146 results on '"Lopez, Emmanuel"'
Search Results
2. Function and expression of N-acetyltransferases 1 and 2 are altered in lymphocytes in type 2 diabetes and obesity
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Paz-Rodríguez, Víctor Alejandro, Herrera-Vargas, Diana Judith, Turiján-Espinoza, Eneida, Martínez-Leija, Miguel Ernesto, Rivera-López, Emmanuel, Hernández-González, Oswaldo, Zavala-Reyes, Daniel, García-Hernández, Mariana Haydee, Vargas-Morales, Juan Manuel, Milán-Segovia, Rosa del Carmen, and Portales-Pérez, Diana Patricia
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- 2024
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3. 2D Surface Brightness Modelling of Large 2MASS Galaxies I: Photometry and Structural Parameters
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Ríos-López, Emmanuel, Añorve, Christopher, Ibarra-Medel, Héctor J., López-Cruz, Omar, Alvira-Enríquez, Joaquín, Iacobuta, Gabriela, and Valerdi, Mabel
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Astrophysics - Astrophysics of Galaxies ,Astrophysics - Cosmology and Nongalactic Astrophysics - Abstract
We have studied a sample of 101 bright 2MASS galaxies from the Large Galaxy Atlas (LGA), whose morphologies span from early to late-types. We have generated estimates for structural parameters through a two-dimensional (2D) surface brightness photometric decomposition in the three 2MASS bands (J, H, Ks). This work represents a detailed multi-component photometric study of nearby galaxies. We report total magnitudes, effective radii, concentration indices, among other parameters, in the three 2MASS bands. We found that the integrated total magnitudes of early-type galaxies (ETGs) measured on 2MASS LGA mosaics are ~0.35 mag dimmer, when compared with images generated from IRSA image tiles service; nevertheless, when comparing late-type galaxies (LTGs) we did not find any difference. Therefore, for ETGs we present the results derived on IRSA image tiles, while for LTGs we used data from the LGA mosaics. Additionally, by combining these structural parameters with scaling relations and kinematic data, we separated classical bulges from pseudobulges. We found that ~40 % of the objects in our sample are classified as pseudobulges, which are found preferentially in LTGs. Also, our findings confirm trends reported earlier in the distributions for some physical parameters, such as S\'ersic index, B/T and q ratios. In general, our results are in agreement with previous one-dimensional studies. In a companion paper, we revise some of the scaling relations among global galaxy properties, as well as their interrelation with Supermassive Black Holes., Comment: 24 pages, 17 figures, 6 tables. Accepted for publication in MNRAS (2021 August 9)
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- 2021
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4. Night-to-night variability of objective sleep outcomes in youth Middle Eastern football players
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Lolli, Lorenzo, Bonanno, Daniele, Lopez, Emmanuel, and Di Salvo, Valter
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- 2024
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5. TOROS Optical follow-up of the Advanced LIGO-VIRGO O2 second observational campaign
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Artola, Rodolfo, Beroiz, Martin, Cabral, Juan, Camuccio, Richard, Castillo, Moises, Chavushyan, Vahram, Colazo, Carlos, Larenas, Hector Cuevas, DePoy, Darren L., Díaz, Mario C., Domínguez, Mariano, Dultzin, Deborah, Fernández, Daniela, Ferreyra, Antonio C., Fonrouge, Aldo, Franco, José, Graña, Darío, Girardini, Carla, Gurovich, Sebastián, Kanaan, Antonio, Lambas, Diego G., Lares, Marcelo, Hinojosa, Alejandro F., Hinojosa, Andrea, Hinojosa, Americo F., López-Cruz, Omar, Macri, Lucas M., Marshall, Jennifer L., Melia, Raul, Mendoza, Wendy, Castellón, José L. Nilo, Padilla, Nelson, Perez, Victor, Peñuela, Tania, Rattray, Wahltyn, Renzi, Víctor, Ríos-López, Emmanuel, Rivera, Amelia Ramírez, Ribeiro, Tiago, Rodriguez, Horacio, Sánchez, Bruno, Schneiter, Matías, Schoenell, William, Starck, Manuel, Vrech, Rubén, Quiñones, Cecilia, Tapia, Luis, Tornatore, Marina, Torres-Flores, Sergio, Vilchis, Ervin, and Zadrożny, Adam
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Astrophysics - High Energy Astrophysical Phenomena ,Astrophysics - Instrumentation and Methods for Astrophysics - Abstract
We present the results of the optical follow-up, conducted by the TOROS collaboration, of gravitational wave events detected during the Advanced LIGO-Virgo second observing run (Nov 2016 -- Aug 2017). Given the limited field of view ($\sim100\arcmin$) of our observational instrumentation we targeted galaxies within the area of high localization probability that were observable from our sites. We analyzed the observations using difference imaging, followed by a Random Forest algorithm to discriminate between real and bogus transients. For all three events that we respond to, except GW170817, we did not find any bona fide optical transient that was plausibly linked with the observed gravitational wave event. Our observations were conducted using telescopes at Estaci\'{o}n Astrof\'{\i}sica de Bosque Alegre, Cerro Tololo Inter-American Observatory, and the Dr. Cristina V. Torres Memorial Astronomical Observatory. Our results are consistent with the LIGO-Virgo detections of a binary black hole merger (GW170104) for which no electromagnetic counterparts were expected, as well as a binary neutron star merger (GW170817) for which an optical transient was found as expected., Comment: 9 pages, 4 figures
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- 2019
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6. Base excess measured at hospital admission is useful for predicting diabetic ketoacidosis severity and resolution time in adult patients
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Jasso-Avila, María Isabel, Castro-Argüelles, Alonso Alberto, Centeno-Del Toro, Sandy Mayela, Rivera-López, Emmanuel, and Valadez-Castillo, Francisco Javier
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- 2022
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7. A randomized controlled trial comparing high and medium power settings for holmium laser enucleation of prostate
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Shah, Hemendra N., Etafy, Mohamed H., Katz, Jonathan E., Garcia Lopez, Emmanuel A., and Shah, Rashmi H.
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- 2021
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8. Immediate effects of Ramadan on objective time asleep in male youth football players from the Middle East: an interrupted time-series study
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Lolli, Lorenzo, Gregson, Warren, Pulford, Adam, Kanope, Tane, Lopez, Emmanuel, Di Salvo, Valter, Lolli, Lorenzo, Gregson, Warren, Pulford, Adam, Kanope, Tane, Lopez, Emmanuel, and Di Salvo, Valter
- Abstract
Objective: To examine the abrupt effects of Ramadan onset on actigraphy-based time asleep in male youth Muslim football players. Methods: We adopted a quasi-experimental, interrupted time-series research design and tracked objective time asleep over a minimum of 12 consecutive nights in the two weeks prior to and immediately after Ramadan onset, respectively. Twenty-two, male academy student-athletes (chronological age range: 12.6 to 16.2 years) participated in the study (464 individual observations). Segmented generalized mixed-effects modelling estimated the effects of Ramadan onset on time asleep during the first period of night sleep only. Results: Ramadan onset led to an immediate mean reduction of 89 min (95% confidence interval [CI], 54 to 123 min) in time asleep during the first period of night sleep compared to pre-Ramadan sleep patterns. Model-adjusted estimated marginal means for time asleep were ~ 5.7 h (95%CI, 5.1 to 6.2 h) before and ~ 4.2 h (95%CI, 3.6 to 4.7 h) after Ramadan onset. Night sleep interruptions resulting in two or more fragmented periods accounted for 8% (95%CI, 2 to 21%) to 19% (95%, 11 to 29%) of sleep observations before and after Ramadan onset, respectively. Conclusions: The onset of Ramadan determined an abrupt reduction in time asleep of ~ 1 h 30 min in the first period of a night cycle and contributed to additional problems of heterogeneous sleep fragmentation that can impact optimal school learning and youth athlete performance development processes.
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- 2024
9. Costos directos de las hospitalizaciones por diabetes mellitus en el Instituto Mexicano del Seguro Social
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Salas-Zapata, Leonardo, Palacio-Mejía, Lina Sofía, Aracena-Genao, Belkis, Hernández-Ávila, Juan Eugenio, and Nieto-López, Emmanuel Salvador
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- 2018
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10. A survey of organizational structure and operational practices of elite youth football academies and national federations from around the world: A performance and medical perspective
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Gregson, Warren, primary, Carling, Christopher, additional, Gualtieri, Antonio, additional, O'Brien, James, additional, Reilly, Patrick, additional, Tavares, Francisco, additional, Bonanno, Daniele, additional, Lopez, Emmanuel, additional, Marques, Joao, additional, Lolli, Lorenzo, additional, and Salvo, Valter Di, additional
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- 2022
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11. Le sevrage de la ventilation invasive et non invasive chez le nouveau-né prématuré
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Lopez, Emmanuel, primary
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- 2017
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12. Les différents modes de ventilation : quelles évidences ?
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Lopez, Emmanuel, primary and Jarreau, Pierre-Henri, additional
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- 2017
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13. Le syndrome d’inhalation méconiale
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Lopez, Emmanuel, primary
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- 2017
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14. Liste des collaborateurs
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Ancel, Pierre-Yves, primary, Aujard, Yannick, additional, Baud, Olivier, additional, Bedu, Antoine, additional, Beltrand, Jacques, additional, Benachi, Alexandra, additional, Bénard, Mélinda, additional, Bertrand, Gérald, additional, Beuchée, Alain, additional, Boubred, Farid, additional, Brissaud, Olivier, additional, Busiah, Kanetee, additional, Caeymaex, Laurence, additional, Cambonie, Gilles, additional, Carré, Aurore, additional, Casper, Charlotte, additional, Cavé, Hélène, additional, Chollat, Clément, additional, Cortey, Anne, additional, de Lagausie†, Pascal, additional, De Luca, Daniele, additional, Delacourt, Christophe, additional, Durrmeyer, Xavier, additional, Epaud, Ralph, additional, Fauret, Anne-Laure, additional, Favrais, Géraldine, additional, Fleiss, Bobbi, additional, Gold, Francis, additional, Gournay, Véronique, additional, Gouyon, Béatrice, additional, Gouyon, Jean-Bernard, additional, Gressens, Pierre, additional, Gruel, Yves, additional, Iacobelli, Silvia, additional, Jacqz-Aigrain, Évelyne, additional, Jarreau, Pierre-Henri, additional, Kaplan, Cécile, additional, Kariyawasam, Dulanjalee, additional, Kermorvant, Elsa, additional, Labarthe, François, additional, Langhendries, Jean-Paul, additional, Lapillonne, Alexandre, additional, Laurence, Michel, additional, Leroux, Philippe, additional, Linglart, Agnès, additional, Lointier, Françoise, additional, Lopez, Emmanuel, additional, Marret, Stéphane, additional, Mitanchez, Delphine, additional, Moll, Marie-Christine, additional, Motte-Signoret, Emmanuelle, additional, Nouyrigat, Emmanuel, additional, Picaud, Jean-Charles, additional, Pinto-Cardoso, Gaëlle, additional, Pitard, Alexandre, additional, Pladys, Patrick, additional, Polak, Michel, additional, Raignoux, Julie, additional, Rasika, Sowmyalakshmi, additional, Renesme, Laurent, additional, Rondeau, Stéphane, additional, Roué, Jean-Michel, additional, Rozé, Jean-Christophe, additional, Saliba, Élie, additional, Saurel-Cubizolles, Marie-Josèphe, additional, Scharfmann, Raphael, additional, Simeoni, Umberto, additional, Sizun, Jacques, additional, Storme, Laurent, additional, Stoupa, Athanasia, additional, Tardieu, Marine, additional, Torchin, Héloïse, additional, Tourneux, Pierre, additional, Truffert, Patrick, additional, Vaivre-Douret, Laurence, additional, Van Steenwinckel, Juliette, additional, Vanhulle, Catherine, additional, Vayne, Caroline, additional, Vieux, Rachel, additional, Vuillerot, Carole, additional, and Wibaut, Bénédicte, additional
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- 2017
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15. A Multi-USB Ports Solar-powered charging Station for Mobile Phones in Duracurve Sheds: From Educational Perspectives
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Morales, Abraham, Lopez, Emmanuel John, Manansala, Jay, Intal, Joeth Francisco, Loria, Mark Christian, Mallari, Sherwin, and Pampo, Freneil
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Charging ,Design ,Developmental ,Lifespan ,Likert ,Mobile ,Quantitative ,Solar - Abstract
The current study proposed a design for a Multi-USB Ports Solar-powered charging Station for Mobile Phones in Duracurve Sheds of Don Honorio Ventura State University. This research specifically aimed at addressing the issue of prohibiting the students of electrical engineering at Don Honorio Ventura State University (DHVSU) to charge their mobile phones inside the classrooms. This study, as quantitative research, utilized a developmental type of method, a Likert scale type of questionnaire through electronically generated forms (google form), and a thorough data analysis. The participants were composed of twenty (20) professionals and were chosen through the use of the purposive sampling technique. The study revealed that the proposed design for the solar-powered charging station, after considering its specifications, the materials and possible cost of its installation, its expected lifespan, and the total expenditure it will take could be an alternative way to provide a solution for each student’s concern, especially for educational purposes.
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- 2022
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16. A survey of organizational structure and operational practices of elite youth football academies and national federations from around the world: a performance and medical perspective
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Gregson, Warren, Carling, Christopher, Gualtieri, Antonio, O'Brien, James, Reilly, Patrick, Tavares, Francisco, Bonanno, Daniele, Lopez, Emmanuel, Marques, Joao, Lolli, Lorenzo, Salvo, Valter D, Gregson, Warren, Carling, Christopher, Gualtieri, Antonio, O'Brien, James, Reilly, Patrick, Tavares, Francisco, Bonanno, Daniele, Lopez, Emmanuel, Marques, Joao, Lolli, Lorenzo, and Salvo, Valter D
- Abstract
Aim: Medical and performance units are integral components of player development programmes in elite football academies. Nevertheless, the nature of the operational processes implemented by practitioners within clubs and national federations remains unexplored. The aim of the present study, therefore, was to survey elite youth professional football academies from around the world regarding the operational processes adopted by their medical and performance units. Methods: Of the 50 organizations invited, 10 national federations and 25 clubs took part in the survey resulting in a response rate of 70% (95% confidence interval, 56%−81%). The respondents represented three groups: senior club and academy management, performance, and medical staff. Results: The majority (60%−90%) of clubs and national federations reported strategic alignment between senior and academy medical and performance units as well as between academy medical and performance units. Survey responses indicated substantial heterogeneity in the composition and number of medical and performance professionals employed in academies. The majority of respondents agreed their medical and performance departments were effective in utilizing staff knowledge and external sources of knowledge to inform their practice (56%−80%). Performance staff (40%−50%) and physiotherapists (30%−32%) were deemed most influential in injury prevention programmes. During the return-to-play process, the influence of specific practitioners in the medical and performance units was dependent upon the phase of return-to-play. Shared decision-making was common practice amongst performance and medical staff in injury prevention and return-to-play processes. Medical and performance data were generally centralized across the first team and academy in majority (50%−72%) of clubs and national federations. Data were integrated within the same data management system to a higher degree in clubs (68%) vs. national federations (40%). Research and d
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- 2022
17. Rougeole et grossesse
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Anselem, Olivia, Tsatsaris, Vassilis, Lopez, Emmanuel, Krivine, Anne, Le Ray, Camille, Loulergue, Pierre, Floret, Daniel, Goffinet, Francois, and Launay, Odile
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- 2012
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18. An objective description of routine sleep habits in elite youth football players from the Middle-East
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Lolli, Lorenzo, Cardinale, Marco, Lopez, Emmanuel, Maasar, Mohd Firdaus, Marthinussen, Johannes, Bonanno, Daniele, Gregson, Warren, and Di Salvo, Valter
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- 2021
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19. Detection of carbon dioxide thresholds using low-flow sidestream capnography in ventilated preterm infants
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Lopez, Emmanuel, Grabar, Sophie, Barbier, Alexandre, Krauss, Baruch, Jarreau, Pierre-Henri, and Moriette, Guy
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- 2009
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20. Use of Indocyanine Green Angiography for Real-Time Assessment of a Sternocleidomastoid Muscle Flap During Complex Facial Reconstruction
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Montorfano, Lisandro, primary, Bordes, Stephen J, additional, Sarmiento Cobos, Mauricio, additional, Garcia Lopez, Emmanuel Alejandro, additional, and Medina, Michael, additional
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- 2021
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21. Procédé de fabrication d'un substrat de composant optoelectronique et dispositifs associés
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Lopez, Emmanuel, Schlegel, Benoît, Buso, David, Zissis, Georges, LAboratoire PLasma et Conversion d'Energie (LAPLACE), Centre National de la Recherche Scientifique (CNRS)-Université Toulouse III - Paul Sabatier (UT3), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-Institut National Polytechnique (Toulouse) (Toulouse INP), Université Fédérale Toulouse Midi-Pyrénées, Centre National de la Recherche Scientifique (CNRS), Lumière et Matière (LAPLACE-LM), Université Fédérale Toulouse Midi-Pyrénées-Centre National de la Recherche Scientifique (CNRS)-Université Toulouse III - Paul Sabatier (UT3), Université Toulouse III - Paul Sabatier (UT3), and Zissis, Georges
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[SPI.OPTI] Engineering Sciences [physics]/Optics / Photonic ,[SPI.OPTI]Engineering Sciences [physics]/Optics / Photonic ,[SPI.MAT] Engineering Sciences [physics]/Materials ,[SPI.MAT]Engineering Sciences [physics]/Materials - Published
- 2020
22. Holmium Laser Enucleation of Prostate Within 6 Weeks of Transrectal Ultrasound Guided Prostate Biopsy is Safe and Effective
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Etafy, Mohamed H., primary, Katz, Jonathan E., additional, Gonzalgo, Mia R., additional, Garcia Lopez, Emmanuel Alejandro, additional, Shah, Rashmi H., additional, Banerjee, Indraneel, additional, Smith, Nicholas, additional, and Shah, Hemendra N., additional
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- 2021
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23. Prise en charge du nouveau-né prématuré hypotrophe
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Lopez, Emmanuel, primary and Jarreau, Pierre-Henri, additional
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- 2012
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24. Liste des auteurs
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Agman, Antoine, primary, Azria, Élie, additional, Baud, Olivier, additional, Benachi, Alexandra, additional, Chavatte-Palmer, Pascale, additional, Choiset, Agnès, additional, Cordier, Anne-Gaelle, additional, Coussement, Aurélie, additional, Dupont, Charlotte, additional, Dupont, Jean-Michel, additional, Ego, Anne, additional, Fontenay, Michaela, additional, Fournier, Thierry, additional, Goussot-Souchet, Michèle, additional, Grangé, Gilles, additional, Guibourdenche, Jean, additional, Jarreau, Pierre-Henri, additional, Jouannic, Jean-Marie, additional, Le Guern, Véronique, additional, Le Ray, Camille, additional, Lecarpentier, Édouard, additional, Le Meaux, Jean-Patrick, additional, Lepercq, Jacques, additional, Lopez, Emmanuel, additional, Morel, Olivier, additional, Pannier, Emmanuelle, additional, Parat, Sophie, additional, Picone, Olivier, additional, Proulx, Francine, additional, Senat, Marie-Victoire, additional, Tarrade, Anne, additional, Tsatsaris, Vassilis, additional, Vaiman, Daniel, additional, Vauloup-Fellous, Christelle, additional, and Viot, Géraldine, additional
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- 2012
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25. Vancomycin continuous infusion in neonates: dosing optimisation and therapeutic drug monitoring
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Zhao, Wei, Lopez, Emmanuel, Biran, Valérie, Durrmeyer, Xavier, Fakhoury, May, and Jacqz-Aigrain, Evelyne
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- 2013
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26. Ont collaboré à cet ouvrage
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Amara, Saad Abu, primary, Alison, Marianne, additional, Andreu-Gallien, Juliette, additional, Angoulvant, Francois, additional, Armengaud, Jean-Baptiste, additional, Arsan, Amine, additional, Azib, Sonia, additional, Azoulay, Robin, additional, Bailleux, Sylvain, additional, Bailly, Céline, additional, Banerjee, Ananda, additional, Barbarot, Sébastien, additional, Bardiaux, Laurent, additional, Baruteau, Julien, additional, Baumann, Clarisse, additional, Beydon, Nicole, additional, Bidat, Étienne, additional, Bingen, Édouard, additional, Blaysat, Gérard, additional, Blondé, Renaud, additional, Boscher, Cécile, additional, Botte, Astrid, additional, Bourdon, Olivier, additional, Bourrillon, Antoine, additional, Boyer, Olivia, additional, Brémond-Gignac, Dominique, additional, Brion, Françoise, additional, Broué, Pierre, additional, Cailho, Anne, additional, Camby, Caroline, additional, Carel, Jean-Claude, additional, Chabrol, Brigitte, additional, Chantepie, Alain, additional, Chedevergne, Frédérique, additional, Chéron, Gérard, additional, Chevallier, Bertrand, additional, Chevenne, Didier, additional, Chouraqui, Jean-Pierre, additional, Cohen, Robert, additional, Czernichow, Paul, additional, Dariel, Anne, additional, Dauger, Stéphane, additional, de Blic, Jacques, additional, De Napoli Cocci, Stephan, additional, Debray, Dominique, additional, Delacourt, Christophe, additional, Deschênes, Georges, additional, Donadieu, Jean, additional, Dossier, Claire, additional, Dubos, François, additional, Duhamel, Jean-François, additional, Dutau, Guy, additional, Duverger, Philippe, additional, Ernenwein, Didier, additional, Faye, Albert, additional, Fellus, Patrick, additional, Fila, Marc, additional, Foucaud, Pierre, additional, Fançois, Martine, additional, Gajdos, Vincent, additional, Gall, Olivier, additional, Garnier, Arnaud, additional, Gaudelus, Joël, additional, Gendrel, Dominique, additional, Gillet, Yves, additional, Girard, Nadine, additional, Girardet, Jean-Philippe, additional, Godon, Nathalie, additional, Gottrand, Frédéric, additional, Gournay, Véronique, additional, Gras-Le Guen, Christèle, additional, Grimprel, Emmanuel, additional, Guédeney, Antoine, additional, Guédeney, Nicole, additional, Haas, Hervé, additional, Hankard, Régis, additional, Hassan, Max, additional, Hentgen, Véronique, additional, Hernandorena, Xavier, additional, Holvoet-Vermaut, Laurent, additional, Houdouin, Véronique, additional, Hurtaud-Roux, Marie-Françoise, additional, Ilharreborde, Brice, additional, Imbert, Patrick, additional, Jacquin, Paul, additional, Jarreau, Pierre-Henri, additional, Javouhey, Étienne, additional, Job-Deslandre, Chantal, additional, Koné-Paut, Isabelle, additional, Kremp, Odile, additional, Krug, Pauline, additional, Labrune, Philippe, additional, Émilie Lampin, Marie, additional, Launay, Élise, additional, Lautridou, Anne, additional, Le Bourgeois, Muriel, additional, Le Guen, Hervé, additional, Le Heuzey, Marie-France, additional, Le Henaff, Gaëlle, additional, Lecendreux, Michel, additional, Lechevallier, Joël, additional, Leclair, Marc-David, additional, Léger, Juliane, additional, Leroyer, Dominique, additional, Levieux, Karine, additional, Levine, Martine, additional, Liet, Jean-Michel, additional, Lopes, David, additional, Lopez, Emmanuel, additional, Lorette, Gérard, additional, Lorrot, Mathie, additional, Macher, Marie-Alice, additional, Mallet, Éric, additional, Marchand, Martine, additional, Marcou, Valérie, additional, Maruani, Annabel, additional, Mary, Pierre, additional, Mention-Mulliez, Karine, additional, Michel, Gérard, additional, Michot, Charlotte, additional, Milh, Mathieu, additional, Minodier, Philippe, additional, Moraillon, Isabelle, additional, Mouren, Marie-Christine, additional, Narcy, Philippe, additional, The Tich, Sylvie N'guyen, additional, Parat-Lesbros, Sophie, additional, Patkai, Juliana, additional, Perel, Yves, additional, Perrier-Cornet, Emilia, additional, Picard, Capucine, additional, Picherot, Georges, additional, Polak, Michel, additional, Prot-Labarthe, Sonia, additional, Richard, Geneviève, additional, Rochcongar, Pierre, additional, Rohrlich, Pierre, additional, Roussey, Michel, additional, Roussey-Kesler, Gwénaëlle, additional, Rybojad, Michel, additional, Scavarda, Didier, additional, Schlemmer, Catherine, additional, Sebag, Guy, additional, Sellier-Leclerc, Anne-Laure, additional, Sermet-Gaudelus, Isabelle, additional, Simon, Dominique, additional, Sorge, Frédéric, additional, Stheneur, Chantal, additional, Tilea, Bogdana, additional, Treluyer, Jean-Marc, additional, Tubiana-Rufi, Nadia, additional, Tudorache, Elena, additional, Vabres, Nathalie, additional, Van Den Abbeele, Thierry, additional, Victor, Anaïs, additional, Vidailhet, Michel, additional, Villeneuve, Nathalie, additional, Vrignaud, Bénédicte, additional, Wiener-Vacher, Sylvette, additional, Wood, Chantal, additional, Zana-Taieb, Élodie, additional, and Zenaty, Delphine, additional
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- 2011
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27. VR Tracker Location and Rotation Predictions using HTC Vive Tracking System and Gradient Boosting Regressor.
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Lin Hall, Ping Wang, Blankenship, Grayson, Lopez, Emmanuel Zenil, Castro, Chris, Zhen Zhu, and Rui Wu
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MACHINE learning ,DATA - Abstract
Machine learning and virtual reality technologies have become focal points for research and development in recent years. In this study, we propose a framework to estimate and visualize the position and rotation of human spines, based on predictions made with machine learning. HTC Vive trackers are used to simulate the bone structure. Truth reference data for position and rotation are collected in the HTC system, which are used to evaluate the performance of our solution. Preliminary results show that the pose of the simulated structure can be accurately predicted. The proposed framework can be beneficial to medical training and surgical operations. [ABSTRACT FROM AUTHOR]
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- 2022
28. Capnography in spontaneously breathing preterm infants with bronchopulmonary dysplasia
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Lopez, Emmanuel, Mathlouthi, Jihene, Lescure, Sandra, Krauss, Baruch, Jarreau, Pierre-Henri, and Moriette, Guy
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- 2011
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29. High voltage pulses for high impedance loads using explosive formed fuses
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Degnan, James H., Kiuttu, Gerald F., Turchi, Peter J., Graham, Jack D., Goforth, James H., Lopez, Emmanuel A., Oona, H., and Tasker, Douglas G.
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Electric fuses -- Research ,Electric power systems -- Load dispatching ,Impedance (Electricity) -- Research ,Magnetic induction (Electromagnetic induction) -- Research ,Business ,Chemistry ,Electronics ,Electronics and electrical industries - Abstract
Explosive formed fuses (EFF's) use conducting elements that are deformed by explosive pressure (typically, against dielectric dies). This causes the fuse geometry to change, so that the conducting element cross section decreases. This enables a higher ratio of current conduction to current interrupt time than for normal fuses, and it enables more control of when current interruption occurs. In combination with a suitable output closing switch, EFF's can be used to obtain several hundred kilovolt voltage pulses from inductive stores to drive several ohm loads. With proper choices of inductive store, EFF geometry and material, and output closing switch features, such a voltage pulse can be approximately flat topped for microsecond duration and have a small fraction of microsecond risetime. We present theoretical analysis and circuit simulations which illustrate this, using scaled empirical EFF parameters for inductive stores in the 1 weber flux, several hundred nanohenry range. The circuit simulations were done using MicroCap-IV, with user defined elements. These simulations were done with static inductive stores and with explosive magnetic flux compression generators driving inductive stores. Index Terms - Explosive formed fuses, explosive magnetic flux compression, high impedance loads, high voltage pulses, inductive stores.
- Published
- 1998
30. Nitric Oxide Donor Restores Lung Growth Factor and Receptor Expression in Hyperoxia-Exposed Rat Pups
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Lopez, Emmanuel, Boucherat, Olivier, Franco-Montoya, Marie-Laure, Bourbon, Jacques R., Delacourt, Christophe, and Jarreau, Pierre-Henri
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- 2006
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31. THE EFFECTS OF POWDERED GINGER DRINK AMONG THE SELECTED STEM STUDENTS AT UNIVERSITY OF THE EAST-CALOOCAN
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Beltran, Nathalie V, Zyrell M Brucelo, Ruth, Danielle, P Hipolito, Joy, Kristian, Lopez, Emmanuel A, Villacarlos, Rico, Jestoni P Carpio, and Hipolito, Danielle Ruth
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- 2018
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32. Acceso a servicios de salud en un establecimiento penitenciario y carcelario masculino de Antioquia (Colombia), 2012
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Nieto Lopez, Emmanuel Salvador, primary, Hernández-Pacheco, Jeniffer, additional, and Mejía-Ortega, Luz M., additional
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- 2019
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33. 24 - Le syndrome d’inhalation méconiale
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Lopez, Emmanuel
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- 2017
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34. 14 - Le sevrage de la ventilation invasive et non invasive chez le nouveau-né prématuré
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Lopez, Emmanuel
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- 2017
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35. 13 - Les différents modes de ventilation : quelles évidences ?
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Lopez, Emmanuel and Jarreau, Pierre-Henri
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- 2017
- Full Text
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36. Effects on Morbidity and Mortality of Critical Episodes of PM2.5 in the City of Medellin, 2015
- Author
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Nieto Lopez, Emmanuel, primary, Grisales Romero, Hugo, additional, Montealegre, Nora Adriana, additional, Orrego, Ana Zuleima, additional, Molina, Angela Lucia, additional, and Piñeros Jiménez, Juan Gabriel, additional
- Published
- 2018
- Full Text
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37. Nutritional strategies and gut microbiota composition as risk factors for necrotizing enterocolitis in very-preterm infants
- Author
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Rozé, Jean-Christophe, primary, Ancel, Pierre-Yves, additional, Lepage, Patricia, additional, Martin-Marchand, Laetitia, additional, Al Nabhani, Ziad, additional, Delannoy, Johanne, additional, Picaud, Jean-Charles, additional, Lapillonne, Alexandre, additional, Aires, Julio, additional, Durox, Mélanie, additional, Darmaun, Dominique, additional, Neu, Josef, additional, Butel, Marie-José, additional, Rozé, Jean-Christophe, additional, Boudred, Farid, additional, Mitanchez, Delphine, additional, Casper, Charlotte, additional, Biran, Valerie, additional, Storme, Laurent, additional, Claris, Olivier, additional, Cambonie, Gilles, additional, Sizun, Jacques, additional, Sauret, Anne, additional, Dicky, Odile, additional, Lopez, Emmanuel, additional, Hascoet, Jean-Michel, additional, Gascoin, Geraldine, additional, Vieux, Rachel, additional, de Lauzon, Blandine, additional, Desfrere, Luc, additional, Chollat, Clement, additional, Butel, Marie-Jose, additional, Rousseau, Clotilde, additional, Doré, Joel, additional, Le Roux, Karine, additional, and Monot, Céline, additional
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- 2017
- Full Text
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38. El sello del sol en Chichň Itz
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Montero, Arturo, López, Emmanuel Hernández, Juárez, Berenice Ceja, Garay, Natalia Ramos, Spitalier, Nathalie Armella, Lucario, Vicente Camacho, Fundación Cultural Armella Spitalier, Montero, Arturo, López, Emmanuel Hernández, Juárez, Berenice Ceja, Garay, Natalia Ramos, Spitalier, Nathalie Armella, Lucario, Vicente Camacho, and Fundación Cultural Armella Spitalier
- Subjects
- Mayas--Mexico--Yucata´n (State)--Antiquities
- Abstract
“La dicha nos invadió la mañana del 23 de mayo de 2012 cuando fuimos testigos de la erudición ancestral reservada por siglos. Gracias a las aportaciones de tantos investigadores e informantes que nos antecedieron y a los colegas que nos compartieron su conocimiento, ese día pudimos advertir impresionados, desde la pirámide de El Castillo, cómo el Sol, durante su día de paso cenital, se levantaba perfectamente alineado sobre el vértice de la pirámide en dirección al Templo de las Mesas.”
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- 2013
39. Outsiders and Outcasts in the Mexica World
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Echeverra̕ García, Jaime, López, Emmanuel Hernández, Vekony, Rose, Juárez, Berenice Ceja, Sota, Alexandra Suberville, Spitalier, Nathalie Armella, Gómez, Jovan Rabel Guzmán, Garay, Natalia Ramos, Lucario, Vicente Camacho, Fundación Cultural Armella Spitalier, Echeverra̕ García, Jaime, López, Emmanuel Hernández, Vekony, Rose, Juárez, Berenice Ceja, Sota, Alexandra Suberville, Spitalier, Nathalie Armella, Gómez, Jovan Rabel Guzmán, Garay, Natalia Ramos, Lucario, Vicente Camacho, and Fundación Cultural Armella Spitalier
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- Social ethics--Mexico
- Abstract
The study of pre-Hispanic societies focuses not only on their most remarkable aspects—their technological developments, military exploits, political events, and economic achievements—but also on the everyday phenomena through which their ideology and identity are reproduced. One such element is the interaction between members of a community and foreigners or socially marginalized figures—those persons on the periphery of a culture who permanently transgress the prevailing social, ethico-moral, and behavioral norms.
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- 2013
40. Shoulder dystocia: guidelines for clinical practice from the French College of Gynecologists and Obstetricians (CNGOF)
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Sentilhes, Loïc, primary, Sénat, Marie-Victoire, additional, Boulogne, Anne-Isabelle, additional, Deneux-Tharaux, Catherine, additional, Fuchs, Florent, additional, Legendre, Guillaume, additional, Le Ray, Camille, additional, Lopez, Emmanuel, additional, Schmitz, Thomas, additional, and Lejeune-Saada, Véronique, additional
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- 2016
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41. Clinical Utility and Safety of a Model-Based Patient-Tailored Dose of Vancomycin in Neonates
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Leroux, Stéphanie, primary, Jacqz-Aigrain, Evelyne, additional, Biran, Valérie, additional, Lopez, Emmanuel, additional, Madeleneau, Doriane, additional, Wallon, Camille, additional, Zana-Taïeb, Elodie, additional, Virlouvet, Anne-Laure, additional, Rioualen, Stéphane, additional, and Zhao, Wei, additional
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- 2016
- Full Text
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42. THE CLINICAL UTILITY AND SAFETY OF A MODEL-BASED PATIENT-TAILORED DOSE REGIMEN OF VANCOMYCIN IN NEONATES
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Leroux, Stéphanie, primary, Biran, Valérie, additional, Lopez, Emmanuel, additional, Madeleneau, Doriane, additional, Jacqz-Aigrain, Evelyne, additional, and Zhao, Wei, additional
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- 2015
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43. The power to transform: a recent refurbishment project has transformed Binga--among the oldest hydroelectric facilities in the Philippines--into a modern, state of the art plant
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Lopez, Emmanuel G. and Santos, Rhoda S.
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Hydroelectric power plants ,Company joint venture ,Business ,Business, international ,Petroleum, energy and mining industries - Abstract
The Binga hydroelectric power facility lies in the Northern region of the Philippines, in a province called Benguet. The 100MW power plant is connected to a zoned earth, rockfill embankment [...]
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- 2014
44. Differential expression of cyclic nucleotide phosphodiesterases 4 in developing rat lung
- Author
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Lopez, Emmanuel, Jarreau, Pierre-Henri, Zana, Elodie, Franco-Montoya, Marie-Laure, Schmitz, Thomas, Evain-Brion, Danièle, Bourbon, Jacques, Delacourt, Christophe, Méhats, Céline, La grossesse normale et pathologique: développement et fonctions du placenta et de l'utérus (UMR_S 767), Institut des sciences du Médicament -Toxicologie - Chimie - Environnement (IFR71), Institut National de la Santé et de la Recherche Médicale (INSERM)-Ecole Nationale Supérieure de Chimie de Paris - Chimie ParisTech-PSL (ENSCP), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Centre National de la Recherche Scientifique (CNRS)-Institut de Recherche pour le Développement (IRD)-Université Paris Descartes - Paris 5 (UPD5)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Ecole Nationale Supérieure de Chimie de Paris - Chimie ParisTech-PSL (ENSCP), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Centre National de la Recherche Scientifique (CNRS)-Institut de Recherche pour le Développement (IRD)-Université Paris Descartes - Paris 5 (UPD5)-Université Paris Descartes - Paris 5 (UPD5)-Institut National de la Santé et de la Recherche Médicale (INSERM), PremUp Foundation, Institut National de la Santé et de la Recherche Médicale (INSERM)-Sorbonne Université (SU)-Université Paris Descartes - Paris 5 (UPD5)-CHI Créteil-Institut de Recherche pour le Développement (IRD)-Université Paris-Sud - Paris 11 (UP11)-Université Pierre et Marie Curie - Paris 6 (UPMC)-Université Paris Diderot - Paris 7 (UPD7), Service de réanimation néonatale Port-Royal, Hôpital Cochin [AP-HP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP), Institut Mondor de Recherche Biomédicale (IMRB), Institut National de la Santé et de la Recherche Médicale (INSERM)-IFR10-Université Paris-Est Créteil Val-de-Marne - Paris 12 (UPEC UP12), Maternité Port-Royal [CHU Cochin], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Hôpital Cochin [AP-HP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP), This work was supported by grants from la Chancellerie des Universités de Paris (Legs Poix 2006) and from Air Liquide Foundation., Institut de Recherche pour le Développement (IRD)-Ecole Nationale Supérieure de Chimie de Paris - Chimie ParisTech-PSL (ENSCP), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Université Paris Descartes - Paris 5 (UPD5)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Institut de Recherche pour le Développement (IRD)-Ecole Nationale Supérieure de Chimie de Paris - Chimie ParisTech-PSL (ENSCP), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Université Paris Descartes - Paris 5 (UPD5)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Université Paris Descartes - Paris 5 (UPD5)-Institut National de la Santé et de la Recherche Médicale (INSERM), Institut de Recherche pour le Développement (IRD)-Université Paris-Sud - Paris 11 (UP11)-Université Pierre et Marie Curie - Paris 6 (UPMC)-Université Paris Diderot - Paris 7 (UPD7)-CHI Créteil-Université Paris Descartes - Paris 5 (UPD5)-Institut National de la Santé et de la Recherche Médicale (INSERM), La grossesse normale et pathologique: développement et fonctions du placenta et de l'utérus ( UMR_S 767 ), Institut des sciences du Médicament -Toxicologie - Chimie - Environnement ( IFR71 ), Institut National de la Santé et de la Recherche Médicale ( INSERM ) -Ecole Nationale Supérieure de Chimie de Paris- Chimie ParisTech-PSL ( ENSCP ) -Centre National de la Recherche Scientifique ( CNRS ) -Institut de Recherche pour le Développement ( IRD ) -Université Paris Descartes - Paris 5 ( UPD5 ) -Institut National de la Santé et de la Recherche Médicale ( INSERM ) -Ecole Nationale Supérieure de Chimie de Paris- Chimie ParisTech-PSL ( ENSCP ) -Centre National de la Recherche Scientifique ( CNRS ) -Institut de Recherche pour le Développement ( IRD ) -Université Paris Descartes - Paris 5 ( UPD5 ) -Université Paris Descartes - Paris 5 ( UPD5 ) -Institut National de la Santé et de la Recherche Médicale ( INSERM ), Institut de Recherche pour le Développement ( IRD ) -Université Paris-Sud - Paris 11 ( UP11 ) -Université Pierre et Marie Curie - Paris 6 ( UPMC ) -Université Paris Diderot - Paris 7 ( UPD7 ) -CHI Créteil-Université Paris Descartes - Paris 5 ( UPD5 ) -Sorbonne Universités-Institut National de la Santé et de la Recherche Médicale ( INSERM ), CHU Cochin [AP-HP], Institut Mondor de Recherche Biomédicale ( IMRB ), Institut National de la Santé et de la Recherche Médicale ( INSERM ) -IFR10-Université Paris-Est Créteil Val-de-Marne - Paris 12 ( UPEC UP12 ), and Assistance publique - Hôpitaux de Paris (AP-HP)-CHU Cochin [AP-HP]
- Subjects
[SDV.BBM]Life Sciences [q-bio]/Biochemistry, Molecular Biology ,[ SDV.BBM ] Life Sciences [q-bio]/Biochemistry, Molecular Biology - Abstract
International audience; During the perinatal period, lungs undergo changes to adapt to air breathing. The genes involved in these changes are developmentally regulated by various signaling pathways, including the cyclic nucleotide cAMP. As PDE4s are critical enzymes for regulation of cAMP levels, the objective of this study was to investigate PDE4's ontogeny in developing rat lung during the perinatal period. Pulmonary PDE4 activity, PDE4A-D, PDE4B, and PDE4D variant expression levels, PDE4B and PDE4D protein levels, and PDE4D localization in distal lung were determined. PDE4 activity increased towards term, dropped at birth, and increased thereafter to reach a plateau at the end of the second week of life. PDE4B2 and PDE4D long forms demonstrated a pattern of expression that increased markedly at birth. After birth, PDE4D was expressed in alveolar epithelial and mesenchymal cells. The study, therefore, evidenced striking variations in expression patterns among the PDE4 family that differed from changes in global PDE4 activity.
- Published
- 2010
45. PDE4 in developing rat lung
- Author
-
Lopez, Emmanuel, Jarreau, Pierre-Henri, Zana, Elodie, Franco-Montoya, Marie-Laure, Schmitz, Thomas, Evain-Brion, Danièle, Bourbon, Jacques, Delacourt, Christophe, Méhats, Céline, La grossesse normale et pathologique: développement et fonctions du placenta et de l'utérus (UMR_S 767), Institut des sciences du Médicament -Toxicologie - Chimie - Environnement (IFR71), Institut de Recherche pour le Développement (IRD)-Ecole Nationale Supérieure de Chimie de Paris - Chimie ParisTech-PSL (ENSCP), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Université Paris Descartes - Paris 5 (UPD5)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Institut de Recherche pour le Développement (IRD)-Ecole Nationale Supérieure de Chimie de Paris - Chimie ParisTech-PSL (ENSCP), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Université Paris Descartes - Paris 5 (UPD5)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Université Paris Descartes - Paris 5 (UPD5)-Institut National de la Santé et de la Recherche Médicale (INSERM), PremUp Foundation, Institut de Recherche pour le Développement (IRD)-Université Paris-Sud - Paris 11 (UP11)-Université Pierre et Marie Curie - Paris 6 (UPMC)-Université Paris Diderot - Paris 7 (UPD7)-CHI Créteil-Université Paris Descartes - Paris 5 (UPD5)-Institut National de la Santé et de la Recherche Médicale (INSERM), Service de réanimation néonatale Port-Royal, Hôpital Cochin [AP-HP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP), Institut Mondor de Recherche Biomédicale (IMRB), Institut National de la Santé et de la Recherche Médicale (INSERM)-IFR10-Université Paris-Est Créteil Val-de-Marne - Paris 12 (UPEC UP12), Maternité Port-Royal [CHU Cochin], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Hôpital Cochin [AP-HP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP), This work was supported by grants from la Chancellerie des Universités de Paris (Legs Poix 2006) and from Air Liquide Foundation., and Méhats, Céline
- Subjects
[SDV.BBM] Life Sciences [q-bio]/Biochemistry, Molecular Biology ,[SDV.BBM]Life Sciences [q-bio]/Biochemistry, Molecular Biology - Abstract
International audience; During the perinatal period, lungs undergo changes to adapt to air breathing. The genes involved in these changes are developmentally regulated by various signaling pathways, including the cyclic nucleotide cAMP. As PDE4s are critical enzymes for regulation of cAMP levels, the objective of this study was to investigate PDE4's ontogeny in developing rat lung during the perinatal period. Pulmonary PDE4 activity, PDE4A-D, PDE4B, and PDE4D variant expression levels, PDE4B and PDE4D protein levels, and PDE4D localization in distal lung were determined. PDE4 activity increased towards term, dropped at birth, and increased thereafter to reach a plateau at the end of the second week of life. PDE4B2 and PDE4D long forms demonstrated a pattern of expression that increased markedly at birth. After birth, PDE4D was expressed in alveolar epithelial and mesenchymal cells. The study, therefore, evidenced striking variations in expression patterns among the PDE4 family that differed from changes in global PDE4 activity.
- Published
- 2010
46. Efficacy of a First Course of Ibuprofen for Patent Ductus Arteriosus Closure in Extremely Preterm Newborns According to Their Gestational Age-Specific Z-Score for Birth Weight
- Author
-
Madeleneau, Doriane, primary, Aubelle, Marie-Stephanie, additional, Pierron, Charlotte, additional, Lopez, Emmanuel, additional, Patkai, Juliana, additional, Roze, Jean-Christophe, additional, Jarreau, Pierre-Henri, additional, and Gascoin, Geraldine, additional
- Published
- 2015
- Full Text
- View/download PDF
47. Effects of phosphodiesterase 4 inhibition on alveolarization and hyperoxia toxicity in newborn rats.: PDE4 inhibition and alveolar development
- Author
-
Méhats, Céline, Franco-Montoya, Marie-Laure, Boucherat, Olivier, Lopez, Emmanuel, Schmitz, Thomas, Zana, Elodie, Evain-Brion, Danièle, Bourbon, Jacques, Delacourt, Christophe, Jarreau, Pierre-Henri, La grossesse normale et pathologique: développement et fonctions du placenta et de l'utérus (UMR_S 767), Institut des sciences du Médicament -Toxicologie - Chimie - Environnement (IFR71), Institut National de la Santé et de la Recherche Médicale (INSERM)-Ecole Nationale Supérieure de Chimie de Paris - Chimie ParisTech-PSL (ENSCP), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Centre National de la Recherche Scientifique (CNRS)-Institut de Recherche pour le Développement (IRD)-Université Paris Descartes - Paris 5 (UPD5)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Ecole Nationale Supérieure de Chimie de Paris - Chimie ParisTech-PSL (ENSCP), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Centre National de la Recherche Scientifique (CNRS)-Institut de Recherche pour le Développement (IRD)-Université Paris Descartes - Paris 5 (UPD5)-Université Paris Descartes - Paris 5 (UPD5)-Institut National de la Santé et de la Recherche Médicale (INSERM), PremUp Foundation, Institut National de la Santé et de la Recherche Médicale (INSERM)-Sorbonne Université (SU)-Université Paris Descartes - Paris 5 (UPD5)-CHI Créteil-Institut de Recherche pour le Développement (IRD)-Université Paris-Sud - Paris 11 (UP11)-Université Pierre et Marie Curie - Paris 6 (UPMC)-Université Paris Diderot - Paris 7 (UPD7), Institut Mondor de recherche biomédicale (IMRB), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Paris-Est Créteil Val-de-Marne - Paris 12 (UPEC UP12), This work was supported by a Legs Poix grant of la Chancellerie des Universités de Paris 2006, Institut de Recherche pour le Développement (IRD)-Ecole Nationale Supérieure de Chimie de Paris - Chimie ParisTech-PSL (ENSCP), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Université Paris Descartes - Paris 5 (UPD5)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Institut de Recherche pour le Développement (IRD)-Ecole Nationale Supérieure de Chimie de Paris - Chimie ParisTech-PSL (ENSCP), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Université Paris Descartes - Paris 5 (UPD5)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Université Paris Descartes - Paris 5 (UPD5)-Institut National de la Santé et de la Recherche Médicale (INSERM), Institut de Recherche pour le Développement (IRD)-Université Paris-Sud - Paris 11 (UP11)-Université Pierre et Marie Curie - Paris 6 (UPMC)-Université Paris Diderot - Paris 7 (UPD7)-CHI Créteil-Université Paris Descartes - Paris 5 (UPD5)-Institut National de la Santé et de la Recherche Médicale (INSERM), La grossesse normale et pathologique: développement et fonctions du placenta et de l'utérus ( UMR_S 767 ), Institut des sciences du Médicament -Toxicologie - Chimie - Environnement ( IFR71 ), Institut National de la Santé et de la Recherche Médicale ( INSERM ) -Ecole Nationale Supérieure de Chimie de Paris- Chimie ParisTech-PSL ( ENSCP ) -Centre National de la Recherche Scientifique ( CNRS ) -Institut de Recherche pour le Développement ( IRD ) -Université Paris Descartes - Paris 5 ( UPD5 ) -Institut National de la Santé et de la Recherche Médicale ( INSERM ) -Ecole Nationale Supérieure de Chimie de Paris- Chimie ParisTech-PSL ( ENSCP ) -Centre National de la Recherche Scientifique ( CNRS ) -Institut de Recherche pour le Développement ( IRD ) -Université Paris Descartes - Paris 5 ( UPD5 ) -Université Paris Descartes - Paris 5 ( UPD5 ) -Institut National de la Santé et de la Recherche Médicale ( INSERM ), Institut de Recherche pour le Développement ( IRD ) -Université Paris-Sud - Paris 11 ( UP11 ) -Université Pierre et Marie Curie - Paris 6 ( UPMC ) -Université Paris Diderot - Paris 7 ( UPD7 ) -CHI Créteil-Université Paris Descartes - Paris 5 ( UPD5 ) -Sorbonne Universités-Institut National de la Santé et de la Recherche Médicale ( INSERM ), Institut Mondor de recherche biomédicale ( IMRB ), and Institut National de la Santé et de la Recherche Médicale ( INSERM ) -Université Paris-Est Créteil Val-de-Marne - Paris 12 ( UPEC UP12 )
- Subjects
MESH: Inflammation ,MESH: Pulmonary Alveoli ,MESH : Phosphodiesterase Inhibitors ,MESH: Rats ,MESH : Cyclic Nucleotide Phosphodiesterases, Type 4 ,MESH: Phosphodiesterase Inhibitors ,lung inflammation ,MESH: Animals, Newborn ,MESH: Hyperoxia ,MESH: Rolipram ,bronchopulmonary dysplasia ,MESH : Lung Injury ,MESH: Animals ,[SDV.BBM]Life Sciences [q-bio]/Biochemistry, Molecular Biology ,phosphodiesterases ,[ SDV.BBM ] Life Sciences [q-bio]/Biochemistry, Molecular Biology ,alveolar development ,MESH : Inflammation ,rolipram ,MESH : Rats ,MESH : Animals, Newborn ,MESH : Weight Gain ,respiratory system ,respiratory tract diseases ,MESH : Rolipram ,MESH: Lung Injury ,MESH : Hyperoxia ,MESH: Weight Gain ,MESH : Animals ,MESH : Pulmonary Alveoli ,MESH: Cyclic Nucleotide Phosphodiesterases, Type 4 - Abstract
International audience; BACKGROUND: Prolonged neonatal exposure to hyperoxia is associated with high mortality, leukocyte influx in airspaces, and impaired alveolarization. Inhibitors of type 4 phosphodiesterases are potent anti-inflammatory drugs now proposed for lung disorders. The current study was undertaken to determine the effects of the prototypal phosphodiesterase-4 inhibitor rolipram on alveolar development and on hyperoxia-induced lung injury. METHODOLOGY/FINDINGS: Rat pups were placed under hyperoxia (FiO2>95%) or room air from birth, and received rolipram or its diluent daily until sacrifice. Mortality rate, weight gain and parameters of lung morphometry were recorded on day 10. Differential cell count and cytokine levels in bronchoalveolar lavage and cytokine mRNA levels in whole lung were recorded on day 6. Rolipram diminished weight gain either under air or hyperoxia. Hyperoxia induced huge mortality rate reaching 70% at day 10, which was prevented by rolipram. Leukocyte influx in bronchoalveolar lavage under hyperoxia was significantly diminished by rolipram. Hyperoxia increased transcript and protein levels of IL-6, MCP1, and osteopontin; rolipram inhibited the increase of these proteins. Alveolarization was impaired by hyperoxia and was not restored by rolipram. Under room air, rolipram-treated pups had significant decrease of Radial Alveolar Count. CONCLUSIONS: Although inhibition of phosphodiesterases 4 prevented mortality and lung inflammation induced by hyperoxia, it had no effect on alveolarization impairment, which might be accounted for by the aggressiveness of the model. The less complex structure of immature lungs of rolipram-treated pups as compared with diluent-treated pups under room air may be explained by the profound effect of PDE4 inhibition on weight gain that interfered with normal alveolarization.
- Published
- 2008
48. Liste des collaborateurs
- Author
-
Ancel, Pierre-Yves, Aujard, Yannick, Baud, Olivier, Bedu, Antoine, Beltrand, Jacques, Benachi, Alexandra, Bénard, Mélinda, Bertrand, Gérald, Beuchée, Alain, Boubred, Farid, Brissaud, Olivier, Busiah, Kanetee, Caeymaex, Laurence, Cambonie, Gilles, Carré, Aurore, Casper, Charlotte, Cavé, Hélène, Chollat, Clément, Cortey, Anne, de Lagausie†, Pascal, De Luca, Daniele, Delacourt, Christophe, Durrmeyer, Xavier, Epaud, Ralph, Fauret, Anne-Laure, Favrais, Géraldine, Fleiss, Bobbi, Gold, Francis, Gournay, Véronique, Gouyon, Béatrice, Gouyon, Jean-Bernard, Gressens, Pierre, Gruel, Yves, Iacobelli, Silvia, Jacqz-Aigrain, Évelyne, Jarreau, Pierre-Henri, Kaplan, Cécile, Kariyawasam, Dulanjalee, Kermorvant, Elsa, Labarthe, François, Langhendries, Jean-Paul, Lapillonne, Alexandre, Laurence, Michel, Leroux, Philippe, Linglart, Agnès, Lointier, Françoise, Lopez, Emmanuel, Marret, Stéphane, Mitanchez, Delphine, Moll, Marie-Christine, Motte-Signoret, Emmanuelle, Nouyrigat, Emmanuel, Picaud, Jean-Charles, Pinto-Cardoso, Gaëlle, Pitard, Alexandre, Pladys, Patrick, Polak, Michel, Raignoux, Julie, Rasika, Sowmyalakshmi, Renesme, Laurent, Rondeau, Stéphane, Roué, Jean-Michel, Rozé, Jean-Christophe, Saliba, Élie, Saurel-Cubizolles, Marie-Josèphe, Scharfmann, Raphael, Simeoni, Umberto, Sizun, Jacques, Storme, Laurent, Stoupa, Athanasia, Tardieu, Marine, Torchin, Héloïse, Tourneux, Pierre, Truffert, Patrick, Vaivre-Douret, Laurence, Van Steenwinckel, Juliette, Vanhulle, Catherine, Vayne, Caroline, Vieux, Rachel, Vuillerot, Carole, and Wibaut, Bénédicte
- Published
- 2017
- Full Text
- View/download PDF
49. Impact of Common Treatments Given in the Perinatal Period on the Developing Brain
- Author
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Favrais, Géraldine, primary, Tourneux, Pierre, additional, Lopez, Emmanuel, additional, Durrmeyer, Xavier, additional, Gascoin, Géraldine, additional, Ramful, Duksha, additional, Zana-Taieb, Elodie, additional, and Baud, Olivier, additional
- Published
- 2014
- Full Text
- View/download PDF
50. Der Nationalpark Port-Cros = Le Parc national de Port-Cros
- Author
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Lopez, Emmanuel and Montmollin, Bertrand de
- Published
- 2002
- Full Text
- View/download PDF
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