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Abstract As COVID-19 vaccines became widely available worldwide, many countries implemented vaccination certification, also known as a “green pass”, to promote and expedite vaccination on containing virus spread from the latter half of 2021. This policy allowed those vaccinated to have more freedom in public activities compared to more constraints on the unvaccinated in addition to existing non-pharmaceutical interventions (NPIs). Accordingly, the vaccination certification also induced heterogeneous behaviors of unvaccinated and vaccinated groups. This makes it essential yet challenging to model the behavioral impact of vaccination certification on the two groups and the transmission dynamics of COVID-19 within and between the groups. Very limited quantitative work is available for addressing these purposes. Here we propose an extended epidemiological model SEIQRD $$^2$$ 2 to effectively distinguish the behavioral impact of vaccination certification on unvaccinated and vaccinated groups through incorporating two contrastive transmission chains. SEIQRD $$^2$$ 2 also quantifies the impact of the green pass policy. With the resurgence of COVID-19 in Greece, Austria, and Israel in 2021, our simulation results indicate that their implementation of vaccination certification brought about more than a 14-fold decrease in the total number of infections and deaths as compared to a scenario with no such a policy. Additionally, a green pass policy may offer a reasonable practical solution to strike the balance between public health and individual’s freedom during the pandemic.

Persistent human papillomavirus (HPV) infections is necessary for the development of cervical cancers. An increasing number of retrospective studies have found the depletion of Lactobacillus microbiota in the cervico-vagina facilitate HPV infection and might be involved in viral persistence and cancer development. However, there have been no reports confirming the immunomodulatory effects of Lactobacillus microbiota isolated from cervico-vaginal samples of HPV clearance in women. Using cervico-vaginal samples from HPV persistent infection and clearance in women, this study investigated the local immune properties in cervical mucosa. As expected, type I interferons, such as IFN-α and IFN-β, and TLR3 globally downregulated in HPV+ persistence group. Luminex cytokine/chemokine panel analysis revealed that L. jannaschii LJV03, L. vaginalis LVV03, L. reuteri LRV03, and L. gasseri LGV03 isolated from cervicovaginal samples of HPV clearance in women altered the host's epithelial immune response, particularly L. gasseri LGV03. Furthermore, L. gasseri LGV03 enhanced the poly (I:C)-induced production of IFN by modulating the IRF3 pathway and attenuating poly (I:C)-induced production of proinflammatory mediators by regulating the NF-κB pathway in Ect1/E6E7 cells, indicating that L. gasseri LGV03 keeps the innate system alert to potential pathogens and reduces the inflammatory effects during persistent pathogen infection. L. gasseri LGV03 also markedly inhibited the proliferation of Ect1/E6E7 cells in a zebrafish xenograft model, which may be attributed to an increased immune response mediated by L. gasseri LGV03.

Abstract The COVID-19 pandemic has posed significant challenges in modeling its complex epidemic transmissions, infection and contagion, which are very different from known epidemics. The challenges in quantifying COVID-19 complexities include effectively modeling its process and data uncertainties. The uncertainties are embedded in implicit and high-proportional undocumented infections, asymptomatic contagion, social reinforcement of infections, and various quality issues in the reported data. These uncertainties become even more apparent in the first 2 months of the COVID-19 pandemic, when the relevant knowledge, case reporting and testing were all limited. Here we introduce a novel hybrid approach SUDR by expanding the foundational compartmental epidemic Susceptible-Infected-Recovered (SIR) model with two compartments to a Susceptible-Undocumented infected-Documented infected-Recovered (SUDR) model. First, SUDR (1) characterizes and distinguishes Undocumented (U) and Documented (D) infections commonly seen during COVID-19 incubation periods and asymptomatic infections. Second, SUDR characterizes the probabilistic density of infections by capturing exogenous processes like clustering contagion interactions, superspreading, and social reinforcement. Lastly, SUDR approximates the density likelihood of COVID-19 prevalence over time by incorporating Bayesian inference into SUDR. Different from existing COVID-19 models, SUDR characterizes the undocumented infections during unknown transmission processes. To capture the uncertainties of temporal transmission and social reinforcement during COVID-19 contagion, the transmission rate is modeled by a time-varying density function of undocumented infectious cases. By sampling from the mean-field posterior distribution with reasonable priors, SUDR handles the randomness, noise and sparsity of COVID-19 observations widely seen in the public COVID-19 case data. The results demonstrate a deeper quantitative understanding of the above uncertainties, in comparison with classic SIR, time-dependent SIR, and probabilistic SIR models.

Abstract Enterprise data typically involves multiple heterogeneous data sources and external data that respectively record business activities, transactions, customer demographics, status, behaviors, interactions and communications with the enterprise, and the consumption and feedback of its products, services, production, marketing, operations, and management, etc. They involve enterprise DNA associated with domain-oriented transactions and master data, informational and operational metadata, and relevant external data. A critical challenge in enterprise data science is to enable an effective ‘whole-of-enterprise’ data understanding and data-driven discovery and decision-making on all-round enterprise DNA. Accordingly, here we introduce a neural encoder Table2Vec for automated universal representation learning of entities such as customers from all-round enterprise DNA with automated data characteristics analysis and data quality augmentation. The learned universal representations serve as representative and benchmarkable enterprise data genomes (similar to biological genomes and DNA in organisms) and can be used for enterprise-wide and domain-specific learning tasks. Table2Vec integrates automated universal representation learning on low-quality enterprise data and downstream learning tasks. Such automated universal enterprise representation and learning cannot be addressed by existing enterprise data warehouses (EDWs), business intelligence and corporate analytics systems, where ‘enterprise big tables’ are constructed with reporting and analytics conducted by specific analysts on respective domain subjects and goals. It addresses critical limitations and gaps of existing representation learning, enterprise analytics and cloud analytics, which are analytical subject, task and data-specific, creating analytical silos in an enterprise. We illustrate Table2Vec in characterizing all-round customer data DNA in an enterprise on complex heterogeneous multi-relational big tables to build universal customer vector representations. The learned universal representation of each customer is all-round, representative and benchmarkable to support both enterprise-wide and domain-specific learning goals and tasks in enterprise data science. Table2Vec significantly outperforms the existing shallow, boosting and deep learning methods typically used for enterprise analytics. We further discuss the research opportunities, directions and applications of automated universal enterprise representation and learning and the learned enterprise data DNA for automated, all-purpose, whole-of-enterprise and ethical machine learning and data science.

Automated next-best action recommendation for each customer in a sequential, dynamic and interactive context has been widely needed in natural, social and business decision-making. Personalized next-best action recommendation must involve past, current and future customer demographics and circumstances (states) and behaviors, long-range sequential interactions between customers and decision-makers, multi-sequence interactions between states, behaviors and actions, and their reactions to their counterpart's actions. No existing modeling theories and tools, including Markovian decision processes, user and behavior modeling, deep sequential modeling, and personalized sequential recommendation, can quantify such complex decision-making on a personal level. We take a data-driven approach to learn the next-best actions for personalized decision-making by a reinforced coupled recurrent neural network (CRN). CRN represents multiple coupled dynamic sequences of a customer's historical and current states, responses to decision-makers' actions, decision rewards to actions, and learns long-term multi-sequence interactions between parties (customer and decision-maker). Next-best actions are then recommended on each customer at a time point to change their state for an optimal decision-making objective. Our study demonstrates the potential of personalized deep learning of multi-sequence interactions and automated dynamic intervention for personalized decision-making in complex systems.

The mobile app market has been surging in recent years. It has some key differentiating characteristics which make it different from traditional markets. To enhance mobile app development and marketing, it is important to study the key research challenges such as app user profiling, usage pattern understanding, popularity prediction, requirement and feedback mining, and so on. This paper reviews CrowdApp, a research field that leverages heterogeneous crowdsourced data for mobile app user understanding and marketing. We first characterize the opportunities of the CrowdApp, and then present the key research challenges and state-of-the-art techniques to deal with these challenges. We further discuss the open issues and future trends of the CrowdApp. Finally, an evolvable app ecosystem architecture based on heterogeneous crowdsourced data is presented.

Coauthorship prediction is challenging yet important for academic collaboration and novel research topics discovery. The challenges lie in the dynamics of social or organizational relationships, changing preferences of suitable collaborators, and the evolution of research interests or topics. However, most current approaches and systems developed so far are mainly based on past coauthorships from a static viewpoint and do not capture the above evolving characteristics in coauthoring. Accordingly, this paper proposes a time-aware approach to capture the evolving coauthorships from online academic databases in terms of capturing the dynamics of social relationships and research interests. In particular, in order to understand the underlying factors influencing researchers to make choices of coauthors, we incorporate choice modeling based on utility theory. More specifically, our model conducts a series of pairwise choices over a poset induced by a utility function so as to learn the preference over all candidate coauthors. To complete the model inference, a gradient-based algorithm is devised to efficiently learn the model parameters for large-scale data. Finally, extensive experiments conducted on a real-world dataset show that our approach consistently outperforms other state-of-the-art methods.

While recommendation plays an increasingly critical role in our living, study, work, and entertainment, the recommendations we receive are often for irrelevant, duplicate, or uninteresting products and services. A critical reason for such bad recommendations lies in the intrinsic assumption that recommended users and items are independent and identically distributed (IID) in existing theories and systems. Another phenomenon is that, while tremendous efforts have been made to model specific aspects of users or items, the overall user and item characteristics and their non-IIDness have been overlooked. In this paper, the non-IID nature and characteristics of recommendation are discussed, followed by the non-IID theoretical framework in order to build a deep and comprehensive understanding of the intrinsic nature of recommendation problems, from the perspective of both couplings and heterogeneity. This non-IID recommendation research triggers the paradigm shift from IID to non-IID recommendation research and can hopefully deliver informed, relevant, personalized, and actionable recommendations. It creates exciting new directions and fundamental solutions to address various complexities including cold-start, sparse data-based, cross-domain, group-based, and shilling attack-related issues.

Short text is widely seen in applications including Internet of Things (IoT). The appropriate representation and classification of short text could be severely disrupted by the sparsity and shortness of short text. One important solution is to enrich short text representation by involving cognitive aspects of text, including semantic concept, knowledge, and category. In this paper, we propose a named Entity-based Concept Knowledge-Aware (ECKA) representation model which incorporates semantic information into short text representation. ECKA is a multi-level short text semantic representation model, which extracts the semantic features from the word, entity, concept and knowledge levels by CNN, respectively. Since word, entity, concept and knowledge entity in the same short text have different cognitive informativeness for short text classification, attention networks are formed to capture these category-related attentive representations from the multi-level textual features, respectively. The final multi-level semantic representations are formed by concatenating all of these individual-level representations, which are used for text classification. Experiments on three tasks demonstrate our method significantly outperforms the state-of-the-art methods.

Attributed networks consist of not only a network structure but also node attributes. Most existing community detection algorithms only focus on network structures and ignore node attributes, which are also important. Although some algorithms using both node attributes and network structure information have been proposed in recent years, the complex hierarchical coupling relationships within and between attributes, nodes and network structure have not been considered. Such hierarchical couplings are driving factors in community formation. This paper introduces a novel coupled node similarity (CNS) to involve and learn attribute and structure couplings and compute the similarity within and between nodes with categorical attributes in a network. CNS learns and integrates the frequency-based intra-attribute coupled similarity within an attribute, the co-occurrence-based inter-attribute coupled similarity between attributes, and coupled attribute-to-structure similarity based on the homophily property. CNS is then used to generate the weights of edges and transfer a plain graph to a weighted graph. Clustering algorithms detect community structures that are topologically well-connected and semantically coherent on the weighted graphs. Extensive experiments verify the effectiveness of CNS-based community detection algorithms on several data sets by comparing with the state-of-the-art node similarity measures, whether they involve node attribute information and hierarchical interactions, and on various levels of network structure complexity.