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This study aims to identify the knowledge and attitude towards emergency contraception among nursing students from a public university in Goiás--a state in Brazil. A descriptive and analytical research methodology with a quantitative approach was used, applying, from February to May 2011 a questionnaire on the sexual knowledge and attitude of students regarding emergency contraception. 178 students participated in the study. Knowledge was confirmed through the high frequency of correct answers to the questions, especially those concerning the correct time and the instructions for use (between 86%-96%). Although many students use this method, there are still some doubts about the mechanism of action, side effects and access availability (frequency of correct answers lower than 50%). We noticed the need to develop educational policies that encourage the promotion of sex education in schools and universities.

Ethnopharmacological Relevance: Rubus imperialis Cham. Schl. (Rosaceae) is frequently used in traditional medicine as hypoglycemic, antinociceptive and antiviral remedy., Materials and Methods: Swiss albino mice were distributed in eight groups for acute treatment with Rubus imperialis extract (24 h). The extract doses selected were 50, 250 and 500 mg/kg b.w. administered by gavage alone or plus to CPA (50 mg/kg b.w.) administered by intraperitoneal injection. Control groups were treated in a similar way. Analyses were performed using the comet assay, on leukocytes (collected 4 and 24h after treatment) and liver (collected 24 h after treatment), and using the micronucleus test (MN) in bone marrow cells. Cytotoxicity was assessed by scoring 200 consecutive polychromatic (PCE) and normochromatic (NCE) erythrocytes (PCE/NCE ratio)., Results and Conclusion: The main compounds identified in the Rubus imperialis extract were saponins and steroidal compounds, with niga-ichigoside and tormentic acid being the major compounds. Tested doses of Rubus imperialis extract showed no genotoxic effects on leukocytes from peripheral blood or liver cells by the comet assay. However, the MN test showed an increase in the frequency of micronucleated cells at the two higher doses tested, indicating that this extract has clastogenic/aneugenic effects on bone marrow cells at higher doses. On the other hand, for all cells evaluated, the three tested doses of the Rubus imperialis extract promoted inhibition of DNA damage induced by CPA. Despite the chemoprevention observed, the clastogenicity/aneugenicity observed suggested caution about either continuous or high-dose usage of Rubus imperialis aerial parts extract by humans., (Copyright © 2014 Elsevier Ireland Ltd. All rights reserved.)