176 results on '"Lorenzo, Ana"'
Search Results
2. Un nuevo título de formación musical: experto universitario en métodos y recursos de educación musical
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Lorenzo, Ana I.
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Music and books on Music - Abstract
El artículo pretende dar a conocer la iniciativa de un grupo de profesores de la Universidad de La Laguna sensibles a los resultados del análisis del contexto social, científico y profesional de la Educación Musical en Canarias, que puso de manifiesto la necesidad de atender a la formación que demandaban los diversos colectivos responsables de la formación musical en nuestra Comunidad. Al amparo de la normativa que regula los estudios de postgrado surge el Título Propio de la Universidad de La Laguna Experto Universitario en Métodos y Recursos de Educación Musical con la finalidad de completar la formación académica musical de los titulados universitarios, de los que han cursado las Enseñanzas de Régimen Especial y de los profesionales de cualquier ámbito musical; ofreciéndoles la posibilidad de perfeccionar su desarrollo profesional, científico, técnico y artístico.
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- 2005
3. El aula de música
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Lorenzo, Ana I. and Racionero, Dácil E.
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Music and books on Music - Abstract
La configuración arquitectónica, la distribución espacial y el equipamiento material del entorno en el que interacciona el profesorado y el alumnado refleja un modelo educativo implícito cuya influencia sobre las actividades, experiencias y aprendizajes merece ser considerada. Teniendo en cuenta esto, hemos querido contrastar la realidad existente con las recomendaciones respecto al patrón de aula de Música que propone la Administración.El objetivo del presente trabajo consiste en estudiar y describir de una manera objetiva, sistemática y crítica el entorno espacial donde se desarrolla la Educación Musical y derivar de ello algunas consideraciones y recomendaciones en aras a mejorar la calidad de la docencia.Las propuestas sugeridas, fruto de contrastar la realidad del medio con las sugerencias de la Administración, aconsejan la adopción de medidas tendentes a subsanar las deficiencias detectadas. En aras a optimizar los recursos, la Administración debería atender tanto a la dotación de material yformación del profesorado, como a la mejora de las condiciones espaciales donde se imparte la Educación Musical, especialmente en la actualidad, cuando nos encontramos inmersos en un periodo de construccióny renovación de los centros para adecuar las edificaciones a las nuevas Etapas educativas.Entendemos, además, que las propuestas formuladas han de ser tomadas como tales, constituyendo una orientación que ha de ser analizada, valorada y ponderada por la comunidad educativa y por la Administración, ya que sólo así estimamos que podría contribuir a mejorar la calidad educativa.
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- 2000
4. Correction to: Transcultural adaptation and validation of IMPACT-III and IMPACT-III-P in Spanish families: a multicenter study from SEGHNP
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Rodríguez-Belvís, Marta Velasco, Palomino, Laura, Pujol-Muncunill, Gemma, Martin-Masot, Rafael, Benítez, Enrique Medina, Fernández-Lorenzo, Ana Estefanía, Moreno-Álvarez, Ana, Arias, Manuel Molina, Montes, Inmaculada Hidalgo, Torres, Josefa Barrio, Navas-López, Víctor Manuel, and de Carpi, Javier Martín
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- 2024
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5. Sex Differences in Chronic Postsurgical Pain after Open Thoracotomy
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Roca, Gisela, Sabate, Sergi, Serrano, Ancor, Benito, María Carmen, Pérez, María, Revuelta, Miren, Lorenzo, Ana, Busquets, Jordi, Rodríguez, Gema, Sanz, David, Jiménez, Anabel, Parera, Ana, de la Gala, Francisco, and Montes, Antonio
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- 2024
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6. Blood gene expression biomarkers of response to anti-TNF drugs in pediatric inflammatory bowel diseases before initiation of treatment
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Salvador-Martín, Sara, Rubbini, Gianluca, Vellosillo, Perceval, Zapata-Cobo, Paula, Velasco, Marta, Palomino, Laura M., Clemente, Susana, Segarra, Oscar, Moreno-Álvarez, Ana, Fernández-Lorenzo, Ana, Pérez-Moneo, Begoña, Montraveta, Montserrat, Sánchez, Cesar, Tolín, Mar, Loverdos, Inés, Fobelo, María José, Navas-López, Victor Manuel, Magallares, Lorena, García-Romero, Ruth, Torres-Peral, Ricardo, Rodríguez, Alejandro, Bossacoma, Ferrán, Merino-Bohórquez, Vicente, Salcedo, Enrique, Álvarez, Rebeca, Dopazo, Ana, Sanjurjo-Sáez, María, and López-Fernández, Luis A.
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- 2024
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7. Assessment of cystic fibrosis related liver disease in a pediatric cohort
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Vicente-Santamaría, Saioa, Torres-Guerrero, María Emilia, García-González, Miguel, Tabares-González, Ana, Gascón-Galindo, Celia, López-Cárdenes, Concepción Marina, Blitz-Castro, Enrique, Morales-Tirado, Ana, Mota-Goitia, María Inmaculada, Gutiérrez-Martínez, José Ramón, Tutau-Gómez, Carlos, García-Romero, Ruth, Salcedo-Lobato, Enrique, Peña-Quintana, Luis, Reyes-Domínguez, Ana, Torcuato-Rubio, Encarnación, Ortiz-Pérez, Pilar, Fernández-Lorenzo, Ana Estefanía, Moreno-Álvarez, Ana, Solar-Boga, Alfredo, Romero-Rey, Henar, Álvarez-Beltrán, Marina, Masip-Simó, Etna, and González-Jiménez, David
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- 2024
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8. Polymorphisms indicating risk of inflammatory bowel disease or antigenicity to anti-TNF drugs as biomarkers of response in children
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Zapata-Cobo, Paula, Salvador-Martín, Sara, Velasco, Marta, Palomino, Laura M., Clemente, Susana, Segarra, Oscar, Moreno-Álvarez, Ana, Fernández-Lorenzo, Ana, Pérez-Moneo, Begoña, Montraveta, Montserrat, Sánchez, Cesar, Tolín, Mar, Loverdos, Inés, Fobelo, María Jesús, Navas-López, Victor Manuel, Magallares, Lorena, García-Romero, Ruth, Sánchez-Hernández, José Germán, Rodríguez, Alejandro, Bossacoma, Ferrán, Balboa, María Jesús, Salcedo, Enrique, Sanjurjo-Sáez, María, and López-Fernández, Luis A.
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- 2023
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9. The landscape of hematology research in Brazil: an analysis of data from citation databases
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De Paula, Erich Vinicius, Martins, Marcio Souza, De Lorenzo, Ana Luisa Bortoluzo, Duarte, Bruno Kosa Lino, Rezende, Suely Meireles, and Costa, Fernando Ferreira
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- 2023
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10. Presbycusis and balance disorders in the elderly. Bibliographical review of ethiopathogenic aspects, consequences on quality of life and positive effects of its treatment
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Manrique, Manuel Jesús, Batuecas, Ángel, Cenjor, Carlos, Ferrán, Sol, Gómez, Justo Ramón, Lorenzo, Ana Isabel, Marco, Jaime, Matiñó, Eusebi, Morant, Antonio, Morera, Constantino, Pérez, Nicolás, Polo, Rubén, Ramos, Ángel, Sánchez, Serafín, and Nuñez, Faustino
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- 2023
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11. Presbiacusia y trastornos del equilibrio en personas mayores. Revision bibliográfica de aspectos etiopatogénicos, consecuencias sobre la calidad de vida y efectos positivos de su tratamiento
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Manrique, Manuel Jesús, Batuecas, Ángel, Cenjor, Carlos, Ferrán, Sol, Gómez, Justo Ramón, Lorenzo, Ana Isabel, Marco, Jaime, Matiñó, Eusebi, Morant, Antonio, Morera, Constantino, Pérez, Nicolás, Polo, Rubén, Ramos, Ángel, Sánchez, Serafín, and Nuñez, Faustino
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- 2023
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12. Pregnancy-Associated Plasma Protein A (PAPP-A) as a Predictor of Third Trimester Obesity: Insights from the CRIOBES Project.
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Gabaldón-Rodríguez, Inmaculada, de Francisco-Montero, Carmen, Menéndez-Moreno, Inmaculada, Balongo-Molina, Álvaro, Gómez-Lorenzo, Ana Isabel, Rodríguez-García, Rubén, Vilches-Arenas, Ángel, and Ortega-Calvo, Manuel
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THIRD trimester of pregnancy ,PREGNANCY complications ,OBESITY in women ,SYSTOLIC blood pressure ,BLOOD proteins ,PREGNANCY - Abstract
Introduction: Our objective in this article was to develop a predictive model for obesity in the third trimester of pregnancy using the plasma and clinical biomarkers that are managed within the Chromosomopathies Programme in the Andalusian Public Healthcare System. Methods: The epidemiological design was observational, of the unmatched case–control type. The geographical environment was the Seville Primary Healthcare District (DSAP Sevilla). The information was collected between 2011 and 2021. The reference cohort consisted of women who had carried a pregnancy to term. The variables and biomarkers studied correspond to those managed within the primary-care Pregnancy Integrated Care Pathway (ICP). Unconditional binary logistic regression (BLR) models were created, with the outcome variable being whether or not the women were obese in their third trimester of pregnancy. Results: A total of 423 controls and 104 cases of obesity were obtained for women in their third trimester who had not been obese in their first trimester. The average age for the sample group (P50) was 34 years old. The final, most parsimonious model included the variables PAPP-A (p = 0.074), beta-hCG (p = 0.1631), and systolic blood pressure (SBP) (p = 0.085). ROC curve = 0.75 (C.I. at 95%: 0.63–0.86). Discussion: The results of this research can only be extrapolated to primary care and to pregnancies with no complications. PAPP-A has been shown in our research to be a significant predictor of obesity risk in the third trimester of pregnancies with no complications (OR = 0.53; C.I. at 95%: 0.39–0.66; p = 0.04 in the single-variant study; OR = 0.58; C.I. at 95%: 0.29–0.93; p = 0.074 in the multi-variant analysis). This predictive capacity is further enhanced from an operational perspective by beta-hCG and 12-week SBP. [ABSTRACT FROM AUTHOR]
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- 2024
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13. Polymorphisms of the Vitamin D Binding Protein (VDBP) and Free Vitamin D in Patients with Cystic Fibrosis.
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Quesada-Colloto, Paula, Avello-Llano, Noelia, García-Romero, Ruth, Garriga-García, María, Álvarez-Beltrán, Marina, Reyes-Domínguez, Ana Isabel, Fernández-Lorenzo, Ana Estefanía, Gil-Peña, Helena, Gómez-Alonso, Carlos, García-Gil-Albert, Carmen, Vicente-Santamaria, Saioa, Peña-Quintana, Luis, Díaz-Martin, Juan José, Gutiérrez-Martínez, José Ramon, Martin-Fernández, Carmen, Mano-Hernández, Agustín De la, Moreno-Álvarez, Ana, and González-Jiménez, David
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Objectives/Background: Vitamin D-binding protein (VDBP) and free vitamin D are new markers that are being studied as a possible markers of vitamin D status. The main aim of our study was to analyze the VDBP genotype and quantify the levels of free vitamin D in a sample of cystic fibrosis (CF) patients. Methods: We conducted a multicenter, cross-sectional, and prospective study including patients with CF and exocrine pancreatic insufficiency who were clinically stable. We investigated vitamin D levels (total and free) and the different VDBP haplotypes. Free vitamin D levels were measured using an electro-chemiluminescence assay. Results: A sample of 48 patients was obtained (52% male; median age 13.8 years). The most common allele of VDBP was Gc1s (72%) > Gc2 (52%) > Gc1f (27%). The median calcidiol was 21.2 ng/mL (IR 15.3–26.9), and 81% had levels in the insufficiency range: 23 patients (48%) below 20 ng/mL, and 16 (33%) between 20 and 30 ng/mL. The median free vitamin D level was 4.2 pg/mL (IR 3.9–5.6). A positive correlation was observed between calcidiol and free vitamin D levels (r = 0.871; p < 0.0001). After adjustment for season, vitamin D supplementation, sex, and CF-related diabetes, patients with Gc1f polymorphism had a lower risk of vitamin D deficiency, OR 0.22 (95% CI 0.05–0.99), and p = 0.027. A negative linear trend was observed between the polymorphisms grouped into three categories (Gc1/Gc1, Gc1/Gc2, and Gc2/Gc2, in that order) and vitamin D and free vitamin D levels (p = 0.025 and p = 0.033, respectively). Conclusion: In CF, as in the general population, the most common VDBP haplotype in the Caucasian race is Gc1s. VDBP polymorphisms influence serum vitamin D and free vitamin D levels in CF patients. There is a good correlation between free vitamin D and calcidiol levels, suggesting that measuring the latter in CF does not seem to provide any additional benefit. [ABSTRACT FROM AUTHOR]
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- 2024
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14. Aplicación de pruebas para mejorar la usabilidad de un portal universitario
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Rodríguez Lorenzo, Ana Berenice, primary
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- 2024
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15. Diseño y desarrollo de un juguete infantil basado en el método Montessori de enseñanza
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Reyna San Lorenzo, Ana, Úbeda Blanco, Marta, Universidad de Valladolid. Escuela de Ingenierías Industriales, Reyna San Lorenzo, Ana, Úbeda Blanco, Marta, and Universidad de Valladolid. Escuela de Ingenierías Industriales
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El presente Trabajo de Fin de Grado se enfoca en el diseño y desarrollo de un juguete infantil basado en la pedagogía Montessori, cuyo propósito es acompañar a los niños durante su crecimiento. Este juguete fomenta el desarrollo de habilidades motoras y capacidades como el pensamiento lógico, la imaginación y la creatividad. Está fabricado en madera, con un diseño minimalista y sencillo, empleando colores vivos que atraen la atención de los niños. Además de su función lúdica, puede utilizarse como elemento decorativo. El proyecto incluye el diseño del packaging, una parte esencial del producto. Este no sólo sirve para transportar y proteger el contenido, sino que también transmite la identidad del juguete y los valores de la marca, añadiendo valor al producto y atrayendo visualmente al consumidor., This Final Degree Project focuses on the design and development of a children's toy based on the Montessori pedagogy, with the purpose of accompanying children during their growth. This toy encourages the development of motor skills and abilities such as logical thinking, imagination, and creativity. It is made of wood, featuring a minimalist and simple design, using bright colors that capture children's attention. In addition to its playful function, it can also be used as a decorative element. The project includes the design of the packaging, an essential part of the product. This packaging not only serves to transport and protect the content, but also conveys the toy's identity and the brand's values, adding value to the product and making it visually appealing to the consumer., Departamento de Urbanismo y Representación de la Arquitectura, Grado en Ingeniería en Diseño Industrial y Desarrollo de Producto
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- 2024
16. Mortality after pulmonary embolism in patients with diabetes. Findings from the RIETE registry
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Miguel Díez, Javier De, López De Andrés, Ana Isabel, Jiménez Trujillo, Isabel, Hernández Barrera, Valentín, Jiménez García, Rodrigo, Lorenzo, Ana, Pedrajas Navas, José María, Visonà, Adriana, López Miguel Patricia, Monreal, Manuel, Miguel Díez, Javier De, López De Andrés, Ana Isabel, Jiménez Trujillo, Isabel, Hernández Barrera, Valentín, Jiménez García, Rodrigo, Lorenzo, Ana, Pedrajas Navas, José María, Visonà, Adriana, López Miguel Patricia, and Monreal, Manuel
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Background: Among patients presenting with pulmonary embolism (PE), those with diabetes are at increased risk to die than those without diabetes. The reasons have not been identified. We used the RIETE (Registro Informatizado Enfermedad Trombo Embólica) database to compare the mortality rate and the causes of death during anticoagulation in patients with PE according to the presence or absence of diabetes. Methods: A matched retrospective cohort study from consecutively enrolled patients in RIETE, from 179 hospitals in 24 countries. For each patient with diabetes we selected two patients with no diabetes matched by age, sex and year of diagnosis of the PE. Results: As of September 2017, there were 2010 PE patients with diabetes and two age-and-gender matched controls. Mean age was 74 ± 11 years, 46% were men. Patients with diabetes were more likely to have co-morbidities, to be using antiplatelets and to have more severe PE. During anticoagulation (median, 219 days), patients with diabetes had a higher mortality (hazard ratio [HR]: 1.45; 95% confidence intervals [CI]: 1.25-1.67) and a higher rate of arterial ischemic events (HR: 2.89; 95%CI: 1.71-4.94) than those without diabetes. On multivariable analysis, diabetes was not associated with an increased risk for death (HR: 1.26; 95%CI: 0.97-1.63). We also failed to find differences according to the use of antiplatelet drugs concomitantly. Conclusions: In our cohort of patients with PE, diabetes was not an independent predictor for death. The influence of arterial events or antiplatelet drugs (if any) was low., Depto. de Medicina, Fac. de Medicina, TRUE, pub
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- 2024
17. The effect of low doses of cadmium and zinc chloride on the Blood-Testis Barrier of Sprague Dawley rats
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Redondo, Andrea, Romero, Raquel, Lorenzo, Ana, Sanz, Noelia, Durán, Esther, Oltra, Beatriz, Pozuelo, José Manuel, Santamaría, Luis, and Arriazu, Riánsares
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Quantitative Biology - Tissues and Organs - Abstract
Background: Cadmium chloride is an environmental toxic that affects the male reproductive system. This study was directed 1) to evaluate whether long-term oral exposures to low doses of Cd in rats causes morphological changes, 2) the immunohistochemical TJ and AJ protein expression; and 3) to evidence that zinc exposure can modify Cd effects. Methods: Testis of normal rats and rats that have received Cd or Cd+Zn in drinking water during 12 months did not show any morphological change. Immunohistochemistry was used to identify BTB integrity, claudin-1, ZO-1, N-Cadherin and {\beta}-catenin were detected by immunohistochemistry and IOD were measure. Results: No immunoexpression changes of claudin-1 and ZO-1 were observed. Cd + Zn group showed a significant increase of IOD of N-Cadherin, and a significant decrease of {\beta}-catenin and transferrin immunoexpression was observed. Conclusions: Ours findings showed that the intake of low oral doses of cadmium chloride over a long time period of time did not cause morphological variation on rat testis. Neither alteration on BTB was found. Zinc chloride was able to strengthen TJ and AJ, and decrease transferrin. Key words: Testis prostate, cadmium, zinc, TJ, AJ, immunohistochemistry, Comment: 7 pages, 4 figures, 1 table
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- 2012
18. Transcultural adaptation and validation of IMPACT-III and IMPACT-III-P in Spanish families: A multicenter study from SEGHNP
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Rodríguez-Belvís, Marta Velasco, primary, Palomino, Laura, additional, Muncunill, Gemma Pujol, additional, Martin-Masot, Rafael, additional, Benítez, Enrique Medina, additional, Fernández-Lorenzo, Ana Estefanía, additional, Moreno-Álvarez, Ana, additional, Arias, Manuel Molina, additional, Montes, Inmaculada Hidalgo, additional, Torres, Josefa Barrio, additional, Navas-López, Víctor Manuel, additional, and de Carpi, Javier Martín, additional
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- 2024
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19. Impact of pediatric inflammatory bowel disease on caregivers' work productivity: A multicenter study by the SEGHNP.
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Velasco Rodríguez‐Belvís, Marta, Palomino, Laura, Pujol Muncunill, Gemma, Martin‐Masot, Rafael, Muñoz Codoceo, Rosa Ana, Barrio Torres, Josefa, Navas‐López, Víctor Manuel, Martín de Carpi, Javier, Benítez, Enrique Medina, Fernández‐Lorenzo, Ana Estefanía, Moreno‐Álvarez, Ana, Arias, Manuel Molina, Montes, Inmaculada Hidalgo, Ruf, Ana Lozano, Blasco‐Alonso, Javier, Montraveta, Montserrat, Peña‐Quintana, Luis, Rueda, Natalia Ramos, Martínez, Alejandro Rodríguez, and Arcos, Gonzalo Botija
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- 2024
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20. Comments on: Polymorphisms indicating risk of inflammatory bowel disease or antigenicity to anti-TNF drugs as biomarkers of response in children
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Zapata-Cobo, Paula, primary, Salvador-Matín, Sara, additional, Velasco, Marta, additional, Palomino, Laura M., additional, Clemente, Susana, additional, Segarra, Oscar, additional, Moreno-Álvarez, Ana, additional, Fernández-Lorenzo, Ana, additional, Pérez-Moneo, Begoña, additional, Montraveta, Montse, additional, Sánchez, Cesar, additional, Tolín, Mar, additional, Loverdos, Inés, additional, Fobelo, María José, additional, Navas-López, Victor Manuel, additional, Magallares, Lorena, additional, García-Romero, Ruth, additional, Sánchez-Hernández, José Germán, additional, Rodríguez, Alejandro, additional, Bossacoma, Ferrán, additional, Balboa, María Jesús, additional, Salcedo, Enrique, additional, Sanjurjo-Sáez, María, additional, and López-Fernández, Luis A., additional
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- 2023
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21. Targeted and untargeted metabolomics and lipidomics in dried blood microsampling: Recent applications and perspectives.
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Couacault, Pauline, Avella, Dennisse, Londoño‐Osorio, Sara, Lorenzo, Ana S., Gradillas, Ana, Kärkkäinen, Olli, Want, Elizabeth, and Witting, Michael
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METABOLOMICS ,LIPIDOMICS ,DRUG monitoring ,FORENSIC toxicology ,FETAL monitoring ,MEDICAL screening - Abstract
Blood microsampling (BµS) offers an alternative to conventional methods that use plasma or serum for profiling human health, being minimally invasive and cost effective, especially beneficial for vulnerable populations. We present a non‐systematic review that offers a synopsis of the analytical methods, applications and perspectives related to dry blood microsampling in targeted and untargeted metabolomics and lipidomics research in the years 2022 and 2023. BµS shows potential in neonatal and paediatric studies, therapeutic drug monitoring, metabolite screening, biomarker research, sports supervision, clinical disorders studies and forensic toxicology. Notably, dried blood spots and volumetric absorptive microsampling options have been more extensively studied than other volumetric technologies. Therefore, we suggest that a further investigation and application of the volumetric technologies will contribute to the use of BµS as an alternative to conventional methods. Conversely, we support the idea that harmonisation of the analytical methods when using BµS would have a positive impact on its implementation. [ABSTRACT FROM AUTHOR]
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- 2024
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22. Association between HLA DNA Variants and Long-Term Response to Anti-TNF Drugs in a Spanish Pediatric Inflammatory Bowel Disease Cohort
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Salvador Martín, Sara, Zapata Cobo, Paula, Velasco, Marta, Palomino Pérez, Laura María, Clemente, Susana, Segarra, Oscar, Sánchez Sánchez, César, Tolín, Mar, Moreno Álvarez, Ana, Fernández Lorenzo, Ana, Pérez-Moneo Agapito, María Begoña, Loverdos, Inés, Navas López, Victor Manuel, Millán Jiménez, Antonio, Magallares, Lorena, Torres Peral, Ricardo, García Romero, Ruth, Pujol Muncunill, Gemma, Merino Bohórquez, Vicente, Rodríguez, Alejandro, Salcedo, Enrique, López Cauce, Beatriz, Marín Jiménez, Ignacio, Menchén Viso, Luis Alberto, Laserna Mendieta, Emilio, Lucendo Villarín, Alfredo J., Sanjurjo Sáez, María, López Fernández, Luis A., Salvador Martín, Sara, Zapata Cobo, Paula, Velasco, Marta, Palomino Pérez, Laura María, Clemente, Susana, Segarra, Oscar, Sánchez Sánchez, César, Tolín, Mar, Moreno Álvarez, Ana, Fernández Lorenzo, Ana, Pérez-Moneo Agapito, María Begoña, Loverdos, Inés, Navas López, Victor Manuel, Millán Jiménez, Antonio, Magallares, Lorena, Torres Peral, Ricardo, García Romero, Ruth, Pujol Muncunill, Gemma, Merino Bohórquez, Vicente, Rodríguez, Alejandro, Salcedo, Enrique, López Cauce, Beatriz, Marín Jiménez, Ignacio, Menchén Viso, Luis Alberto, Laserna Mendieta, Emilio, Lucendo Villarín, Alfredo J., Sanjurjo Sáez, María, and López Fernández, Luis A.
- Abstract
This research was funded by Instituto de Salud Carlos III, grant number PI19/00792 (L.A.L.-F.) and Juan Rodes program JR19/00005 (E.L.-M.), by Instituto de Investigación Sanitaria Gregorio Marañón, grant number 2021-II-postdoc-01 (S.S.-M.), and by Consejería de Educación, Universidades, Ciencia y Portavocía Comunidad de Madrid, grant number PEJ-2021-AI/BMD-21866 (P.Z.-C.). The study was co-funded by the European Union., The genetic polymorphisms rs2395185 and rs2097432 in HLA genes have been associated with the response to anti-TNF treatment in inflammatory bowel disease (IBD). The aim was to analyze the association between these variants and the long-term response to anti-TNF drugs in pediatric IBD. We performed an observational, multicenter, ambispective study in which we selected 340 IBD patients under 18 years of age diagnosed with IBD and treated with anti-TNF drugs from a network of Spanish hospitals. Genotypes and failure of anti-TNF drugs were analyzed using Kaplan-Meier curves and Cox logistic regression. The homozygous G allele of rs2395185 and the C allele of rs2097432 were associated with impaired long-term response to anti-TNF drugs in children with IBD after 3 and 9 years of follow-up. Being a carrier of both polymorphisms increased the risk of anti-TNF failure. The SNP rs2395185 but not rs2097432 was associated with response to infliximab in adults with CD treated with infliximab but not in children after 3 or 9 years of follow-up. Conclusions: SNPs rs2395185 and rs2097432 were associated with a long-term response to anti-TNFs in IBD in Spanish children. Differences between adults and children were observed in patients diagnosed with CD and treated with infliximab., European Union, Consejería de Educación, Universidades, Ciencia y Portavocía Comunidad de Madrid, Instituto de Salud Carlos III, Juan Rodes program, Instituto de Investigación Sanitaria Gregorio Marañón, Depto. de Medicina, Fac. de Medicina, TRUE, pub
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- 2023
23. Prognostic significance of plasma chloride in elderly patients hospitalized for acute heart failure
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Llàcer, Pau, primary, Croset, François, additional, Núñez, Julio, additional, Campos, Jorge, additional, Fernández, Cristina, additional, Fabregate, Martín, additional, Del Hoyo, Beatriz, additional, Ruiz, Raúl, additional, López, Genoveva, additional, Tello, Susana, additional, Lorenzo, Ana, additional, Fernández, José María, additional, and Manzano, Luis, additional
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- 2023
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24. Contribution of the National Mycology Laboratory Network to Surveillance of Cryptococcosis in Argentina
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Mazza, Mariana, Davel, Graciela O., Taverna, Constanza G., Refojo, Nicolás, Canteros, Cristina E., Bueno, Nadia S., Isla, Guillermina, Abrantes, Ruben A., Hevia, Alejandra I., Toranzo, Adriana I., Albera, Adriana R., Tuduri, Alicia, Mariñansky, Ana Laura, D’ Angelo, Cecilia, Santiso, Gabriela María, Turcazo, Gabriela, Posse, Gladys Beatriz, Vallespi, Graciela, Gullo, Hebe, Herrera, Jorge Osvaldo, Pidalá, Silvina, Verona, Julián, Pereyra, Ricardo, Morvay, Laura, Psenda, Laura, Bardi, Leticia, Jorda, Liliana Vargas, Giampaoli, Luis Fernando, Schiaffino, María Anastasia, Lovigne, María Antonia, Pérez, Johana, de Magistris, María, Jofré, María Estela, Tacchella, María Eugenia, Psenda, Laura, Zuiani, María Fernanda, Zuliani, María Victoria, Allende, Miguel Angel García, Machain, Mónica, Moretti, Mónica, Sparo, Mónica, Featherston, Patricia L., Capece, Paula, Franco, Raul J., Mónaco, Liliana, Traverso, Silvia, Altamiranda, Stella Maris, Pérez, Susana, Chávez, Claudio, Sallaber, Susana, Ardizzoli, Karina, Monzani, Victoria, Farfán, Silvia, Rubio, Mirian, González, Vilma Ruth, del V. David, Viviana, Lorenzo, Ana Cecilia, Dakoff, Ana María Zaloff, Giusiano, Gustavo, Tracogna, María Fernanda, de Jiménez, Marisa Gunia, Cech, Norma E., Barrera, Claudia Ileana, Berry, Diana, de Quiros, Marcia Bernaldo, Ricciardi, Mirian, Sorge, Adriana, Arechavala, Alicia, Santiso, Gabriela María, Fernández, Analía, Burkett, Andrés, Alfonso, Claudia, Garbasz, Claudia, Paternay, Eugenia, Vázquez, Raúl, Snitman, Gabriela, Maldonado, Ivana, Mucci, Josefina, Lancillota, Antonio, Rébori, Juan Antonio, Bustamante, Juan Cruz, Zalazar, Natalia, Moral, Laura López, Guelfand, Liliana, del C. Perrone, María, Romeo, Ana María, Gallego, María José, Coco, Bárbara, Schijman, Mariela, López, Mónica Estela, Franco, Nora, Fernández, Norma, Tiraboschi, Nora, Minervini, Patricia, Pereda, Rosana, Cataldi, Silvana Patricia, Relloso, Silvia, Smayevski, Jorgelina, de Costabella, Claudia Aimaretto, Carballo, Graciela Mariel, Fraenza, Laura Beatriz, Rustan, María Elena, Jiménez, María Graciela, Borletto, Noemí Lucía, Montanaro, Patricia, Orecchini, Alejandra, Carrizo, Silvia, Littvik, Ana, Pato, Ana María, González, Etel Mariel, de los Angeles Sosa, María, Ferrero, Susana Marta, Almará, Adriana, Posse, Graciela, de Canteros, Maria Cristina Schaab, Yoya, Norma, Carballo, Ricardo G., de Tichellio, Ana Gladys, Formosa, Patricia, Miranda, Carola, González, Lidia Estela, de Pizarro, María Rosa Mernes, Baroni, Andrea, Casabona, Luis Marcelo, Saavedra, Romina, Romanazzi, Adriana, Zanuso, Ada, Ampuero, Adela, Pagella, Hugo, Rosaenz, Liliana Beatriz, Urrea, Mirta, Berducci, Octavio Carlos, Rúffolo, Selva Myriam, Leguizamón, Anastacio Romero, Rodriguez, Beda Elizabeth Mereles, Vedoya, Maria Celina, Gerlach, Erica, Doubnia, María Inés, Von Specht, Martha, Pino, Ana Lidia, Codorniú, Carlos Eduardo, Chavarría, Esther, Campion, Guadalupe, Echenique, Luz, Schinchirimini, María Martha, Britez, Myriam, Rihl, Norma, Kissner, Claudia, Durany, Daniela Alejandra, Suppo, Gabriel Carlos, Suárez, Laura, Rivollier, María Gabriela, Roncallo, Mariela, Chavarría, R. Esther, De Bunder, Sabrina, Cruz, Emilce, Dávalos, Florencia, Amador, Silvia, Cacace, María Luisa, Chacón, Yone Alejandra, Castro, Hugo, Carrió, Virginia, Navarro, Roberto, López, Marisa, Melo, Maria Carolina, Sánchez, César Omar, Martínez, Javier, Bonardello, Nelsa María, Lopresti, Roberto, Hasuoka, Raul, Vargas, Alejandra V., Villegas, Josefina, Cicconetti, María Laura, Luque, Alicia, Gómez, Carlos, Amigot, Susana, Ferrero, Claudia, Colombo, Laura, Nardín, María Elena, Argaraña, María Fernanda, Rico, Marina, Sellarés, Otilia, Ramírez, Rodrigo, de Ronchi, Stella Maris Virgolini, Martínez, Doris, Serrano, Julián, Guerra, Alejandra, Boutureira, Manuel, Gorostiaga, José Luis, Runco, Rosa, Antich, Constanza, and National Mycology Laboratory Network of Argentina (NMLN)
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- 2017
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25. Association between HLA DNA Variants and Long-Term Response to Anti-TNF Drugs in a Spanish Pediatric Inflammatory Bowel Disease Cohort
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Salvador-Martín, Sara, primary, Zapata-Cobo, Paula, additional, Velasco, Marta, additional, Palomino, Laura M., additional, Clemente, Susana, additional, Segarra, Oscar, additional, Sánchez, Cesar, additional, Tolín, Mar, additional, Moreno-Álvarez, Ana, additional, Fernández-Lorenzo, Ana, additional, Pérez-Moneo, Begoña, additional, Loverdos, Inés, additional, Navas López, Victor Manuel, additional, Millán, Antonio, additional, Magallares, Lorena, additional, Torres-Peral, Ricardo, additional, García-Romero, Ruth, additional, Pujol-Muncunill, Gemma, additional, Merino-Bohorquez, Vicente, additional, Rodríguez, Alejandro, additional, Salcedo, Enrique, additional, López-Cauce, Beatriz, additional, Marín-Jiménez, Ignacio, additional, Menchén, Luis, additional, Laserna-Mendieta, Emilio, additional, Lucendo, Alfredo J., additional, Sanjurjo-Sáez, María, additional, and López-Fernández, Luis A., additional
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- 2023
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26. Capítulo 9 - Enfermera de práctica avanzada y enfermedades neurológicas. Esclerosis múltiple y enfermedad de Parkinson
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Andrés, Ana Hernando and Lorenzo, Ana Cámara
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- 2023
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27. The Role of Partial Enteral Nutrition for Induction of Remission in Crohn’s Disease: A Systematic Review of Controlled Trials
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González-Torres, Lucía, primary, Moreno-Álvarez, Ana, additional, Fernández-Lorenzo, Ana Estefanía, additional, Leis, Rosaura, additional, and Solar-Boga, Alfonso, additional
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- 2022
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28. Tobacco control campaign in Uruguay: a population-based trend analysis
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Abascal, Winston, Esteves, Elba, Goja, Beatriz, Mora, Franco González, Lorenzo, Ana, Sica, Amanda, Triunfo, Patricia, and Harris, Jeffrey E
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- 2012
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29. Evaluación de resultados del proyecto educativo alcohol: Conciencia con ciencia del programa ARGOS-Región de Murcia de prevención del consumo de alcohol en alumnado de 1º de Educación Secundaria Obligatoria
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Medina Infante, Berta Almudena, Villar Lorenzo, Ana Belen, Puerta Ortuño, Consuelo, López Davis, Sylvia, Monteagudo Piqueras, O., Medina Infante, Berta Almudena, Villar Lorenzo, Ana Belen, Puerta Ortuño, Consuelo, López Davis, Sylvia, and Monteagudo Piqueras, O.
- Abstract
Background: Alcohol: Conciencia con ciencia is an educational-community universal prevention project for 12-year-old students (1st of ESO) which consists of three sessions and it is being implemented every school year since 2012. The objective was to evaluate its effect on alcohol consumption, attitudes and knowledge in the subsequent courses (2nd and 3rd of ESO), in order to know its durability. Methods: It is a cross-sectional observational study in different phases (applied in October and April), quasi-experimental with a comparison group. In the 2017/2018 academic year, all 2nd (n=2,892) and 3rd of ESO (n=2,601) students completed a questionnaire based on knowledge, opinions and consumption patterns in selected educational centers (18 centers in 13 municipalities). Statistical analysis: chi-square tests of contingency and difference of differences. Results: The number of students who started drinking is less in the intervention group during the subsequent school year, with differences between groups (31.5% vs. 36.6% in October, and 35.9% vs. 43.4% in April) (October p=0.037, April p=0.006) and difference in negative differences in favour of the intervention (-2.6%), more pronounced in girls (-8.1%). Although the study includes alcohol, the greatest perception of risk extends to tobacco and cannabis. The effect on knowledge maintained the following year, being the differences statistically significant. The group pressure recognized by those who suffer it was significantly higher during 2nd of ESO in the comparison group (October p=0.002, April p=0.015), being its durability longer in girls. Conclusions: The intervention stops the beginning of consumption, drunkenness and every-week consumption the hole next school year (2nd ESO) after intervention, but in 3rd of ESO the effect of the intervention disappears, being therefore necessary to reinforce it with the implementation of the project Drogas: ALTACAN in 2nd of ESO., Fundamentos: Alcohol: Conciencia con ciencia es un proyecto educativo-comunitario de prevención universal para alumnado de 12 años (1º ESO) que consta de tres sesiones y se desarrolla desde 2012 cada curso escolar. El objetivo de este trabajo fue evaluar su efecto en el consumo de alcohol, actitudes y conocimientos en cursos posteriores (segundo y tercero), para conocer su durabilidad. Métodos: Estudio observacional transversal en distintas fases (octubre/abril), cuasiexperimental con grupo comparación. Se realizó en centros educativos seleccionados (18 centros, 13 municipios) el curso 2017/2018, completando todo el alumnado de 2º (2.892) y 3º ESO (2.601) un cuestionario de conocimientos, opiniones y consumos. Análisis estadístico: pruebas chi-cuadrado de contingencia y diferencia de las diferencias. Resultados: Fue menor el alumnado que inició el consumo en el grupo intervención durante el curso escolar posterior, con diferencias entre grupos (31,5% frente a 36,6% en octubre y 35,9% frente al 43,4% en abril) (octubre p=0,037, abril p=0,006) y diferencia de las diferencias negativa a favor de la intervención (-2,6%), más acusada en chicas (-8,1%). Aunque trabajó el alcohol, se extendió esta mayor percepción de riesgo al tabaco y el cánnabis. El efecto en conocimientos se mantuvo el siguiente curso, con diferencias estadísticamente significativas. La presión de grupo reconocida por el que la sufrió, fue significativamente mayor durante 2º ESO en grupo comparación (octubre p=0,002, abril p=0,015), más duradera en chicas. Conclusiones: La implementación de este proyecto frena el inicio del consumo de alcohol, borracheras y consumo todas las semanas, durante todo el siguiente curso escolar (2º ESO) a la intervención, en 3º ESO el efecto de la intervención desaparece siendo necesario reforzar con Drogas: ALTACAN en 2º.
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- 2022
30. A highly unstable and elusive plasmid that encodes the type III secretion system is necessary for full virulence in the marine fish pathogen photobacterium damselae subsp. piscicida
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Universidade de Santiago de Compostela. Departamento de Microbioloxía e Parasitoloxía, Abushattal, Saqr, Vences Lorenzo, Ana, Rodríguez Osorio, Carlos, Universidade de Santiago de Compostela. Departamento de Microbioloxía e Parasitoloxía, Abushattal, Saqr, Vences Lorenzo, Ana, and Rodríguez Osorio, Carlos
- Abstract
The marine bacterium Photobacterium damselae subsp. piscicida (Pdp) causes photobacteriosis in fish and important financial losses in aquaculture, but knowledge of its virulence factors is still scarce. We here demonstrate that an unstable plasmid (pPHDPT3) that encodes a type III secretion system (T3SS) is highly prevalent in Pdp strains from different geographical origins and fish host species. We found that pPHDPT3 undergoes curing upon in vitro cultivation, and this instability constitutes a generalized feature of pPHDPT3-like plasmids in Pdp strains. pPHDPT3 markers were detected in tissues of naturally-infected moribund fish and in the Pdp colonies grown directly from the fish tissues but were undetectable in a fraction of the colonies produced upon the first passage of the primeval colonies on agar plates. Notably, cured strains exhibited a marked reduction in virulence for fish, demonstrating that pPHDPT3 is a major virulence factor of Pdp. The attempts to stabilize pPHDPT3 by insertion of antibiotic resistance markers by allelic exchange caused an even greater reduction in virulence. We hypothesize that the existence of a high pressure to shed pPHDPT3 plasmid in vitro caused the selection of clones with off-target mutations and gene rearrangements during the process of genetic modification. Collectively, these results show that pPHDPT3 constitutes a novel, hitherto unreported virulence factor of Pdp that shows a high instability in vitro and warn that the picture of Pdp virulence genes has been historically underestimated, since the loss of the T3SS and other plasmid-borne genes may have occurred systematically in laboratories for decades
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- 2022
31. Parkinson’s Progression Markers Initiative (PPMI) Online expands biomarker research in Parkinson’s disease (PD) (P9-11.006)
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Brown, Ethan, primary, Alonso, David, additional, Chahine, Lana, additional, Coffey, Christopher, additional, Dobkin, Roseanne, additional, Korell, Monica, additional, Lorenzo, Ana, additional, Marras, Connie, additional, Poewe, Werner, additional, Sherer, Todd, additional, Siderowf, Andrew, additional, Simuni, Tanya, additional, Tolosa, Eduardo, additional, Weintraub, Daniel, additional, Chowdhury, Sohini, additional, Marek, Kenneth, additional, and Tanner, Caroline, additional
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- 2022
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32. Experiencia: Seguimiento a I Cohorte del Plan Especial de Becas. Programa Profesionalizacion en Servicio. Escuela de Educacion. Universidad Metropolitana
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Lorenzo, Ana and Bello, María Eugenia
- Published
- 2015
33. Conocimiento y valoración del profesorado sobre la necesidad de la enfermería escolar y sus competencias
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Crespo Lorenzo, Ana Belén, Pérez Jorge, David, Crespo Lorenzo, Ana Belen, and Máster Univ. Intervención Psicopedagógica Contex. Educ. Formal y no Formal
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El objetivo de este estudio es conocer la opinión del profesorado en ejercicio en las etapas de Educación Infantil, Primaria y Secundaria, sobre la necesidad de la enfermería escolar en los centros educativos en Canarias. Para ello se llevó a cabo un estudio cuantitativo, no paramétrico, transversal, con finalidad descriptiva y analítica, con el fin de recoger la valoración del profesorado sobre las competencias que podría desempeñar la enfermería escolar en los centros educativos. La muestra está constituida por 262 profesores/as ejerciendo actualmente en centros públicos, privados y concertados de la Comunidad Autónoma de Canarias, con edades comprendidas entre los 22 y 65 años. Para la recogida de datos se utilizó un cuestionario Ad hoc, que permitió constatar que el profesorado considera que las competencias presentadas son más propias de la enfermería escolar que de su profesión, aunque, debido a la ausencia de esta figura en los centros educativos, sean ellos los que asumen y desempeñan esas funciones. Asimismo, manifestaron la necesidad de la presencia de esta figura, pudiendo resolver situaciones de emergencia que se dan durante la jornada escolar, así como el desempeño de otras funciones. The objective of this study is to know the opinion of practicing teachers in the Early Childhood, Primary and Secondary Education stages on the need for school nursing in educational centers in the Canary Islands. For this purpose, a quantitative, nonparametric, cross-sectional study was carried out, with a descriptive and analytical purpose, in order to collect the teachers' assessment of the competencies that school nursing could perform in educational centers. The sample is made up of 262 teachers currently practicing in public, private and subsidized centers in the Autonomous Community of the Canary Islands, aged between 22 and 65 years. For data collection, there is an ad hoc questionnaire, which confirms that teachers consider that the specified competences are more typical of school nursing than of their profession, although, due to the absence of this figure in educational centers, it is they who assume and perform these functions. Likewise, they expressed the need for the presence of this figure, being able to resolve emergency situations that occur during the school day, as well as the performance of other functions
- Published
- 2021
34. La proyección de relaxin-3 sobre el núcleo supramaxilar. Implicaciones sobre la memoria
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Reverte Lorenzo, Ana, Olucha Bordonau, Francisco Eliseo, and Universitat Jaume I. Unitat Predepartamental de Medicina.
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relaxin3 ,Grau en Medicina ,hippocampus ,Bachelor's Degree in Medicine ,hipocampo ,supramamillary region ,nucleus incertus ,Grado en Medicina ,región supramamilar - Abstract
Treball Final de Grau en Medicina. Codi: MD1158. Curs acadèmic: 2020/2021 El hipocampo constituye el órgano central de procesamiento de la memoria explícita. Su actividad está modulada por proyecciones subcorticales con origen en los cuerpos mamilares y en el núcleo incertus. Estas dos estructuras participan en la generación del ritmo theta hipocámpico, una onda de 4 a 12 Hz del potencial de campo asociada a la memoria espacial. Los cuerpos mamilares son la principal estructura afectada en el síndrome de Korsakoff resulta en una amnesia global. Los cuerpos mamilares y el hipocampo reciben proyecciones desde el núcleo incertus y, en este sentido, nuestra hipótesis es que esta proyección juega un papel relevante en la generación de memoria. El objetivo de este estudio es la comprobación de la existencia de conexión sináptica entre el núcleo incertus y las neuronas supramamilares con proyección hipocámpica. Para ello, se han realizado inyecciones del trazador retrógrado fluorogold en el hipocampo y a la vez del anterógrado BDA en el núcleo incertus. En estos casos, se observó que, efectivamente, en el núcleo supramamilar lateral aparecían neuronas marcadas con fluorogold que tenían a su alrededor fibras marcadas con BDA. En estas mismas preparaciones se hizo un triple revelado para observar, además, la presencia del marcador sináptico sinaptofisina. Se observó que, efectivamente, las fibras marcadas anterógradamente que se localizaban en la proximidad de somas marcados retrógtadamente contenían el marcador sináptico. Por lo tanto, el núcleo incertus envía fibras a los cuerpos mamilares que realizan contactos sinápticos con las neuronas de este centro que proyectan al hipocampo. The hippocampus is considered to be the central organ for processing explicit memory. Its activity is modulated by subcortical projections originating from the mammillary bodies and the nucleus incertus. These two structures participate in the generation of the hippocampal theta rhythm, a 4 to 12 Hz wave of the field potential associated with spatial memory. The mammillary bodies are the main structure affected in Korsakoff syndrome resulting in global amnesia. The mammillary bodies and the hippocampus receive projections from the nucleus incertus and, in this sense, our hypothesis is that this projection plays a relevant role in memory generation. The aim of this study is to verify the occurrence of a synaptic connection between the nucleus incertus and hippocampally projecting supramamillary neurons. To do this, injections of the retrograde fluorogold tracer have been made in the hippocampus and at the same time the antegrade BDA in the nucleus incertus. In these cases, it was observed that, indeed, in the lateral supramamillary nucleus there were fluorogold neurons surrounded by BDA labeled fibers. In these same preparations, a triple development was made to observe, in addition, the occurrence of the synaptic marker synaptophysin. It was observed that, indeed, anterograde labeled fibers that were located in the vicinity of retrograde labeled somata contained the synaptic marker. Therefore, the nucleus incertus sends fibers to the mammillary bodies that make synaptic contacts with the neurons of this center that project to the hippocampus.
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- 2021
35. Alteraciones del equilibrio en pacientes menores de 16 años distribuidos por grupos de edad
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Manrique Lipa, Rubén Duilio, Soto Varela, Andrés, Santos Pérez, Sofía, Manrique Lipa, Roslyn Kathryn, Lorenzo Lorenzo, Ana Isabel, and Labella Caballero, Torcuato
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- 2008
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36. Alterations of Balance in Patients Under 16 Years of Age Distributed by Age Groups
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Manrique Lipa, Rubén Duilio, Soto Varela, Andrés, Santos Pérez, Sofía, Manrique Lipa, Roslyn Kathryn, Lorenzo Lorenzo, Ana Isabel, and Labella Caballero, Torcuato
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- 2008
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37. Cribado neonatal y estudio genético: condicionantes clínico-epidemiológicos y del pronóstico en la fibrosis quística. Área sanitaria A Coruña-Cee
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Fernández Lorenzo, Ana Estefanía, Leis Trabazo, María Rosaura, Couce Pico, María Luz (dir.), Moreno Álvarez, Ana, Universidade de Santiago de Compostela. Escola de Doutoramento Internacional (EDIUS), Universidade de Santiago de Compostela. Programa de Doutoramento en Investigación Clínica en Medicina, and Couce Pico, María de la Luz
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función pulmonar ,estudio genético ,cribado neonatal ,Investigación::32 Ciencias médicas::3205 Medicina interna::320503 Gastroenterología [Materias] ,Investigación::32 Ciencias médicas::3201 Ciencias clínicas::320102 Genética clínica [Materias] ,CFTR ,Investigación::32 Ciencias médicas::3205 Medicina interna::320508 Enfermedades pulmonares [Materias] ,Fibrosis Quística - Abstract
En el presente trabajo se analiza el impacto del cribado neonatal como método de detección para el diagnóstico de la Fibrosis Quística, se describen las características clínicoepidemiológicas y se examina la influencia de determinadas variables en el curso evolutivo (sexo, estado nutricional, función pancreática y presencia de mutación ΔF508), estableciéndose factores pronósticos. La muestra estudiada presenta una mayor heterogeneidad alélica y edad media superior que las descritas en Europa. El cribado neonatal se asocia a un mejor pronóstico en la muestra estudiada. El sexo femenino se relaciona con una peor evolución, siendo la función pulmonar el factor más influyente en el pronóstico.
- Published
- 2021
38. Oda a la existencia
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Gomila Lorenzo, Ana and Coll, Tónia, 1965
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Painting ,Human figure in art ,Figura humana en l'art ,Bachelor's theses ,Arts ,Pintura ,Treballs de fi de grau - Abstract
Treballs Finals de Grau de Belles Arts. Facultat de Belles Arts. Universitat de Barcelona, Curs: 2019-2020, Tutor: Coll Florit, Antonia, [spa] Teniendo como punto de partida el cuerpo, basándome en la intensidad y el espacio, nace un proceso artístico en el cual exploro los conflictos que surgen de mi propia existencia. La intensidad entendida como un proceso de tensión entre la obra y el espectador, entre la obra y el yo, entre la obra y el entorno, entre otros, y el espacio como método de articulación de las obras, pero también como espacio de trabajo, como diálogo directo entre el yo y lo que me rodea. Nace de la necesidad de expresar, pensar y reflexionar sobre cuestiones como la cultura, la política, el género, la vulnerabilidad, la frustración… Es un proceso de tensión entre la identidad del yo y la obra., [eng] An artistic process is born taking the body as a starting point, based on intensity and space. In this project I explore the conflicts that arise from my own existence. Intensity understood as a process of tension between the work and the spectator, the work and the self, the work and the environment, among others. And space understood as a method of articulation of the works, but also as a work space, as a direct dialogue between the self and my surroundings. It arises from necessity to express, think and reflect on issues such as culture, politics, gender, vulnerability, frustration... It is a process of tension between the identity and the work.
- Published
- 2020
39. Study of the variable genome of Photobacterium damselae: acquisition of new metabolic traits, antimicrobial resistance and a novel virulence plasmid
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Rodríguez Osorio, Carlos, Vences Lorenzo, Ana, Universidade de Santiago de Compostela. Escola de Doutoramento Internacional (EDIUS), Universidade de Santiago de Compostela. Programa de Doutoramento en Avances en Bioloxía Microbiana e Parasitaria, Suleiman Salameh Abushattal, Saqr, Rodríguez Osorio, Carlos, Vences Lorenzo, Ana, Universidade de Santiago de Compostela. Escola de Doutoramento Internacional (EDIUS), Universidade de Santiago de Compostela. Programa de Doutoramento en Avances en Bioloxía Microbiana e Parasitaria, and Suleiman Salameh Abushattal, Saqr
- Abstract
The two subspecies of Photobacterium damselae, namely subsp. damselae and subsp. piscicida, are pathogenic for diverse fish species of financial importance in marine aquaculture. In the present thesis we have characterized the variable genome in these two subspecies, which proved to be highly diverse. We have demonstrated that horizontal gene transfer has played a major role in the acquisition of the ability to metabolize sucrose, and in antimicrobial resistance in the subspecies damselae. Notably, this study has unveiled the existence of a novel, highly unstable virulence plasmid, encoding a Type III secretion system (T3SS) that is highly prevalent in the subspecies piscicida, and which constitutes a new virulence factor in this pathogen.
- Published
- 2021
40. Multisectoral Interventions to Promote Healthy Living in Latin America and the Caribbean
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Barbieri, María Eugenia, primary, Sarmiento, Olga L., additional, Castillo, Adriana Díaz del, additional, Durán, Ethel Segura, additional, Rodriguez, Evelyne, additional, Sica, Amanda, additional, Mora, Franco González, additional, Abascal, Winston, additional, and Lorenzo, Ana, additional
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- 2013
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41. A cross-country comparison of secondhand smoke exposure among adults: findings from the Global Adult Tobacco Survey (GATS)
- Author
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King, Brian A, Mirza, Sara A, Babb, Stephen D, Hasan, Md Amirul, Malta, Deborah Carvalho, Gonghuan, Yang, Yan, Yang, Lin, Xiao, Qiang, Li, Labib, Sahar Latif, Hussein, Awatef, Vemuri, Anuradha, Kaur, Jagdish, Ram, F, Parasuraman, Sulabha, Avila, Mauricio Hernandez, Miriam, Luz, Shigematsu, Reynales-, Segarra, Agnes, Barcenas, Glenn, Yabut, Benedicta, Parchimowicz, Tadeusz, Zatonski, Witold, Przewozniak, Krzysztof, Raciborski, Filip, Siekierski, Krzysztof, Shevireva, Maria, Kostenko, Natalya, Nesterov, Vadim, Chernisheva, Tamara, Konik, Tatiana, Sakharova, Galina, Benjakul, Sarunya, Termsirikulchai, Lakkhana, Kengganpanich, Mondha, Lohtongmongkol, Areerat, Puckcharern, Hataichanok, Touchchai, Chitrlada, İlter, Hüseyin, Tasti, Enver, Celikkaya, Ramazan, Erdogan, Guzin, Bilir, Nazmi, Özcebe, Hilal, Grygorenko, Alla, Krasovsky, Konstantin, Kharchenko, Natalia, Paniotto, Volodymyr, Andreeva, Tatiana, Abascal, Winston, Lorenzo, Ana, Mora, Franco González, Hai, Phan Thi, Quan, Nguyen The, Minh, Hoang Van, Giang, Kim Bao, Bettcher, Douglas, Bhatti, Lubna, dʼEspaignet, Edouard Tursan, Pujari, Sameer, Yurekli, Ayda, Ouma, AE Ogwell, Ramanandraibe, Nivo, Blanco, Adriana, Caixeta, Roberta de Betania, Gil, Enrique, Gamez, Carlos, Vignolo, Julio, Awa, Fatimah El, Fouad, Heba, Naga, Randa Abou El, Mauer-Stender, Kristina, Khoury, Rula, Koziel, Anna, Migliorini, Luigi, Storozhenko, Oleg, Ergüder, Toker, Korol, Nataliya, Sinha, Dhirendra N, Choudhury, Sohel, Zaman, M Mostafa, Gill, Vineet Munish, Kritiyapichatkul, Chai, Mercado, Susan, Rarick, James, England, Sarah, Miguel-Baquilod, Marina, Nga, Pham Thi Quynh, Khanh, Pham Huyen, Andes, Linda, Asma, Samira, Bilukha, Oksana, Frieden, Thomas R, Blutcher-Nelson, Glenda, Edwards, Peter, Hsia, Jason, Kostova, Deliana, Lea, Veronica, Lee, Juliette, Lindsey, Ronney, McAfee, Timothy, Mirza, Sara, Morton, Jeremy, Palipudi, Krishna, Pechacek, Terry, Shelton, Dana, Song, Sophia, Warren, Charles, Zhao, Luhua, Parra, William, Talley, Brandon, Granoff, Connie, Green, Michael, Cohen, Joanna, Cherukupalli, Rajeev, Litavecz, Steve, Apelberg, Benjamin, Miguel-Baquilod, Marina, Borland, Ron, Giovino, Gary, Gupta, Prakash C, Ferrante, Daniel, Mohammed, Mostafa, Bowling, Michael, Kalsbeek, William, Palipudi, Krishna, Roy, TK, Angell, Sonia, Bhalla, Neeraj, Chaloupka, Frank, Jha, Prabhat, Peto, Richard, Samet, Jonathan, Vendhan, Gajalakshmi, Zatonski, Witold, Henning, Kelly, and Ellis, Jennifer
- Published
- 2013
- Full Text
- View/download PDF
42. Innovación educativa en el teatro : metodología y praxis
- Author
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Gómez Lorenzo, Ana María
- Subjects
enseñanza de lenguas ,teatro escolar ,enseñanza bilingüe - Abstract
Resumen en inglés Se presenta un trabajo en el que se propone al teatro como vehículo y herramienta de comunicación para el aprendizaje de lenguas extranjeras. El teatro permite la intercomunicación al mismo tiempo que permite contextualizar y vivir la palabra. Los objetivos del proyecto son: fomentar en el alumnado el plurilingüismo, potenciando el uso de lenguas extranjeras en el día a día de forma habitual y natural; desarrollar las competencias claves curriculares del alumnado poniendo el acento en la competencia lingüística –verbal y no verbal– y en la socio-cultural, así como en el desarrollo del pensamiento crítico, creativo y emprendedor; establecer un enfoque metodológico basado en proyectos y tareas que incorporen el teatro para dar mejor respuesta a la diversidad; crear un espacio lúdico, dinámico y motivador que permita al alumno aumentar su autoestima y confianza fomentando las relaciones interpersonales y el trabajo responsable y colaborativo y valorar la dramatización como forma de aprendizaje activo y modo de expresión artístico y comunicativo para dinamizar una clase ESP
- Published
- 2019
43. Métodos de pago online
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Martínez Lorenzo, Ana María, Pérez Garzón, José Ignacio, and Universidad de Valladolid. Facultad de Comercio
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Comercio online ,Comercio electrónico - España - Abstract
Los métodos de pago online están en todo el mundo y millones de personas los utilizan a través de dispositivos móviles o por ordenadores en cualquier momento. Por los nuevos canales, se realizan compras de productos y servicios. La metodología que se ha utilizado en este trabajo ha sido analizar las gráficas aportadas por la Comisión Nacional del Mercado de la Competencia a través de las cuales se va a destacar la evolución que ha tenido el comercio electrónico en España, el sector más demandado en este tipo de comercio y el porcentaje de transacciones a lo largo de estos años., Grado en Comercio
- Published
- 2019
44. La inversión exterior y la problemática de la doble imposición
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Martínez Lorenzo, Ana Isabel, Izquierdo Rebollo, Patricia, and Departamentos de la UMH::Estudios Económicos y Financieros
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Comporation tax ,Internacionalización, doble imposición, filial, sucursal, establecimiento permanente, Impuesto de sociedades ,Internationalization, Double taxation, affiliated, brach office, Comporation tax ,internacionalización ,Impuesto de Sociedades ,6 - Ciencias aplicadas::65 - Gestión y organización. Administración y dirección de empresas. Publicidad. Relaciones públicas. Medios de comunicación de masas [CDU] ,affiliated ,filial ,internationalization ,double taxation ,sucursal ,doble imposición - Abstract
Este trabajo pretende analizar desde una perspectiva fiscal, la problemática de la internacionalización de una empresa que decide realizar una inversión en un país extranjero, y en concreto las situaciones doble imposición y sus causas. Para ello tomaremos como ejemplo el caso real de una empresa alicantina en pleno proceso de expansión internacional, que no sólo se ha abierto a la venta internacional, sino que ha dado el paso de invertir fuera del territorio del estado. Se hace un breve repaso por las principales formas jurídicas que utilizan las empresas a la hora de establecerse en el extranjero. Identificando al mismo tiempo la problemática objeto de este trabajo, las situaciones de doble imposición internacional que se dan tanto en el caso de las filiales como en el de las sucursales o establecimientos permanentes. Se nombran los principios tributarios que originan esta situación, y como, tanto los países implicados, como la Unión Europea, y otros organismos internacionales como la OCDE, han tratado de establecer soluciones a través de los modelos de convenio de doble imposición y otros tratados internacionales. A continuación, y tras un breve comentario sobre el país destino de la inversión, se pasa a analizar el Convenio de Doble Imposición, y la legislación interna española sobre del Impuesto de Sociedades, poniendo varios ejemplos prácticos a medida que se analizan los métodos para eliminar la doble imposición. Para finalizar, se repasan los principales apuntes contables que debe realizar la empresa según la forma jurídica elegida para la inversión. Comprobando así, cómo se produce el retorno de las rentas y se integran en la contabilidad de la empresa matriz. This Project looks to analyce, throught a fiscal perspective, the topic of the international expansión of a company who decided to do an investment in a foreing country, and the problematical about doble taxation situations and their causes. For that, there is a real example of an Alicante’s company who is in international expansión process. In the begining of this proyect, there is a little review over the main legal forms witch are usually used by companies to set up abroad. At the same time it is identified this proyect’s topic, the double international taxation’s situations wich there are with affiliated companies and with branch office. There are named the tax principles who originate this situation, and how the countries involved, the European Union and other international organizations like OECD, have tried to establish solutions through the models os double taxation agreement and other international treaties. To continue, and after a brief comment about the investment destination ’s country, it is analiced the Double Taxation Agreement and the Spanish internal legislation on Comporation tax, throught some examples. In the end, there are a reviewed to the main accouinting notes that the companies must make according to the legal form chosed for the investment.
- Published
- 2019
45. V232D mutation in patients with cystic fibrosis
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Fernández-Lorenzo, Ana E., Moreno-Álvarez, Ana, Colon-Mejeras, Cristóbal, Barros-Angueira, Francisco, Solar-Boga, Alfonso, Sirvent-Gómez, Josep, Couce, María L., and Leis, Rosaura
- Subjects
Adult ,Male ,Aspartic Acid ,Cystic Fibrosis ,newborn screening ,Infant, Newborn ,Observational Study ,Cystic Fibrosis Transmembrane Conductance Regulator ,Infant ,lung function ,Valine ,pancreatic insufficiency ,Middle Aged ,genetic testing ,Neonatal Screening ,Amino Acid Substitution ,Forced Expiratory Volume ,Mutation ,Humans ,Exocrine Pancreatic Insufficiency ,Female ,CFTR ,Research Article ,Aged - Abstract
The frequency of some Cystic Fibrosis (CF) Transmembrane Conductance Regulator gene (CFTR) mutations varies between populations. Genetic testing during newborn screening (NBS) for CF can identify less common mutations with low clinical expression in childhood and previously considered mild but not fully characterized, such as the mutation p.Val232Asp (c.695T > A). The aim of this study was to describe CF patients with the V232D mutation. We identify CF children with the V232D mutation detected by NBS and compare them with CF adults with this mutation whose diagnosis was prompted by clinical symptoms in the same period. We studied clinical, biochemical, spirometric, and prognostic features in both populations. NBS program tested 276,523 children during a period of 14 years (2003–2017) and identified 54 cases of CF. Six children (11%) had the V232D mutation. Over the same period, 5 adults (age 37.6 ± 16.29 years old) with symptoms of CF and this mutation were also diagnosed. Follow-up duration was mean 10.1 years for adults and mean 6.5 years for children. In the adult group, lung function was impaired at diagnosis in all patients (Forced Expiratory Volume1—FEV1—67.12% ± 13.09) and worsened in children tested during evolution (FEV1first: 113%; FEV1last: 64%). Pancreatic insufficiency was present in adult group, with recurrent pancreatitis in 1 present. Although with less clinical expression in children, V232D is associated with pulmonary and pancreatic involvement during adulthood and CF cannot be considered mild. This mutation is present in 11% of all patients diagnosed with CF in our region. Its inclusion in some NBS programs should be taken into account in order to improve the prognosis of affected children.
- Published
- 2018
46. Thoracic epidurals in heart valve surgery: Neurologic risk evaluation
- Author
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Cantó, Miguel, Casas, Angeles, Sánchez, Maria J., Lorenzo, Ana, and Bataller, Luisa
- Published
- 2002
- Full Text
- View/download PDF
47. Draft genome sequences of photobacterium damselae subsp. piscicida SNW-8.1 and PP3, two fish-isolated strains containing a type III secretion system
- Author
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Universidade de Santiago de Compostela. Departamento de Microbioloxía e Parasitoloxía, Universidade de Santiago de Compostela. Instituto de Acuicultura, Abushattal, Saqr, Vences Lorenzo, Ana, Santos, Nuno M.S. dos, Vale, Ana do, Rodríguez Osorio, Carlos, Universidade de Santiago de Compostela. Departamento de Microbioloxía e Parasitoloxía, Universidade de Santiago de Compostela. Instituto de Acuicultura, Abushattal, Saqr, Vences Lorenzo, Ana, Santos, Nuno M.S. dos, Vale, Ana do, and Rodríguez Osorio, Carlos
- Abstract
Here, we report the draft genome sequences of two strains of the fishpathogenPhotobacterium damselaesubsp.piscicida, isolated fromSalmo salar(SNW-8.1) andSeriola quinqueradiata(PP3). The identification of a type III secretion systemin the two genomes furthers our understanding of the pathobiology of this sub-species
- Published
- 2019
48. The RstAB System Impacts Virulence, Motility, Cell Morphology, Penicillin Tolerance and Production of Type II Secretion System-Dependent Factors in the Fish and Human Pathogen Photobacterium damselae subsp. damselae
- Author
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Universidade de Santiago de Compostela. Departamento de Bioloxía Funcional, Universidade de Santiago de Compostela. Departamento de Microbioloxía e Parasitoloxía, Universidade de Santiago de Compostela. Instituto de Acuicultura, Terceti, Mateus de Souza, Vences Lorenzo, Ana, Matanza Fente, José Manuel, Vázquez Barca, Alba, Noia Guldrís, Manuel, Lisboa, Johnny, Santos, Nuno Miguel Simões dos, Vale, Ana do, Rodríguez Osorio, Carlos, Universidade de Santiago de Compostela. Departamento de Bioloxía Funcional, Universidade de Santiago de Compostela. Departamento de Microbioloxía e Parasitoloxía, Universidade de Santiago de Compostela. Instituto de Acuicultura, Terceti, Mateus de Souza, Vences Lorenzo, Ana, Matanza Fente, José Manuel, Vázquez Barca, Alba, Noia Guldrís, Manuel, Lisboa, Johnny, Santos, Nuno Miguel Simões dos, Vale, Ana do, and Rodríguez Osorio, Carlos
- Abstract
The RstB histidine kinase of the two component system RstAB positively regulates the expression of damselysin (Dly), phobalysin P (PhlyP) and phobalysin C (PhlyC) cytotoxins in the fish and human pathogen Photobacterium damselae subsp. damselae, a marine bacterium of the family Vibrionaceae. However, the function of the predicted cognate response regulator RstA has not been studied so far, and the role of the RstAB system in other cell functions and phenotypes remain uninvestigated. Here, we analyzed the effect of rstA and rstB mutations in cell fitness and in diverse virulence-related features. Both rstA and rstB mutants were severely impaired in virulence for sea bream and sea bass fish. Mutants in rstA and rstB genes were impaired in hemolysis and in Dly-dependent phospholipase activity but had intact PlpV-dependent phospholipase and ColP-dependent gelatinase activities. rstA and rstB mutants grown at 0.5% NaCl exhibited impaired swimming motility, enlarged cell size and impaired ability to eparate after cell division, whereas at 1% NaCl the mutants exhibited normal henotypes. Mutation of any of the two genes also impacted tolerance to benzylpenicillin. Notably, rstA and rstB mutants showed impaired secretion of a number of type II secretion system (T2SS)-dependent proteins, which included the three major cytotoxins Dly, PhlyP and PhlyC, as well as a putative delta-endotoxin and three additional uncharacterized proteins which might constitute novel virulence factors of this pathogenic bacterium. The analysis of the T2SS-dependent secretome of P. damselae subsp. damselae also led to the identification of RstAB-independent potential virulence factors as lipoproteins, Frontiers in sialidases and proteases. The RstAB regulon included plasmid, chromosome I and chromosome II-encoded genes that showed a differential distribution among isolates of this subspecies. This study establishes RstAB as a major regulator of virulence and diverse cellular functions in P. damselae
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- 2019
49. Identificación y caracterización de genes de virulencia en Photobacterium damselae subsp. damselae: un patógeno de la acuicultura marina
- Author
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Vences Lorenzo, Ana, Rodríguez Osorio, Carlos (dir.), Universidade de Santiago de Compostela. Centro Internacional de Estudos de Doutoramento e Avanzados (CIEDUS), Universidade de Santiago de Compostela. Escola de Doutoramento Internacional en Ciencias da Saúde, and Universidade de Santiago de Compostela. Programa de Doutoramento en Avances en Bioloxía Microbiana e Parasitaria
- Subjects
virulencia ,acuicultura ,Photobacterium damselae subsp. damselae ,Investigación::24 Ciencias de la vida::2401 Biología animal (zoología)::240111 Patología animal [Materias] ,Investigación::24 Ciencias de la vida::2414 Microbiología::241404 Bacteriología [Materias] - Abstract
La bacteria marina Photobacterium damselae subsp. damselae es considerada un patógeno primario de una amplia variedad de especies de peces de interés en acuicultura. Además, es responsable de septicemias hemorrágicas letales en seres humanos, evidenciando su potencial zoonótico. Estudios recientes han puesto de manifiesto que el carácter altamente hemolítico de ciertas cepas de P. damselae subsp. damselae es debido a la presencia del plásmido pPHDD1(150 Kb). Dicho elemento móvil codifica dos hemolisinas: la fosfolipasa D damselisina (Dly) y la hemolisina formadora de poro fobalisina (PhlyP), las cuales juegan un papel crucial en la virulencia para animales homeotermos y poiquilotermos. Cabe destacar que el plásmido pPHDD1 se limita a tan solo una pequeña fracción de las cepas aisladas de brotes en cultivos de peces. Las cepas sin plásmido también presentan una menor actividad hemolítica, debida a la presencia de una toxina cromosómica (PhlyC). A pesar de que las cepas carentes de pPHDD1 son comúnmente aisladas como responsables de brotes en plantas acuícolas, hasta la fecha no se han realizado estudios genéticos destinados a la búsqueda de factores de virulencia adicionales. En el presente estudio, demostramos que la hemolisina PhlyC codificada en el cromosoma I juega un papel en la virulencia y en la citotoxicidad en cepas de P. damselae subsp. damselae carentes de pPHDD1. Además, combinando la secuenciación completa de genomas con la obtención de mutantes por deleción de genes candidatos, hemos identificado dos genes que hasta la fecha no habían sido caracterizados en esta subespecie, y que codifican respectivamente una colagenasa (ColP) y una fosfolipasa (PlpV). Mientras que el gen colP está presente en una fracción pequeña de los aislados estudiados, plpV está presente en todas las cepas. Asimismo, basándonos en la técnica de transposición con mini-Tn10, localizamos al gen lip80 como responsable de la actividad lipolítica detectada en el medio tween 80 en la mayoría de las cepas de P. damselae subsp. damselae. Consecuente con la predicción de péptidos señal en las secuencias aminoacídicas de PhlyC, ColP y PlpV, mutantes para los genes epsL y pilD del Sistema de Secreción de tipo II mostraron una disminución total en la producción de la hemolisina PhlyC y la fosfolipasa PlpV, y parcial de la colagenasa ColP. Datos que ponen de manifiesto la secreción de este tipo de enzimas a través del Sistema de Secreción de tipo II. En contraposición, la enzima lipolítica Lip80 no es translocada al medio extracelular a través de esta vía. Asimismo, ensayos de virulencia en lubina y de citotoxicidad para cultivos celulares de peces y de humanos con los mutantes para diferentes combinaciones de genes, demostraron que hlyAcr, colP y plpV contribuyen a la virulencia y toxicidad celular, siendo los mutantes para hlyAcr y plpV los que exhibieron una mayor reducción en la virulencia en peces. Nuestros resultados confirman el potencial patogénico de las cepas de P. damselae subsp. damselae carentes del plásmido pPHDD1 y demuestran el papel de la hemolisina PhlyC, la fosfolipasa ubicua PlpV y la colagenasa ColP en la virulencia para lubina, y de PhlyC y PlpV en la toxicidad celular para cultivos celulares de peces y humanos.
- Published
- 2018
50. Characterization of Carotid Smooth Muscle Cells during Phenotypic Transition
- Author
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Neurociencias, Neurozientziak, Goikuria Iriondo, Haize, Freijo, María del Mar, Vega Manrique, Reyes, Sastre, María, Elizagaray, Elena, Lorenzo, Ana, Vandenbroeck, Koen, Alloza Moral, Iraide, Neurociencias, Neurozientziak, Goikuria Iriondo, Haize, Freijo, María del Mar, Vega Manrique, Reyes, Sastre, María, Elizagaray, Elena, Lorenzo, Ana, Vandenbroeck, Koen, and Alloza Moral, Iraide
- Abstract
Vascular smooth muscle cells (VSMCs) are central players in carotid atherosclerosis plaque development. Although the precise mechanisms involved in plaque destabilization are not completely understood, it is known that VSMC proliferation and migration participate in plaque stabilization. In this study, we analyzed expression patterns of genes involved in carotid atherosclerosis development (e.g., transcription factors of regulation of SMC genes) of VSMCs located inside or outside the plaque lesion that may give clues about changes in phenotypic plasticity during atherosclerosis. VSMCs were isolated from 39 carotid plaques extracted from symptomatic and asymptomatic patients by endarterectomy. Specific biomarker expression, related with VSMC phenotype, was analyzed by qPCR, western immunoblot, and confocal microscopy. MYH11, CNN1, SRF, MKL2, and CALD1 were significantly underexpressed in VSMCs from plaques compared with VSMCs from a macroscopically intact (MIT) region, while SPP1, KLF4, MAPLC3B, CD68, and LGALS3 were found significantly upregulated in plaque VSMCs versus MIT VSMCs. The gene expression pattern of arterial VSMCs from a healthy donor treated with 7-ketocholesterol showed high similarity with the expression pattern of carotid plaque VSMCs. Our results indicate that VSMCs isolated from plaque show a typical SMC dedifferentiated phenotype with macrophage-like features compared with VSMCs isolated from a MIT region of the carotid artery. Additionally, MYH11, KLF5, and SPP1 expression patterns were found to be associated with symptomatology of human carotid atherosclerosis.
- Published
- 2018
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