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1,277 results on '"Longo, N."'

1. Radical Nephroureterectomy Tetrafecta: A Proposal Reporting Surgical Strategy Quality at Surgery

Author

Soria, Francesco, Pradere, B., Hurle, R., D'Andrea, D., Albisinni, S., Diamand, R., Laukhtina, E., Di Trapani, E., Aziz, A., Krajewski, W., Teoh, J.Y., Mari, A., Moschini, M., Chiancone, F., Autorino, R., Porreca, A., Marchioni, M., Liguori, G., Lucarelli, G., Busetto, G.M., Foschi, N., Antonelli, A., Bove, P., Russo, G.I., Crisan, N., Borghesi, M., Boeri, L., Veccia, A., Greco, F., Longo, N., De Cobelli, O., Shariat, S.F., Gontero, P., and Ferro, M.

Published
2022
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2. Focus on Silodosin: Pros and Cons of Uroselectivity

Author

Califano G, Collà Ruvolo C, Creta M, Capece M, La Rocca R, Celentano G, Napolitano L, Calace FP, Spena G, Trama F, Crocetto F, Mangiapia F, Longo N, and Fusco F

Subjects
alpha-1 adrenergic antagonists, benign prostate enlargement, lower urinary tract symptoms, bladder outlet obstruction., Diseases of the genitourinary system. Urology, RC870-923
Abstract

Gianluigi Califano,1 Claudia Collà Ruvolo,1 Massimiliano Creta,1 Marco Capece,1 Roberto La Rocca,1 Giuseppe Celentano,1 Luigi Napolitano,1 Francesco Paolo Calace,1 Gianluca Spena,1 Francesco Trama,1 Felice Crocetto,1 Francesco Mangiapia,1 Nicola Longo,1 Ferdinando Fusco2 1Department of Neurosciences, Reproductive Sciences and Odontostomatology – Federico II University of Naples, Naples, Italy; 2Department of Urology, Luigi Vanvitelli University of Naples, Naples, ItalyCorrespondence: Massimiliano CretaDepartment of Neurosciences, Reproductive Sciences and Odontostomatology, University of Naples Federico II, via Sergio Pansini 5, Naples 80131, ItalyTel/Fax +390817462611Email max.creta@gmail.comAbstract: Medical management of lower urinary tract symptoms related to benign prostatic obstruction engages healthcare professionals worldwide. Currently, alpha-1 adrenergic antagonists are strongly recommended as first-line therapy for patients with moderate to severe symptoms because of their safety, efficacy and good tolerability. These agents are highly heterogeneous in terms of pharmacological selectivity for the adrenergic receptor subtypes with silodosin being the agent characterized by the highest α1A/α1B affinity ratio. This property has been proposed to confer to silodosin advantages in terms of bladder outlet obstruction improvement and lower incidence of cardiovascular side effects at the cost of a higher incidence of ejaculatory dysfunction. These aspects should be carefully taken in consideration when personalizing medical therapy for lower urinary tract symptoms related to benign prostatic obstruction.Keywords: alpha-1 adrenergic antagonists, benign prostate enlargement, lower urinary tract symptoms, bladder outlet obstruction

Published
2020

3. Perceptions, Expectations, Preferences, and Attitudes Toward Premature Ejaculation, Its Diagnosis and Topical Treatment with Fortacin™ Spray: Results from an Expert Panel Discussion

Author

Fusco F, Creta M, Mangiapia F, Cirigliano L, Trama F, Pandolfo SD, Imbimbo C, Longo N, and Mirone V

Subjects
intravaginal ejaculatory latency time, premature ejaculation, survey, Diseases of the genitourinary system. Urology, RC870-923
Abstract

Ferdinando Fusco,1 Massimiliano Creta,2 Francesco Mangiapia,2 Lorenzo Cirigliano,2 Francesco Trama,2 Savio Domenico Pandolfo,2 Ciro Imbimbo,2 Nicola Longo,2 Vincenzo Mirone2 1Department of Urology, Luigi Vanvitelli University of Naples, Naples, Italy; 2Department of Neurosciences, Reproductive Sciences and Odontostomatology, University of Naples Federico II, Naples, ItalyCorrespondence: Massimiliano CretaDepartment of Neurosciences, Reproductive Sciences and Odontostomatology, University of Naples Federico II, via Sergio Pansini 5, Naples 80131, ItalyEmail max.creta@gmail.comIntroduction: Premature ejaculation (PE) represents the most prevalent male sexual issue. Before beginning treatment, it is essential to discuss the patient’s expectations thoroughly.Methods: Herein, we report the results of an expert panel discussion about perceptions, expectations, preferences, and attitudes towards PE, its diagnosis and treatment. The panel took place in October 2019 and involved 30 Italian urologists experienced in the management of male sexual dysfunction. It aimed at investigating physicians’ points of view about selected aspects of PE management which emerged during the counselling of PE patients over the previous two years. Treatment-related questions were mainly focused on topical treatment with Fortacin™.Results: Overall, 83.3% of those interviewed declared that most of their patients perceive PE as a bother rather than a disease. The percentage of urologists interviewed perceived that improved subjective control over ejaculation and prolonged intravaginal ejaculatory latency time (IELT) as the main benefit expected by the majority of their patients was 56.5% and 10%, respectively. Eighty percent of urologists reported on-demand regimen as the dosage modality preferred by the majority of their patients and half of them reported the topical route to be the way of administration preferred in most cases. Moreover, 73.3% of urologists reported that adherence to treatment was higher in patients undergoing topical treatment. Finally, 80% of urologists perceived Fortacin to be efficacious in patients with acquired PE and 70% of them perceived its efficacy to be independent from IELT.Discussion: Most patients perceive PE as a bother rather than a disease and mainly advocate an improved control over ejaculation. Fortacin is perceived as efficacious in patients with acquired PE, and independent from IELT.Keywords: intravaginal ejaculatory latency time (IELT), premature ejaculation (PE), survey

Published
2020

4. Expanded phenotypic spectrum of neurodevelopmental and neurodegenerative disorder Bryant-Li-Bhoj syndrome with 38 additional individuals

Author

Layo-Carris, DE, Lubin, EE, Sangree, AK, Clark, KJ, Durham, EL, Gonzalez, EM, Smith, S, Angireddy, R, Wang, XM, Weiss, E, Mendoza-Londono, R, Dupuis, L, Damseh, N, Velasco, D, Valenzuela, I, Codina-Sola, M, Ziats, C, Have, J, Clarkson, K, Steel, D, Kurian, M, Barwick, K, Carrasco, D, Dagli, AI, Nowaczyk, MJM, Hancarova, M, Bendova, S, Prchalova, D, Sedlacek, Z, Baxova, A, Nowak, CB, Douglas, J, Chung, WK, Longo, N, Platzer, K, Kloeckner, C, Averdunk, L, Wieczorek, D, Krey, I, Zweier, C, Reis, A, Balci, T, Simon, M, Kroes, HY, Wiesener, A, Vasileiou, G, Marinakis, NM, Veltra, D, Sofocleous, C, Kosma, K, Synodinos, JT, Voudris, KA, Vuillaume, M-L, Gueguen, P, Derive, N, Colin, E, Battault, C, Au, B, Delatycki, M, Wallis, M, Gallacher, L, Majdoub, F, Smal, N, Weckhuysen, S, Schoonjans, A-S, Kooy, RF, Meuwissen, M, Cocanougher, BT, Taylor, K, Pizoli, CE, McDonald, MT, James, P, Roeder, ER, Littlejohn, R, Borja, NA, Thorson, W, King, K, Stoeva, R, Suerink, M, Nibbeling, E, Baskin, S, Guyader, GLE, Kaplan, J, Muss, C, Carere, DA, Bhoj, EJK, Bryant, LM, Layo-Carris, DE, Lubin, EE, Sangree, AK, Clark, KJ, Durham, EL, Gonzalez, EM, Smith, S, Angireddy, R, Wang, XM, Weiss, E, Mendoza-Londono, R, Dupuis, L, Damseh, N, Velasco, D, Valenzuela, I, Codina-Sola, M, Ziats, C, Have, J, Clarkson, K, Steel, D, Kurian, M, Barwick, K, Carrasco, D, Dagli, AI, Nowaczyk, MJM, Hancarova, M, Bendova, S, Prchalova, D, Sedlacek, Z, Baxova, A, Nowak, CB, Douglas, J, Chung, WK, Longo, N, Platzer, K, Kloeckner, C, Averdunk, L, Wieczorek, D, Krey, I, Zweier, C, Reis, A, Balci, T, Simon, M, Kroes, HY, Wiesener, A, Vasileiou, G, Marinakis, NM, Veltra, D, Sofocleous, C, Kosma, K, Synodinos, JT, Voudris, KA, Vuillaume, M-L, Gueguen, P, Derive, N, Colin, E, Battault, C, Au, B, Delatycki, M, Wallis, M, Gallacher, L, Majdoub, F, Smal, N, Weckhuysen, S, Schoonjans, A-S, Kooy, RF, Meuwissen, M, Cocanougher, BT, Taylor, K, Pizoli, CE, McDonald, MT, James, P, Roeder, ER, Littlejohn, R, Borja, NA, Thorson, W, King, K, Stoeva, R, Suerink, M, Nibbeling, E, Baskin, S, Guyader, GLE, Kaplan, J, Muss, C, Carere, DA, Bhoj, EJK, and Bryant, LM

Abstract

Bryant-Li-Bhoj syndrome (BLBS), which became OMIM-classified in 2022 (OMIM: 619720, 619721), is caused by germline variants in the two genes that encode histone H3.3 (H3-3A/H3F3A and H3-3B/H3F3B) [1-4]. This syndrome is characterized by developmental delay/intellectual disability, craniofacial anomalies, hyper/hypotonia, and abnormal neuroimaging [1, 5]. BLBS was initially categorized as a progressive neurodegenerative syndrome caused by de novo heterozygous variants in either H3-3A or H3-3B [1-4]. Here, we analyze the data of the 58 previously published individuals along 38 unpublished, unrelated individuals. In this larger cohort of 96 people, we identify causative missense, synonymous, and stop-loss variants. We also expand upon the phenotypic characterization by elaborating on the neurodevelopmental component of BLBS. Notably, phenotypic heterogeneity was present even amongst individuals harboring the same variant. To explore the complex phenotypic variation in this expanded cohort, the relationships between syndromic phenotypes with three variables of interest were interrogated: sex, gene containing the causative variant, and variant location in the H3.3 protein. While specific genotype-phenotype correlations have not been conclusively delineated, the results presented here suggest that the location of the variants within the H3.3 protein and the affected gene (H3-3A or H3-3B) contribute more to the severity of distinct phenotypes than sex. Since these variables do not account for all BLBS phenotypic variability, these findings suggest that additional factors may play a role in modifying the phenotypes of affected individuals. Histones are poised at the interface of genetics and epigenetics, highlighting the potential role for gene-environment interactions and the importance of future research.

Published
2024

5. Correction: Expanded phenotypic spectrum of neurodevelopmental and neurodegenerative disorder Bryant-Li-Bhoj syndrome with 38 additional individuals (vol 3, 2024, 59)

Author

Layo-Carris, DE, Lubin, EE, Sangree, AK, Clark, KJ, Durham, EL, Gonzalez, EM, Smith, S, Angireddy, R, Wang, XM, Weiss, E, Toutain, A, Mendoza-Londono, R, Dupuis, L, Damseh, N, Velasco, D, Valenzuela, I, Codina-Sola, M, Ziats, C, Have, J, Clarkson, K, Steel, D, Kurian, M, Barwick, K, Carrasco, D, Dagli, AI, Nowaczyk, MJM, Hancarova, M, Bendova, S, Prchalova, D, Sedlacek, Z, Baxova, A, Nowak, CB, Douglas, J, Chung, WK, Longo, N, Platzer, K, Klockner, C, Averdunk, L, Wieczorek, D, Krey, I, Zweier, C, Reis, A, Balci, T, Simon, M, Kroes, HY, Wiesener, A, Vasileiou, G, Marinakis, NM, Veltra, D, Sofocleous, C, Kosma, K, Synodinos, JT, Voudris, KA, Vuillaume, M-L, Gueguen, P, Derive, N, Colin, E, Battault, C, Au, B, Delatycki, M, Wallis, M, Gallacher, L, Majdoub, F, Smal, N, Weckhuysen, S, Schoonjans, A-S, Kooy, RF, Meuwissen, M, Cocanougher, BT, Taylor, K, Pizoli, CE, Mcdonald, MT, James, P, Roeder, ER, Littlejohn, R, Borja, NA, Thorson, W, King, K, Stoeva, R, Suerink, M, Nibbeling, E, Baskin, S, Guyader, GLE, Kaplan, J, Muss, C, Carere, DA, Bhoj, EJK, Bryant, LM, Layo-Carris, DE, Lubin, EE, Sangree, AK, Clark, KJ, Durham, EL, Gonzalez, EM, Smith, S, Angireddy, R, Wang, XM, Weiss, E, Toutain, A, Mendoza-Londono, R, Dupuis, L, Damseh, N, Velasco, D, Valenzuela, I, Codina-Sola, M, Ziats, C, Have, J, Clarkson, K, Steel, D, Kurian, M, Barwick, K, Carrasco, D, Dagli, AI, Nowaczyk, MJM, Hancarova, M, Bendova, S, Prchalova, D, Sedlacek, Z, Baxova, A, Nowak, CB, Douglas, J, Chung, WK, Longo, N, Platzer, K, Klockner, C, Averdunk, L, Wieczorek, D, Krey, I, Zweier, C, Reis, A, Balci, T, Simon, M, Kroes, HY, Wiesener, A, Vasileiou, G, Marinakis, NM, Veltra, D, Sofocleous, C, Kosma, K, Synodinos, JT, Voudris, KA, Vuillaume, M-L, Gueguen, P, Derive, N, Colin, E, Battault, C, Au, B, Delatycki, M, Wallis, M, Gallacher, L, Majdoub, F, Smal, N, Weckhuysen, S, Schoonjans, A-S, Kooy, RF, Meuwissen, M, Cocanougher, BT, Taylor, K, Pizoli, CE, Mcdonald, MT, James, P, Roeder, ER, Littlejohn, R, Borja, NA, Thorson, W, King, K, Stoeva, R, Suerink, M, Nibbeling, E, Baskin, S, Guyader, GLE, Kaplan, J, Muss, C, Carere, DA, Bhoj, EJK, and Bryant, LM

Published
2024

7. Prognostic significance of lymph node count in surgically treated patients with T2-4 stage non-metastatic adrenocortical carcinoma

Author

Assad, A., primary, Barletta, F., additional, Incesu, R.B., additional, Scheipner, L., additional, Morra, S., additional, Baudo, A., additional, Cano Garcia, C., additional, Tian, Z., additional, Ahyai, S., additional, Longo, N., additional, Chun, F.K.H., additional, Tilki, D., additional, Briganti, A., additional, Saad, F., additional, and Karakiewicz, P.I., additional

Published
2024
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8. Conditional cancer-specific survival in surgically treated retroperitoneal liposarcoma and leiomyosarcoma patients: A stage-specific analysis

Author

Baudo, A., primary, Scheipner, L., additional, Jannello, L.M.I., additional, de Angelis, M., additional, Siech, C., additional, Di Bello, F., additional, Morra, S., additional, Tian, Z., additional, Acquati, P., additional, Ahyai, S., additional, de Cobelli, O., additional, Briganti, A., additional, Chun, F., additional, Longo, N., additional, Saad, F., additional, Shariat, S., additional, Carmignani, L., additional, and Karakiewicz, P., additional

Published
2024
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9. Upgrading risk in prostate cancer after combined prostate biopsy according to the site of positive cores: Results in 658 patients treated with robot-assisted radical prostatectomy in tertiary referral centers

Author

Bianchi, A., primary, Califano, G., additional, Morra, S., additional, Gallina, S., additional, Collà Ruvolo, C., additional, Ornaghi, P.I., additional, Di Bello, F., additional, Ditonno, F., additional, Montanaro, F., additional, Cerruto, M.A., additional, Imbimbo, C., additional, Antonelli, A., additional, and Longo, N., additional

Published
2024
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10. Survival benefit of nephroureterectomy in systemic therapy exposed metastatic upper tract urinary urothelial carcinoma patients

Author

Morra, S., primary, Incesu, R.B., additional, Scheipner, L., additional, Baudo, A., additional, Jannello, L.M.I., additional, Siech, C., additional, DE ANGELIS, M., additional, Tian, Z., additional, Califano, G., additional, Colla’ Ruvolo, C., additional, Creta, M., additional, Saad, F., additional, Shariat, S., additional, Chun, F., additional, De Cobelli, O., additional, Musi, G., additional, Briganti, A., additional, Tilki, D., additional, Ahyai, S., additional, Carmignani, L., additional, Longo, N., additional, and Karakiewicz, P.I., additional

Published
2024
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11. Differences in other-cause mortality in metastatic renal cell carcinoma according to partial vs. radical nephrectomy

Author

Siech, C., primary, Incesu, R.B., additional, Morra, S., additional, Scheipner, L., additional, Baudo, A., additional, Jannello, L.M.I., additional, de Angelis, M., additional, Goyal, J.A., additional, Tian, Z., additional, Saad, F., additional, Shariat, S.F., additional, Tilki, D., additional, Longo, N., additional, Carmignani, L., additional, De Cobelli, O., additional, Ahyai, S., additional, Briganti, A., additional, Mandel, P., additional, Kluth, L.A., additional, Chun, F.K.H., additional, and Karakiewicz, P.I., additional

Published
2024
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12. The European network for the study of adrenal tumors staging system (2015): A North American validation

Author

Jannello, L.M.I., primary, Incesu, R.B., additional, Morra, S., additional, Scheipner, L., additional, Baudo, A., additional, de Angelis, M., additional, Siech, C., additional, Tian, Z., additional, Luzzago, S., additional, Mistretta, F.A., additional, Ferro, M., additional, Saad, F., additional, Shariat, S.F., additional, Chun, F.K.H., additional, Briganti, A., additional, Tilki, D., additional, Ahyai, S., additional, Carmignani, L., additional, Longo, N., additional, de Cobelli, O., additional, Musi, G., additional, and Karakiewicz, P.I., additional

Published
2024
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14. Urinary phenylacetylglutamine as dosing biomarker for patients with urea cycle disorders

Author

Mokhtarani, M, Diaz, GA, Rhead, W, Lichter-Konecki, U, Bartley, J, Feigenbaum, A, Longo, N, Berquist, W, Berry, SA, Gallagher, R, Bartholomew, D, Harding, CO, Korson, MS, McCandless, SE, Smith, W, Vockley, J, Bart, S, Kronn, D, Zori, R, Cederbaum, S, Dorrani, N, Merritt, JL, Sreenath-Nagamani, Sandesh, Summar, M, LeMons, C, Dickinson, K, Coakley, DF, Moors, TL, Lee, B, and Scharschmidt, BF

Subjects
Clinical Research, Adolescent, Adult, Ammonia, Biomarkers, Pharmacological, Child, Cross-Over Studies, Drug Administration Schedule, Female, Glutamine, Glycerol, Humans, Male, Phenylacetates, Phenylbutyrates, Urea Cycle Disorders, Inborn, Urea cycle disorders, Phenylacetic acid, Glycerol phenylbutyrate, Sodium phenylbutyrate, Phenylacetylglutamine, Phenylbutyric acid, Clinical Sciences, Genetics & Heredity
Abstract

UnlabelledWe have analyzed pharmacokinetic data for glycerol phenylbutyrate (also GT4P or HPN-100) and sodium phenylbutyrate with respect to possible dosing biomarkers in patients with urea cycle disorders (UCD).Study designThese analyses are based on over 3000 urine and plasma data points from 54 adult and 11 pediatric UCD patients (ages 6-17) who participated in three clinical studies comparing ammonia control and pharmacokinetics during steady state treatment with glycerol phenylbutyrate or sodium phenylbutyrate. All patients received phenylbutyric acid equivalent doses of glycerol phenylbutyrate or sodium phenylbutyrate in a cross over fashion and underwent 24-hour blood samples and urine sampling for phenylbutyric acid, phenylacetic acid and phenylacetylglutamine.ResultsPatients received phenylbutyric acid equivalent doses of glycerol phenylbutyrate ranging from 1.5 to 31.8 g/day and of sodium phenylbutyrate ranging from 1.3 to 31.7 g/day. Plasma metabolite levels varied widely, with average fluctuation indices ranging from 1979% to 5690% for phenylbutyric acid, 843% to 3931% for phenylacetic acid, and 881% to 1434% for phenylacetylglutamine. Mean percent recovery of phenylbutyric acid as urinary phenylacetylglutamine was 66.4 and 69.0 for pediatric patients and 68.7 and 71.4 for adult patients on glycerol phenylbutyrate and sodium phenylbutyrate, respectively. The correlation with dose was strongest for urinary phenylacetylglutamine excretion, either as morning spot urine (r = 0.730, p < 0.001) or as total 24-hour excretion (r = 0.791 p

Published
2012

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Author

Morleo, M., Venditti, R., Theodorou, E., Briere, L. C., Rosello, M., Tirozzi, A., Tammaro, R., Al-Badri, N., High, F. A., Shi, J., Acosta, M. T., Adam, M., Adams, D. R., Alvarez, R. L., Alvey, J., Amendola, L., Andrews, A., Ashley, E. A., Bacino, C. A., Bademci, G., Balasubramanyam, A., Baldridge, D., Bale, J., Bamshad, M., Barbouth, D., Bayrak-Toydemir, P., Beck, A., Beggs, A. H., Behrens, E., Bejerano, G., Bellen, H. J., Bennett, J., Berg-Rood, B., Bernstein, J. A., Berry, G. T., Bican, A., Bivona, S., Blue, E., Bohnsack, J., Bonner, D., Botto, L., Boyd, B., Brown, G., Burke, E. A., Burrage, L. C., Butte, M. J., Byers, P., Byrd, W. E., Carey, J., Carrasquillo, O., Cassini, T., Chang, T. C. P., Chanprasert, S., Chao, H. -T., Clark, G. D., Coakley, T. R., Cobban, L. A., Cogan, J. D., Coggins, M., Cole, F. S., Colley, H. A., Cooper, C. M., Cope, H., Corona, R., Craigen, W. J., Crouse, A. B., Cunningham, M., D'Souza, P., Dai, H., Dasari, S., Davis, J., Dayal, J. G., Dell'Angelica, E. C., Dipple, K., Doherty, D., Dorrani, N., Doss, A. L., Douine, E. D., Earl, D., Eckstein, D. J., Emrick, L. T., Eng, C. M., Falk, M., Fieg, E. L., Fisher, P. G., Fogel, B. L., Forghani, I., Gahl, W. A., Glass, I., Gochuico, B., Goddard, P. C., Godfrey, R. A., Golden-Grant, K., Grajewski, A., Hadley, D., Hahn, S., Halley, M. C., Hamid, R., Hassey, K., Hayes, N., High, F., Hing, A., Hisama, F. M., Holm, I. A., Hom, J., Horike-Pyne, M., Huang, A., Hutchison, S., Introne, W., Isasi, R., Izumi, K., Jamal, F., Jarvik, G. P., Jarvik, J., Jayadev, S., Jean-Marie, O., Jobanputra, V., Karaviti, L., Ketkar, S., Kiley, D., Kilich, G., Kobren, S. N., Kohane, I. S., Kohler, J. N., Korrick, S., Kozuira, M., Krakow, D., Krasnewich, D. M., Kravets, E., Lalani, S. R., Lam, B., Lam, C., Lanpher, B. C., Lanza, I. R., Leblanc, K., Lee, B. H., Levitt, R., Lewis, R. A., Liu, P., Liu, X. Z., Longo, N., Loo, S. K., Loscalzo, J., Maas, R. L., Macnamara, E. F., Macrae, C. A., Maduro, V. V., Maghiro, A., Mahoney, R., Malicdan, M. C. V., Mamounas, L. A., Manolio, T. A., Mao, R., Maravilla, K., Marom, R., Marth, G., Martin, B. A., Martin, M. G., Martinez-Agosto, J. A., Marwaha, S., Mccauley, J., McConkie-Rosell, A., Mccray, A. T., Mcgee, E., Mefford, H., Merritt, J. L., Might, M., Mirzaa, G., Morava, E., Moretti, P., Mulvihill, J., Nakano-Okuno, M., Nelson, S. F., Newman, J. H., Nicholas, S. K., Nickerson, D., Nieves-Rodriguez, S., Novacic, D., Oglesbee, D., Orengo, J. P., Pace, L., Pak, S., Pallais, J. C., Palmer, C. G. S., Papp, J. C., Parker, N. H., Phillips III, J. A., Posey, J. E., Potocki, L., Pusey Swerdzewski, B. N., Quinlan, A., Rao, D. A., Raper, A., Raskind, W., Renteria, G., Reuter, C. M., Rives, L., Robertson, A. K., Rodan, L. H., Rosenfeld, J. A., Rosenwasser, N., Rossignol, F., Ruzhnikov, M., Sacco, R., Sampson, J. B., Saporta, M., Schaechter, J., Schedl, T., Schoch, K., Scott, D. A., Scott, C. R., Shashi, V., Shin, J., Silverman, E. K., Sinsheimer, J. S., Sisco, K., Smith, E. C., Smith, K. S., Solnica-Krezel, L., Solomon, B., Spillmann, R. C., Stoler, J. M., Sullivan, K., Sullivan, J. A., Sun, A., Sutton, S., Sweetser, D. A., Sybert, V., Tabor, H. K., Tan, Q. K. -G., Tan, A. L. M., Tekin, M., Telischi, F., Thorson, W., Tifft, C. J., Toro, C., Tran, A. A., Ungar, R. A., Urv, T. K., Vanderver, A., Velinder, M., Viskochil, D., Vogel, T. P., Wahl, C. E., Walker, M., Wallace, S., Walley, N. M., Wambach, J., Wan, J., Wang, L. -K., Wangler, M. F., Ward, P. A., Wegner, D., Weisz Hubshman, M., Wener, M., Wenger, T., Westerfield, M., Wheeler, M. T., Whitlock, J., Wolfe, L. A., Worley, K., Xiao, C., Yamamoto, S., Yang, J., Zhang, Z., Zuchner, S., Nigro, V., Torella, A., Spampanato, C., Pinelli, M., Banfi, S., Varavallo, A., Selicorni, A., Mariani, M., Massimello, M., Daolio, C., Capra, V., Accogli, A., Scala, M., Leuzzi, V., Nardecchia, F., Galosi, S., Mastrangelo, M., Milani, D., Vitiello, G., Piluso, G., Romano, C., Failla, P., Greco, D., Pantaleoni, C., Ciaccio, C., D'Arrigo, S., Brunetti Pierri, N., Parenti, G., Coppola, A., Mattina, T., Zollino, Marcella, Amenta, Simona, Tummolo, A., Santoro, C., Grandone, A., De Brasi, D., Varone, A., Garavelli, L., Marini, C., Bigoni, S., Piscopo, C., Trabacca, A., De Rinaldis, M., Peron, A., Putti, E., Ferrante, L., Cetrangolo, V., Walker, M. A., Tenconi, R., Iascone, M., Mei, D., Guerrini, R., van der Smagt, J., Kroes, H. Y., van Gassen, K. L. I., Bilal, M., Umair, M., Pingault, V., Attie-Bitach, T., Amiel, J., Ejaz, R., Rodan, L., Agrawal, P. B., Del Bene, F., Franco, B., Zollino M. (ORCID:0000-0003-4871-9519), Amenta S., Morleo, M., Venditti, R., Theodorou, E., Briere, L. C., Rosello, M., Tirozzi, A., Tammaro, R., Al-Badri, N., High, F. A., Shi, J., Acosta, M. T., Adam, M., Adams, D. R., Alvarez, R. L., Alvey, J., Amendola, L., Andrews, A., Ashley, E. A., Bacino, C. A., Bademci, G., Balasubramanyam, A., Baldridge, D., Bale, J., Bamshad, M., Barbouth, D., Bayrak-Toydemir, P., Beck, A., Beggs, A. H., Behrens, E., Bejerano, G., Bellen, H. J., Bennett, J., Berg-Rood, B., Bernstein, J. A., Berry, G. T., Bican, A., Bivona, S., Blue, E., Bohnsack, J., Bonner, D., Botto, L., Boyd, B., Brown, G., Burke, E. A., Burrage, L. C., Butte, M. J., Byers, P., Byrd, W. E., Carey, J., Carrasquillo, O., Cassini, T., Chang, T. C. P., Chanprasert, S., Chao, H. -T., Clark, G. D., Coakley, T. R., Cobban, L. A., Cogan, J. D., Coggins, M., Cole, F. S., Colley, H. A., Cooper, C. M., Cope, H., Corona, R., Craigen, W. J., Crouse, A. B., Cunningham, M., D'Souza, P., Dai, H., Dasari, S., Davis, J., Dayal, J. G., Dell'Angelica, E. C., Dipple, K., Doherty, D., Dorrani, N., Doss, A. L., Douine, E. D., Earl, D., Eckstein, D. J., Emrick, L. T., Eng, C. M., Falk, M., Fieg, E. L., Fisher, P. G., Fogel, B. L., Forghani, I., Gahl, W. A., Glass, I., Gochuico, B., Goddard, P. C., Godfrey, R. A., Golden-Grant, K., Grajewski, A., Hadley, D., Hahn, S., Halley, M. C., Hamid, R., Hassey, K., Hayes, N., High, F., Hing, A., Hisama, F. M., Holm, I. A., Hom, J., Horike-Pyne, M., Huang, A., Hutchison, S., Introne, W., Isasi, R., Izumi, K., Jamal, F., Jarvik, G. P., Jarvik, J., Jayadev, S., Jean-Marie, O., Jobanputra, V., Karaviti, L., Ketkar, S., Kiley, D., Kilich, G., Kobren, S. N., Kohane, I. S., Kohler, J. N., Korrick, S., Kozuira, M., Krakow, D., Krasnewich, D. M., Kravets, E., Lalani, S. R., Lam, B., Lam, C., Lanpher, B. C., Lanza, I. R., Leblanc, K., Lee, B. H., Levitt, R., Lewis, R. A., Liu, P., Liu, X. Z., Longo, N., Loo, S. K., Loscalzo, J., Maas, R. L., Macnamara, E. F., Macrae, C. A., Maduro, V. V., Maghiro, A., Mahoney, R., Malicdan, M. C. V., Mamounas, L. A., Manolio, T. A., Mao, R., Maravilla, K., Marom, R., Marth, G., Martin, B. A., Martin, M. G., Martinez-Agosto, J. A., Marwaha, S., Mccauley, J., McConkie-Rosell, A., Mccray, A. T., Mcgee, E., Mefford, H., Merritt, J. L., Might, M., Mirzaa, G., Morava, E., Moretti, P., Mulvihill, J., Nakano-Okuno, M., Nelson, S. F., Newman, J. H., Nicholas, S. K., Nickerson, D., Nieves-Rodriguez, S., Novacic, D., Oglesbee, D., Orengo, J. P., Pace, L., Pak, S., Pallais, J. C., Palmer, C. G. S., Papp, J. C., Parker, N. H., Phillips III, J. A., Posey, J. E., Potocki, L., Pusey Swerdzewski, B. N., Quinlan, A., Rao, D. A., Raper, A., Raskind, W., Renteria, G., Reuter, C. M., Rives, L., Robertson, A. K., Rodan, L. H., Rosenfeld, J. A., Rosenwasser, N., Rossignol, F., Ruzhnikov, M., Sacco, R., Sampson, J. B., Saporta, M., Schaechter, J., Schedl, T., Schoch, K., Scott, D. A., Scott, C. R., Shashi, V., Shin, J., Silverman, E. K., Sinsheimer, J. S., Sisco, K., Smith, E. C., Smith, K. S., Solnica-Krezel, L., Solomon, B., Spillmann, R. C., Stoler, J. M., Sullivan, K., Sullivan, J. A., Sun, A., Sutton, S., Sweetser, D. A., Sybert, V., Tabor, H. K., Tan, Q. K. -G., Tan, A. L. M., Tekin, M., Telischi, F., Thorson, W., Tifft, C. J., Toro, C., Tran, A. A., Ungar, R. A., Urv, T. K., Vanderver, A., Velinder, M., Viskochil, D., Vogel, T. P., Wahl, C. E., Walker, M., Wallace, S., Walley, N. M., Wambach, J., Wan, J., Wang, L. -K., Wangler, M. F., Ward, P. A., Wegner, D., Weisz Hubshman, M., Wener, M., Wenger, T., Westerfield, M., Wheeler, M. T., Whitlock, J., Wolfe, L. A., Worley, K., Xiao, C., Yamamoto, S., Yang, J., Zhang, Z., Zuchner, S., Nigro, V., Torella, A., Spampanato, C., Pinelli, M., Banfi, S., Varavallo, A., Selicorni, A., Mariani, M., Massimello, M., Daolio, C., Capra, V., Accogli, A., Scala, M., Leuzzi, V., Nardecchia, F., Galosi, S., Mastrangelo, M., Milani, D., Vitiello, G., Piluso, G., Romano, C., Failla, P., Greco, D., Pantaleoni, C., Ciaccio, C., D'Arrigo, S., Brunetti Pierri, N., Parenti, G., Coppola, A., Mattina, T., Zollino, Marcella, Amenta, Simona, Tummolo, A., Santoro, C., Grandone, A., De Brasi, D., Varone, A., Garavelli, L., Marini, C., Bigoni, S., Piscopo, C., Trabacca, A., De Rinaldis, M., Peron, A., Putti, E., Ferrante, L., Cetrangolo, V., Walker, M. A., Tenconi, R., Iascone, M., Mei, D., Guerrini, R., van der Smagt, J., Kroes, H. Y., van Gassen, K. L. I., Bilal, M., Umair, M., Pingault, V., Attie-Bitach, T., Amiel, J., Ejaz, R., Rodan, L., Agrawal, P. B., Del Bene, F., Franco, B., Zollino M. (ORCID:0000-0003-4871-9519), and Amenta S.

Published
2023

19. Unterschiede im 5-Jahres-Überleben von Peniskarzinompatienten vs. populationsbasierten Kontrollpatienten

Author

Scheipner, L, Tappero, S, Piccinelli, ML, Barletta, F, Cano Garcia, C, Incesu, RB, Morra, S, Tian, Z, Saad, F, Shariat, SF, Terrone, C, De Cobelli, O, Briganti, A, Chun, FKH, Tilki, D, Longo, N, Seles, M, Ahyai, S, Karakiewicz, PI, Scheipner, L, Tappero, S, Piccinelli, ML, Barletta, F, Cano Garcia, C, Incesu, RB, Morra, S, Tian, Z, Saad, F, Shariat, SF, Terrone, C, De Cobelli, O, Briganti, A, Chun, FKH, Tilki, D, Longo, N, Seles, M, Ahyai, S, and Karakiewicz, PI

Published
2023

21. An open-label clinical trial of agalsidase alfa enzyme replacement therapy in children with Fabry disease who are naïve to enzyme replacement therapy

Author

Goker-Alpan O, Longo N, McDonald M, Shankar SP, Schiffmann R, Chang P, Shen Y, and Pano A

Subjects
agalsidase alfa, efficacy, enzyme replacement therapy, Fabry disease, pediatric study, safety, Therapeutics. Pharmacology, RM1-950
Abstract

Ozlem Goker-Alpan,1 Nicola Longo,2 Marie McDonald,3 Suma P Shankar,4,5 Raphael Schiffmann,6 Peter Chang,7 Yinghua Shen,7 Arian Pano7 1Lysosomal Disorders Unit, Fairfax, VA, 2University of Utah, Salt Lake City, UT, 3Department of Pediatrics, Duke University, Durham, NC, 4Department of Ophthalmology, 5Department of Human Genetics, Emory University School of Medicine, Atlanta, GA, 6Institute of Metabolic Disease, Baylor Research Institute, Dallas, TX, 7Shire, Lexington, MA, USA Background: Following a drug manufacturing process change, safety/efficacy of agalsidase alfa were evaluated in enzyme replacement therapy (ERT)-naïve children with Fabry disease. Methods: In an open-label, multicenter, Phase II study (HGT-REP-084; Shire), 14 children aged ≥7 years received 0.2 mg/kg agalsidase alfa every other week for 55 weeks. Primary endpoints: safety, changes in autonomic function (2-hour Holter monitoring). Secondary endpoints: estimated glomerular filtration rate, left ventricular mass index (LVMI), midwall fractional shortening, pharmacodynamic parameters, and patient-reported quality-of-life. Results: Among five boys (median 10.2 [range 6.7, 14.4] years) and nine girls (14.8 [10.1, 15.9] years), eight patients experienced infusion-related adverse events (vomiting, n=4; nausea, n=3; dyspnea, n=3; chest discomfort, n=2; chills, n=2; dizziness, n=2; headache, n=2). One of these had several hypersensitivity episodes. However, no patient discontinued for safety reasons and no serious adverse events occurred. One boy developed immunoglobulin G (IgG) and neutralizing antidrug antibodies. Overall, no deterioration in cardiac function was observed in seven patients with low/abnormal SDNN (standard deviation of all filtered RR intervals;

Published
2016

22. First results of a head-to-head trial of pegunigalsidase alfa vs. agalsidase beta in Fabry disease: 2 year results of the phase 3 randomized, double-blind, BALANCE study

Author

Wallace, Eric, primary, Goker-Alpan, Wilcox, additional, Holida, Bernat, additional, Longo, N., additional, Hughes, D., additional, Giraldo, P., additional, Molnar, M.J., additional, Ortiz, Hopkin, additional, Tøndel, C., additional, Linhart, A., additional, Deegan, Jovanovic, additional, Muriello, M., additional, Barshop, Kimonis, additional, Vujkovac, B., additional, Nowak, A., additional, Geberhiwot, T., additional, Pisani, A., additional, Germain, D.P., additional, Kantola, I., additional, Knoll, J., additional, Mehta, Ankit, additional, Waldek, Stephen, additional, Chertkoff, Raul, additional, Almon, Einat, additional, Alon, Sari, additional, Rocco, Rossana, additional, and Warnock, David G., additional

Published
2023
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23. Translation and validation of the italian version of the wisconsin stone quality of life (WISQOL) questionnaire: a multicentric study

Author

Serafin, E., Mazzon, G., Ferretti, S., Claps, F., Zhong, W., Fiori, C., Celentano, G., Guarino, G. G., Zamengo, D., Piasentin, A., Creta, M., Longo, N., Dordoni, R., Pavan, N., Brancelli, C., Franceschini, A., Cerruto, M. A., Antonelli, A., Celia, A., Serafin, E., Mazzon, G., Ferretti, S., Claps, F., Zhong, W., Fiori, C., Celentano, G., Guarino, G. G., Zamengo, D., Piasentin, A., Creta, M., Longo, N., Dordoni, R., Pavan, N., Brancelli, C., Franceschini, A., Cerruto, M. A., Antonelli, A., and Celia, A.

Subjects
Urology
Published
2022
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25. Re: Toward Individualized Approaches to Partial Nephrectomy: Assessing the Correlation between Ischemia Time and Patient Health Status (RECORD2 Project)

Author

Bravi C. A., Mari A., Larcher A., Amparore D., Antonelli A., Artibani W., Bertini R., Bove P., Brunocilla E. U., Da Pozzo L., Di Maida F., Fiori C., Gallioli A., Gontero P., Marzi V. L., Longo N., Mirone V., Porpiglia F., Rocco B., Schiavina R., Schips L., Simeone C., Siracusano S., Tellini R., Terrone C., Trombetta C., Ficarra V., Carini M., Montorsi F., Capitanio U., Minervini A., Bravi, C. A., Mari, A., Larcher, A., Amparore, D., Antonelli, A., Artibani, W., Bertini, R., Bove, P., Brunocilla, E. U., Da Pozzo, L., Di Maida, F., Fiori, C., Gallioli, A., Gontero, P., Marzi, V. L., Longo, N., Mirone, V., Porpiglia, F., Rocco, B., Schiavina, R., Schips, L., Simeone, C., Siracusano, S., Tellini, R., Terrone, C., Trombetta, C., Ficarra, V., Carini, M., Montorsi, F., Capitanio, U., and Minervini, A.

Subjects
Retroperitoneal Neoplasm, Humans, Kidney, Medical Oncology, Retroperitoneal Neoplasms, Ureter, Urology, Human
Abstract

Not applicable

Published
2022

26. Perioperative Outcomes of Open, Laparoscopic, and Robotic Partial Nephrectomy: A Prospective Multicenter Observational Study (The RECORd 2 Project)

Author

Bravi, C, Larcher, A, Capitanio, U, Mari, A, Antonelli, A, Artibani, W, Barale, M, Bertini, R, Bove, P, Brunocilla, E, Da Pozzo, L, Di Maida, F, Fiori, C, Gontero, P, Li Marzi, V, Longo, N, Mirone, V, Montanari, E, Porpiglia, F, Schiavina, R, Schips, L, Simeone, C, Siracusano, S, Terrone, C, Trombetta, C, Volpe, A, Montorsi, F, Ficarra, V, Carini, M, Minervini, A, Bravi C. A., Larcher A., Capitanio U., Mari A., Antonelli A., Artibani W., Barale M., Bertini R., Bove P., Brunocilla E., Da Pozzo L., Di Maida F., Fiori C., Gontero P., Li Marzi V., Longo N., Mirone V., Montanari E., Porpiglia F., Schiavina R., Schips L., Simeone C., Siracusano S., Terrone C., Trombetta C., Volpe A., Montorsi F., Ficarra V., Carini M., Minervini A., Bravi, C, Larcher, A, Capitanio, U, Mari, A, Antonelli, A, Artibani, W, Barale, M, Bertini, R, Bove, P, Brunocilla, E, Da Pozzo, L, Di Maida, F, Fiori, C, Gontero, P, Li Marzi, V, Longo, N, Mirone, V, Montanari, E, Porpiglia, F, Schiavina, R, Schips, L, Simeone, C, Siracusano, S, Terrone, C, Trombetta, C, Volpe, A, Montorsi, F, Ficarra, V, Carini, M, Minervini, A, Bravi C. A., Larcher A., Capitanio U., Mari A., Antonelli A., Artibani W., Barale M., Bertini R., Bove P., Brunocilla E., Da Pozzo L., Di Maida F., Fiori C., Gontero P., Li Marzi V., Longo N., Mirone V., Montanari E., Porpiglia F., Schiavina R., Schips L., Simeone C., Siracusano S., Terrone C., Trombetta C., Volpe A., Montorsi F., Ficarra V., Carini M., and Minervini A.

Abstract

Background: Partial nephrectomy (PN) has a non-negligible perioperative morbidity. Comparative evidence of the available surgical techniques is limited. Objective: To compare the perioperative outcomes of open, laparoscopic, and robotic PN. Methods: Data of 2331 patients treated with PN for cT1 renal tumors were extracted from the RECORd2 database, a prospective multicenter project. Multivariable regression models assessed the relationship between surgical technique and surgical margins, warm ischemia time, postoperative complications, and acute kidney injury (AKI). The probability of achieving a modified trifecta (negative margins, warm ischemia time <25 min, and no Clavien–Dindo ≥2 complications) was examined for each surgical approach. Results: Minimally invasive techniques had lower rate of Clavien–Dindo ≥2 complications than that of open surgery (odds ratio [OR] for robotic surgery: 0.27; 95% confidence interval [95% CI]: 0.15–0.47, p < 0.0001; OR for laparoscopy: 0.52; 95% CI: 0.34–0.78; p = 0.002). The probability of receiving ischemia was highest for robotic PN (p < 0.001). Among on-clamp PN, laparoscopy had longer ischemia than open (estimate: 1.09; 95% CI: –0.00 to 2.18; p = 0.050) and robotic (estimate: 1.36; 95% CI: 0.31–2.40; p = 0.011) surgery. When compared with open PN, the risk of AKI was roughly halved for patients treated by robotic and laparoscopic surgery (both p < 0.0001). Positive margins rate did not differ between the groups (all p ≥ 0.1). The likelihood to achieve a modified trifecta was not affected by surgical technique in the overall population (all p ≥ 0.075). In Preoperative Aspects and Dimensions Used for an Anatomical (PADUA) score < 10 lesions, robotic surgery had higher probability of achieving a modified trifecta than open PN (OR: 1.66; 95% CI: 1.09–2.53; p = 0.018) and laparoscopy (OR: 1.34; 95% CI: 0.94–1.90; p = 0.11). Conclusions: In PADUA < 10 renal tumors, robotic PN allows for higher rates of trifecta than

Published
2021

27. Radical cystectomy in octogenary, symptomatic patients with muscle-invasive bladder cancers

Author

Ficarra, V., primary, Bartoletti, R., additional, Borghesi, M., additional, Cimino, S., additional, De Nunzio, C., additional, Esperto, F., additional, Giannarini, G., additional, Gregori, A., additional, Longo, N., additional, Mirone, V., additional, Rossanese, M., additional, Scarpa, R.M., additional, Simonato, A., additional, Terrone, C., additional, Tubaro, A., additional, and Valotto, C., additional

Published
2022
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29. Robot-assisted partial nephrectomy versus percutaneous thermal ablation for renal mass in solitary kidney: a multicenter analysis

Author

Loizzo, D., primary, Pandolfo, S.D., additional, Beksac, A.T., additional, Derweesh, I., additional, Celia, A., additional, Schiavina, R., additional, Napolitano, L., additional, Longo, N., additional, Bianchi, L., additional, Kaouk, J., additional, Capitanio, U., additional, Basile, G., additional, Mirone, V., additional, Del Giudice, F., additional, Ditonno, P., additional, Lucarelli, G., additional, and Autorino, R., additional

Published
2022
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30. Elevated phenylacetic acid levels do not correlate with adverse events in patients with urea cycle disorders or hepatic encephalopathy and can be predicted based on the plasma PAA to PAGN ratio

Author

Mokhtarani, M., Diaz, G.A., Rhead, W., Berry, S.A., Lichter-Konecki, U., Feigenbaum, A., Schulze, A., Longo, N., Bartley, J., Berquist, W., Gallagher, R., Smith, W., McCandless, S.E., Harding, C., Rockey, D.C., Vierling, J.M., Mantry, P., Ghabril, M., Brown, R.S., Jr., Dickinson, K., Moors, T., Norris, C., Coakley, D., Milikien, D.A., Nagamani, S.C., LeMons, C., Lee, B., and Scharschmidt, B.F.

Published
2013
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31. Perioperative Outcomes of Open, Laparoscopic, and Robotic Partial Nephrectomy: A Prospective Multicenter Observational Study (The RECORd 2 Project)

Author

Bravi, C. A., Larcher, A., Capitanio, U., Mari, A., Antonelli, A., Artibani, W., Barale, M., Bertini, R., Bove, P., Brunocilla, E., Da Pozzo, L., Di Maida, F., Fiori, C., Gontero, P., Li Marzi, V., Longo, N., Mirone, V., Montanari, E., Porpiglia, F., Schiavina, R., Schips, L., Simeone, C., Siracusano, S., Terrone, C., Trombetta, C., Volpe, A., Montorsi, F., Ficarra, V., Carini, M., Minervini, A., Altieri, V., Berardinelli, F., Borghesi, M., Celia, A., Cindolo, L., Costantini, E., Daja, J., Falsaperla, M., Furlan, M., Morgia, G., Porreca, A., Roscigno, M., Selli, C., Simonato, A., Tellini, R., Vespasiani, G., Villari, D., Bravi, C, Larcher, A, Capitanio, U, Mari, A, Antonelli, A, Artibani, W, Barale, M, Bertini, R, Bove, P, Brunocilla, E, Da Pozzo, L, Di Maida, F, Fiori, C, Gontero, P, Li Marzi, V, Longo, N, Mirone, V, Montanari, E, Porpiglia, F, Schiavina, R, Schips, L, Simeone, C, Siracusano, S, Terrone, C, Trombetta, C, Volpe, A, Montorsi, F, Ficarra, V, Carini, M, Minervini, A, Bravi, C. A., Larcher, A., Capitanio, U., Mari, A., Antonelli, A., Artibani, W., Barale, M., Bertini, R., Bove, P., Brunocilla, E., Da Pozzo, L., Di Maida, F., Fiori, C., Gontero, P., Li Marzi, V., Longo, N., Mirone, V., Montanari, E., Porpiglia, F., Schiavina, R., Schips, L., Simeone, C., Siracusano, S., Terrone, C., Trombetta, C., Volpe, A., Montorsi, F., Ficarra, V., Carini, M., Minervini, A., and Bravi CA, Larcher A, Capitanio U, Mari A, Antonelli A, Artibani W, Barale M, Bertini R, Bove P, Brunocilla E, Da Pozzo L, Di Maida F, Fiori C, Gontero P, Li Marzi V, Longo N, Mirone V, Montanari E, Porpiglia F, Schiavina R, Schips L, Simeone C, Siracusano S, Terrone C, Trombetta C, Volpe A, Montorsi F, Ficarra V, Carini M, Minervini A

Subjects
Male, medicine.medical_specialty, Urology, medicine.medical_treatment, 030232 urology & nephrology, Acute kidney injury, Laparoscopy, Partial nephrectomy, Perioperative outcomes, Renal cell carcinoma, Robotic surgery, Trifecta, Nephrectomy, 03 medical and health sciences, 0302 clinical medicine, Robotic Surgical Procedures, Ischemia, Medicine, Humans, Minimally Invasive Surgical Procedures, Prospective Studies, Perioperative Period, Aged, medicine.diagnostic_test, business.industry, renal carcinoma, Odds ratio, Perioperative, Middle Aged, medicine.disease, Confidence interval, Kidney Neoplasms, Surgery, Settore MED/24, 030220 oncology & carcinogenesis, Female, Acute kidney injury, Laparoscopy, Partial nephrectomy, Perioperative outcomes, Renal cell carcinoma, Robotic surgery, Trifecta, business, Perioperative outcome
Abstract

Background: Partial nephrectomy (PN) has a non-negligible perioperative morbidity. Comparative evidence of the available surgical techniques is limited. Objective: To compare the perioperative outcomes of open, laparoscopic, and robotic PN. Methods: Data of 2331 patients treated with PN for cT1 renal tumors were extracted from the RECORd2 database, a prospective multicenter project. Multivariable regression models assessed the relationship between surgical technique and surgical margins, warm ischemia time, postoperative complications, and acute kidney injury (AKI). The probability of achieving a modified trifecta (negative margins, warm ischemia time

Published
2021

33. Clinical Reasoning: Pediatric Seizures of Unknown Cause

Author

Tseng, L.A., Konijnenburg, E.M.M. Hoytema van, Longo, N., Andrews, A., Wegberg, A.M.J. van, Coene, K.L.M., Coughlin, C.R., Karnebeek, C.D.M. van, Tseng, L.A., Konijnenburg, E.M.M. Hoytema van, Longo, N., Andrews, A., Wegberg, A.M.J. van, Coene, K.L.M., Coughlin, C.R., and Karnebeek, C.D.M. van

Abstract

Item does not contain fulltext

Published
2022

39. Risk factors and action thresholds for the novel coronavirus pandemic. Insights from the Italian Society of Nephrology COVID-19 Survey

Author

Nordio, M., Reboldi, G., Di Napoli, A., Quintaliani, G., Alberici, F., Postorino, M., Aucella, F., Messa, P., Brunori, G., Bosco, M., Malberti, F., Mandreoli, M., Mazzaferro, S., Movilli, E., Ravera, M., Salomone, M., Santoro, D., Postorinolimido, M. A., Bonomini, M., Stingone, A., Maccarone, M., Di Loreto, E., Stacchiotti, L., Malandra, R., Chiarella, S., D'Agostino, F., Fuiano, G., Nicodemo, L., Bonofiglio, R., Greco, S., Mallamaci, F., Barreca, E., Caserta, C., Bruzzese, V., Galati, D., Tramontana, D., Viscione, M., Chiuchiolo, L., Tuccillo, S., Sepe, M., Vitale, F., Ciriana, E., Martignetti, V., Caserta, D., Stizzo, A., Romano, A., Iulianiello, G., Cascone, E., Minicone, P., Chiricone, D., Delgado, G., Barbato, A., Celentano, S., Molfino, I., Coppola, S., Raiola, I., Abategiovanni, M., Borrelli, S., Margherita, C., Bruno, F., Ida, M., Aliperti, E., Potito, D., Cuomo, G., De Luca, M., Merola, M., Botta, C., Garofalo, G., Alinei, P., Paglionico, C., Roano, M., Vitale, S., Ierardi, R., Fimiani, V., Conte, G., Di Natale, G., Romano, M., Di Marino, V., Scafarto, A., Meccariello, S., Pecoraro, C., Di Stazio, E., Di Meglio, E., Cuomo, A., Maresca, B., Rotaia, E., Capasso, G., Auricchio, M., Pluvio, C., Maddalena, L., De Maio, A., Palladino, G., Buono, F., Gigliotti, G., Mancini, E., La Manna, G., Storari, A., Mosconi, G., Cappelli, G., Scarpioni, R., Gregorini, M., Rigotti, A., Mancini, W., Bianco, F., Boscutti, G., Amici, G., Tosto, M., Fini, R., Pace, G., Cioffi, A., Boccia, E., Di Lullo, L., Di Zazzo, G., Simonelli, R., Bondatti, F., Miglio, L., Rifici, N., Treglia, A., Muci, M., Baldinelli, G., Rizzi, E., Lonzi, M., De Cicco, C., Forte, F., De Paolis, P., Grandaliano, Giuseppe, Cuzziol, C., Torre, V. M., Sfregola, P., Rossi, V., Fabio, G., Flammini, A., Filippini, A., Onorato, L., Vendola, F., Di Daniela, N., Alfarone, C., Scabbia, L., Ferrazzano, M., Grotta, B. D., Gamberini, M., Fazzari, L., Mene, P., Morgia, A., Catucci, A., Palumbo, R., Puliti, M., Marinelli, R., Polito, P., Marrocco, F., Morabito, S., Rocca, R., Nazzaro, L., Lavini, R., Iamundo, V., Chiappini, M., Casarci, M., Morosetti, M., Hassan, S., Firmi, G., Galliani, M., Serraiocco, M., Feriozzi, S., Valentini, W., Sacco, P., Garibotto, G., Cappelli, V., Saffioti, C., Repetto, M., Rolla, D., Lorenz, M., Pedrini, L., Polonioli, D., Galli, E., Ruggenenti, P., Scolari, F., Bove, S., Costantino, E., Bracchi, M., Mangano, S., Depetri, G., La Milia, V., Farina, M., Zecchini, S., Savino, R., Melandri, M., Guastoni, C., Paparella, M., Gallieni, M., Minetti, E., Bisegna, S., Righetti, M., Badalamenti, S., Alberghini, E., Bertoli, S., Fabbrini, P., Albrizio, P., Rampino, T., Colturi, C., Rombola, G., Lucatello, A., Guerrini, E., Ranghino, A., Lenci, F., Fanciulli, E., Santarelli, S., Damiani, C., Garofalo, D., Sopranzi, F., Santoferrara, A., Di Luca, M., Galiotta, P., Brigante, M., Manganaro, M., Maffei, S., Berto, I., Besso, L., Viglino, G., Cusinato, S., Chiarinottichiappero, D. F., Tognarelli, G., Gianoglio, B., Forneris, G., Biancone, L., Savoldi, S., Vitale, C., Boero, R., Filiberti, O., Borzumati, M., Gesualdo, L., Lomonte, C., Gernone, G., Pallotta, G., Di Paolo, S., Vernaglione, L., Specchio, A., Stallone, G., Dell'Aquila, R., Sandri, G., Russo, F., Napoli, M., Marangi, A., Morrone, L., Di Stratis, C., Fresu, A., Cicu, F., Murtas, S., Manca, O., Pani, A., Pilloni, M., Pistis, R., Cadoni, M., Contu, B., Logias, F., Ivaldi, R., Fancello, S., Cossu, M., Lepori, G., Vittoria, S., Battiati, E., Arnone, M., Rome, M., Barbera, A., Granata, A., Collura, G., Dico, C. L., Pugliese, G., Di Natale, E., Rizzari, G., Cottone, L., Longo, N., Battaglia, G., Marcantoni, C., Giannetto, G., Tumino, G., Randazzo, F., Bellissimo, L., Faro, F. L., Grippaldi, F., Urso, S., Quattrone, G., Todaro, I., Vincenzo, D., Murgo, A., Masuzzo, M., Pisacane, A., Monardo, P., Pontorierro, M., Quari, C., Bauro, A., Chimenz, R. R., Alfio, D., Girasole, F., Cascio, A. L., Caviglia, A., Tornese, F., Sirna, F., Altieri, C., Cusumano, R., Saveriano, V., La Corte, A., Locascio, G., Rotolo, U., Musso, S., Risuglia, L., Blanco, G., Minardo, G., Castellino, S., Zappulla, Z., Randone, S., Di Francesca, M., Cassetti, C. C., Oddo, G., Buscaino, G., Mucaria, F., Barraco, V. I., Di Martino, A., Rallo, D., Dani, L., Campolo, G., Manescalchi, F., Biagini, M., Agate, M., Panichi, V., Casani, A., Traversari, L., Garosi, G., Tabbi, M., Selvi, A., Cencioni, L., Fagugli, R., Timio, F., Leveque, A., Manes, M., Mennella, G., Calo, L., Fiorini, F., Abaterusso, C., Calzavara, P., Meneghel, G., Bonesso, C., Gambaro, G., Gammaro, L., Rugiu, C., Ronco, C., Nordio M., Reboldi G., Di Napoli A., Quintaliani G., Alberici F., Postorino M., Aucella F., Messa P., Brunori G., Bosco M., Malberti F., Mandreoli M., Mazzaferro S., Movilli E., Ravera M., Salomone M., Santoro D., PostorinoLimido M.A., Bonomini M., Stingone A., Maccarone M., Di Loreto E., Stacchiotti L., Malandra R., Chiarella S., D'Agostino F., Fuiano G., Nicodemo L., Bonofiglio R., Greco S., Mallamaci F., Barreca E., Caserta C., Bruzzese V., Galati D., Tramontana D., Viscione M., Chiuchiolo L., Tuccillo S., Sepe M., Vitale F., Ciriana E., Martignetti V., Caserta D., Stizzo A., Romano A., Iulianiello G., Cascone E., Minicone P., Chiricone D., Delgado G., Barbato A., Celentano S., Molfino I., Coppola S., Raiola I., Abategiovanni M., Borrelli S., Margherita C., Bruno F., Ida M., Aliperti E., Potito D., Cuomo G., De Luca M., Merola M., Botta C., Garofalo G., Alinei P., Paglionico C., Roano M., Vitale S., Ierardi R., Fimiani V., Conte G., Di Natale G., Romano M., Di Marino V., Scafarto A., Meccariello S., Pecoraro C., Di Stazio E., Di Meglio E., Cuomo A., Maresca B., Rotaia E., Capasso G., Auricchio M., Pluvio C., Maddalena L., De Maio A., Palladino G., Buono F., Gigliotti G., Mancini E., La Manna G., Storari A., Mosconi G., Cappelli G., Scarpioni R., Gregorini M., Rigotti A., Mancini W., Bianco F., Boscutti G., Amici G., Tosto M., Fini R., Pace G., Cioffi A., Boccia E., Di Lullo L., Di Zazzo G., Simonelli R., Bondatti F., Miglio L., Rifici N., Treglia A., Muci M., Baldinelli G., Rizzi E., Lonzi M., De Cicco C., Forte F., De Paolis P., Grandaliano G., Cuzziol C., Torre V.M., Sfregola P., Rossi V., Fabio G., Flammini A., Filippini A., Onorato L., Vendola F., Di Daniela N., Alfarone C., Scabbia L., Ferrazzano M., Grotta B.D., Gamberini M., Fazzari L., Mene P., Morgia A., Catucci A., Palumbo R., Puliti M., Marinelli R., Polito P., Marrocco F., Morabito S., Rocca R., Nazzaro L., Lavini R., Iamundo V., Chiappini M., Casarci M., Morosetti M., Hassan S., Firmi G., Galliani M., Serraiocco M., Feriozzi S., Valentini W., Sacco P., Garibotto G., Cappelli V., Saffioti C., Repetto M., Rolla D., Lorenz M., Pedrini L., Polonioli D., Galli E., Ruggenenti P., Scolari F., Bove S., Costantino E., Bracchi M., Mangano S., Depetri G., La Milia V., Farina M., Zecchini S., Savino R., Melandri M., Guastoni C., Paparella M., Gallieni M., Minetti E., Bisegna S., Righetti M., Badalamenti S., Alberghini E., Bertoli S., Fabbrini P., Albrizio P., Rampino T., Colturi C., Rombola G., Lucatello A., Guerrini E., Ranghino A., Lenci F., Fanciulli E., Santarelli S., Damiani C., Garofalo D., Sopranzi F., Santoferrara A., Di Luca M., Galiotta P., Brigante M., Manganaro M., Maffei S., Berto I., Besso L., Viglino G., Cusinato S., ChiarinottiChiappero D.F., Tognarelli G., Gianoglio B., Forneris G., Biancone L., Savoldi S., Vitale C., Boero R., Filiberti O., Borzumati M., Gesualdo L., Lomonte C., Gernone G., Pallotta G., Di Paolo S., Vernaglione L., Specchio A., Stallone G., Dell'Aquila R., Sandri G., Russo F., Napoli M., Marangi A., Morrone L., Di Stratis C., Fresu A., Cicu F., Murtas S., Manca O., Pani A., Pilloni M., Pistis R., Cadoni M., Contu B., Logias F., Ivaldi R., Fancello S., Cossu M., Lepori G., Vittoria S., Battiati E., Arnone M., Rome M., Barbera A., Granata A., Collura G., Dico C.L., Pugliese G., Di Natale E., Rizzari G., Cottone L., Longo N., Battaglia G., Marcantoni C., Giannetto G., Tumino G., Randazzo F., Bellissimo L., Faro F.L., Grippaldi F., Urso S., Quattrone G., Todaro I., Vincenzo D., Murgo A., Masuzzo M., Pisacane A., Monardo P., Pontorierro M., Quari C., Bauro A., Chimenz R.R., Alfio D., Girasole F., Cascio A.L., Caviglia A., Tornese F., Sirna F., Altieri C., Cusumano R., Saveriano V., La Corte A., Locascio G., Rotolo U., Musso S., Risuglia L., Blanco G., Minardo G., Castellino S., Zappulla Z., Randone S., Di Francesca M., Cassetti C.C., Oddo G., Buscaino G., Mucaria F., Barraco V.I., Di Martino A., Rallo D., Dani L., Campolo G., Manescalchi F., Biagini M., Agate M., Panichi V., Casani A., Traversari L., Garosi G., Tabbi M., Selvi A., Cencioni L., Fagugli R., Timio F., Leveque A., Manes M., Mennella G., Calo L., Fiorini F., Abaterusso C., Calzavara P., Meneghel G., Bonesso C., Gambaro G., Gammaro L., Rugiu C., and Ronco C.

Subjects
Male, Contextual analysis, medicine.medical_treatment, Population, 030232 urology & nephrology, Recursive partitioning, 030204 cardiovascular system & hematology, Rate ratio, Risk Assessment, 03 medical and health sciences, 0302 clinical medicine, Classification tree, COVID-19, Renal replacement therapy, Risk Factors, Medical, Surveys and Questionnaires, Health care, medicine, Settore MED/14 - NEFROLOGIA, Humans, education, Pandemics, Societies, Medical, Female, Italy, Nephrology, education.field_of_study, business.industry, Multilevel model, Decision rule, Confidence interval, Original Article, Hemodialysis, business, Contextual analysi, Societies, Demography
Abstract

Background and aim: Over 80% (365/454) of the nation’s centers participated in the Italian Society of Nephrology COVID-19 Survey. Out of 60,441 surveyed patients, 1368 were infected as of April 23rd, 2020. However, center-specific proportions showed substantial heterogeneity. We therefore undertook new analyses to identify explanatory factors, contextual effects, and decision rules for infection containment. Methods: We investigated fixed factors and contextual effects by multilevel modeling. Classification and Regression Tree (CART) analysis was used to develop decision rules. Results: Increased positivity among hemodialysis patients was predicted by center location [incidence rate ratio (IRR) 1.34, 95% confidence interval (CI) 1.20–1.51], positive healthcare workers (IRR 1.09, 95% CI 1.02–1.17), test-all policy (IRR 5.94, 95% CI 3.36–10.45), and infected proportion in the general population (IRR 1.002, 95% CI 1.001–1.003) (all p < 0.01). Conversely, lockdown duration exerted a protective effect (IRR 0.95, 95% CI 0.94–0.98) (p < 0.01). The province-contextual effects accounted for 10% of the total variability. Predictive factors for peritoneal dialysis and transplant cases were center location and infected proportion in the general population. Using recursive partitioning, we identified decision thresholds at general population incidence ≥ 229 per 100,000 and at ≥ 3 positive healthcare workers. Conclusions: Beyond fixed risk factors, shared with the general population, the increased and heterogeneous proportion of positive patients is related to the center’s testing policy, the number of positive patients and healthcare workers, and to contextual effects at the province level. Nephrology centers may adopt simple decision rules to strengthen containment measures timely.

Published
2021

40. Isometric force development of single horizontal eye muscles in esotropia and exotropia

Author

SCHIAVI, COSTANTINO, BOLZANI, ROBERTO, BENASSI, MARIAGRAZIA, CAMPOS, EMILIO, LENNERSTRAND G., TIAN S., LONGO N., EUROPEAN STRABISMOLOGICAL ASSOCIATION, J.T. DE FABER, SCHIAVI C., BOLZANI R., LENNERSTRAND G., TIAN S., BENASSI M.G., LONGO N., and CAMPOS E.C.

Subjects
EXOTROPIA, genetic structures, HORIZONTAL EYE MUSCLES, sense organs, ESOTROPIA, eye diseases, ISOMETRIC MUSCLE TENSION
Abstract

A comparison was done between force development in the medial and lateral rectus muscles during saccadic movements in 8 adult patients, 2 with esotropia and 6 with exotropia who underwent surgery under topical anesthesia. Five medial rectus muscles and 8 lateral rectus muscles were studied. Isometric muscle tension was recorded with a strain gauge system from the detached muscle. Patients made saccadic eye movements with the non recorded eye. In the tension signals produced by saccades, peak tension (Fp) and steady tension (Fs) were measured. The values of Fp and Fs at different amplitudes of the saccadic eye movements were compared in the lateral and the medial rectus muscles of patients with esotropia and exotropia. There were no consistent statistical differences between values of Fp and Fs obtained in the two strabismus conditions. The force development was the same in both horizontal eye muscles of patients with esotropia and exotropia.

Published
2020
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41. Gender disparities in kidney surgery: A real-life snapshot for a large prospective, multicenter observational study (the RECORd2 Project)

Author

Mari, A., primary, Antonelli, A., additional, Tafuri, A., additional, Tellini, R., additional, Brunocilla, E., additional, Capitanio, U., additional, Di Maida, F., additional, Gontero, P., additional, Grosso, A.A., additional, Nardoni, S., additional, Li Marzi, V., additional, Longo, N., additional, Montorsi, F., additional, Porpiglia, F., additional, Porreca, A., additional, Rocco, B., additional, Simeone, C., additional, Schiavina, R., additional, Schips, L., additional, Siracusano, S., additional, Terrone, C., additional, Ficarra, V., additional, Carini, M., additional, and Minervini, A., additional

Published
2022
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42. Laparoscopic versus robotic partial nephrectomy in obese patients: Perioperative and early functional outcomes from a large contemporary series (RECORD2 project)

Author

Tellini, R., primary, Mari, A., additional, Antonelli, A., additional, Lambertini, L., additional, Bove, P., additional, Brunocilla, E., additional, Capitanio, U., additional, Checcucci, E., additional, Di Maida, F., additional, Gontero, P., additional, Longo, N., additional, Montorsi, F., additional, Porpiglia, F., additional, Porreca, A., additional, Rocco, B., additional, Schiavina, R., additional, Serni, S., additional, Simeone, C., additional, Trombetta, C., additional, Ficarra, V., additional, Carini, M., additional, and Minervini, A., additional

Published
2022
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43. Prediction of significant renal function decline after open, laparoscopic and robotic partial nephrectomy: Refinement of the Martini’s nomogram on the RECORD2 project cohort

Author

Tafuri, A., primary, Mari, A., additional, Tellini, R., additional, Antonelli, A., additional, Brunocilla, E., additional, Capitanio, U., additional, Di Maida, F., additional, Diminutto, A., additional, Gontero, P., additional, Longo, N., additional, Montorsi, F., additional, Porpiglia, F., additional, Porreca, A., additional, Rocco, B., additional, Simeone, C., additional, Schiavina, R., additional, Schips, L., additional, Siracusano, S., additional, Terrone, C., additional, Ficarra, V., additional, Carini, M., additional, and Minervini, A., additional

Published
2022
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