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2. Exploring APOE genotype effects on Alzheimer's disease risk and amyloid β burden in individuals with subjective cognitive decline: The FundacioACE Healthy Brain Initiative (FACEHBI) study baseline results

Author

Abdelnour, C., Aguilera, N., Alegret, M., Berthier, M., Boada, M., Buendia, M., Bullich, S., Campos, F., Cañabate, P., Cuevas, C., de Rojas, I., Espinosa, A., Gailhajenet, A., Diego, S., Gil, S., Giménez, J., Gismondi, R., Gómez-Chiari, M., Guitart, M., Hernández-Olasagarre, B., Hernández, I., Ibarria, M., Lafuente, A., Lomeña, F., Martín, E., Martínez, J., Mauleón, A., Monté, G., Moreno, M., Moreno-Grau, S., Núñez, L., Orellana, A., Ortega, G., Páez, A., Pancho, A., Pavía, J., Pelejà, E., Pérez-Cordon, A., Pérez-Grijalba, V., Pesini, P., Preckler, S., Rodríguez-Gómez, O., Romero, J., Rosende-Roca, M., Ruiz, A., Ruiz, S., Sanabria, A., Sánchez-Ruiz, D., Santos-Santos, M.A., Sarasa, M., Sotolongo-Grau, O., Tárraga, L., Tejero, M.A., Torres, M., Valero, S., Vargas, L., Vivas, A., Moreno–Grau, Sonia, Rodríguez-Gómez, Octavio, Sanabria, Ángela, Pérez-Cordón, Alba, Sánchez-Ruiz, Domingo, Abdelnour, Carla, Valero, Sergi, Hernández, Isabel, Rosende-Roca, Maitée, Mauleón, Ana, Vargas, Liliana, Lafuente, Asunción, Gil, Silvia, Santos-Santos, Miguel Ángel, Alegret, Montserrat, Espinosa, Ana, Ortega, Gemma, Guitart, Marina, Gailhajanet, Anna, de Rojas, Itziar, Sotolongo-Grau, Óscar, Ruiz, Susana, Aguilera, Nuria, Papasey, Judith, Martín, Elvira, Peleja, Esther, Lomeña, Francisco, Campos, Francisco, Vivas, Assumpta, Gómez-Chiari, Marta, Tejero, Miguel Ángel, Giménez, Joan, Serrano-Ríos, Manuel, Orellana, Adelina, Tárraga, Lluís, Ruiz, Agustín, and Boada, Mercè

Published
2018
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7. QuantiDOPA: A Quantification Software for Dopaminergic Neurotransmission SPECT

Author

Niñerola, A., Marti, B., Esteban, O., Planes, X., Frangi, A. F., Ledesma-Carbayo, M. J., Santos, A., Cot, A., Lomeña, F., Pavia, J., Ros, D., Magjarevic, Ratko, Editor-in-chief, Ładyzynsk, Piotr, Series editor, Ibrahim, Fatimah, Series editor, Lacković, Igor, Series editor, Rock, Emilio Sacristan, Series editor, and Roa Romero, Laura M., editor

Published
2014
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11. Correlations between plasma and PET beta-amyloid levels in individuals with subjective cognitive decline: the Fundació ACE Healthy Brain Initiative (FACEHBI)

Author

de Rojas, Itziar, Romero, J., Rodríguez-Gomez, O., Pesini, P., Sanabria, A., Pérez-Cordon, A., Abdelnour, C., Hernández, I., Rosende-Roca, M., Mauleón, A., Vargas, L., Alegret, M., Espinosa, A., Ortega, G., Gil, S., Guitart, M., Gailhajanet, A., Santos-Santos, M. A., Moreno-Grau, Sonia, Sotolongo-Grau, O., Ruiz, S., Montrreal, L., Martín, E., Pelejà, E., Lomeña, F., Campos, F., Vivas, A., Gómez-Chiari, M., Tejero, M. A., Giménez, J., Pérez-Grijalba, V., Marquié, G. M., Monté-Rubio, G., Valero, S., Orellana, A., Tárraga, L., Sarasa, M., Ruiz, A., Boada, M., and on behalf of the FACEHBI study

Published
2018
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49. Exploring APOE genotype effects on Alzheimer's disease risk and amyloid beta burden in individuals with subjective cognitive decline: The FundacioACE Healthy Brain Initiative (FACEHBI) study baseline results

Author

Moreno-Grau S, Rodríguez-Gómez O, Sanabria Á, Pérez-Cordón A, Sánchez-Ruiz D, Abdelnour C, Valero S, Hernández I, Rosende-Roca M, Mauleón A, Vargas L, Lafuente A, Gil S, Santos-Santos MÁ, Alegret M, Espinosa A, Ortega G, Guitart M, Gailhajanet A, de Rojas I, Sotolongo-Grau Ó, Ruiz S, Aguilera N, Papasey J, Martín E, Peleja E, Alzheimer's Disease Neuroimaging Initiative, Lomeña F, Campos F, Vivas A, Marta Gómez Chiari, Tejero MÁ, Giménez J, Serrano-Ríos M, Orellana A, Tárraga L, Ruiz A, Boada M, and FACEHBI study group

Subjects
congenital, hereditary, and neonatal diseases and abnormalities, hemic and lymphatic diseases, APOE alleles, Alzheimer's disease, Amyloid burden, PET, Subjective cognitive decline, cardiovascular diseases
Abstract

Subjective cognitive decline (SCD) has been proposed as a potential preclinical stage of Alzheimer's disease (AD). Nevertheless, the genetic and biomarker profiles of SCD individuals remain mostly unexplored.

Published
2018

50. PISCOM: a new procedure for epilepsy combining ictal SPECT and interictal PET

Author

Perissinotti A, Niñerola-Baizán A, Rubí S, Carreño M, Marti-Fuster B, Aparicio J, Mayoral M, Donaire A, Sanchez-Izquierdo N, Bargalló N, Rumiá J, Boget T, Pons F, Lomeña F, Ros D, Pavía J, and Setoain X

Subjects
Functional neuroimaging, PET in epilepsy, SISCOM, PISCOM, SPECT in epilepsy
Abstract

PURPOSE: We present a modified version of the SISCOM procedure that uses interictal PET instead of interictal SPECT for seizure onset zone localization. We called this new nuclear imaging processing technique PISCOM (PET interictal subtracted ictal SPECT coregistered with MRI). METHODS: We retrospectively studied 23 patients (age range 4-61 years) with medically refractory epilepsy who had undergone MRI, ictal SPECT, interictal SPECT and interictal FDG PET and who had been seizure-free for at least 2 years after surgical treatment. FDG PET images were reprocessed (rFDG PET) to assimilate SPECT features for image subtraction. Interictal SPECT and rFDG PET were compared using statistical parametric mapping (SPM). PISCOM and SISCOM images were evaluated visually and using an automated volume of interest-based analysis. The results of the two studies were compared with each other and with the known surgical resection site. RESULTS: SPM showed no significant differences in cortical activity between SPECT and rFDG PET images. PISCOM and SISCOM showed equivalent results in 17 of 23 patients (74%). The seizure onset zone was successfully identified in 19 patients (83%) by PISCOM and in 17 (74%) by SISCOM: in 15 patients (65%) the two techniques showed concordant successful results. The volume of interest-based analysis showed no significant differences between PISCOM and SISCOM in identifying the extension of the seizure onset zone. However, PISCOM showed a lower amount of indeterminate activity due to propagation, background or artefacts. CONCLUSION: Preliminary findings of this initial proof-of-concept study suggest that perfusion and glucose metabolism in the cerebral cortex can be correlated and that PISCOM may be a valid technique for identification of the seizure onset zone. However, further studies are needed to validate these results.

Published
2018

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