieve, David J., and Margariti, Andriana

Published
2020
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29. Retinal ischaemia in diabetic retinopathy: understanding and overcoming a therapeutic challenge: understanding and overcoming a therapeutic challenge

Author

Mohite, Ajay A, Perais, Jennifer A, McCullough, Philip, and Lois, Noemi

Subjects
Medicine(all), diabetes, ultra-widefield fluorescein angiography, diabetic macular ischaemia, OCT angiography, optical coherence tomography angiography, retinal ischaemia, diabetic retinopathy, DR, retinal nonperfusion, DMI, OCT, SDG 3 - Good Health and Well-being, FFA, OCTA, retinal capillary dropout, retinal function, UWF FFA
Abstract

BACKGROUND: Retinal ischaemia is present to a greater or lesser extent in all eyes with diabetic retinopathy (DR). Nonetheless, our understanding of its pathogenic mechanisms, risk factors, as well as other characteristics of retinal ischaemia in DR is very limited. To date, there is no treatment to revascularise ischaemic retina.METHODS: Review of the literature highlighting the current knowledge on the topic of retinal ischaemia in DR, important observations made, and underlying gaps for which research is needed.RESULTS: A very scarce number of clinical studies, mostly cross-sectional, have evaluated specifically retinal ischaemia in DR. Interindividual variability on its natural course and consequences, including the development of its major complications, namely diabetic macular ischaemia and proliferative diabetic retinopathy, have not been investigated. The in situ, surrounding, and distance effect of retinal ischaemia on retinal function and structure and its change over time remains also to be elucidated. Treatments to prevent the development of retinal ischaemia and, importantly, to achieve retinal reperfusion once capillary drop out has ensued, are very much needed and remain to be developed.CONCLUSION: Research into retinal ischaemia in diabetes should be a priority to save sight.

Published
2023

32. The Effect of Macular Hole Duration on Surgical Outcomes

Author

Murphy, Declan C., primary, Al-Zubaidy, Mo, additional, Lois, Noemi, additional, Scott, Neil, additional, Steel, David H., additional, Qu, Jinfeng, additional, Zhao, Mingwei, additional, Sadda, Srinivas, additional, Manasa, Sreekumar, additional, Agarwal, Divya, additional, Kumar, Atul, additional, Kakkar, Prateek, additional, Bourgault, Serge, additional, Tourville, Eric, additional, Velez-Montoya, Raul, additional, Hernandez-Da Mota, Sergio E., additional, Ramirez-Estudillo, J. Abel, additional, Nawrocki, Jerzy, additional, Nawrocka, Zofia Anna, additional, Lange, Clemens, additional, Bainbridge, James, additional, Yorston, David, additional, Alberti, Mark, additional, Cour, Morten la, additional, Christensen, Ulrik, additional, and Ho Alvin, Kwok Kwan, additional

Published
2023
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35. Structural covariance predictors of clinical improvement at 2-year follow-up in first-episode psychosis

Author

Saiz-Masvidal, Cristina, primary, Contreras, Fernando, additional, Soriano-Mas, Carles, additional, Mezquida, Gisela, additional, Díaz-Caneja, Covadonga M., additional, Vieta, Eduard, additional, Amoretti, Silvia, additional, Lobo, Antonio, additional, González-Pinto, Ana, additional, Janssen, Joost, additional, Sagué-Vilavella, Maria, additional, Castro-Fornieles, Josefina, additional, Bergé, Daniel, additional, Bioque, Miquel, additional, Lois, Noemi G., additional, Parellada, Mara, additional, Bernardo, Miguel, additional, García-Rizo, Clemente, additional, González-Díaz, Jairo M., additional, Pina-Camacho, Laura, additional, Rodríguez-Toscano, Elisa, additional, Zorrilla, Iñaki, additional, Lopez-Pena, Purificación, additional, De-la-Cámara, Concepción, additional, Modrego-Pardo, Pedro, additional, Escartí, Mª. Jose, additional, Nacher, Juan, additional, Vázquez, Guillermo, additional, Cristeto, Sílvia, additional, Valli, Isabel, additional, Torrent, Carla, additional, Baeza, Imma, additional, de la Serna, Elena, additional, Menchón, J.M., additional, Martínez-Zalacaín, Ignacio, additional, Sáiz, Pilar A., additional, González-Blanco, Leticia, additional, Rodriguez-Jimenez, Roberto, additional, Sanchez-Pastor, Luis, additional, Usall, Judith, additional, Butjosa, Anna, additional, Pomarol-Clotet, Edith, additional, and Salvador, Raymond, additional

Published
2023
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36. Diabetic Macular Edema and Diode Subthreshold Micropulse Laser

Author

Lois, Noemi, primary, Campbell, Christina, additional, Waugh, Norman, additional, Azuara-Blanco, Augusto, additional, Maredza, Mandy, additional, Mistry, Hema, additional, McAuley, Danny, additional, Acharya, Nachiketa, additional, Aslam, Tariq M., additional, Bailey, Clare, additional, Chong, Victor, additional, Downey, Louise, additional, Eleftheriadis, Haralabos, additional, Fatum, Samia, additional, George, Sheena, additional, Ghanchi, Faruque, additional, Groppe, Markus, additional, Hamilton, Robin, additional, Menon, Geeta, additional, Saad, Ahmed, additional, Sivaprasad, Sobha, additional, Shiew, Marianne, additional, Steel, David H., additional, Talks, James Stephen, additional, Doherty, Paul, additional, McDowell, Cliona, additional, and Clarke, Mike, additional

Published
2023
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37. In vivo white matter microstructure in adolescents with early-onset psychosis: a multi-site mega-analysis

Author

Barth, Claudia, primary, Kelly, Sinead, additional, Nerland, Stener, additional, Jahanshad, Neda, additional, Alloza, Clara, additional, Ambrogi, Sonia, additional, Andreassen, Ole A., additional, Andreou, Dimitrios, additional, Arango, Celso, additional, Baeza, Inmaculada, additional, Banaj, Nerisa, additional, Bearden, Carrie E., additional, Berk, Michael, additional, Bohman, Hannes, additional, Castro-Fornieles, Josefina, additional, Chye, Yann, additional, Crespo-Facorro, Benedicto, additional, de la Serna, Elena, additional, Díaz-Caneja, Covadonga M., additional, Gurholt, Tiril P., additional, Hegarty, Catherine E., additional, James, Anthony, additional, Janssen, Joost, additional, Johannessen, Cecilie, additional, Jönsson, Erik G., additional, Karlsgodt, Katherine H., additional, Kochunov, Peter, additional, Lois, Noemi G., additional, Lundberg, Mathias, additional, Myhre, Anne M., additional, Pascual-Diaz, Saül, additional, Piras, Fabrizio, additional, Smelror, Runar E., additional, Spalletta, Gianfranco, additional, Stokkan, Therese S., additional, Sugranyes, Gisela, additional, Suo, Chao, additional, Thomopoulos, Sophia I., additional, Tordesillas-Gutiérrez, Diana, additional, Vecchio, Daniela, additional, Wedervang-Resell, Kirsten, additional, Wortinger, Laura A., additional, Thompson, Paul M., additional, and Agartz, Ingrid, additional

Published
2022
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39. Standard threshold laser versus subthreshold micropulse laser for adults with diabetic macular oedema: the DIAMONDS non-inferiority RCT

Author

Lois, Noemi, primary, Campbell, Christina, additional, Waugh, Norman, additional, Azuara-Blanco, Augusto, additional, Maredza, Mandy, additional, Mistry, Hema, additional, McAuley, Danny, additional, Acharya, Nachiketa, additional, Aslam, Tariq M, additional, Bailey, Clare, additional, Chong, Victor, additional, Downey, Louise, additional, Eleftheriadis, Haralabos, additional, Fatum, Samia, additional, George, Sheena, additional, Ghanchi, Faruque, additional, Groppe, Markus, additional, Hamilton, Robin, additional, Menon, Geeta, additional, Saad, Ahmed, additional, Sivaprasad, Sobha, additional, Shiew, Marianne, additional, Steel, David H, additional, Talks, James Stephen, additional, Doherty, Paul, additional, McDowell, Clíona, additional, and Clarke, Mike, additional

Published
2022
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42. The effect of macular hole duration on surgical outcomes: An individual participant data study of randomised controlled trials

Author

Murphy, Declan C., Al-Zubaidy, Mo, Lois, Noemi, Scott, Neil, Steel, David H., Qu, Jinfeng, Zhao, Mingwei, Sadda, Srinivas, Manasa, Sreekumar, Agarwal, Divya, Kumar, Atul, Kakkar, Prateek, Bourgault, Serge, Tourville, Eric, Velez-Montoya, Raul, Hernandez-Da Mota, Sergio E., Ramirez-Estudillo, J. Abel, Nawrocki, Jerzy, Nawrocka, Zofia Anna, Lange, Clemens, Bainbridge, James, Yorston, David, Alberti, Mark, Cour, Morten la, Christensen, Ulrik, and Ho Alvin, Kwok Kwan

Subjects
Ophthalmology, Visual acuity, Closure, Symptom duration, Randomized controlled trial, Individual participant analysis, Macular hole
Abstract

TOPIC: To define the effect of symptom duration on outcomes in people undergoing surgery for idiopathic full thickness macular holes (iFTMH) by means of an individual participant data (IPD) study of randomised controlled trials (RCT). The outcomes assessed were primary iFTMH closure and post-operative best corrected visual acuity (BCVA) CLINICAL RELEVANCE: IFTMH are visually disabling with a prevalence of up to 0.5%. Untreated BCVA is typically reduced to 20/200. Surgery can close holes and improve vision. Symptom duration is thought to affect outcomes with surgery, but the effect unclear.METHODS: A systematic review identified eligible RCTs which included adults with iFTMH undergoing vitrectomy with gas tamponade where symptom duration, primary iFTMH closure and post-operative BCVA were recorded. Bibliographic databases were searched for articles published between 2000 and 2020. IPD was requested from eligible studies.RESULTS: 20 eligible RCTs were identified. Data was requested from all studies and obtained from 12 representing 940 eyes in total. Median symptom duration was 6-months (interquartile (IQR) range 3-10). Primary closure was achieved in 81.5% of eyes. The was a linear relationship between predicted probability of closure and symptom duration. Multilevel logistic regression showed each additional month of duration was associated with 0.965 times lower odds of closure (95% CI: 0.935 to 0.996, p=0.026). Internal limiting membrane (ILM) peeling, intra-operative ILM flap use, better pre-operative BCVA, face-down positioning and smaller iFTMH size were associated with increased odds of primary closure. Mean post-operative BCVA in eyes achieving primary closure was 0.52 logMAR (20/66). Multilevel logistic regression showed for eyes achieving primary iFTMH closure, each additional month of symptom duration was associated with worsening BCVA by 0.008 logMAR units (95% CI: 0.005 to 0.011, pCONCLUSIONS: Symptom duration was independently associated with both anatomical and visual outcomes in persons undergoing surgery for iFTMH. Time to surgery for iFTMHs should be minimised and care pathways designed to enable this.

Published
2023

43. Diabetic macular edema and diode subthreshold micropulse laser: A randomized double-masked noninferiority clinical trial

Author

Lois, Noemi, Campbell, Christina, Waugh, Norman, Azuara-Blanco, Augusto, Maredza, Mandy, Mistry, Hema, McAuley, Danny, Acharya, Nachiketa, Aslam, Tariq M., Bailey, Clare, Chong, Victor, Downey, Louise, Eleftheriadis, Haralabos, Fatum, Samia, George, Sheena, Ghanchi, Faruque, Groppe, Markus, Hamilton, Robin, Menon, Geeta, Saad, Ahmed, Sivaprasad, Sobha, Shiew, Marianne, Steel, David H., Talks, James Stephen, Doherty, Paul, McDowell, Cliona, and Clarke, Mike

Subjects
SDG 3 - Good Health and Well-being
Abstract

PurposeTo determine clinical effectiveness, safety, and cost-effectiveness of subthreshold micropulse laser (SML), compared with standard laser (SL), for diabetic macular edema (DME) with central retinal thickness (CRT) < 400 μm.DesignPragmatic, multicenter, allocation-concealed, double-masked, randomized, noninferiority trial.ParticipantsAdults with center-involved DME < 400 μm and best-corrected visual acuity (BCVA) of > 24 Early Treatment Diabetic Retinopathy Study (ETDRS) letters in one/both eyes.MethodsRandomization 1:1 to 577 nm SML or SL treatment. Retreatments were allowed. Rescue with intravitreal anti–vascular endothelial growth factor therapies or steroids was permitted if 10 or more ETDRS letter loss occurred, CRT increased > 400 μm, or both.Main Outcome MeasuresPrimary outcome was mean change in BCVA in the study eye at 24 months (noninferiority margin 5 ETDRS letters). Secondary outcomes were mean change from baseline to month 24 in binocular BCVA; CRT and mean deviation of Humphrey 10-2 visual field in the study eye; percentage meeting driving standards; EuroQoL EQ-5D-5L, 25-item National Eye Institute Visual Function Questionnaire (NEI-VFQ-25), and Vision and Quality of Life Index (VisQoL) scores; cost per quality-adjusted life-years (QALYs) gained; adverse effects; and number of laser and rescue treatments.ResultsThe study recruited fully (n = 266); 87% of SML-treated and 86% of SL-treated patients had primary outcome data. Mean ± standard deviation BCVA change from baseline to month 24 was –2.43 ± 8.20 letters and –0.45 ± 6.72 letters in the SML and SL groups, respectively. Subthreshold micropulse laser therapy was deemed not only noninferior but also equivalent to SL therapy because the 95% confidence interval (CI; –3.9 to –0.04 letters) lay wholly within both upper and lower margins of the permitted maximum difference (5 ETDRS letters). No statistically significant difference was found in binocular BCVA (0.32 ETDRS letters; 95% CI, –0.99 to 1.64 ETDRS letters; P = 0.63); CRT (–0.64 μm; 95% CI, –14.25 to 12.98 μm; P = 0.93); mean deviation of the visual field (0.39 decibels (dB); 95% CI, –0.23 to 1.02 dB; P = 0.21); meeting driving standards (percentage point difference, 1.6%; 95% CI, –25.3% to 28.5%; P = 0.91); adverse effects (risk ratio, 0.28; 95% CI, 0.06–1.34; P = 0.11); rescue treatments (percentage point difference, –2.8%; 95% CI, –13.1% to 7.5%; P = 0.59); or EQ-5D, NEI-VFQ-25, or VisQoL scores. Number of laser treatments was higher in the SML group (0.48; 95% CI, 0.18–0.79; P = 0.002). Base-case analysis indicated no differences in costs or QALYs.ConclusionsSubthreshold micropulse laser therapy was equivalent to SL therapy, requiring slightly higher laser treatments.

Published
2023

44. Standard threshold laser versus subthreshold micropulse laser for adults with diabetic macular oedema: the DIAMONDS non-inferiority RCT: the DIAMONDS non-inferiority RCT

Author

Lois, Noemi, Campbell, Christina, Waugh, Norman, Azuara-Blanco, Augusto, Maredza, Mandy, Mistry, Hema, McAuley, Danny, Acharya, Nachiketa, Aslam, Tariq M, Bailey, Clare, Chong, Victor, Downey, Louise, Eleftheriadis, Haralabos, Fatum, Samia, George, Sheena, Ghanchi, Faruque, Groppe, Markus, Hamilton, Robin, Menon, Geeta, Saad, Ahmed, Sivaprasad, Sobha, Shiew, Marianne, Steel, David H, Talks, James Stephen, Doherty, Paul, McDowell, Clíona, and Clarke, Mike

Subjects
Adult, Macular Edema/surgery, SDG 3 - Good Health and Well-being, Lasers, Quality of Life, Diabetes Mellitus, Humans, Laser Coagulation/adverse effects, Diabetic Retinopathy/surgery, Ranibizumab/adverse effects, Endothelial Growth Factors/therapeutic use, Bevacizumab/adverse effects
Abstract

BackgroundThe National Institute for Health and Care Excellence recommends macular laser to treat diabetic macular oedema with a central retinal subfield thickness of ObjectivesDetermining the clinical effectiveness, safety and cost-effectiveness of subthreshold micropulse laser compared with standard threshold macular laser to treat diabetic macular oedema with a central retinal subfield thickness of DesignA pragmatic, multicentre, allocation-concealed, double-masked, randomised, non-inferiority, clinical trial.SettingHospital eye services in the UK.ParticipantsAdults with diabetes and centre-involving diabetic macular oedema with a central retinal subfield thickness of 24 Early Treatment Diabetic Retinopathy Study letters (Snellen equivalent > 20/320) in one/both eyes.InterventionsParticipants were randomised 1 : 1 to receive 577 nm subthreshold micropulse laser or standard threshold macular laser (e.g. argon laser, frequency-doubled neodymium-doped yttrium aluminium garnet 532 nm laser); laser treatments could be repeated as needed. Rescue therapy with intravitreal anti-vascular endothelial growth factor therapies or steroids was allowed if a loss of ≥ 10 Early Treatment Diabetic Retinopathy Study letters between visits occurred and/or central retinal subfield thickness increased to > 400 µm.Main outcome measuresThe primary outcome was the mean change in best-corrected visual acuity in the study eye at 24 months (non-inferiority margin 5 Early Treatment Diabetic Retinopathy Study letters). Secondary outcomes included the mean change from baseline to 24 months in the following: binocular best-corrected visual acuity; central retinal subfield thickness; the mean deviation of the Humphrey 10–2 visual field in the study eye; the percentage of people meeting driving standards; and the EuroQol-5 Dimensions, five-level version, National Eye Institute Visual Function Questionnaire – 25 and Vision and Quality of Life Index scores. Other secondary outcomes were the cost per quality-adjusted life-years gained, adverse effects, number of laser treatments and additional rescue treatments.ResultsThe DIAMONDS trial recruited fully (n = 266); 87% of participants in the subthreshold micropulse laser group and 86% of participants in the standard threshold macular laser group had primary outcome data. Groups were balanced regarding baseline characteristics. Mean best-corrected visual acuity change in the study eye from baseline to month 24 was –2.43 letters (standard deviation 8.20 letters) in the subthreshold micropulse laser group and –0.45 letters (standard deviation 6.72 letters) in the standard threshold macular laser group. Subthreshold micropulse laser was deemed to be not only non-inferior but also equivalent to standard threshold macular laser as the 95% confidence interval (–3.9 to –0.04 letters) lay wholly within both the upper and lower margins of the permitted maximum difference (5 Early Treatment Diabetic Retinopathy Study letters). There was no statistically significant difference between groups in any of the secondary outcomes investigated with the exception of the number of laser treatments performed, which was slightly higher in the subthreshold micropulse laser group (mean difference 0.48, 95% confidence interval 0.18 to 0.79; p = 0.002). Base-case analysis indicated no significant difference in the cost per quality-adjusted life-years between groups.Future workA trial in people with ≥ 400 µm diabetic macular oedema comparing anti-vascular endothelial growth factor therapy alone with anti-vascular endothelial growth factor therapy and macular laser applied at the time when central retinal subfield thickness has decreased to LimitationsThe majority of participants enrolled had poorly controlled diabetes.ConclusionsSubthreshold micropulse laser was equivalent to standard threshold macular laser but required a slightly higher number of laser treatments.

Published
2022

46. Diabetic macular oedema and diode subthreshold micropulse laser (DIAMONDS): study protocol for a randomised controlled trial

Author

Lois, Noemi, Gardner, Evie, Waugh, Norman, Azuara-Blanco, Augusto, Mistry, Hema, McAuley, Danny, Acharya, Nachiketa, Aslam, Tariq M., Bailey, Clare, Chong, Victor, Downey, Louise, Eleftheriadis, Haralabos, Fatum, Samia, George, Sheena, Ghanchi, Faruque, Groppe, Markus, Hamilton, Robin, Menon, Geeta, Saad, Ahmed, Sivaprasad, Sobha, Shiew, Marianne, Steel, David H., Talks, James Stephen, Adams, Catherine, Campbell, Christina, Mills, Matthew, Clarke, Mike, and On behalf of the DIAMONDS Study Group

Published
2019
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