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14 results on '"Lontok, Erik"'

1. Barth Syndrome: Psychosocial Impact and Quality of Life Assessment

Author

Bath, Anandbir, primary, Akbilgic, Oguz, additional, Wilbanks, David, additional, Patel, Jay, additional, Wallen, Morgan, additional, Haji, Shereen, additional, Das, Arnab, additional, Alexander, John, additional, Pour-Ghaz, Issa, additional, Alkhatib, Deya, additional, Huang, Yonglin, additional, Lontok, Erik, additional, and Jefferies, John, additional

Published
2022
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6. Standard of care for lipedema in the United States

Author

Herbst, Karen L, primary, Kahn, Linda Anne, additional, Iker, Emily, additional, Ehrlich, Chuck, additional, Wright, Thomas, additional, McHutchison, Lindy, additional, Schwartz, Jaime, additional, Sleigh, Molly, additional, Donahue, Paula MC, additional, Lisson, Kathleen H, additional, Faris, Tami, additional, Miller, Janis, additional, Lontok, Erik, additional, Schwartz, Michael S, additional, Dean, Steven M, additional, Bartholomew, John R, additional, Armour, Polly, additional, Correa-Perez, Margarita, additional, Pennings, Nicholas, additional, Wallace, Edely L, additional, and Larson, Ethan, additional

Published
2021
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7. Letter to the Editor regarding Lipoedema – myths and facts, Part 1 and Part 5. European Best Practice of Lipoedema – Summary of the European Lipoedema Forum consensus. Phlebologie 2020; 49: 31–49

Author

Herbst, Karen L., additional, Kahn, Linda Anne, additional, Iker, Emily, additional, Crescenzi, Rachelle, additional, Ehrlich, Chuck, additional, Faris, Tami, additional, Wright, Thomas, additional, McHutchison, Lindy, additional, Schwartz, Jaime, additional, Lontok, Erik, additional, Schwartz, Michael S., additional, Sleigh, Molly, additional, Dean, Steven M., additional, Bartholomew, John R., additional, Armour, Polly, additional, Correa-Perez, Margarita, additional, Lisson, Kathleen H., additional, Harten, Ingrid A., additional, Pennings, Nicholas, additional, Larson, Ethan, additional, Brennan, Andrea, additional, and Zuther, Joachim, additional

Published
2020
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8. In Vitro Studies of Steriodogenic Factor-1 Sumoylation, a Post-translational Modification Critical for Adrenal and Gonadal Development

Author

Lontok, Erik Tugna

Subjects
Biochemistry, Protein inhbitor of activated STAT (PIAS), Steriodogenic Factor-1 (SF-1), SUMOylation
Abstract

Steroidogenic Factor-1 (SF-1) is a constitutively active nuclear hormone receptor, thus its post-translational modifications play an even more important role in its regulation. SF-1 is sumoylated at two sites, K119 and K194 of which the former has been shown to determine SF-1 binding specificity to sumo-sensitive response elements. The basic enzymology behind sumoylation of SF-1 K119 sumoylation is not fully understood nor optimized with the reaction taking well over 8 hours while still not reaching completion. Similarly, sensitive visualization assays are not currently available in order to facilitate kinetic studies of this in vitro reaction. This graduate work focuses on sumoylation of the SF-1 DBD with the goal of developing a more robust and sensitive in vitro system in order to assay new potential SF-1 binding sequences and apply the revamped protocol to other sumoylation substrates. Our work demonstrates that the rate-limiting step of the enzymatic reaction is the loading of the E2 enzyme, Ubc9, and pre-loading this enzyme prior to incubation with substrate dramatically enhances the rate of sumoylation. Finally, we attempt to determine how the putative E3 ligase, PIASγ, functions to enhance SF-1 sumoylation in vitro.

Published
2011

11. Reply

Author

Miller, Veronica, primary, Harrington, Patrick, additional, Howe, Anita, additional, Kieffer, Tara, additional, Lennerstrand, Johan, additional, Lenz, Oliver, additional, Lontok, Erik, additional, McPhee, Fiona, additional, Mo, Hongmei, additional, Parkin, Neil, additional, and Pilot‐Matias, Tami, additional

Published
2016
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14. Letter to the Editor regarding Lipoedema – myths and facts, Part 1 and Part 5. European Best Practice of Lipoedema – Summary of the European Lipoedema Forum consensus. Phlebologie 2020; 49: 31–49

Author

Herbst, Karen L., Kahn, Linda Anne, Iker, Emily, Crescenzi, Rachelle, Ehrlich, Chuck, Faris, Tami, Wright, Thomas, McHutchison, Lindy, Schwartz, Jaime, Lontok, Erik, Schwartz, Michael S., Sleigh, Molly, Dean, Steven M., Bartholomew, John R., Armour, Polly, Correa-Perez, Margarita, Lisson, Kathleen H., Harten, Ingrid A., Pennings, Nicholas, Larson, Ethan, Brennan, Andrea, and Zuther, Joachim

Published
2021
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